{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:04:21Z","timestamp":1792735461688,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374484"],"award-info":[{"award-number":["82374484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014881","name":"Guangzhou University","doi-asserted-by":"publisher","award":["GZYHZ2025Y06"],"award-info":[{"award-number":["GZYHZ2025Y06"]}],"id":[{"id":"10.13039\/501100014881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014881","name":"Guangzhou University","doi-asserted-by":"publisher","award":["GZYZS2024G42"],"award-info":[{"award-number":["GZYZS2024G42"]}],"id":[{"id":"10.13039\/501100014881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025A04J2851"],"award-info":[{"award-number":["2025A04J2851"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022QN16"],"award-info":[{"award-number":["2022QN16"]}],"id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ecoenv.2026.119780","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:52:31Z","timestamp":1770983551000},"page":"119780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["N-(1,3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine-quinone (6PPD-Q) induces osteoporosis by a mechanism involving CX43-mediated mitochondrial autophagy dysfunction in bone marrow mesenchymal stem cells"],"prefix":"10.1016","volume":"311","author":[{"given":"Haitao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chudan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.119780_bib1","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/jbmr.3152","article-title":"Connexin43 and Runx2 interact to affect cortical bone geometry, skeletal development, and osteoblast and osteoclast function","volume":"32","author":"Buo","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ecoenv.2026.119780_bib2","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fimmu.2013.00361","article-title":"The interplay between NLRs and autophagy in immunity and inflammation","volume":"4","author":"Carneiro","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/15419060302064","article-title":"BMP regulation of the mouse connexin43 promoter in osteoblastic cells and embryos","volume":"10","author":"Chatterjee","year":"2003","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.ecoenv.2026.119780_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126489","article-title":"Enantioselectivity in human urinary excretion of N-(1,3-dimethylbutyl)-N\u2032-phenyl-1,4-benzenediamine (6PPD) and 6PPD-quinone","volume":"378","author":"Chen","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119780_bib5","article-title":"Aspartame carcinogenic potential revealed through network toxicology and molecular docking insights","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.119780_bib6","doi-asserted-by":"crossref","first-page":"17617","DOI":"10.1021\/acs.est.4c06357","article-title":"Environmentally relevant concentrations of S-6PPD-quinone caused more serious hepatotoxicity than R-enantiomer and racemate in Oncorhynchus mykiss","volume":"58","author":"Di","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib7","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.estlett.2c00821","article-title":"First report on the occurrence of N-(1,3-Dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from South China","volume":"9","author":"Du","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.ecoenv.2026.119780_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.lfs.2019.05.027","article-title":"Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells","volume":"229","author":"Fan","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2026.119780_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133312","article-title":"6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by \u03b1-synuclein preformed fibrils seeding","volume":"465","author":"Fang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134357","article-title":"6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes","volume":"471","author":"Fang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132265","article-title":"Tire-rubber related pollutant 6-PPD quinone: a review of its transformation, environmental distribution, bioavailability, and toxicity","volume":"459","author":"Hua","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119492","article-title":"Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: A review","volume":"258","author":"Ihenetu","year":"2024","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.119780_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133640","article-title":"Exploration of emerging environmental pollutants 6PPD and 6PPDQ in honey and fish samples","volume":"396","author":"Ji","year":"2022","journal-title":"FOOD Chem."},{"key":"10.1016\/j.ecoenv.2026.119780_bib14","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2026.119780_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jbmr.262","article-title":"The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?","volume":"26","author":"Khosla","year":"2011","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.ecoenv.2026.119780_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00441-005-1091-y","article-title":"Inhibition of connexin 43 alters Shh and Bmp-2 expression patterns in embryonic mouse tongue","volume":"320","author":"Kim","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ecoenv.2026.119780_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s12975-025-01374-w","article-title":"Astrocyte-derived exosomal GJA1-20 k targets Pink1-mediated mitophagy to attenuate traumatic brain injury","author":"Li","year":"2025","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.ecoenv.2026.119780_bib18","doi-asserted-by":"crossref","first-page":"8586","DOI":"10.1128\/JVI.72.11.8586-8596.1998","article-title":"Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein","volume":"72","author":"Liang","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s13287-021-02520-5","article-title":"New insights into mitophagy and stem cells","volume":"12","author":"Lin","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.ecoenv.2026.119780_bib20","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/acs.est.4c09276","article-title":"Long-term exposure to tire-derived 6-PPD quinone causes neurotoxicity and neuroinflammation via inhibition of HTR2A in C57BL\/6 mice","volume":"59","author":"Ma","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib21","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.ecoenv.2026.119780_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11914-017-0345-4","article-title":"Connexin43 and the intercellular signaling network regulating skeletal remodeling","volume":"15","author":"Moorer","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.ecoenv.2026.119780_bib23","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1001\/jama.2025.6003","article-title":"Osteoporosis: a review","volume":"334","author":"Morin","year":"2025","journal-title":"Jama"},{"key":"10.1016\/j.ecoenv.2026.119780_bib24","doi-asserted-by":"crossref","first-page":"C1035","DOI":"10.1152\/ajpcell.00262.2011","article-title":"ERK acts in parallel to PKC\u03b4 to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts","volume":"302","author":"Niger","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109455","article-title":"Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers","volume":"199","author":"Qin","year":"2025","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.119780_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118122","article-title":"Abiotic oxidative transformation of 6-PPD and 6-PPD quinone from tires and occurrence of their products in snow from urban roads and in municipal wastewater","volume":"212","author":"Seiwert","year":"2022","journal-title":"Water Res"},{"key":"10.1016\/j.ecoenv.2026.119780_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118593","article-title":"Multi-level evidence reveals PANK2 as a potential target of PFOA\/PFOS-induced bone metabolism disruption: from network toxicology to in vitro validation","volume":"302","author":"Shao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119780_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105483","article-title":"Molecular chaperonin HSP60: current understanding and future prospects","volume":"25","author":"Singh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.119780_bib30","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ecoenv.2026.119780_bib31","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/jcp.25938","article-title":"Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts","volume":"233","author":"Talbot","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.119780_bib33","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s10753-021-01443-w","article-title":"MiR-23a is involved in myocardial ischemia\/reperfusion injury by directly targeting CX43 and regulating mitophagy","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.ecoenv.2026.119780_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jes.2025.11.004","article-title":"Exposure to 6-PPD quinone suppresses the proliferation and differentiation of osteoblasts by Nr4a1-p38 MAPK signal axis","author":"Wang","year":"2025","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2026.119780_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137574","article-title":"Low-dose tire wear chemical 6PPD-Q exposure elicit fatty liver via promoting fatty acid biosynthesis in ICR mice","volume":"489","author":"Wang","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118148","article-title":"Lycium barbarum polysaccharide protects BMSCs against cadmium-induced suppression of osteogenic differentiation by modulating autophagy","volume":"295","author":"Wei","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119780_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114876","article-title":"Hydrogen mitigates brain injury by prompting NEDD4-CX43- mediated mitophagy in traumatic brain injury","volume":"379","author":"Wu","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib38","article-title":"Spatiotemporal distribution of 6PPD-Q in China revealed by a national-scale quantification framework","author":"Xu","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.est.5c12242","article-title":"Spatiotemporal distribution of 6PPD-Q in China revealed by a national-scale quantification framework","volume":"60","author":"Xu","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.119780_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118456","article-title":"6PPD and 6PPDQ embryonic exposure induced distinct developmental neurotoxicity in zebrafish","volume":"300","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119780_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134165","article-title":"Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice","volume":"470","author":"Yao","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126352","article-title":"Environmental fate, toxicity, and mitigation of 6PPD and 6PPD-quinone: current understanding and future directions","volume":"375","author":"Yi","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119780_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131601","article-title":"6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish","volume":"455","author":"Zhang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.119780_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102196","article-title":"Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis","volume":"94","author":"Zhang","year":"2024","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.ecoenv.2026.119780_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127303","article-title":"Developing water quality criteria and assessing ecological risks for 6PPD and 6PPD-Q in freshwater ecosystems","volume":"387","author":"Zhang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119780_bib46","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/jcmm.16103","article-title":"Glucocorticoids decreased Cx43 expression in osteonecrosis of femoral head: the effect on proliferation and osteogenic differentiation of rat BMSCs","volume":"25","author":"Zhao","year":"2021","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.ecoenv.2026.119780_bib47","article-title":"Bisphenol A exacerbates osteoblast ferroptosis via the p53\/SLC7A11 axis: a novel mechanistic insight into environmental osteoporosis pathogenesis","volume":"309","author":"Zhao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326001090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326001090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:03:17Z","timestamp":1776114197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326001090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"alternative-id":["S0147651326001090"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119780","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-(1,3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine-quinone (6PPD-Q) induces osteoporosis by a mechanism involving CX43-mediated mitochondrial autophagy dysfunction in bone marrow mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119780","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119780"}}