{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:30:01Z","timestamp":1793806201498,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010716","name":"City of Vienna","doi-asserted-by":"publisher","award":["21134"],"award-info":[{"award-number":["21134"]}],"id":[{"id":"10.13039\/501100010716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/ESP 87"],"award-info":[{"award-number":["10.55776\/ESP 87"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2025.119636","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:17:46Z","timestamp":1767687466000},"page":"119636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The mycotoxin zearalenone and its metabolite \u03b1-zearalenol impair anticancer activity of doxorubicin in estrogen receptor-positive breast cancer cells"],"prefix":"10.1016","volume":"309","author":[{"given":"Judith","family":"Gufler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Max","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Marko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-1044","authenticated-orcid":false,"given":"Sonja","family":"Hager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119636_bib1","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.2903\/j.efsa.2011.2407","article-title":"Scientific Opinion on the risks for animal and public health related to the presence of Alternaria toxins in feed and food","volume":"9","author":"Alexander","year":"2011","journal-title":"EFSA J."},{"key":"10.1016\/j.ecoenv.2025.119636_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2011.09.029","article-title":"Urinary mycoestrogens, body size and breast development in New Jersey girls","volume":"409","author":"Bandera","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119636_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/CAD.0b013e3282ef4571","article-title":"Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells","volume":"18","author":"Bar-On","year":"2007","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ecoenv.2025.119636_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2004.03.118","article-title":"Rapid yeast estrogen bioassays stably expressing human estrogen receptors \u03b1 and \u03b2, and green fluorescent protein: A comparison of different compounds with both receptor types","volume":"91","author":"Bovee","year":"2004","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/377552a0","article-title":"Radiation-induced cell cycle arrest compromised by p21 deficiency","volume":"377","author":"Brugarolas","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.119636_bib6","first-page":"30","article-title":"Signal transduction through the Ras\/Erk pathway is essential for the mycoestrogen Zearalenone-induced cell-cycle progression in MCF-7 cells","author":"Calaluce","year":"2001","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ecoenv.2025.119636_bib7","article-title":"The story of MCF-7 breast cancer cell line: 40 Years of experience in research","volume":"35","author":"Com\u015fa \u015e","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ecoenv.2025.119636_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2013.02.016","article-title":"Human exposure to mycotoxins and their masked forms through cereal-based foods in Belgium","volume":"218","author":"De Boevre","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119636_bib9","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.45.32099","article-title":"Mechanisms of transcriptional activation of bcl-2 gene expression by 17\u03b2-estradiol in breast cancer cells","volume":"274","author":"Dong","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.119636_bib10","article-title":"Appropriateness to set a group health-based guidance value for zearalenone and its modified forms","volume":"14","author":"EFSA Panel on Contaminants in the Food Chain C","year":"2016","journal-title":"EFSA J."},{"key":"10.1016\/j.ecoenv.2025.119636_bib11","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1607303","article-title":"Palbociclib and Letrozole in Advanced Breast Cancer","volume":"375","author":"Finn","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ecoenv.2025.119636_bib12","doi-asserted-by":"crossref","unstructured":"Foster N. Doxorubicin: Anticancer Antibiotics. vol. 5. 1982.","DOI":"10.1097\/00000421-198206000-00020"},{"key":"10.1016\/j.ecoenv.2025.119636_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.20689","article-title":"The p53 tumor suppressor participates in multiple cell cycle checkpoints","volume":"209","author":"Giono","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib14","doi-asserted-by":"crossref","DOI":"10.1677\/erc.0.0100193","article-title":"The expression and function of estrogen receptor \u03b1 and \u03b2 in human breast cancer and its clinical application","volume":"10","author":"Hayashi","year":"2003","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ecoenv.2025.119636_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2017.08.010","article-title":"Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30","volume":"461","author":"He","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-008-8020-0","article-title":"Phytoestrogens and breast cancer: A complex story","volume":"16","author":"Helferich","year":"2008","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ecoenv.2025.119636_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2016.05.161","article-title":"Exploration of Bcl-2 family and caspases-dependent apoptotic signaling pathway in Zearalenone-treated mouse endometrial stromal cells","volume":"476","author":"Hu","year":"2016","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.ecoenv.2025.119636_bib18","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.pharmtox.39.1.295","article-title":"Cyclins and cell cycle checkpoints","volume":"39","author":"Johnson","year":"1999","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1634\/theoncologist.2012-0373","article-title":"A review of breast cancer care and outcomes in Latin America","volume":"18","author":"Justo","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.ecoenv.2025.119636_bib20","first-page":"470","article-title":"Mycotoxins: Diffuse and point source contributions of natural contaminants of emerging concern to streams","author":"Kolpin","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119636_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2016.10.015","article-title":"Zearalenone as an endocrine disruptor in humans","volume":"48","author":"Kowalska","year":"2016","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119636_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109081","article-title":"Longitudinal biomonitoring of mycotoxin exposure during pregnancy in the Yale Pregnancy Outcome Prediction Study","volume":"194","author":"Krausov\u00e1","year":"2024","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.119636_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ecoenv.2025.119636_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-016-1704-0","article-title":"Biomonitoring of the mycotoxin Zearalenone: current state-of-the art and application to human exposure assessment","volume":"90","author":"Mally","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.fct.2018.04.027","article-title":"Circulating zearalenone and its metabolites differ in women due to body mass index and food intake","volume":"116","author":"Mauro","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbr.2017.04.002","article-title":"Climate change, food security and mycotoxins: Do we know enough?","volume":"31","author":"Medina","year":"2017","journal-title":"Fungal Biol. Rev."},{"key":"10.1016\/j.ecoenv.2025.119636_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2011.01.028","article-title":"Mycoestrogen pollution of Italian infant food","volume":"159","author":"Meucci","year":"2011","journal-title":"J. Pedia"},{"key":"10.1016\/j.ecoenv.2025.119636_bib28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.toxlet.2005.05.017","article-title":"Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters","volume":"159","author":"Minervini","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119636_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2005.05.017","article-title":"Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters","volume":"159","author":"Minervini","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119636_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/0015-6264(81)90299-6","article-title":"Comparative metabolism of zearalenone and transmission into bovine milk","volume":"19","author":"Mirocha","year":"1981","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2018.06.037","article-title":"Sant\u2019Ana AS. Prevalence and concentration of ochratoxin A, zearalenone, deoxynivalenol and total aflatoxin in cereal-based products: A systematic review and meta-analysis","volume":"118","author":"Mousavi Khaneghah","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.foodcont.2016.07.033","article-title":"Natural mycotoxin contamination of maize (Zea mays L.) in the South region of Brazil","volume":"73","author":"Oliveira","year":"2017","journal-title":"Food Control"},{"key":"10.1016\/j.ecoenv.2025.119636_bib33","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.50.33533","article-title":"Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis: lesson from an uncleavable mutant","volume":"273","author":"Oliver","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.119636_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2014.06.012","article-title":"Estrogen receptors alpha (ER\u03b1) and beta (ER\u03b2): Subtype-selective ligands and clinical potential","volume":"90","author":"Paterni","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.ecoenv.2025.119636_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.20.8.2890-2901.2000","article-title":"17\u03b2-Estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence","volume":"20","author":"Perillo","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.25268","article-title":"The phytoestrogen genistein affects breast cancer cells treatment depending on the ER\u03b1\/ER\u03b2 Ratio","volume":"117","author":"Pons","year":"2016","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.ecoenv.2025.119636_bib37","doi-asserted-by":"crossref","DOI":"10.1159\/000341394","article-title":"A mechanistic study of the effect of doxorubicin\/adriamycin on the estrogen response in a breast cancer model","volume":"83","author":"Pritchard","year":"2012","journal-title":"Oncol"},{"key":"10.1016\/j.ecoenv.2025.119636_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2006.02.005","article-title":"Cyclin D1 and breast cancer","volume":"15","author":"Roy","year":"2006","journal-title":"Breast"},{"key":"10.1016\/j.ecoenv.2025.119636_bib39","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2025.119636_bib40","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202209125","article-title":"Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications","volume":"222","author":"Soliman","year":"2023","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib41","article-title":"Breast cancer in premenopausal and postmenopausal women. J Natl Cancer Inst","volume":"53","author":"Stavraky","year":"1974"},{"key":"10.1016\/j.ecoenv.2025.119636_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jsfa.6225","article-title":"Mycotoxin occurrence in feed and feed raw materials worldwide: Long-term analysis with special focus on Europe and Asia","volume":"93","author":"Streit","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.ecoenv.2025.119636_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2006.08.008","article-title":"Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro","volume":"103","author":"Takemura","year":"2007","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/biology9120427","article-title":"Phytoestrogens for cancer prevention and treatment","volume":"9","author":"Torrens-Mas","year":"2020","journal-title":"Biology"},{"key":"10.1016\/j.ecoenv.2025.119636_bib45","article-title":"Breast cancer treatment: a review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA J. Am. Med Assoc."},{"key":"10.1016\/j.ecoenv.2025.119636_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.583572","article-title":"Estrogen receptor \u03b1 mediates doxorubicin sensitivity in breast cancer cells by regulating E-Cadherin","volume":"9","author":"Wan","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2017.12.010","article-title":"Metabolomics reveals that dietary xenoestrogens alter cellular metabolism induced by palbociclib\/letrozole combination cancer therapy","volume":"25","author":"Warth","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ecoenv.2025.119636_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2004.10.003","article-title":"Anti-apoptotic action of zearalenone in MCF-7 cells","volume":"62","author":"Yu","year":"2005","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325019815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:10:59Z","timestamp":1793805059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325019815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":48,"alternative-id":["S0147651325019815"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119636","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mycotoxin zearalenone and its metabolite \u03b1-zearalenol impair anticancer activity of doxorubicin in estrogen receptor-positive breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119636"}}