{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:29:10Z","timestamp":1793806150345,"version":"4.6.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471196"],"award-info":[{"award-number":["82471196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFF1202900"],"award-info":[{"award-number":["2022YFF1202900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010229","name":"Natural Science Foundation of Tianjin Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["22JCQNJC00890"],"award-info":[{"award-number":["22JCQNJC00890"]}],"id":[{"id":"10.13039\/501100010229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2026.119690","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:32:31Z","timestamp":1768458751000},"page":"119690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Airborne polystyrene nanoplastic exposure leads to splenic cell senescence and immune imbalance"],"prefix":"10.1016","volume":"309","author":[{"given":"Meixue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.119690_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126084","article-title":"Micro\/nanoplastics effects on organisms: a review focusing on 'dose","volume":"417","author":"Agathokleous","year":"2021","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119690_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2026.119690_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envint.2017.02.013","article-title":"Distribution and importance of microplastics in the marine environment: a review of the sources, fate, effects, and potential solutions","volume":"102","author":"Auta","year":"2017","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.119690_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/eap.2044","article-title":"What is known and unknown about the effects of plastic pollution: a meta-analysis and systematic review","volume":"30","author":"Bucci","year":"2020","journal-title":"Ecol. Appl."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.119690_bib5","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/etc.4268","article-title":"Microplastics in the aquatic environment: evidence for or against adverse impacts and major knowledge gaps","volume":"37","author":"Burns","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2026.119690_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176469","article-title":"Airborne polystyrene nanoplastics exposure leads to heart failure via ECM-receptor interaction and PI3K\/AKT\/BCL-2 pathways","volume":"954","author":"Chang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.119690_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137393","article-title":"Toxicological effects and mechanisms of renal injury induced by inhalation exposure to airborne nanoplastics","volume":"488","author":"Chen","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119690_bib8","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cell.2012.03.043","article-title":"Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair","volume":"149","author":"D'Angiolella","year":"2012","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.ecoenv.2026.119690_bib9","doi-asserted-by":"crossref","first-page":"9660","DOI":"10.1073\/pnas.1002298107","article-title":"Paradoxical suppression of cellular senescence by p53","volume":"107","author":"Demidenko","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2026.119690_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169514","article-title":"Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: oxidative stress related-DNA damage and potential carcinogenicity","volume":"912","author":"Ding","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.119690_bib11","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1073\/pnas.1115201109","article-title":"Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration","volume":"109","author":"Diril","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2026.119690_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.marpolbul.2018.11.022","article-title":"Microplastics: Finding a consensus on the definition","volume":"138","author":"Frias","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2026.119690_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170342","article-title":"Ferroptosis participated in inhaled polystyrene nanoplastics-induced liver injury and fibrosis","volume":"916","author":"Ge","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119690_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2026.119690_bib15","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.envpol.2018.01.024","article-title":"Current opinion: what is a nanoplastic?","volume":"235","author":"Gigault","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119690_bib16","article-title":"New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress","author":"Guo","year":"2024","journal-title":"Poult. Sci."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.119690_bib17","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/tox.23886","article-title":"Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL\/6J mice","volume":"38","author":"Guo","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib18","article-title":"Toxic effects of nanoplastics with different sizes and surface charges on epithelial-to-mesenchymal transition in A549 cells and the potential toxicological mechanism","volume":"430","author":"Halimu","year":"2022","journal-title":"o. H. M."},{"key":"10.1016\/j.ecoenv.2026.119690_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.scitotenv.2017.01.190","article-title":"Microplastics in freshwater and terrestrial environments: evaluating the current understanding to identify the knowledge gaps and future research priorities","volume":"586","author":"Horton","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.119690_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107817","article-title":"Cellular senescence and hematological malignancies: from pathogenesis to therapeutics","volume":"223","author":"Hu","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ecoenv.2026.119690_bib21","article-title":"Microplastics induce immune suppression via S100A8 downregulation","volume":"242","author":"Juan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119690_bib22","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1021\/acs.est.5b06069","article-title":"Microplastic as a vector for chemicals in the aquatic environment: critical review and model-supported reinterpretation of empirical studies","volume":"50","author":"Koelmans","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00018-017-2681-z","article-title":"Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2\/M","volume":"75","author":"Li","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2026.119690_bib24","article-title":"Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt\/\u03b2-catenin signaling pathway in mice","volume":"232","author":"Li","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119690_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2026.119690_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174360","article-title":"Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei","volume":"946","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.119690_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176718","article-title":"Polystyrene nanoplastics induce apoptosis, histopathological damage, and glutathione metabolism disorder in the intestine of juvenile East Asian river prawns (Macrobrachium nipponense)","volume":"954","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"18","key":"10.1016\/j.ecoenv.2026.119690_bib28","doi-asserted-by":"crossref","first-page":"10612","DOI":"10.1021\/acs.est.9b03427","article-title":"Consistent transport of terrestrial microplastics to the ocean through atmosphere","volume":"53","author":"Liu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126069","article-title":"Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology","volume":"416","author":"Lu","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"21","key":"10.1016\/j.ecoenv.2026.119690_bib30","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3390\/cells13211788","article-title":"Molecular and cellular effects of microplastics and nanoplastics: focus on inflammation and senescence","volume":"13","author":"Mahmud","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119690_bib31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/acel.12588","article-title":"Residual Cdk1\/2 activity after DNA damage promotes senescence","volume":"16","author":"M\u00fcllers","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.ecoenv.2026.119690_bib32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.canlet.2020.09.016","article-title":"Reality CHEK: understanding the biology and clinical potential of CHK1","volume":"497","author":"Neizer-Ashun","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ecoenv.2026.119690_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psep.2020.05.050","article-title":"Review of microplastic occurrence and toxicological effects in marine environment: experimental evidence of inflammation","volume":"142","author":"Pirsaheb","year":"2020","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.ecoenv.2026.119690_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: An overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.119690_bib35","unstructured":"Prevention, C. f D.C. a, 1988. OSHA PEL Project Documentation. National Institute for Occupational Safety and Health."},{"issue":"7881","key":"10.1016\/j.ecoenv.2026.119690_bib36","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-021-03864-x","article-title":"Direct radiative effects of airborne microplastics","volume":"598","author":"Revell","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.119690_bib37","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.7150\/ijbs.4989","article-title":"IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6","volume":"8","author":"Rose-John","year":"2012","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119690_bib38","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/s41467-017-01883-9","article-title":"DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells","volume":"8","author":"Sato","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.119690_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118986","article-title":"Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS\/STING pathway","volume":"300","author":"Shen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119690_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116925","article-title":"Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice","volume":"284","author":"Shi","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119690_bib41","article-title":"Rethinking and optimising plastic waste management under COVID-19 pandemic: Policy solutions based on redesign and reduction of single-use plastics and personal protective equipment","volume":"742","author":"Silva","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"18","key":"10.1016\/j.ecoenv.2026.119690_bib42","doi-asserted-by":"crossref","first-page":"11191","DOI":"10.1021\/acs.est.0c02288","article-title":"Rapid production of micro-and nanoplastics by fragmentation of expanded polystyrene exposed to sunlight","volume":"54","author":"Song","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109699","article-title":"Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos","volume":"271","author":"Suman","year":"2023","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138404","article-title":"Polystyrene nanoplastics exposure trigger cognitive impairment mitigated by luteolin modulated glucose-6-phosphate dehydrogenase\/glutathione-dependent pathway","author":"Tan","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.119690_bib45","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/tox.23618","article-title":"Polystyrene nanoplastics exacerbated lipopolysaccharide-induced necroptosis and inflammation via the ROS\/MAPK pathway in mice spleen","volume":"37","author":"Tang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109550","article-title":"Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish","volume":"345","author":"Umamaheswari","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119690_bib47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jcp.10140","article-title":"GADD45b and GADD45g are cdc2\/cyclinB1 kinase inhibitors with a role in S and G2\/M cell cycle checkpoints induced by genotoxic stress","volume":"192","author":"Vairapandi","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125918","article-title":"Polystyrene nanoplastics alter virus replication in orange-spotted grouper (Epinephelus coioides) spleen and brain tissues and spleen cells","volume":"416","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"17","key":"10.1016\/j.ecoenv.2026.119690_bib49","doi-asserted-by":"crossref","first-page":"12368","DOI":"10.1021\/acs.est.1c08888","article-title":"The lung microbiota affects pulmonary inflammation and oxidative stress induced by PM2. 5 exposure","volume":"56","author":"Wang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"50","key":"10.1016\/j.ecoenv.2026.119690_bib50","doi-asserted-by":"crossref","first-page":"76378","DOI":"10.1007\/s11356-022-21061-9","article-title":"Assessment of the inhalation exposure and incremental lifetime cancer risk of PM2. 5 bounded polycyclic aromatic hydrocarbons (PAHs) by different toxic equivalent factors and occupancy probability, in the case of Xi\u2019an","volume":"29","author":"Wang","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2026.119690_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119060","article-title":"Polystyrene nanoplastics induced lung injury in mice: Insights into lung metabolic disorders","volume":"303","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119690_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105411","article-title":"Atmospheric microplastic deposition in an urban environment and an evaluation of transport","volume":"136","author":"Wright","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.119690_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109266","article-title":"Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics","volume":"195","author":"Yang","year":"2025","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119690_bib54","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s40726-023-00273-8","article-title":"Human microplastics exposure and potential health risks to target organs by different routes: A review","volume":"9","author":"Yang","year":"2023","journal-title":"Curr. Pollut. Rep."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119690_bib55","first-page":"3108","article-title":"Airborne nanoplastics exposure inducing irreversible glucose increase and complete hepatic insulin resistance","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119690_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119133","article-title":"Polystyrene nanoplastics induce cognitive dysfunction and dendritic spine deterioration via excessive mitochondrial fission","volume":"304","author":"Yu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119690_bib57","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1021\/acs.est.9b04535","article-title":"A review of microplastics in table salt, drinking water, and air: direct human exposure","volume":"54","author":"Zhang","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"27","key":"10.1016\/j.ecoenv.2026.119690_bib58","doi-asserted-by":"crossref","first-page":"18085","DOI":"10.1074\/jbc.M109.003020","article-title":"Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.119690_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112882","article-title":"Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL\/6J mice through polarization of macrophages and increased infiltration of natural killer cells","volume":"227","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:03:25Z","timestamp":1793804605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"alternative-id":["S0147651326000199"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119690","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Airborne polystyrene nanoplastic exposure leads to splenic cell senescence and immune imbalance","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119690","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119690"}}