{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:28:33Z","timestamp":1793806113244,"version":"4.6.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020758","name":"Science and Technology Innovation Group of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276118"],"award-info":[{"award-number":["22276118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22076109"],"award-info":[{"award-number":["22076109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476119"],"award-info":[{"award-number":["22476119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2025.119621","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:17:46Z","timestamp":1767687466000},"page":"119621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exposure to responsible components of PM2.5 induces hepatic steatosis: An in silico, in vitro, and in vivo study based on adverse outcome pathway"],"prefix":"10.1016","volume":"309","author":[{"given":"Zhipeng","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-4798","authenticated-orcid":false,"given":"Guohua","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119621_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"Gromacs: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","author":"Abraham","year":"2015","journal-title":"SoftwareX 12"},{"key":"10.1016\/j.ecoenv.2025.119621_bib2","series-title":"Environmental Geochemistry and Health","article-title":"A systematic review on global pollution status of particulate matter-associated potential toxic elements and health perspectives in urban environment","author":"Ali","year":"2019"},{"key":"10.1016\/j.ecoenv.2025.119621_bib3","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1021\/tx500345j","article-title":"Defining molecular initiating events in the adverse outcome pathway framework for risk assessment","volume":"27","author":"Allen","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib4","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1021\/acs.chemrestox.6b00341","article-title":"A history of the molecular initiating event","volume":"29","author":"Allen","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abe8244","article-title":"From cohorts to molecules: adverse impacts of endocrine disrupting mixtures","volume":"375","author":"Caporale","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.119621_bib7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1074\/jbc.M113.522847","article-title":"Ceramides and glucosylceramides are independent antagonists of insulin signaling","volume":"289","author":"Chavez","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib8","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1021\/acs.est.0c02237","article-title":"Uptake, accumulation, and biomarkers of PM2.5-associated organophosphate flame retardants in C57BL\/6 mice after chronic exposure at real environmental concentrations","volume":"54","author":"Chen","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.chemosphere.2019.04.226","article-title":"Seasonally varied cytotoxicity of organic components in PM2.5 from urban and industrial areas of a Chinese megacity","volume":"230","author":"Chen","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119621_bib10","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1038\/nutd.2014.38","article-title":"Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults","volume":"4","author":"Hanamatsu","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.ecoenv.2025.119621_bib11","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal"},{"key":"10.1016\/j.ecoenv.2025.119621_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106339","article-title":"Identification of toxicity pathway of diesel particulate matter using AOP of PPAR\u03b3 inactivation leading to pulmonary fibrosis","volume":"147","author":"Jeong","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119621_bib13","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.3c07395","article-title":"Nontargeted identification of organic components in fine particulate matter related to lung tumor metastasis based on an adverse outcome pathway strategy","author":"Ji","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib14","doi-asserted-by":"crossref","first-page":"10589","DOI":"10.1021\/acs.est.1c02023","article-title":"Organic components of personal PM 2.5 exposure associated with in fl ammation: evidence from an untargeted exposomic approach","volume":"55","author":"Jiang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-anchem-061516-045135","article-title":"Molecular characterization of atmospheric organic aerosol by mass spectrometry","volume":"12","author":"Johnston","year":"2019","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.scitotenv.2010.11.035","article-title":"Estimation of the contribution of ultrafine particles to lung deposition of particle-bound mutagens in the atmosphere","volume":"409","author":"Kawanaka","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00535-013-0758-5","article-title":"Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease","volume":"48","author":"Kawano","year":"2013","journal-title":"J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119621_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12989-020-00343-5","article-title":"Sex-dependent effects of ambient PM 2. 5 pollution on insulin sensitivity and hepatic lipid metabolism in mice","volume":"17","author":"Li","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161375","article-title":"Higher toxicity induced by co-exposure of polystyrene microplastics and chloramphenicol to Microcystis aeruginosa: Experimental study and molecular dynamics simulation","volume":"866","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envint.2015.10.016","article-title":"Review on recent progress in observations, source identifications and countermeasures of PM2.5","volume":"86","author":"Liang","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119621_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111283","article-title":"An adverse outcome pathway-based approach to assess steatotic mixture effects of hepatotoxic pesticides in vitro","volume":"139","author":"Lichtenstein","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118898","article-title":"Toxicological effects of atenolol and venlafaxine on zebrafish tissues: Bioaccumulation, DNA hypomethylation, and molecular mechanism","volume":"299","author":"Lin","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119621_bib23","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1021\/acs.est.0c08578","article-title":"Plastic Additives in Ambient Fine Particulate Matter in the Pearl River Delta, China: High-Throughput Characterization and Health Implications","volume":"55","author":"Liu","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/139875","article-title":"Nuclear receptors in nonalcoholic fatty liver disease","volume":"2012","author":"L\u00f3pez-Vel\u00e1zquez","year":"2012","journal-title":"J. Lipids"},{"key":"10.1016\/j.ecoenv.2025.119621_bib25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib26","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1021\/acs.chemrestox.8b00112","article-title":"Adverse outcome pathway-driven analysis of liver steatosis in vitro: a case study with cyproconazole","volume":"31","author":"Luckert","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib27","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1021\/es501973d","article-title":"Health risk characterization for resident inhalation exposure to particle-bound halogenated flame retardants in a typical e-waste recycling zone","volume":"48","author":"Luo","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib28","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.ecoenv.2025.119621_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/10408444.2015.1089471","article-title":"The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways","volume":"46","author":"Mellor","year":"2016","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib30","doi-asserted-by":"crossref","unstructured":"Metrics, G.H., 2020. Global burden of 87 risk factors in 204 countries and territories, 1990 \u2013 2019: a systematic analysis for the Global Burden of Disease Study 2019 1223\u20131249. https:\/\/doi.org\/10.1016\/S0140-6736(20)30752-2.","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"10.1016\/j.ecoenv.2025.119621_bib31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cbi.2010.01.008","article-title":"Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile","volume":"184","author":"Moya","year":"2010","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2025.119621_bib32","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1074\/jbc.M610072200","article-title":"Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver","volume":"282","author":"Nakamura","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.apr.2021.101122","article-title":"Atmospheric PM2.5-bound polycyclic aromatic hydrocarbons in China\u2019s four cities: characterization, risk assessment, and epithelial-to-mesenchymal transition induced by PM2.5","volume":"12","author":"Nan","year":"2021","journal-title":"Atmos. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2025.119621_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/wcms.1327","article-title":"Software update: the ORCA program system, version 4.0","volume":"8","author":"Neese","year":"2018","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119621_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122611","article-title":"Risk assessment of the lipid metabolism-disrupting effects of nitro-PAHs","volume":"396","author":"Ning","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119621_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.119621_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/tx500428r","article-title":"Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis","volume":"28","author":"Qian","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42004-020-0291-4","article-title":"Non-bonded force field model with advanced restrained electrostatic potential charges (RESP2)","volume":"3","author":"Schauperl","year":"2020","journal-title":"Commun. Chem."},{"key":"10.1016\/j.ecoenv.2025.119621_bib39","article-title":"Lipidomics insight into chronic exposure to ambient air pollution in","volume":"262","author":"Shui","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119621_bib40","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-med.2023.100042","article-title":"Exposure to airborne PM2.5 chemical exposome increases heart rate of middle- and old-aged populations","volume":"1","author":"Sun","year":"2023","journal-title":"Innov. Med."},{"key":"10.1016\/j.ecoenv.2025.119621_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gutjnl-2021-324364","article-title":"Long-term exposure to fine particulate matter and non-alcoholic fatty liver disease: a prospective cohort study","volume":"71","author":"Sun","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2025.119621_bib42","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science (80. )"},{"key":"10.1016\/j.ecoenv.2025.119621_bib43","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1021\/acs.chemrestox.5b00208","article-title":"Adverse outcome pathways and drug-induced liver injury testing","volume":"28","author":"Vinken","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113611","article-title":"PM 2. 5 air pollution exposure and nonalcoholic fatty liver disease in the nationwide inpatient sample","volume":"213","author":"Vopham","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.119621_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160286","article-title":"Environmental exposure to triazole fungicide causes left-right asymmetry defects and contributes to abnormal heart development in zebrafish embryos by activating PPAR\u03b3-coupled Wnt\/\u03b2-catenin signaling pathway","volume":"859","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib46","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.celrep.2017.02.019","article-title":"Plasma dihydroceramides are diabetes susceptibility biomarker candidates in mice and humans","volume":"18","author":"Wigger","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2025.119621_bib47","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.chemosphere.2018.12.016","article-title":"Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p\/ transforming growth factor \u0392 type II receptor axis","volume":"219","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119621_bib48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/BJ20102012","article-title":"Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P2 in regulating insulin sensitivity defined by knock-in analysis","volume":"434","author":"Wullschleger","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.ecoenv.2025.119621_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145179","article-title":"Comparative studies on regional variations in PM2.5 in the induction of myocardial hypertrophy in mice","volume":"775","author":"Xing","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159258","article-title":"Biochemical evidence of PM2.5 critical components for inducing myocardial fibrosis in vivo and in vitro","volume":"857","author":"Xing","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib51","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.freeradbiomed.2018.11.016","article-title":"Prolonged PM2. 5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia","volume":"130","author":"Xu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2025.119621_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121220","article-title":"Effects of differential regional PM 2.5 induced hepatic steatosis and underlying mechanism \u2606","volume":"323","author":"Yan","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119621_bib53","doi-asserted-by":"crossref","first-page":"10458","DOI":"10.1021\/acs.est.3c10012","article-title":"Multilevel screening strategy to identify the hydrophobic organic components of ambient PM2.5 associated with hepatocellular steatosis","volume":"58","author":"Yan","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128368","article-title":"Adverse outcome pathway of fine particulate matter leading to increased cardiovascular morbidity and mortality: an integrated perspective from toxicology and epidemiology","volume":"430","author":"Yu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119621_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111399","article-title":"Occurrence and human exposure assessment of organophosphate esters in atmospheric PM2.5 in the Beijing-Tianjin-Hebei region, China","volume":"206","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119621_bib56","first-page":"1768","article-title":"role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"20","author":"Zhang","year":"2014"},{"key":"10.1016\/j.ecoenv.2025.119621_bib57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.scitotenv.2012.05.059","article-title":"Calculated respiratory exposure to indoor size-fractioned polycyclic aromatic hydrocarbons in an urban environment","volume":"431","author":"Zhang","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119621_bib58","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2012.08.009","article-title":"Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model","volume":"58","author":"Zheng","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2025.119621_bib59","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1074\/jbc.M511116200","article-title":"A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:57:59Z","timestamp":1793804279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325019669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"alternative-id":["S0147651325019669"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119621","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to responsible components of PM2.5 induces hepatic steatosis: An in silico, in vitro, and in vivo study based on adverse outcome pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119621"}}