{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:50:56Z","timestamp":1773881456505,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ecoenv.2025.119507","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:25:32Z","timestamp":1764728732000},"page":"119507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Unveiling the role of Hedgehog signaling pathway in mitigating methylisothiazolinone-induced anxiety in zebrafish"],"prefix":"10.1016","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-1325","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangbo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianjia","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunXia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119507_bib1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jcb.30296","article-title":"Quercetin ameliorates thioacetamide-induced hepatic fibrosis and oxidative stress by antagonizing the Hedgehog signaling pathway","volume":"123","author":"Aslam","year":"2022","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.ecoenv.2025.119507_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: the core pathogenesis and mechanism of Alzheimer's disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ecoenv.2025.119507_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115784","article-title":"Critical window of exposure of CMIT\/MIT with respect to developmental effects on zebrafish embryos: multi-level endpoint and proteomics analysis","volume":"268","author":"Chatterjee","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119507_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.ecoenv.2025.119507_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.numecd.2020.02.014","article-title":"Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells","volume":"30","author":"Chen","year":"2020","journal-title":"Nutr. Metab. Cardiovasc Dis."},{"key":"10.1016\/j.ecoenv.2025.119507_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111488","article-title":"A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner","volume":"41","author":"Chung","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2025.119507_bib7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.mcn.2003.10.024","article-title":"Hedgehog interacting protein in the mature brain: membrane-associated and soluble forms","volume":"25","author":"Coulombe","year":"2004","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ecoenv.2025.119507_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/hmg\/ddaf016","article-title":"HHIP protein interactions in lung cells provide insight into COPD pathogenesis","volume":"34","author":"Deritei","year":"2025","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.ecoenv.2025.119507_bib10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00204-020-02930-z","article-title":"A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn(2+) and generating reactive oxygen species","volume":"95","author":"Do","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib11","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1523\/JNEUROSCI.22-17-07408.2002","article-title":"In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway","volume":"22","author":"Du","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1011669","article-title":"Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy","volume":"13","author":"Du","year":"2022","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/10715762.2018.1475733","article-title":"The role of oxidative stress in anxiety disorder: cause or consequence?","volume":"52","author":"Fedoce","year":"2018","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.ecoenv.2025.119507_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202405655","article-title":"Calcium Hexacyanoferrate (III) nanocatalyst enables redox homeostasis for autism spectrum disorder treatment","volume":"36","author":"Feng","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ecoenv.2025.119507_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.tins.2019.07.002","article-title":"Anxiety and brain mitochondria: a bidirectional crosstalk","volume":"42","author":"Filiou","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139593","article-title":"The impaired swim bladder via ROS-mediated inhibition of the Wnt \/ Hedgehog pathway in zebrafish embryos exposed to eight toxic chemicals and binary chemical mixtures","volume":"338","author":"Gao","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119507_bib17","doi-asserted-by":"crossref","first-page":"7171","DOI":"10.1038\/s41467-021-27475-2","article-title":"Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling","volume":"12","author":"Griffiths","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119507_bib18","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1124\/jpet.106.103044","article-title":"Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons","volume":"317","author":"He","year":"2006","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.ecoenv.2025.119507_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yexcr.2016.11.008","article-title":"Sonic hedgehog promotes neurite outgrowth of cortical neurons under oxidative stress: Involving of mitochondria and energy metabolism","volume":"350","author":"He","year":"2017","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.ecoenv.2025.119507_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136229","article-title":"Individual and combined effects of sodium dichloroisocyanurate and isothiazolinone on the cyanobacteria-Vallisneria natans-microbe aquatic ecosystem","volume":"480","author":"Huang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.119507_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114634","article-title":"Compound Tongluo decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction","volume":"283","author":"Hui","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41392-023-01559-5","article-title":"Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies","volume":"8","author":"Jing","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2025.119507_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40104-022-00824-x","article-title":"Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway","volume":"14","author":"Joo","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/jamapsychiatry.2022.2066","article-title":"Association of oxidative stress-induced nucleic acid damage with psychiatric disorders in adults: a systematic review and meta-analysis","volume":"79","author":"Jorgensen","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ecoenv.2025.119507_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/15287394.2024.2420083","article-title":"The effect of biocide chloromethylisothiazolinone\/methylisothiazolinone (CMIT\/MIT) mixture on C2C12 muscle cell damage attributed to mitochondrial reactive oxygen species overproduction and autophagy activation","volume":"88","author":"Kim","year":"2025","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ecoenv.2025.119507_bib27","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1007\/s00204-020-02915-y","article-title":"Shedding new light on early sex determination in zebrafish","volume":"94","author":"King","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib28","doi-asserted-by":"crossref","first-page":"E4681","DOI":"10.1073\/pnas.1602342113","article-title":"Hhip haploinsufficiency sensitizes mice to age-related emphysema","volume":"113","author":"Lao","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2025.119507_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138392","article-title":"Nociceptive effects and gene alterations of CMIT\/MIT mixture in zebrafish embryos and larvae","volume":"493","author":"Lee","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.119507_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1471-4159.2011.07308.x","article-title":"Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation","volume":"118","author":"Li","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ecoenv.2025.119507_bib31","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143767","article-title":"Anxiety caused by chronic exposure to methylisothiazolinone in zebrafish: Behavioral analysis, brain histology and gene responses","volume":"368","author":"Li","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119507_bib33","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/tox.23545","article-title":"Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety-like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae","volume":"37","author":"Lite","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib34","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s10815-024-03131-8","article-title":"PDLIM3 knockdown promotes ferroptosis in endometriosis progression via inducing Gli1 degradation and blocking Hedgehog signaling pathway","volume":"41","author":"Liu","year":"2024","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.ecoenv.2025.119507_bib35","first-page":"3374","article-title":"An Nfic-hedgehog signaling cascade regulates tooth root development","volume":"142","author":"Liu","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2025.119507_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188890","article-title":"GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochim Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.ecoenv.2025.119507_bib37","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/01.wnr.0000187632.91375.81","article-title":"Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells","volume":"16","author":"Loulier","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.ecoenv.2025.119507_bib38","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176214","article-title":"Deacetylepoxyazadiradione ameliorates diabesity in in-vivo zebrafish larval model by influencing the level of regulatory adipokines and oxidative stress","volume":"961","author":"Murugan","year":"2023","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119507_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154807","article-title":"Lobetyolin Alleviates Ferroptosis of Skeletal Muscle in 5\/6 Nephrectomized Mice via Activation of Hedgehog-GLI1 Signaling","volume":"115","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2025.119507_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123765","article-title":"Urban pathways of biocides towards surface waters during dry and wet weathers: Assessment at the Paris conurbation scale","volume":"402","author":"Paijens","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.119507_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13164227","article-title":"Casein Kinase 1D Encodes a novel drug target in hedgehog-GLI-driven cancers and tumor-initiating cells resistant to SMO inhibition","volume":"13","author":"Peer","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ecoenv.2025.119507_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154026","article-title":"Long-term exposure to environmental relevant triclosan induces reproductive toxicity on adult zebrafish and its potential mechanism","volume":"826","author":"Qiao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119507_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jes.2025.02.004","article-title":"Auramine O, food dye induces cognitive impairment, anxiety, alters synaptic transmission and neural growth in zebrafish model","volume":"158","author":"Ramamurthy","year":"2025","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69423-y","article-title":"Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio)","volume":"10","author":"Rassier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119507_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrn704","article-title":"Hedgehog-Gli signalling and the growth of the brain","volume":"3","author":"Ruiz i Altaba","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143410","article-title":"Hedgehog\/GLI signaling pathway: transduction, regulation, and implications for disease","volume":"13","author":"Sigafoos","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ecoenv.2025.119507_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25040991","article-title":"Isothiazolinone biocides: chemistry, biological, and toxicity profiles","volume":"25","author":"Silva","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.119507_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2023.01.032","article-title":"Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.ecoenv.2025.119507_bib50","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jad.2022.11.072","article-title":"Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials","volume":"323","author":"Wang","year":"2023","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ecoenv.2025.119507_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbrc.2019.04.047","article-title":"Hhip inhibits proliferation and promotes differentiation of adipocytes through suppressing hedgehog signaling pathway","volume":"514","author":"Wei","year":"2019","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.ecoenv.2025.119507_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.711710","article-title":"The Role of Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases","volume":"8","author":"Yang","year":"2021","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.ecoenv.2025.119507_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2020.113547","article-title":"Growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) are potential intraovarian regulators of steroidogenesis in Japanese flounder (Paralichthys olivaceus)","volume":"297","author":"Yu","year":"2020","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119507_bib54","article-title":"The dual-target nanoparticles with ROS sensitivity inhibit the Hedgehog signaling pathway and decrease oxidative stress in activated hepatic stellate cells to alleviate liver fibrosis","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ecoenv.2025.119507_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7126976","article-title":"Chidamide inhibits glioma cells by increasing oxidative stress via the miRNA-338-5p regulation of Hedgehog signaling","volume":"2020","author":"Zhou","year":"2020","journal-title":"Oxid. Med Cell Longev."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325018524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325018524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:21:31Z","timestamp":1773861691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325018524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":55,"alternative-id":["S0147651325018524"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119507","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the role of Hedgehog signaling pathway in mitigating methylisothiazolinone-induced anxiety in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119507"}}