{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:03:30Z","timestamp":1789020210018,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ecoenv.2026.120006","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:41:16Z","timestamp":1773970876000},"page":"120006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mechanism of benzophenone-3 in promoting proliferation and migration of prostate cancer cells via the acyl-CoA dehydrogenase 9 axis"],"prefix":"10.1016","volume":"314","author":[{"given":"Jinhui","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongxuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihe","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120006_bib1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.scitotenv.2018.04.217","article-title":"Organic UV filters exposure induces the production of inflammatory cytokines in human macrophages","volume":"635","author":"Ao","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120006_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/s22051848","article-title":"A new framework for precise identification of prostatic adenocarcinoma","volume":"22","author":"Ayyad","year":"2022","journal-title":"Sensors"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120006_bib3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1289\/ehp.11269","article-title":"Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: national health and nutrition examination survey 2003--2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120006_bib4","article-title":"Advances in ferroptosis for castration-resistant prostate cancer treatment: novel drug targets and combination therapy strategies","author":"Chen","year":"2024","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13046-023-02928-2","article-title":"RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPK\u03b12 to activate oxidative phosphorylation and fatty acid oxidation","volume":"42","author":"Cheng","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120006_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210058","article-title":"Adoptive cell therapy for cancer treatment","volume":"3","author":"Du","year":"2023","journal-title":"Exploration"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120006_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000526022","article-title":"Severe antenatal hypertrophic cardiomyopathy secondary to ACAD9-related mitochondrial complex I deficiency","volume":"14","author":"Dubucs","year":"2023","journal-title":"Mol. Syndr."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120006_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41370-020-0209-3","article-title":"UV filters in matched seminal fluid-, urine-, and serum samples from young men","volume":"31","author":"Frederiksen","year":"2021","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108797","article-title":"Prenatal exposure to benzophenone-type UV filters and the associations with neonatal birth outcomes and maternal health in south China","volume":"189","author":"Fu","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120006_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.reprotox.2017.08.015","article-title":"Exposure to benzophenone-3 and reproductive toxicity: a systematic review of human and animal studies","volume":"73","author":"Ghazipura","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120006_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1200\/JCO.2010.28.7078","article-title":"Reduced melanoma after regular sunscreen use: randomized trial follow-up","volume":"29","author":"Green","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154737","article-title":"Biomonitoring bisphenols, parabens, and benzophenones in breast milk from a human milk bank in Southern Spain","volume":"830","author":"Iribarne-Dur\u00e1n","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120006_bib13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1468-3083.2007.02492.x","article-title":"Sunscreens in human plasma and urine after repeated whole-body topical application","volume":"22","author":"Janjua","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.0022-202X.2004.22725.x","article-title":"Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans","volume":"123","author":"Janjua","year":"2004","journal-title":"J. Investig. Dermatol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib15","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41467-022-29137-3","article-title":"Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120006_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115854","article-title":"Diet-dependent BP-3 modulation of immune function in murine mammary tumorigenesis","volume":"207","author":"Kariagina","year":"2026","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envint.2014.05.015","article-title":"Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review","volume":"70","author":"Kim","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120006_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envint.2014.05.015","article-title":"Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review","volume":"70","author":"Kim","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120006_bib19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.taap.2017.11.021","article-title":"Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes","volume":"338","author":"Kim","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217903","article-title":"Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression","volume":"630","author":"Li","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ecoenv.2026.120006_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217903","article-title":"Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression","volume":"630","author":"Li","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ecoenv.2026.120006_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110293","article-title":"Associations of urinary levels of phenols and parabens with osteoarthritis among US adults in NHANES 2005\u20132014","volume":"192","author":"Li","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120006_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115650","article-title":"The environmental sources of benzophenones: distribution, pretreatment, analysis and removal techniques","volume":"267","author":"Liu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120006_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/es051380x","article-title":"Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in southern California","volume":"40","author":"Loraine","year":"2006","journal-title":"Environ. Sci. & Technol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107915","article-title":"Precision targeting of androgen receptor-ferroptosis crosstalk in prostate cancer: from mechanisms to therapeutic strategies","volume":"219","author":"Lv","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib26","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5221","article-title":"Effects of benzophenone-3 and propylparaben on estrogen receptor\u2013dependent R-loops and DNA damage in breast epithelial cells and mice","volume":"128","author":"Majhi","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib27","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1289\/EHP5221","article-title":"Effects of benzophenone-3 and propylparaben on estrogen receptor-dependent R-loops and DNA damage in breast epithelial cells and mice","volume":"128","author":"Majhi","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120006_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/jama.2019.20747","article-title":"Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial","volume":"323","author":"Matta","year":"2020","journal-title":"Jama"},{"key":"10.1016\/j.ecoenv.2026.120006_bib29","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.scitotenv.2019.04.452","article-title":"Urinary concentrations of benzophenone-3 and reproductive outcomes among women undergoing infertility treatment with assisted reproductive technologies","volume":"678","author":"M\u00ednguez-Alarc\u00f3n","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120006_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.adcanc.2022.100080","article-title":"Benzophenone-3 exposure alters composition of tumor infiltrating immune cells and increases lung seeding of 4T1 breast cancer cells","volume":"7","author":"Morin","year":"2023","journal-title":"Adv. Cancer Biol. Metastas.."},{"key":"10.1016\/j.ecoenv.2026.120006_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114540","article-title":"Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis","volume":"186","author":"Morozova","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120006_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107739","article-title":"Benzophenone-3: comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies","volume":"173","author":"Mustieles","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120006_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107739","article-title":"Benzophenone-3: comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies","volume":"173","author":"Mustieles","year":"2023","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120006_bib34","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/hmg\/ddt521","article-title":"ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies","volume":"23","author":"Nouws","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120006_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10565-016-9368-3","article-title":"Benzophenone-3 increases metastasis potential in lung cancer cells via epithelial to mesenchymal transition","volume":"33","author":"Phiboonchaiyanan","year":"2017","journal-title":"Cell Biol. Toxicol."},{"issue":"16","key":"10.1016\/j.ecoenv.2026.120006_bib36","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2025.0228","article-title":"Prostate cancer: a review","volume":"333","author":"Raychaudhuri","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2026.120006_bib37","doi-asserted-by":"crossref","DOI":"10.1177\/1533034618775530","article-title":"Deep learning role in early diagnosis of prostate cancer","volume":"17","author":"Reda","year":"2018","journal-title":"Technol. Cancer Res. Treat."},{"issue":"50","key":"10.1016\/j.ecoenv.2026.120006_bib38","doi-asserted-by":"crossref","first-page":"E1802","DOI":"10.1503\/cmaj.201085","article-title":"The efficacy and safety of sunscreen use for the prevention of skin cancer","volume":"192","author":"Sander","year":"2020","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.ecoenv.2026.120006_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2018.12.016","article-title":"The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures","volume":"303","author":"Santamar\u00eda","year":"2019","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120006_bib40","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1007\/s00204-020-02865-5","article-title":"Reproductive toxicity of benzophenone-3","volume":"94","author":"Seidel","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib41","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120006_bib42","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.fertnstert.2024.04.032","article-title":"Urinary benzophenone-3 concentrations and ovarian reserve in a cohort of subfertile women","volume":"122","author":"Silva","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2026.120006_bib43","doi-asserted-by":"crossref","unstructured":"Velickovic, L.J., 2024. Histopathological and molecular markers in the assessment of prostate cancer aggressivity [M]. Prostate Cancer: Advancements in the Pathogenesis, Diagnosis and Personalized Therapy. pp. 179-206.","DOI":"10.1007\/978-3-031-51712-9_9"},{"key":"10.1016\/j.ecoenv.2026.120006_bib44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.22203\/eCM.v050a09","article-title":"Hypoxia-derived mesenchymal stem-cell exosomes delivering naringin enhance osteoblast migration and fracture healing by upregulating integrin \u03b21 via the BDNF-TrkB\/ERK1\/2 signaling pathway","volume":"50","author":"Yao","year":"2025","journal-title":"Eur. Cell Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120006_bib45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12964-025-02109-y","article-title":"SLC25A35 enhances fatty acid oxidation and mitochondrial biogenesis to promote the carcinogenesis and progression of hepatocellular carcinoma by upregulating PGC-1\u03b1","volume":"23","author":"Yu","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120006_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13121014","article-title":"Study on hepatotoxicity of benzophenone-3 at environmental concentration in postpartum mice","volume":"13","author":"Zhai","year":"2025","journal-title":"Toxics"},{"issue":"13","key":"10.1016\/j.ecoenv.2026.120006_bib47","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1021\/acs.est.4c13355","article-title":"Decidual disrupting effects of low-dose benzophenone-type UV filters in human endometrial stromal cells via ER\/PR\/FOXO1 signaling","volume":"59","author":"Zhan","year":"2025","journal-title":"Environ. Sci. Technol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326003350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326003350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:06:10Z","timestamp":1775549170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326003350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"alternative-id":["S0147651326003350"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120006","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism of benzophenone-3 in promoting proliferation and migration of prostate cancer cells via the acyl-CoA dehydrogenase 9 axis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120006"}}