{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:02:14Z","timestamp":1793419334558,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273086"],"award-info":[{"award-number":["32273086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072933"],"award-info":[{"award-number":["32072933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172923"],"award-info":[{"award-number":["32172923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801100"],"award-info":[{"award-number":["2023YFD1801100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ecoenv.2026.119761","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:20:08Z","timestamp":1768843208000},"page":"119761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Role of FXR\/PPAR\u03b3 pathway mediated fatty acid oxidation in acute kidney injury induced by cadmium in rats"],"prefix":"10.1016","volume":"310","author":[{"given":"Jiaqiao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.119761_bib1","first-page":"055","article-title":"Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney","volume":"1","author":"Cai-Yu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ecoenv.2026.119761_bib2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12944-025-02557-y","article-title":"Environmental cadmium exposure aggravates renal fibrosis and reduced renal lipid accumulation in diabetic mice","volume":"24","author":"Changhao","year":"2025","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ecoenv.2026.119761_bib3","first-page":"555","article-title":"Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model","volume":"38","author":"Cihan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jare.2024.07.013","article-title":"Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury","volume":"72","author":"Dong","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ecoenv.2026.119761_bib5","article-title":"Synthetic cannabinoid CUMYL-4CN-BINACA induces oxidative stress, ER stress, and apoptosis in brain and testicular tissues of male albino rats","volume":"204","author":"Erdem","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib6","article-title":"Dataset on biochemical markers and histological alterations in rat kidney intoxicated with cadmium chloride and treated with antioxidant","volume":"43","author":"Esmaeil","year":"2022","journal-title":"Data Brief."},{"key":"10.1016\/j.ecoenv.2026.119761_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.115040","article-title":"\u03b2-carotene protects against \u03b1-amanitin nephrotoxicity via modulation of oxidative, autophagic, nitric oxide signaling, and polyol pathways in rat kidneys","volume":"193","author":"Gezer","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/09603271211054436","article-title":"Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of \u03bb-Carrageenan-induced paw edema in rats","volume":"40","author":"Halil Sezgin","year":"2021","journal-title":"J. Hum. Exp. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib9","first-page":"327","article-title":"Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury","volume":"97","author":"Hee-Seong","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.ecoenv.2026.119761_bib10","article-title":"Deletion of hepatic FXR leads to more severe MASH development in female mice","volume":"9","author":"Henry","year":"2025"},{"key":"10.1016\/j.ecoenv.2026.119761_bib11","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.2147\/DDDT.S530823","article-title":"DHLCA Alleviates Diabetic Kidney Disease via TGR5\/FXR Activation and Gut Microbiota Remodeling","volume":"19","author":"Hua","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.ecoenv.2026.119761_bib12","article-title":"Pharmacological activation of PPAR\u03b2\/\u03b4 preserves mitochondrial respiratory function in ischemia\/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1\u03b1\/NRF-1 signaling","volume":"13","author":"Ioanna","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib13","first-page":"2383","article-title":"Study on inhibitory effect of calycosin on hepatic stellate cell activation in rats by up-regulating peroxisome proliferator-activated receptor \u03b3","volume":"40","author":"Jian","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.ecoenv.2026.119761_bib14","doi-asserted-by":"crossref","first-page":"19667","DOI":"10.1021\/acs.jafc.4c05702","article-title":"mTORC1 and mTORC2 Co-Protect against Cadmium-Induced Renal Tubular Epithelial Cell Apoptosis and Acute Kidney Injury by Regulating Protein Kinase B","volume":"72","author":"Jiaqiao","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.119761_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.freeradbiomed.2025.03.021","article-title":"Carboxylesterase 2A gene knockout or enzyme inhibition alleviates steatohepatitis in rats by regulating PPAR\u03b3 and endoplasmic reticulum stress","volume":"232","author":"Jie","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.119761_bib16","article-title":"Low-level, chronic ingestion of lead and cadmium: The unspoken danger for at-risk populations","volume":"478","author":"Jordyn Ann","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119761_bib17","article-title":"Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner","volume":"43","author":"Joseph","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2026.119761_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoleng.2024.107385","article-title":"Developing a sustainable nature-based agricultural vertical system in cadmium polluted urban environments","volume":"208","author":"Kazemi","year":"2024","journal-title":"Ecol. Eng."},{"key":"10.1016\/j.ecoenv.2026.119761_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102382","article-title":"Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes","volume":"54","author":"Kim","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib20","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3389\/fphys.2020.00794","article-title":"The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury","volume":"11","author":"Lara","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib21","article-title":"Energy metabolic reprogramming regulates programmed cell death of renal tubular epithelial cells and might serve as a new therapeutic target for acute kidney injury","volume":"11","author":"Limei","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib22","article-title":"Lactic acid bacteria supplementation: A bioprotective approach to mitigating cadmium-induced toxicity and modulating gene expression in murine models","volume":"193","author":"Nadia","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib23","first-page":"70730","article-title":"Farnesoid X Receptor Alleviates Cisplatin-Induced Kidney Inflammatory Injury by Inhibiting Tlr4\/NF-\u03baB Pathway","volume":"29","author":"Peng","year":"2025","journal-title":"J. Cell."},{"key":"10.1016\/j.ecoenv.2026.119761_bib24","article-title":"Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury","volume":"72","author":"Peng-Fei","year":"2024"},{"key":"10.1016\/j.ecoenv.2026.119761_bib25","article-title":"Cadmium and kidney function: Concentrations, variabilities, and associations across various stages of glomerular function","volume":"256","author":"Ram","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119761_bib26","article-title":"Exposure to cadmium and its impacts on human health: A short review","volume":"17","author":"Rasin","year":"2025","journal-title":"J. Hazard. Mater. Adv."},{"key":"10.1016\/j.ecoenv.2026.119761_bib27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.kint.2021.08.031","article-title":"Loss of proximal tubular transcription factor Kr\u00fcppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation","volume":"100","author":"Sian","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecoenv.2026.119761_bib28","first-page":"12040718","article-title":"Is Chronic Kidney Disease Due to Cadmium Exposure Inevitable and Can It Be Reversed?","volume":"12","author":"Soisungwan","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.ecoenv.2026.119761_bib29","article-title":"The synthetic cannabinoid CUMYL-4CN-BINACA induces hepatic injury in rats via oxidative stress, NF-\u03baB activation, Nrf2 suppression, EDEM-1, ER stress-mediated apoptotic pathways","volume":"207","author":"Tuba","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119761_bib30","article-title":"Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity","volume":"66","author":"Weinan","year":"2025","journal-title":"Lipid Res"},{"key":"10.1016\/j.ecoenv.2026.119761_bib31","article-title":"Soil cadmium pollution decreases phosphorus-mineralizing microbial diversity and reduces phosphorus availability","volume":"371","author":"Wenzhe","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119761_bib32","article-title":"Cadmium exposure exacerbates kidney damage by inhibiting autophagy in diabetic rats","volume":"267","author":"Yonggang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119761_bib33","article-title":"Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress","volume":"423","author":"Zhong-Gui","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119761_bib34","first-page":"45","article-title":"TFPI2 hypermethylation promotes diabetic atherosclerosis progression through the Ap2\u03b1\/PPAR\u03b3 axis","volume":"198","author":"Zongyi","year":"2024","journal-title":"Mol. Cell Cardiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326000904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:38:14Z","timestamp":1776717494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326000904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S0147651326000904"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119761","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of FXR\/PPAR\u03b3 pathway mediated fatty acid oxidation in acute kidney injury induced by cadmium in rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119761"}}