{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:30:51Z","timestamp":1793806251151,"version":"4.6.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YDZJ202501ZYTS218"],"award-info":[{"award-number":["YDZJ202501ZYTS218"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2025.119558","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:43:21Z","timestamp":1765647801000},"page":"119558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Vitexin ameliorates PM2.5-triggered pulmonary toxicity through dual modulation of endoplasmic reticulum stress and ferroptosis pathways"],"prefix":"10.1016","volume":"309","author":[{"given":"Xuyang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonggang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaopeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-5294","authenticated-orcid":false,"given":"Junpeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119558_bib1","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis [Article]","author":"Bin","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119558_bib2","article-title":"PM 2.5 induces autophagy-dependent ferroptosis by endoplasmic reticulum stress in SH-SY5Y cells [Article]","author":"Can Can","year":"2023","journal-title":"J Appl. toxicol. JAT"},{"key":"10.1016\/j.ecoenv.2025.119558_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155282","article-title":"Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1\/Nrf2\/SLC7A11\/GPX4 pathway [Article]","volume":"124","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"issue":"19","key":"10.1016\/j.ecoenv.2025.119558_bib4","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/bph.16085","article-title":"Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury","volume":"180","author":"Dong","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.119558_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.apr.2022.101407","article-title":"Experimental rodent models exposed to fine particulate matter (PM2.5) highlighting the injuries in the central nervous system: a systematic review [Review]","volume":"13","author":"Ferreira","year":"2022","journal-title":"Atmos. Pollut. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119558_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12989-024-00585-7","article-title":"Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro [Article]","volume":"21","author":"Gunasingam","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.119558_bib7","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s11064-022-03829-0","article-title":"Vitexin improves cerebral ischemia-reperfusion injury by attenuating oxidative injury and ferroptosis via Keap1\/Nrf2\/HO-1signaling [Article]","volume":"48","author":"Guo","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ecoenv.2025.119558_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114362","article-title":"Oxidative stress is the pivot for PM2.5-induced lung injury [Review]","volume":"184","author":"Hou","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119558_bib9","article-title":"PM2.5 induces epithelial-to-mesenchymal transition by oxidative stress in renal tubular kidney cells [Meeting Abstract]","volume":"35","author":"Kang","year":"2024","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.119558_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173264","article-title":"Vitexin ameliorates chronic stress plub high fat diet-induced nonalcoholic fatty liver disease by inhibiting inflammation [Article]","volume":"882","author":"Li","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ecoenv.2025.119558_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124145","article-title":"Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK\/ATF4-mediated endoplasmic reticulum stress [Article]","volume":"352","author":"Li","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119558_bib12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.freeradbiomed.2021.05.028","article-title":"Vitexin alleviates high-fat diet induced brain oxidative stress and inflammation via anti-oxidant, anti-inflammatory and gut microbiota modulating properties [Article]","volume":"171","author":"Li","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2025.119558_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171396","article-title":"Atmospheric fine particulate matter (PM2.5) induces pulmonary fibrosis by regulating different cell fates via autophagy [Article]","volume":"923","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119558_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108290","article-title":"PM2.5 triggers autophagic degradation of Caveolin-1 via endoplasmic reticulum stress (ERS) to enhance the TGF-\u03b21\/Smad3 axis promoting pulmonary fibrosis [Article]","volume":"181","author":"Liu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119558_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160839","article-title":"Glyphosate-triggered hepatocyte ferroptosis via suppressing Nrf2\/GSH\/GPX4 axis exacerbates hepatotoxicity [Article]","volume":"862","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119558_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125997","article-title":"Microglia-derived IL-1\u03b2 promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK\/eIF2\u03b1\/ATF4\/CHOP upon arsenic exposure [Article]","volume":"417","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119558_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121659","article-title":"PM2.5 induces vascular permeability increase through activating MAPK\/ERK signaling pathway and ROS generation [Article]","volume":"386","author":"Long","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119558_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153514","article-title":"Wnt5a\/Ca2+signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance [Article]","volume":"490","author":"Ma","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119558_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120981","article-title":"Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM2.5-induced lung cancer development [Article]","volume":"319","author":"Ma","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119558_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168578","article-title":"PM2.5 exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway [Article]","volume":"910","author":"Mei","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119558_bib21","article-title":"Protective role of vitamin D receptor against mitochondrial calcium overload from PM 2.5 -Induced injury in renal tubular cells [Article]","author":"Mengqiu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.119558_bib22","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.2c02470","article-title":"Sesamin Ameliorates Fine Particulate Matter (PM2.5)-Induced Lung Injury via Suppression of Apoptosis and Autophagy in Rats br [Article; Early Access]","author":"Ren","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119558_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s11658-023-00513-1","article-title":"Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis [Article]","volume":"28","author":"Ren","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119558_bib24","article-title":"Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis [Article]","author":"Sheng","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119558_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s10020-023-00735-1","article-title":"Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation [Article]","volume":"29","author":"Song","year":"2023","journal-title":"Mol. Med."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119558_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046902","article-title":"Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a Comparative Study [Article]","volume":"7","author":"Spiliotopoulos","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.ecoenv.2025.119558_bib27","article-title":"Dual role of Baimao-Longdan-Congrong-Fang in inhibiting Staphylococcus aureus virulence factors and regulating TNF-\u03b1\/TNFR1\/NF-\u03baB\/MMP9 axis [Article]","author":"Tao","year":"2025","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.119558_bib28","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.3390\/ijerph19127511","article-title":"Recent insights into Particulate Matter (PM2.5)-mediated toxicity in humans: an overview [Review]","volume":"19","author":"Thangavel","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2025.119558_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109186","article-title":"Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice [Article]","volume":"112","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119558_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121798","article-title":"linc01515 regulates PM2.5-induced oxidative stress via targeting NRF2 in airway epithelial cells*","volume":"331","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119558_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114708","article-title":"YAP1 protects against PM2.5-induced lung toxicity by suppressing pyroptosis and ferroptosis [Article]","volume":"253","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119558_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124130","article-title":"PM2.5-induced ferroptosis by Nrf2\/Hmox1 signaling pathway led to inflammation in microglia [Article]","volume":"352","author":"Wei","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119558_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112433","article-title":"PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice [Article]","volume":"221","author":"Xiong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119558_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153568","article-title":"Vitamin B ameliorates PM2.5-induced kidney damage by reducing endoplasmic reticulum stress and oxidative stress in pregnant mice and HK-2 [Article]","volume":"494","author":"Xu","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119558_bib35","article-title":"Vitexin attenuates smoke inhalation induced acute lung injury in rats by inhibiting oxidative stress via PKC \u03b2\/p66Shc signaling pathway [Article]","author":"Xuxin","year":"2023","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.ecoenv.2025.119558_bib36","article-title":"Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver [Article]","author":"Yan","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ecoenv.2025.119558_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114083","article-title":"PM2.5 inhibits system Xc- activity to induce ferroptosis by activating the AMPK-Beclin1 pathway in acute lung injury [Article]","volume":"245","author":"Yan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119558_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41419-020-03027-2","article-title":"Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis [Article]","volume":"11","author":"Yang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"24","key":"10.1016\/j.ecoenv.2025.119558_bib39","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1039\/D3FO03641C","article-title":"Astaxanthin alleviates fine particulate matter (PM2.5)-induced lung injury in rats by suppressing ferroptosis and apoptosis [Article]","volume":"14","author":"Yin","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.119558_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109608","article-title":"rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice [Article]","volume":"114","author":"Zeng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119558_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116866","article-title":"Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway [Article]","volume":"176","author":"Zhao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2025.119558_bib42","article-title":"Sestrin2 regulates endoplasmic reticulum stress-dependent ferroptosis to engage pulmonary fibrosis by nuclear factor erythroid 2-related factor 2\/activating transcription factor 4 (NRF2\/ATF4) [Article]","author":"Zhaoxing","year":"2023","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.ecoenv.2025.119558_bib43","article-title":"Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma [Article]","author":"Zhongren","year":"2022","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.ecoenv.2025.119558_bib44","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1158\/1078-0432.CCR-09-0661","article-title":"Vitexins, Nature-derived lignan compounds, induce apoptosis and suppress tumor growth [Article]","volume":"15","author":"Zhou","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.119558_bib45","article-title":"Organelle symphony: nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology [Article]","author":"Ziliang","year":"2025","journal-title":"Neural Regen. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:17:44Z","timestamp":1793805464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325019037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"alternative-id":["S0147651325019037"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119558","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitexin ameliorates PM2.5-triggered pulmonary toxicity through dual modulation of endoplasmic reticulum stress and ferroptosis pathways","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119558"}}