{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:16:56Z","timestamp":1792156616606,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017590","name":"Hubei University of Science and Technology","doi-asserted-by":"publisher","award":["2023T08"],"award-info":[{"award-number":["2023T08"]}],"id":[{"id":"10.13039\/501100017590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42477452"],"award-info":[{"award-number":["42477452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177416"],"award-info":[{"award-number":["42177416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ecoenv.2026.119862","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:57:22Z","timestamp":1770908242000},"page":"119862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The mediating role of ferroptosis and mitochondrial dynamics disorder in the aggravation of cardiac injury by polystyrene microplastics"],"prefix":"10.1016","volume":"311","author":[{"given":"Xiao","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-6299","authenticated-orcid":false,"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2026.119862_bib1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.marpolbul.2015.04.007","article-title":"Microplastic in a macro filter feeder: humpback whale megaptera novaeangliae","volume":"95","author":"Besseling","year":"2015","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2026.119862_bib2","article-title":"Periodontitis and atherosclerotic cardiovascular disease: a critical appraisal","volume":"2000","author":"Carra","year":"2023","journal-title":"Periodontology"},{"key":"10.1016\/j.ecoenv.2026.119862_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110841","article-title":"Kynurenine pathway, NAD+ synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and healthspan","volume":"132","author":"Castro-Portuguez","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ecoenv.2026.119862_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.119862_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41419-023-05803-2","article-title":"CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2026.119862_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138087","article-title":"A potent fluorescent probe for HOCl with dual NIR emissions: achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis","volume":"492","author":"Cui","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119862_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.119862_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","article-title":"Malondialdehyde determination as index of lipid peroxidation","volume":"186","author":"Draper","year":"1990","journal-title":"Methods Enzymol."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.119862_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119862_bib10","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s00125-012-2495-3","article-title":"Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db\/db mouse model of type 2 diabetes","volume":"55","author":"Huynh","year":"2012","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.ecoenv.2026.119862_bib11","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1158\/2159-8290.CD-19-0338","article-title":"Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11","volume":"9","author":"Lang","year":"2019","journal-title":"Cancer Discov."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.119862_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2\u2032,7\u2032-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem. Res. Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.119862_bib13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/CIRCULATIONAHA.123.062405","article-title":"Cardiomuscular biomarkers in the diagnosis and prognostication of immune checkpoint inhibitor myocarditis","volume":"148","author":"Lehmann","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ecoenv.2026.119862_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105466","article-title":"Ferroptosis and its emerging roles in cardiovascular diseases","volume":"166","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119862_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2374608","article-title":"Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3\/IKK\/NF-\u03baB signaling via gut microbial tryptophan metabolites","volume":"16","author":"Li","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ecoenv.2026.119862_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114848","article-title":"Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice","volume":"256","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2026.119862_bib17","article-title":"Polystyrene microplastics cause cardiac fibrosis by activating Wnt\/\u03b2-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats","volume":"265","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119862_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118708","article-title":"Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac fibrosis\/dysfunction and the protective effects of vitamin E and salidroside: a molecular toxicological study in Sprague-Dawley rats","volume":"302","author":"Liang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119862_bib19","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41418-024-01407-1","article-title":"The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma","volume":"32","author":"Liu","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2026.119862_bib20","article-title":"Role of GTPase-dependent mitochondrial dynamins in heart diseases","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"22","key":"10.1016\/j.ecoenv.2026.119862_bib21","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.119862_bib22","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tips.2024.05.006","article-title":"Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges","volume":"45","author":"Liu","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ecoenv.2026.119862_bib23","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fphar.2017.00692","article-title":"Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119862_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12989-023-00560-8","article-title":"Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism","volume":"20","author":"Ma","year":"2023","journal-title":"Part. Fibre Toxicol."},{"issue":"7824","key":"10.1016\/j.ecoenv.2026.119862_bib25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41586-020-2475-6","article-title":"Mitochondrial ubiquinol oxidation is necessary for tumour growth","volume":"585","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.119862_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153296","article-title":"Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-\u03baB and RIP1\/RIP3\/MLKL pathway in chicken kidney","volume":"478","author":"Meng","year":"2022","journal-title":"Toxicology"},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2026.119862_bib27","article-title":"Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.119862_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: an overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119862_bib29","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/antiox14050604","article-title":"Environmental toxins and oxidative stress: the link to cardiovascular diseases","volume":"14","author":"Sule","year":"2025","journal-title":"Antioxid."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119862_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s12967-023-04715-1","article-title":"WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis","volume":"21","author":"Tai","year":"2023","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.119862_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2026.119862_bib32","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119862_bib33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41420-022-01183-2","article-title":"Emerging roles of ferroptosis in cardiovascular diseases","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.119862_bib34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.119862_bib35","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1038\/s41401-021-00623-6","article-title":"Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119862_bib36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/tox.23095","article-title":"The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3\/Caspase-1 signaling pathway and oxidative stress in Wistar rats","volume":"36","author":"Wei","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119862_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119862_bib38","first-page":"1","article-title":"Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease","author":"Wei","year":"2025","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.119862_bib39","first-page":"1477","article-title":"Luteolin attenuates sepsis-induced myocardial injury by enhancing autophagy in mice","volume":"45","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.119862_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117712","article-title":"Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice","volume":"290","author":"Xiong","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.119862_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122058","article-title":"Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae","volume":"388","author":"Yang","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.119862_bib42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.119862_bib43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejphar.2017.07.031","article-title":"Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia\/reperfusion injury via the mechanism of mitochondrial dynamics mechanism","volume":"813","author":"Yang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.119862_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119449","article-title":"Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis","volume":"307","author":"Yin","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119862_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-\u03baB-NLRP3-GSDMD and AMPK-PGC-1\u03b1 axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326001910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326001910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:01:14Z","timestamp":1776096074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326001910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S0147651326001910"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119862","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mediating role of ferroptosis and mitochondrial dynamics disorder in the aggravation of cardiac injury by polystyrene microplastics","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119862"}}