{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:41:01Z","timestamp":1783705261426,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["24ZR1410200"],"award-info":[{"award-number":["24ZR1410200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010108","name":"Zhongshan Hospital","doi-asserted-by":"publisher","award":["ZHUPEI2023\\u2013021"],"award-info":[{"award-number":["ZHUPEI2023\\u2013021"]}],"id":[{"id":"10.13039\/501100010108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800844"],"award-info":[{"award-number":["81800844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501325"],"award-info":[{"award-number":["82501325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ecoenv.2026.119889","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:16:25Z","timestamp":1771078585000},"page":"119889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mechanistic insights into PM2.5-induced myopia in mice: Role of NRF2\/HIF-1\u03b1 signaling and therapeutic potential of sulforaphane"],"prefix":"10.1016","volume":"311","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-9644","authenticated-orcid":false,"given":"Yichao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2228-0073","authenticated-orcid":false,"given":"Jinhui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.119889_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.envres.2017.11.020","article-title":"The association between exposure to air pollutants including PM, PM, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration and the relative risk of developing STEMI: a case-crossover design","volume":"161","author":"Akbarzadeh","year":"2018","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.119889_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ecoenv.2026.119889_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108255","article-title":"The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases","volume":"201","author":"Chan","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ecoenv.2026.119889_bib4","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCULATIONAHA.121.057179","article-title":"Hourly air pollutants and acute coronary syndrome onset in 1.29 million patients","volume":"145","author":"Chen","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ecoenv.2026.119889_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1167\/iovs.64.14.38","article-title":"Time spent outdoors partly accounts for the effect of education on Myopia","volume":"64","author":"Clark","year":"2023","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ecoenv.2026.119889_bib6","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/ije\/dyx068","article-title":"Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study","volume":"46","author":"Cuellar-Partida","year":"2017","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/519276a","article-title":"The myopia boom","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.119889_bib8","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2026.119889_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102587","article-title":"PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4\/Nrf2 redox imbalance-mediated mitophagy","volume":"59","author":"Fan","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/eye.2013.280","article-title":"Epidemiology of myopia","volume":"28","author":"Foster","year":"2014","journal-title":"Eye"},{"key":"10.1016\/j.ecoenv.2026.119889_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/eye.2013.254","article-title":"Genetic and environmental effects on myopia development and progression","volume":"28","author":"Goldschmidt","year":"2014","journal-title":"Eye"},{"key":"10.1016\/j.ecoenv.2026.119889_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12989-023-00558-2","article-title":"Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood-retinal barrier damages and disease susceptibilities","volume":"20","author":"Gu","year":"2023","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101537","article-title":"MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium","volume":"34","author":"Han","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib14","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ecoenv.2026.119889_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res Commun."},{"key":"10.1016\/j.ecoenv.2026.119889_bib16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1365-2443.2003.00640.x","article-title":"Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles","volume":"8","author":"Itoh","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.ecoenv.2026.119889_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.64.10.19","article-title":"Association of behavioral and clinical risk factors with cataract: a two-sample Mendelian randomization study","volume":"64","author":"Jiang","year":"2023","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ecoenv.2026.119889_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.envpol.2007.06.012","article-title":"Human health effects of air pollution","volume":"151","author":"Kampa","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119889_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10653-015-9720-1","article-title":"Air pollution and public health: emerging hazards and improved understanding of risk","volume":"37","author":"Kelly","year":"2015","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.ecoenv.2026.119889_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3346\/jkms.2017.32.1.143","article-title":"Outdoor air pollution and Pterygium in Korea","volume":"32","author":"Lee","year":"2017","journal-title":"J. Korean Med Sci."},{"key":"10.1016\/j.ecoenv.2026.119889_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12989-021-00403-4","article-title":"Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis","volume":"18","author":"Li","year":"2021","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-021-00437-4","article-title":"High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3","volume":"16","author":"Li","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ecoenv.2026.119889_bib23","first-page":"684","article-title":"Epidemiologic study of the prevalence and severity of myopia among schoolchildren in Taiwan in 2000","volume":"100","author":"Lin","year":"2001","journal-title":"J. Formos. Med Assoc."},{"key":"10.1016\/j.ecoenv.2026.119889_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/8994901","article-title":"LINC01278 induces autophagy to inhibit tumour progression by suppressing the mTOR signalling pathway","volume":"2023","author":"Liu","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2026.119889_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41419-023-05590-w","article-title":"PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2026.119889_bib26","doi-asserted-by":"crossref","first-page":"A12","DOI":"10.1289\/ehp.122-A12","article-title":"Myopia: the evidence for environmental factors","volume":"122","author":"Lougheed","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.119889_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109017","article-title":"Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes","volume":"106","author":"Masuda","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ecoenv.2026.119889_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109062","article-title":"Pathogenesis of keratoconus: NRF2-antioxidant, extracellular matrix and cellular dysfunctions","volume":"219","author":"Monteiro de Barros","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ecoenv.2026.119889_bib29","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/OPX.0000000000000980","article-title":"What public policies should be developed to deal with the epidemic of Myopia?","volume":"93","author":"Morgan","year":"2016","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.ecoenv.2026.119889_bib30","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.119889_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2004.06.004","article-title":"How genetic is school myopia?","volume":"24","author":"Morgan","year":"2005","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.ecoenv.2026.119889_bib32","article-title":"Education and myopia: assessing the direction of causality by mendelian randomisation","volume":"361","author":"Mountjoy","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2026.119889_bib33","first-page":"378","article-title":"Sulforaphane recovers cone function in an Nrf2-dependent manner in middle-aged mice undergoing RPE oxidative stress","volume":"28","author":"Qi","year":"2022","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ecoenv.2026.119889_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108581","article-title":"Ambient fine particulate matter and ozone higher than certain thresholds associated with myopia in the elderly aged 50 years and above","volume":"177","author":"Ruan","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.119889_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/oxfordjournals.epirev.a017924","article-title":"Epidemiology of myopia","volume":"18","author":"Saw","year":"1996","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.ecoenv.2026.119889_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2471\/BLT.08.055673","article-title":"Potential lost productivity resulting from the global burden of uncorrected refractive error","volume":"87","author":"Smith","year":"2009","journal-title":"Bull. World Health Organ"},{"key":"10.1016\/j.ecoenv.2026.119889_bib37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/S0004-27492008000700015","article-title":"Tearful relations: oxidative stress, inflammation and eye diseases","volume":"71","author":"Wakamatsu","year":"2008","journal-title":"Arq. Bras. Oftalmol."},{"key":"10.1016\/j.ecoenv.2026.119889_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202217014","article-title":"PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway","volume":"15","author":"Wang","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.119889_bib39","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/eye.2008.184","article-title":"Changes of the ocular refraction among freshmen in National Taiwan University between 1988 and 2005","volume":"23","author":"Wang","year":"2009","journal-title":"Eye"},{"key":"10.1016\/j.ecoenv.2026.119889_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113031","article-title":"PM2.5 and NOx exposure promote myopia: clinical evidence and experimental proof","volume":"254","author":"Wei","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.119889_bib41","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.3390\/ijerph10115378","article-title":"Is household air pollution a risk factor for eye disease?","volume":"10","author":"West","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2026.119889_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1399-0004.2010.01592.x","article-title":"Nature and nurture: the complex genetics of myopia and refractive error","volume":"79","author":"Wojciechowski","year":"2011","journal-title":"Clin. Genet."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326002186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326002186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:09:24Z","timestamp":1776114564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326002186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":42,"alternative-id":["S0147651326002186"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119889","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into PM2.5-induced myopia in mice: Role of NRF2\/HIF-1\u03b1 signaling and therapeutic potential of sulforaphane","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119889"}}