{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:17:34Z","timestamp":1781788654661,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ecoenv.2026.119912","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:12:02Z","timestamp":1772529122000},"page":"119912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa cascade through modulation of the STAT3-TP53-MMP9 molecular axis"],"prefix":"10.1016","volume":"312","author":[{"given":"Jiajia","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiYu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-3382","authenticated-orcid":false,"given":"Guangxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.119912_bib1","unstructured":"Anone. 2019. Protein Data Bank: the Single Global Archive for 3D Macromolecular Structure Data. Nucleic Acids Res. 47, D520-d528."},{"key":"10.1016\/j.ecoenv.2026.119912_bib2","unstructured":"Anone. 2023. UniProt: the Universal Protein Knowledgebase in 2023. Nucleic Acids Res. 51, D523-d531."},{"key":"10.1016\/j.ecoenv.2026.119912_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2026.119912_bib4","first-page":"24","article-title":"Metabolic activation of benzo[a]pyrene by human tissue organoid cultures","author":"Caipa Garcia","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.119912_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.ecoenv.2026.119912_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.119912_bib7","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ecoenv.2026.119912_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf388","article-title":"TIMER3: an enhanced resource for tumor immune analysis","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib9","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.3748\/wjg.v16.i42.5380","article-title":"STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer","volume":"16","author":"Deng","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ecoenv.2026.119912_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.274.5286.430","article-title":"Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53","volume":"274","author":"Denissenko","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.119912_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.matbio.2015.04.004","article-title":"Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature","volume":"44-46","author":"Deryugina","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ecoenv.2026.119912_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ecoenv.2026.119912_bib14","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.ecoenv.2026.119912_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac297","article-title":"SuperPred 3.0: drug classification and target prediction-a machine learning approach","volume":"50","author":"Gallo","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal"},{"key":"10.1016\/j.ecoenv.2026.119912_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ecoenv.2026.119912_bib18","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.ecoenv.2026.119912_bib19","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2026.119912_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1158\/1055-9965.EPI-13-1057","article-title":"Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention","volume":"23","author":"Karimi","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ecoenv.2026.119912_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.119912_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10937404.2010.483176","article-title":"Toxicity testing in the 21st century: a vision and a strategy","volume":"13","author":"Krewski","year":"2010","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.ecoenv.2026.119912_bib25","article-title":"Characterization of differentially expressed genes involved in pathways associated with gastric cancer","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2026.119912_bib26","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1038\/s41598-019-43924-x","article-title":"FN1, SPARC, and SERPINE1 are highly expressed and significantly related to a poor prognosis of gastric adenocarcinoma revealed by microarray and bioinformatics","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.119912_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106440","article-title":"Berberine for gastric cancer prevention and treatment: multi-step actions on the Correa's cascade underlie its therapeutic effects","volume":"184","author":"Liu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib28","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jcc.10117","article-title":"Structure and dynamics of liquid water with different long-range interaction truncation and temperature control methods in molecular dynamics simulations","volume":"23","author":"Mark","year":"2002","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2026.119912_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41576-024-00767-1","article-title":"Progress in toxicogenomics to protect human health","volume":"26","author":"Meier","year":"2025","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ecoenv.2026.119912_bib30","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1161\/ATVBAHA.108.173898","article-title":"Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability","volume":"28","author":"Newby","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ecoenv.2026.119912_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Chemin."},{"key":"10.1016\/j.ecoenv.2026.119912_bib32","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/s41467-018-04179-8","article-title":"Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype","volume":"9","author":"Oh","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.119912_bib33","article-title":"JASPAR 2026: expansion of transcription factor binding profiles and integration of deep learning models","volume":"54","author":"Ovek Baydar","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1289\/ehp.1001925","article-title":"Computational toxicology: realizing the promise of the toxicity testing in the 21st century","volume":"118","author":"Rusyn","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.119912_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ccell.2018.07.004","article-title":"Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits Stat3-mediated tumor growth and invasion","volume":"34","author":"Schulz-Heddergott","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ecoenv.2026.119912_bib36","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.ecoenv.2026.119912_bib37","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.119912_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae032","article-title":"Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay","volume":"25","author":"Srinivasan","year":"2024","journal-title":"Brief. Bioinf."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.119912_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinf."},{"key":"10.1016\/j.ecoenv.2026.119912_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2026.119912_bib43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2026.119912_bib44","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ecoenv.2026.119912_bib45","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","article-title":"Interactome networks and human disease","volume":"144","author":"Vidal","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.119912_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.119912_bib48","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3892\/ijo.2016.3674","article-title":"Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc","volume":"49","author":"Wei","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ecoenv.2026.119912_bib49","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ecoenv.2026.119912_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkad1004","article-title":"The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods","volume":"52","author":"Zdrazil","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326002411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326002411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:12:45Z","timestamp":1777489965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326002411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":50,"alternative-id":["S0147651326002411"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119912","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa cascade through modulation of the STAT3-TP53-MMP9 molecular axis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.119912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119912"}}