{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:07:20Z","timestamp":1782536840602,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2026.119739","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:44:47Z","timestamp":1768553087000},"page":"119739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Elucidating the mechanism of polycyclic aromatic hydrocarbons-induced osteoporosis through network toxicology and molecular docking approaches: BaP as a model compound"],"prefix":"10.1016","volume":"310","author":[{"given":"Jianfu","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ecoenv.2026.119739_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s12403-023-00596-3","article-title":"Exposure to Environmental Chemicals and Human Bone Health; A Systematic Review and Meta-Analysis","volume":"16","author":"Baradaran Mahdavi","year":"2024","journal-title":"Expo. Health"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119739_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/10937404.2022.2164390","article-title":"Polycyclic aromatic hydrocarbons (PAHs): Updated aspects of their determination, kinetics in the human body, and toxicity","volume":"26","author":"Barbosa","year":"2023","journal-title":"J. Toxicol. Environ. Health Part B"},{"key":"10.1016\/j.ecoenv.2026.119739_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129869","article-title":"Effects of polycyclic aromatic hydrocarbons on marine and freshwater microalgae - A review","volume":"441","author":"Ben Othman","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119739_bib4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s11270-011-0953-z","article-title":"Impact of Emission Reductions between 1980 and 2020 on Atmospheric Benzo[a]pyrene Concentrations over Europe","volume":"223","author":"Bieser","year":"2012","journal-title":"Water Air Soil Pollut."},{"issue":"7674","key":"10.1016\/j.ecoenv.2026.119739_bib5","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1038\/550S15a","article-title":"Osteoporosis: Staying strong","volume":"550","author":"Brown","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119739_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10653-012-9462-2","article-title":"Promoting the use of BaP as a marker for PAH exposure in UK soils","volume":"35","author":"Bull","year":"2013","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.ecoenv.2026.119739_bib7","article-title":"Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme","author":"Chen","year":"2025","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119739_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/EJE-19-0750","article-title":"Association between polycyclic aromatic hydrocarbons exposure and bone turnover in adults","volume":"182","author":"Chen","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.119739_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mrrev.2015.03.001","article-title":"Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment","volume":"764","author":"Chepelev","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.ecoenv.2026.119739_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114687","article-title":"Network toxicology and molecular docking for the toxicity analysis of food contaminants: A case of Aflatoxin B(1)","volume":"188","author":"Chu","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119739_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11657-018-0527-4","article-title":"Association between polycyclic aromatic hydrocarbons and osteoporosis: data from NHANES, 2005-2014","volume":"13","author":"Duan","year":"2018","journal-title":"Arch. Osteoporos."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.119739_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/ijerph18020738","article-title":"Environmental Substances Associated with Osteoporosis-A Scoping Review","volume":"18","author":"Elonheimo","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2026.119739_bib13","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene Ontology Consortium: going forward","volume":"43","author":"GeneOntologyConsortium","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119739_bib14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2174\/1871530321666210118163538","article-title":"Bone Disruption and Environmental Pollutants","volume":"22","author":"Giannattasio","year":"2022","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.ecoenv.2026.119739_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.envpol.2018.04.108","article-title":"Associations of urinary polycyclic aromatic hydrocarbons with bone mass density and osteoporosis in U.S. adults, NHANES 2005-2010","volume":"240","author":"Guo","year":"2018","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.119739_bib16","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.7150\/ijbs.94339","article-title":"Cigarette smoke promotes IL-6-dependent lung cancer migration and osteolytic bone metastasis","volume":"20","author":"Guo","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.119739_bib17","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41551-019-0470-8","article-title":"Computationally designed antibody\u2013drug conjugates self-assembled via affinity ligands","volume":"3","author":"Gupta","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ecoenv.2026.119739_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126642","article-title":"Investigating the potential molecular mechanisms of dibutyltin dilaurate induced brain injury: a network toxicology and molecular docking approach","volume":"381","author":"Hao","year":"2025","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.119739_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrrheum.2015.48","article-title":"A look behind the scenes: the risk and pathogenesis of primary osteoporosis","volume":"11","author":"Hendrickx","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ecoenv.2026.119739_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164753","article-title":"Higher allochthonous organic carbon increases polycyclic aromatic hydrocarbon concentration whereas fossil fuel combustion alters the composition: Evidence from a eutrophic plateau lake in southwest China","volume":"893","author":"Huang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.119739_bib21","first-page":"1","article-title":"Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures","volume":"92","author":"Humans","year":"2010","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"issue":"27","key":"10.1016\/j.ecoenv.2026.119739_bib22","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1073\/pnas.1220919110","article-title":"Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes","volume":"110","author":"Iqbal","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2026.119739_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.reprotox.2021.01.011","article-title":"Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats","volume":"100","author":"Jorge","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119739_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2013.07.019","article-title":"A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects","volume":"60","author":"Kim","year":"2013","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.119739_bib25","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S8756-3282(02)00726-3","article-title":"Polycyclic aromatic hydrocarbons present in cigarette smoke cause bone loss in an ovariectomized rat model","volume":"30","author":"Lee","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2026.119739_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118301","article-title":"Network toxicology and molecular docking to investigate the mechanism of bisphenol A toxicity in human diabetic cardiomyopathy","volume":"299","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"21","key":"10.1016\/j.ecoenv.2026.119739_bib27","doi-asserted-by":"crossref","first-page":"10204","DOI":"10.1021\/acs.est.5c03906","article-title":"Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice","volume":"59","author":"Li","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119739_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cytogfr.2019.09.001","article-title":"Collagen and non-collagenous proteins molecular crosstalk in the pathophysiology of osteoporosis","volume":"49","author":"Licini","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"issue":"22","key":"10.1016\/j.ecoenv.2026.119739_bib29","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1002\/jssc.201800612","article-title":"Determination of nitenpyram and 6-chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector","volume":"41","author":"Muhammad","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.ecoenv.2026.119739_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134467","article-title":"Large-scale soil application of hydrochar: Reducing its polycyclic aromatic hydrocarbon content and toxicity by heating","volume":"471","author":"Si","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.119739_bib31","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.foodchem.2015.12.074","article-title":"Polycyclic aromatic hydrocarbons' formation and occurrence in processed food","volume":"199","author":"Singh","year":"2016","journal-title":"Food Chem."},{"issue":"20","key":"10.1016\/j.ecoenv.2026.119739_bib32","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1002\/jssc.202000635","article-title":"Simultaneous determination of acetamiprid and 6-chloronicotinic acid in environmental samples by using ion chromatography hyphenated to online photoinduced fluorescence detector","volume":"43","author":"Subhani","year":"2020","journal-title":"J. Sep. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119739_bib33","first-page":"523","article-title":"UniProt: the universal protein knowledgebase","volume":"51","author":"UniProtConsortium","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119739_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112547","article-title":"Polycyclic aromatic hydrocarbons in bone homeostasis","volume":"146","author":"Ye","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119739_bib35","doi-asserted-by":"crossref","first-page":"14927","DOI":"10.1038\/s41598-021-94470-4","article-title":"Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR\/Cyp1a1 signaling axis","volume":"11","author":"Yoshikawa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.119739_bib36","doi-asserted-by":"crossref","first-page":"1428772","DOI":"10.3389\/fpubh.2025.1428772","article-title":"Exposure to polycyclic aromatic hydrocarbons and bone mineral density in children and adolescents: results from the 2011-2016 National Health and Nutrition Examination Survey","volume":"13","author":"Zhang","year":"2025","journal-title":"Front. Public Health"},{"key":"10.1016\/j.ecoenv.2026.119739_bib37","article-title":"Machine learning models to predict the bioaccessibility of parent and substituted polycyclic aromatic hydrocarbons (PAHs) in food: Impact on accurate health risk assessment","volume":"480","author":"Zhang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.119739_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.154009","article-title":"Efficient analysis of toxicity and mechanisms of Acetyl tributyl citrate on aging with network toxicology and molecular docking strategy","volume":"510","author":"Zheng","year":"2025","journal-title":"Toxicology"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:31:33Z","timestamp":1776717093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326000680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":38,"alternative-id":["S0147651326000680"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119739","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating the mechanism of polycyclic aromatic hydrocarbons-induced osteoporosis through network toxicology and molecular docking approaches: BaP as a model compound","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119739","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119739"}}