{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:24:46Z","timestamp":1793809486909,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703500"],"award-info":[{"award-number":["2022YFC2703500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC2708000"],"award-info":[{"award-number":["2025YFC2708000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["882088102"],"award-info":[{"award-number":["882088102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2024-10"],"award-info":[{"award-number":["2024-10"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2025.119605","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:17:46Z","timestamp":1767687466000},"page":"119605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction"],"prefix":"10.1016","volume":"309","author":[{"given":"Yanhui","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7581-1104","authenticated-orcid":false,"given":"Yingyu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119605_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/862982","article-title":"Levels of oxidized LDL, estrogens, and progesterone in placenta tissues and serum paraoxonase activity in preeclampsia","volume":"2013","author":"Acikgoz","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ecoenv.2025.119605_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/dead016","article-title":"Paraben exposure and couple fecundity: a preconception cohort study","author":"Ao","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2025.119605_bib3","series-title":"Williams Textbook of Endocrinology (Thirteenth Edition)","first-page":"831","article-title":"Chapter 21 - Endocrine Changes in Pregnancy","author":"Berga","year":"2016"},{"issue":"2","key":"10.1016\/j.ecoenv.2025.119605_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1210\/er.2016-1065","article-title":"From pregnancy to preeclampsia: a key role for estrogens","volume":"38","author":"Berkane","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2025.119605_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.placenta.2018.07.004","article-title":"Abnormal steroidogenesis and aromatase activity in preeclampsia","volume":"69","author":"Berkane","year":"2018","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.ecoenv.2025.119605_bib6","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1997","key":"10.1016\/j.ecoenv.2025.119605_bib7","first-page":"20230191","article-title":"The human placenta: new perspectives on its formation and function during early pregnancy","volume":"290","author":"Burton","year":"2023","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119605_bib8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3389\/fphar.2018.01027","article-title":"Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta","volume":"9","author":"Chatuphonprasert","year":"2018","journal-title":"Front Pharm."},{"key":"10.1016\/j.ecoenv.2025.119605_bib9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.envpol.2017.06.025","article-title":"Comparative toxicity and endocrine disruption potential of urban and rural atmospheric organic PM1 in JEG-3 human placental cells","volume":"230","author":"van Drooge","year":"2017","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.119605_bib10","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/AOG.0000000000004251","article-title":"ACOG practice bulletin, number 227","volume":"137","author":"Fetal Growth Restriction","year":"2021","journal-title":"Obstet. Gynecol."},{"issue":"31","key":"10.1016\/j.ecoenv.2025.119605_bib11","doi-asserted-by":"crossref","first-page":"13687","DOI":"10.1021\/acs.est.4c04940","article-title":"Sex-Specific and trimester-specific associations of prenatal exposure to bisphenols, parabens, and triclosan with neonatal birth size and gestational age","volume":"58","author":"Fu","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"7226","key":"10.1016\/j.ecoenv.2025.119605_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature07614","article-title":"Structural basis for androgen specificity and oestrogen synthesis in human aromatase","volume":"457","author":"Ghosh","year":"2009","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119605_bib13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","article-title":"Placenta disrupted: endocrine disrupting chemicals and pregnancy","volume":"31","author":"Gingrich","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2025.119605_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113502","article-title":"Association between parabens concentrations in human amniotic fluid and the offspring birth size: a sub-study of the PERSIAN birth cohort","volume":"212","author":"Golestanzadeh","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.119605_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117244","article-title":"Aromatase as a novel target of parabens in human and rat placentas: 3D-quantitative structure-activity relationship and docking analysis","volume":"286","author":"Gong","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119605_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.envint.2018.03.017","article-title":"Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts","volume":"115","author":"Govarts","year":"2018","journal-title":"Environ. Int"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.119605_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJMra000471","article-title":"Mechanisms of disease - production and actions of estrogens","volume":"346","author":"Gruber","year":"2002","journal-title":"N. Engl. J. Med"},{"issue":"10389","key":"10.1016\/j.ecoenv.2025.119605_bib18","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0140-6736(23)00573-1","article-title":"Biological and pathological mechanisms leading to the birth of a small vulnerable newborn","volume":"401","author":"Hunter","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.119605_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1529071","article-title":"Impact of pregnancy on the levels of parabens and bisphenol a: data from NHANES 2005-2010","volume":"2016","author":"Jain","year":"2016","journal-title":"J. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119605_bib20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41467-019-14202-1","article-title":"Maternal paraben exposure triggers childhood overweight development","volume":"11","author":"Leppert","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119605_bib21","article-title":"Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocation","author":"Li","year":"2025","journal-title":"Placenta"},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119605_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072592","article-title":"Influence of estrogens on uterine vascular adaptation in normal and preeclamptic pregnancies","volume":"21","author":"Mandal\u00e0","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.119605_bib23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/jes.2016.65","article-title":"Daily intake and hazard index of parabens based upon 24\u2009h urine samples of the German environmental specimen Bank from 1995 to 2012","volume":"27","author":"Moos","year":"2017","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.ecoenv.2025.119605_bib24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.mce.2018.03.014","article-title":"Parabens and their effects on the endocrine system","volume":"474","author":"Nowak","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.119605_bib25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humupd\/dmad016","article-title":"The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester","volume":"29","author":"Parisi","year":"2023","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119605_bib26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/HYPERTENSIONAHA.116.08468","article-title":"Testosterone represses estrogen signaling by upregulating miR-22: a mechanism for imbalanced steroid hormone production in preeclampsia","volume":"69","author":"Shao","year":"2017","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119605_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/HYPERTENSIONAHA.116.08468","article-title":"Testosterone represses estrogen signaling by upregulating mir-22: a mechanism for imbalanced steroid hormone production in preeclampsia","volume":"69","author":"Shao","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.ecoenv.2025.119605_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110235","article-title":"Profiles of parabens and their metabolites in paired maternal-fetal serum, urine and amniotic fluid and their implications for placental transfer","volume":"191","author":"Song","year":"2020","journal-title":"Ecotox Environ. Safe"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119605_bib29","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1038\/s41467-024-48897-8","article-title":"Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype","volume":"15","author":"Symeonides","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.119605_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1530\/REP-11-0288","article-title":"The complete control of murine pregnancy from embryo implantation to parturition","volume":"143","author":"Terakawa","year":"2012","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119605_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-020-00635-5","article-title":"Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study","volume":"19","author":"Vrijens","year":"2020","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.119605_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146150","article-title":"Parabens as chemicals of emerging concern in the environment and humans: A review","volume":"778","author":"Wei","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119605_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/acs.est.8b01857","article-title":"Repeated measurements of paraben exposure during pregnancy in relation to fetal and early childhood growth","volume":"53","author":"Wu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119605_bib34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.chemosphere.2019.05.133","article-title":"A mechanism for the effect of endocrine disrupting chemicals on placentation","volume":"231","author":"Yang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119605_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109419","article-title":"Urinary parabens in adults from South China: implications for human exposure and health risks","volume":"182","author":"Yu","year":"2019","journal-title":"Ecotox Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.119605_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ecoenv.2019.04.083","article-title":"Occurrence, distribution, bioaccumulation, and ecological risk of bisphenol analogues, parabens and their metabolites in the Pearl River Estuary, South China","volume":"180","author":"Zhao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119605_bib37","article-title":"HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia","volume":"15","author":"Zheng","year":"2025","journal-title":"Sci. Rep."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:24:39Z","timestamp":1793805879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325019505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":37,"alternative-id":["S0147651325019505"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119605","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119605"}}