{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:42:22Z","timestamp":1790664142001,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012404","name":"Fuyang Normal University","doi-asserted-by":"publisher","award":["2020FSKJ10ZD"],"award-info":[{"award-number":["2020FSKJ10ZD"]}],"id":[{"id":"10.13039\/501100012404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012404","name":"Fuyang Normal University","doi-asserted-by":"publisher","award":["2022FSKJ02"],"award-info":[{"award-number":["2022FSKJ02"]}],"id":[{"id":"10.13039\/501100012404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012404","name":"Fuyang Normal University","doi-asserted-by":"publisher","award":["RCXM202209"],"award-info":[{"award-number":["RCXM202209"]}],"id":[{"id":"10.13039\/501100012404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH050433"],"award-info":[{"award-number":["2023AH050433"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH051343"],"award-info":[{"award-number":["2022AH051343"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2022AH051331"],"award-info":[{"award-number":["2022AH051331"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ecoenv.2025.119392","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:54:36Z","timestamp":1763535276000},"page":"119392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["BPP disrupts spermatogenesis via mitochondrial-ER stress-mediated autophagic flux blockade in mice"],"prefix":"10.1016","volume":"307","author":[{"given":"Shangrong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingmei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9958-8655","authenticated-orcid":false,"given":"Xiaoqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119392_bib1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11626-025-01068-5","article-title":"Cyto-genotoxic assessment of bisphenol P through expression of DNA damage\/repair genes in MDBK cell line","volume":"61","author":"Ali","year":"2025","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.ecoenv.2025.119392_bib2","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.3390\/cells11223601","article-title":"Mechanisms of cadmium-induced testicular injury: a risk to Male fertility","volume":"11","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2025.119392_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.37358\/RC.21.2.8415","article-title":"Comparative study of the biochemical response behavior of some highly toxic minerals on selenosis in rats","volume":"72","author":"Aljerf","year":"2021","journal-title":"Rev. Chim."},{"key":"10.1016\/j.ecoenv.2025.119392_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2025.119392_bib5","doi-asserted-by":"crossref","first-page":"R727","DOI":"10.1016\/j.cub.2022.05.063","article-title":"Endocrine-disrupting chemicals","volume":"32","author":"Bertram","year":"2022","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.ecoenv.2025.119392_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","article-title":"p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death","volume":"171","author":"Bj\u00f8rk\u00f8y","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/10408444.2019.1701986","article-title":"Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances","volume":"50","author":"den Braver-Sewradj","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib8","doi-asserted-by":"crossref","first-page":"123309","DOI":"10.1007\/s11356-023-30815-y","article-title":"Bisphenol a exposure decreases sperm production and Male fertility through inhibition PCBP2 expression","volume":"30","author":"Cao","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2025.119392_bib9","article-title":"Cooperative application of transcriptomics and ceRNA hypothesis: lncRNA-00742\/miR-116 targets CD74 to mediate vanadium-induced mitochondrial apoptosis in duck liver","volume":"480","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119392_bib10","doi-asserted-by":"crossref","first-page":"73174","DOI":"10.1007\/s11356-023-27578-x","article-title":"Bisphenol a substitutes and childhood obesity at 7 years: a cross-sectional study in shandong, china","volume":"30","author":"Chen","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2025.119392_bib11","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.3390\/ijms21165761","article-title":"Potential mechanisms of bisphenol a (BPA) contributing to human disease","volume":"21","author":"Cimmino","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119392_bib12","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1055\/s-0036-1586500","article-title":"Endocrine disruptors: a potential risk factor for gestational diabetes mellitus","volume":"33","author":"Ehrlich","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib13","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1021\/acs.est.0c07587","article-title":"Oxidative stress, endocrine disturbance, and immune interference in humans showed relationships to serum bisphenol concentrations in a dense industrial area","volume":"55","author":"Gao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116202","article-title":"Polystyrene microplastics impair the functions of cultured mouse leydig (TM3) and sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage","volume":"274","author":"Grillo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108383","article-title":"Perfluorooctanoic acid induces cell death in TM3 cells via the ER stress-mitochondrial apoptosis pathway","volume":"118","author":"Han","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109444","article-title":"Polystyrene microplastics induce apoptosis in chicken testis via crosstalk between NF-\u03baB and Nrf2 pathways","volume":"262","author":"Hou","year":"2022","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol. CBP"},{"key":"10.1016\/j.ecoenv.2025.119392_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101282","article-title":"Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis","volume":"97","author":"Ishiguro","year":"2024","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.ecoenv.2025.119392_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35787-5","article-title":"Exposure of environmental bisphenol a in relation to routine sperm parameters and sperm movement characteristics among fertile men","volume":"8","author":"Ji","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119392_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114517","article-title":"Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis","volume":"251","author":"Jia","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S2213-8587(20)30129-7","article-title":"Endocrine-disrupting chemicals: implications for human health","volume":"8","author":"Kahn","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.18502\/ijrm.v22i3.16166","article-title":"Naringenin ameliorates cytotoxic effects of bisphenol a on mouse sertoli cells by suppressing oxidative stress and modulating mitophagy: an experimental study","volume":"22","author":"Khorsandi","year":"2023","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.ecoenv.2025.119392_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2018.12.001","article-title":"Profiling of bisphenol a and eight its analogues on transcriptional activity via human nuclear receptors","volume":"413","author":"Kojima","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119392_bib23","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3390\/ijerph20042877","article-title":"Migration of BPA from food packaging and household products on the croatian market","volume":"20","author":"Krivohlavek","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2025.119392_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114667","article-title":"SWATH-MS reveals that bisphenol a and its analogs regulate pathways leading to disruption in insulin signaling and fatty acid metabolism","volume":"188","author":"Kulsange","year":"2024","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.ecoenv.2025.119392_bib25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/19440049.2013.868611","article-title":"A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China","volume":"31","author":"Liao","year":"2014","journal-title":"Food Addit. Contam. Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.ecoenv.2025.119392_bib26","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/s41556-023-01264-z","article-title":"Mitopherogenesis, a form of mitochondria-specific ectocytosis, regulates sperm mitochondrial quantity and fertility","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164748","article-title":"Bisphenol P and bisphenol M promote triple-negative breast cancer metastasis through activation of AKT pathways","volume":"892","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119392_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127880","article-title":"Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice","volume":"262","author":"Liu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119392_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111481","article-title":"Occurrence, toxicity and ecological risk of bisphenol a analogues in aquatic environment - a review","volume":"208","author":"Liu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/toxics12040294","article-title":"Bisphenol a exposure interferes with reproductive hormones and decreases sperm counts: a systematic review and meta-analysis of epidemiological studies","volume":"12","author":"L\u00fc","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.119392_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107949","article-title":"Bisphenol P exposure in C57BL\/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS\/TLR4\/NF-\u03baB signaling pathway","volume":"175","author":"Ma","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119392_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175159","article-title":"Bisphenol P induces increased oxidative stress in renal tissues of C57BL\/6 mice and human renal cortical proximal tubular epithelial cells, resulting in kidney injury","volume":"949","author":"Ma","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119392_bib33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ecoenv.2025.119392_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/10408444.2021.1908224","article-title":"Toxicity of bisphenol analogues on the reproductive, nervous, and immune systems, and their relationships to gut microbiome and metabolism: insights from a multi-species comparison","volume":"51","author":"McDonough","year":"2021","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib35","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2025.119392_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41585-023-00838-8","article-title":"The effect of red blood cell disorders on Male fertility and reproductive health","volume":"21","author":"Naelitz","year":"2024","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119392_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100766","article-title":"Molecular insights underlying the adverse effects of bisphenol a on gonadal somatic cells\u2019 steroidogenic activity","volume":"23","author":"Palak","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118790","article-title":"Bisphenol a-induced testicular immune dysfunction leads to suppressed steroidogenesis and excessive histamine production","volume":"303","author":"Park","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12594","article-title":"Sperm morphology: evaluating its clinical relevance in contemporary fertility practice","volume":"23","author":"Pelzman","year":"2024","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136797","article-title":"Copper as the driver of the lncRNA-TCONS-6251\/miR-novel-100\/TC2N axis: unraveling ferroptosis in duck kidney","volume":"282","author":"Peng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib42","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/tox.22339","article-title":"Bisphenol a induces autophagy and apoptosis concurrently involving the Akt\/mTOR pathway in testes of pubertal SD rats","volume":"32","author":"Quan","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143408","article-title":"Cytotoxic impacts of seven alternative bisphenols on human in vitro cellular models","volume":"366","author":"Rifa","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119392_bib44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/07482337241233312","article-title":"A biochemical and histological evaluation of in vivo exposure of bisphenol P for multi-organ toxicity and pathology in rats","volume":"40","author":"Sattar","year":"2024","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ecoenv.2025.119392_bib45","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.reprotox.2017.06.134","article-title":"Effects of bisphenol a analogues on reproductive functions in mice","volume":"73","author":"Shi","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106049","article-title":"Microplastics hamper the fertilization success of a broadcast spawning bivalve through reducing gamete collision and gamete fusion efficiency","volume":"242","author":"Shi","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib47","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1038\/s41467-022-34990-3","article-title":"Targeting APLN\/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models","volume":"13","author":"Song","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119392_bib48","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0748233719831528","article-title":"Bisphenol a analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study","volume":"35","author":"Ullah","year":"2019","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ecoenv.2025.119392_bib49","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s11356-019-07111-9","article-title":"Human exposure of bisphenol a and its analogues: understandings from human urinary excretion data and wastewater-based epidemiology","volume":"27","author":"Wang","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int"},{"key":"10.1016\/j.ecoenv.2025.119392_bib50","article-title":"Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy","volume":"135","author":"Wang","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.ecoenv.2025.119392_bib51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ecoenv.2019.03.018","article-title":"Bisphenol P activates hormonal genes and introduces developmental outcomes in Chironomus tentans","volume":"174","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2025.110298","article-title":"EGCG attenuates BPA -induced male reproductive toxicity by regulating the blood-testis barrier by suppressing autophagy via AMPK\/AKT\/mTOR signaling pathway","volume":"297","author":"Wang","year":"2025","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol. CBP"},{"key":"10.1016\/j.ecoenv.2025.119392_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.01.002","article-title":"Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic\u2013pituitary\u2013testicular axis","volume":"329","author":"Wisniewski","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119392_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104150","article-title":"Co-exposure of bisphenol A and selenium deficiency induces pyroptosis via ROS\/NLRP3 pathway in chicken spleen","volume":"103","author":"Xu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2025.119392_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117691","article-title":"Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition","volume":"289","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib56","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41419-022-05364-w","article-title":"Cadmium-induced apoptosis of leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.119392_bib57","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.taap.2016.11.013","article-title":"The regulation of cellular apoptosis by the ROS-triggered PERK\/EIF2\u03b1\/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity","volume":"314","author":"Yin","year":"2017","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119392_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116465","article-title":"The male reproductive toxicity after 5-fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo","volume":"278","author":"Yuan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114703","article-title":"Obesogenic effect of bisphenol P on mice via altering the metabolic pathways","volume":"253","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119963","article-title":"Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds","volume":"311","author":"Zhang","year":"2022","journal-title":"Environ. Pollut. (barking Essex 1987)"},{"key":"10.1016\/j.ecoenv.2025.119392_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106280","article-title":"An in-depth analysis of the effects of excessive acetochlor exposure on chicken liver health","volume":"208","author":"Zhang","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137952","article-title":"Cardiovascular toxicity and mechanism of bisphenol a and emerging risk of bisphenol S","volume":"723","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119392_bib63","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1021\/acsnano.4c15112","article-title":"Polylactic acid micro\/nanoplastic exposure induces male reproductive toxicity by disrupting spermatogenesis and mitochondrial dysfunction in mice","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ecoenv.2025.119392_bib64","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.4103\/NRR.NRR-D-23-00794","article-title":"Endoplasmic reticulum stress and autophagy in cerebral ischemia\/reperfusion injury: PERK as a potential target for intervention","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ecoenv.2025.119392_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114984","article-title":"BPA induces testicular damage in Male rodents via apoptosis, autophagy, and ferroptosis","volume":"193","author":"Zhi","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119392_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117646","article-title":"Effects of environmental bisphenol S exposure on Male rat reproductive health and gut-blood-testicular axis integrity","volume":"289","author":"Zhu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119392_bib67","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/acs.chemrestox.4c00328","article-title":"Mitochondrial dysfunction in environmental toxicology: mechanisms, impacts, and health implications","volume":"37","author":"Zuo","year":"2024","journal-title":"Chem. Res. Toxicol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325017373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325017373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:45:23Z","timestamp":1781271923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325017373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":67,"alternative-id":["S0147651325017373"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119392","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BPP disrupts spermatogenesis via mitochondrial-ER stress-mediated autophagic flux blockade in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119392"}}