{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:45:48Z","timestamp":1791913548300,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070723"],"award-info":[{"award-number":["82070723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42107219"],"award-info":[{"award-number":["42107219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ecoenv.2025.119481","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:12:04Z","timestamp":1764519124000},"page":"119481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization"],"prefix":"10.1016","volume":"308","author":[{"given":"Heng","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhe","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119481_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102576","article-title":"Attenuation of inflammation, oxidative stress and TGF-\u03b21\/Smad3 signaling and upregulation of Nrf2\/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity","volume":"91","author":"Alruhaimi","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.ecoenv.2025.119481_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112564","article-title":"Sulfated Undaria pinnatifida polysaccharide inhibits the formation of kidney stones by inhibiting HK-2 cell damage and reducing the adhesion of nano\u2011calcium oxalate crystals","volume":"134","author":"Chen","year":"2022","journal-title":"Biomater. Adv."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.imlet.2010.04.003","article-title":"Differential roles of Annexin A1 (ANXA1\/lipocortin-1\/lipomodulin) and thioredoxin binding protein-2 (TBP-2\/VDUP1\/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells","volume":"131","author":"Chen","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119481_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154603","article-title":"Guhong injection mitigates myocardial ischemia\/reperfusion injury by activating GST P to inhibit ASK1-JNK\/p38 pathway","volume":"109","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119481_bib5","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","article-title":"TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target","volume":"55","author":"Choi","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119481_bib6","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1021\/pr3000738","article-title":"High calcium enhances calcium oxalate crystal binding capacity of renal tubular cells via increased surface annexin A1 but impairs their proliferation and healing","volume":"11","author":"Chutipongtanate","year":"2012","journal-title":"J. Proteome Res"},{"issue":"15","key":"10.1016\/j.ecoenv.2025.119481_bib7","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1007\/s11356-018-1631-0","article-title":"Cadmium exposure and early renal effects in the children and adults living in a tungsten-molybdenum mining areas of South China","volume":"25","author":"Cui","year":"2018","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2025.119481_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110042","article-title":"Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3\u03b2\/Nrf2 signaling-mediated ferroptosis in vivo and in vitro","volume":"117","author":"Dong","year":"2023","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ki.2012.320","article-title":"Temporal trends in the incidence of kidney stone disease","volume":"83","author":"Edvardsson","year":"2013","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119481_bib10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1039\/c2mt20024d","article-title":"Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells","volume":"4","author":"Fujishiro","year":"2012","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/ijmm.2020.4770","article-title":"Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis","volume":"47","author":"He","year":"2021","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.ecoenv.2025.119481_bib12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1186\/1471-2458-13-590","article-title":"Exposure assessment of dietary cadmium: findings from Shanghainese over 40 years, China","volume":"13","author":"He","year":"2013","journal-title":"BMC Public Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.119481_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1023\/B:BIOM.0000045730.01633.45","article-title":"Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment","volume":"17","author":"Jin","year":"2004","journal-title":"Biometals"},{"issue":"3","key":"10.1016\/j.ecoenv.2025.119481_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.mayocp.2017.11.018","article-title":"The changing incidence and presentation of urinary stones over 3 decades","volume":"93","author":"Kittanamongkolchai","year":"2018","journal-title":"Mayo Clin. Proc."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.119481_bib15","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s00204-021-03157-2","article-title":"Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS\/MAPK\/NF-\u03baB pathway in vitro and in vivo","volume":"95","author":"Li","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119481_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cca.2022.05.009","article-title":"Annexin A protein family in atherosclerosis","volume":"531","author":"Li","year":"2022","journal-title":"Clin. Chim. Acta"},{"issue":"6","key":"10.1016\/j.ecoenv.2025.119481_bib17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00240-012-0507-x","article-title":"Renal tubular epithelial cell injury, apoptosis and inflammation are involved in melamine-related kidney stone formation","volume":"40","author":"Lu","year":"2012","journal-title":"Urol. Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.21037\/tcr-23-1532","article-title":"Comprehensive profiling of cell subsets of gastric cancer and liver metastasis based on single cell RNA-sequencing analysis","volume":"13","author":"Pan","year":"2024","journal-title":"Transl. Cancer Res"},{"key":"10.1016\/j.ecoenv.2025.119481_bib19","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.ijbiomac.2020.09.085","article-title":"Differential bound proteins and adhesive capabilities of calcium oxalate monohydrate crystals with various sizes","volume":"163","author":"Peerapen","year":"2020","journal-title":"Int J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.119481_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00269-017-0907-0","article-title":"Crystal structure and spectroscopic behavior of synthetic novgorodovaite Ca2(C2O4)Cl2\u00b72H2O and its twinned triclinic heptahydrate analog","volume":"45","author":"Piro","year":"2018","journal-title":"Phys. Chem. Miner."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119481_bib21","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1016\/j.apt.2021.08.021","article-title":"Elucidating the role of hyaluronic acid in the structure and morphology of calcium oxalate crystals","volume":"32","author":"Polat","year":"2021","journal-title":"Adv. Powder Technol."},{"key":"10.1016\/j.ecoenv.2025.119481_bib22","article-title":"Environmental cadmium exposure and the risk of kidney stones: a systematic review and dose-response meta-analysis","volume":"12","author":"Ren","year":"2025","journal-title":"Front Med (Lausanne)"},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2025.119481_bib23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.fct.2017.06.013","article-title":"Current health risk assessment practice for dietary cadmium: Data from different countries","volume":"106","author":"Satarug","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.eururo.2012.03.052","article-title":"Prevalence of kidney stones in the United States","volume":"62","author":"Scales","year":"2012","journal-title":"Eur. Urol."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119481_bib25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/CIRCULATIONAHA.118.039345","article-title":"Novel Role for the AnxA1-Fpr2\/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation","volume":"140","author":"Senchenkova","year":"2019","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ecoenv.2025.119481_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.02.010","article-title":"Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2\/PI3K\/AKT signaling to promote the progression of kidney stones","volume":"14","author":"Song","year":"2024","journal-title":"J. Pharm. Anal."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.119481_bib27","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00345-017-2008-6","article-title":"Epidemiology of stone disease across the world","volume":"35","author":"Sorokin","year":"2017","journal-title":"World J. Urol."},{"key":"10.1016\/j.ecoenv.2025.119481_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcrysgro.2018.08.020","article-title":"Preparation and characterization of calcium oxalate dihydrate seeds suitable for crystal growth kinetic analyses","volume":"500","author":"Stankovi\u0107","year":"2018","journal-title":"J. Cryst. Growth"},{"key":"10.1016\/j.ecoenv.2025.119481_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.863364","article-title":"Exosomes Derived From Human Gingival Mesenchymal Stem Cells Attenuate the Inflammatory Response in Periodontal Ligament Stem Cells","volume":"10","author":"Sun","year":"2022","journal-title":"Front Chem."},{"key":"10.1016\/j.ecoenv.2025.119481_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103682","article-title":"Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion","volume":"84","author":"Tan","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.119481_bib31","first-page":"415","article-title":"Toxicology of cadmium and its damage to mammalian organs","volume":"11","author":"Th\u00e9venod","year":"2013","journal-title":"Met Ions Life Sci."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2025.119481_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cca.2005.11.033","article-title":"Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, pH, stirring and temperature","volume":"367","author":"Thongboonkerd","year":"2006","journal-title":"Clin. Chim. Acta"},{"issue":"12","key":"10.1016\/j.ecoenv.2025.119481_bib33","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41581-020-0320-7","article-title":"Determining the true burden of kidney stone disease","volume":"16","author":"Thongprayoon","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.119481_bib34","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.envpol.2019.03.063","article-title":"Cadmium contamination in agricultural soils of China and the impact on food safety","volume":"249","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"issue":"18","key":"10.1016\/j.ecoenv.2025.119481_bib35","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.kint.2021.02.025","article-title":"Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy","volume":"100","author":"Wu","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecoenv.2025.119481_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9019404","article-title":"Downregulation of TNF-\u03b1\/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury","volume":"2019","author":"Yu","year":"2019","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119481_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/bju.13828","article-title":"Prevalence of kidney stones in China: an ultrasonography based cross-sectional study","volume":"120","author":"Zeng","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.ecoenv.2025.119481_bib39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.scitotenv.2013.09.070","article-title":"Cadmium exposure and its health effects: a 19-year follow-up study of a polluted area in China","volume":"470-471","author":"Zhang","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119481_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170488","article-title":"Assessment of human exposure to cadmium and its nephrotoxicity in the Chinese population","volume":"918","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325018263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325018263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:52:40Z","timestamp":1773845560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325018263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":40,"alternative-id":["S0147651325018263"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119481","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119481"}}