{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:35:53Z","timestamp":1793252153794,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2021-NR061941"],"award-info":[{"award-number":["RS-2021-NR061941"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2022-NR069006"],"award-info":[{"award-number":["RS-2022-NR069006"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2026-RISE-15\\u2013108"],"award-info":[{"award-number":["2026-RISE-15\\u2013108"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031505","name":"Ministry of Education, Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ecoenv.2026.120022","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:17:24Z","timestamp":1773641844000},"page":"120022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["IRE1\/FAM134B-mediated ER-phagy alleviates zearalenone-induced ER stress and developmental defects in porcine embryos"],"prefix":"10.1016","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-9598","authenticated-orcid":false,"given":"Dong-Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deog-Bon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-2914","authenticated-orcid":false,"given":"Hyo-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120022_bib1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/tox.21802","article-title":"Reproductive toxicity and histopathological changes induced by lambda-cyhalothrin in male mice","volume":"29","author":"Al-Sarar","year":"2014","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib2","article-title":"Calcium signaling in oocyte quality and functionality and its application","volume":"15","author":"Chen","year":"2024","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119277","article-title":"The pivotal role of FAM134B in selective ER-phagy and diseases","volume":"1869","author":"Chen","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ecoenv.2026.120022_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2026.120022_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.997235","article-title":"ER stress as a trigger of UPR and ER-phagy in cancer growth and spread","volume":"12","author":"Cherubini","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169151","article-title":"Autophagy, ER-phagy and ER dynamics during cell differentiation","author":"Cillo","year":"2025","journal-title":"J. Mol. Bio."},{"key":"10.1016\/j.ecoenv.2026.120022_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146511","article-title":"Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity","volume":"829","author":"Feng","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.ecoenv.2026.120022_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15070471","article-title":"Combination of zearalenone and deoxynivalenol induces apoptosis by mitochondrial pathway in piglet sertoli cells: role of endoplasmic reticulum stress","volume":"15","author":"Hai","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120022_bib9","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/tox.21995","article-title":"Zearalenone exposure affects mouse oocyte meiotic maturation and granulosa cell proliferation","volume":"30","author":"Hou","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib10","doi-asserted-by":"crossref","first-page":"18726","DOI":"10.1074\/jbc.REV119.007036","article-title":"Emerging roles for the ER stress sensor IRE1alpha in metabolic regulation and disease","volume":"294","author":"Huang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120022_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114633","article-title":"Deoxynivalenol leads to endoplasmic reticulum stress-mediated apoptosis via the IRE1\/JNK\/CHOP pathways in porcine embryos","volume":"188","author":"Kim","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ydbio.2013.12.025","article-title":"The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes","volume":"386","author":"Kim","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbrc.2010.06.022","article-title":"Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress","volume":"397","author":"Lee","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2026.120022_bib14","article-title":"Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in mammalian oocyte maturation and preimplantation embryo development","volume":"20","author":"Lin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120022_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae276","article-title":"Zearalenone triggers programmed cell death and impairs milk fat synthesis via the AKT-mTOR-PPARgamma-ACSL4 pathway in bovine mammary epithelial cells","volume":"102","author":"Ma","year":"2024","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ecoenv.2026.120022_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41419-024-06663-0","article-title":"IRE1 signaling increases PERK expression during chronic ER stress","volume":"15","author":"Ong","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2026.120022_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1071\/RD20273","article-title":"Invivo zearalenone exposure dose-dependently compromises mouse oocyte competence by impairing chromatin configuration and gene transcription","volume":"33","author":"Pan","year":"2021","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.ecoenv.2026.120022_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12458","article-title":"Melatonin improves the meiotic maturation of porcine oocytes by reducing endoplasmic reticulum stress during in vitro maturation","volume":"64","author":"Park","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2026.120022_bib19","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1080\/10408398.2019.1655388","article-title":"Occurrence and toxicity of a fusarium mycotoxin, zearalenone","volume":"60","author":"Rai","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120022_bib20","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2026.120022_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ani12192651","article-title":"The improvement of porcine in vitro embryo development through regulating autophagy by miRNA-143 inhibition","volume":"12","author":"Ridlo","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2026.120022_bib22","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","article-title":"ER stress-induced cell death mechanisms","volume":"1833","author":"Sano","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2026.120022_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.reprotox.2012.03.004","article-title":"Transgenerational toxicity of Zearalenone in pigs","volume":"34","author":"Schoevers","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120022_bib25","doi-asserted-by":"crossref","first-page":"19656","DOI":"10.1074\/jbc.M117.796920","article-title":"Inhibition of the sarco\/endoplasmic reticulum (ER) Ca(2+)-ATPase by thapsigargin analogs induces cell death via ER Ca(2+) depletion and the unfolded protein response","volume":"292","author":"Sehgal","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120022_bib26","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/1947601910383011","article-title":"The unfolded protein response, degradation from endoplasmic reticulum and cancer","volume":"1","author":"Tsai","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1016\/j.ecoenv.2026.120022_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7453\/gahmj.2014.017","article-title":"The unexpected uses of Urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases","volume":"3","author":"Vang","year":"2014","journal-title":"Glob. Adv. Health Med."},{"key":"10.1016\/j.ecoenv.2026.120022_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.theriogenology.2021.10.008","article-title":"Zearalenone exposure impairs organelle function during porcine oocyte meiotic maturation","volume":"177","author":"Wang","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2026.120022_bib29","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s10571-020-00814-5","article-title":"FAM134B attenuates seizure-induced apoptosis and endoplasmic reticulum stress in hippocampal neurons by promoting autophagy","volume":"40","author":"Xie","year":"2020","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14090641","article-title":"Resveratrol protects against zearalenone-induced mitochondrial defects during porcine oocyte maturation via PINK1\/parkin-mediated mitophagy","volume":"14","author":"Xu","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120022_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/em.22399","article-title":"Modified hydrated sodium calcium aluminosilicate-supplemented diet protects porcine oocyte quality from zearalenone toxicity","volume":"62","author":"Xu","year":"2021","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.ecoenv.2026.120022_bib32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fphar.2019.00327","article-title":"Protective effects of melatonin against zearalenone toxicity on porcine embryos in vitro","volume":"10","author":"Xu","year":"2019","journal-title":"Front Pharm."},{"key":"10.1016\/j.ecoenv.2026.120022_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2018.06.003","article-title":"Toxic effects of zearalenone on gametogenesis and embryonic development: a molecular point of review","volume":"119","author":"Yang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111511","article-title":"Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells","volume":"207","author":"Yao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120022_bib35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2019.00190","article-title":"Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways","volume":"13","author":"Yi","year":"2019","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120022_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12010002","article-title":"Zearalenone induces endoplasmic reticulum stress and Modulates the expression of phase I\/II enzymes in human liver cells","volume":"12","author":"Yoon","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120022_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep39838","article-title":"Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein","volume":"6","author":"Yoon","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120022_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100732","article-title":"vitro effect of zearalenone on sperm parameters, oocyte maturation and embryonic development in buffalo","volume":"23","author":"Yousef","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1095\/biolreprod.111.095059","article-title":"Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro","volume":"86","author":"Zhang","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2026.120022_bib40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.theriogenology.2023.06.021","article-title":"IP(3)R1 regulates calcium balance in porcine oocyte maturation and early embryonic development","volume":"209","author":"Zhang","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2026.120022_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.580876","article-title":"Mitochondrial Ca(2+) overload leads to mitochondrial oxidative stress and delayed meiotic resumption in mouse oocytes","volume":"8","author":"Zhang","year":"2020","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120022_bib42","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.bbrc.2019.05.067","article-title":"Disturbed intracellular calcium homeostasis in neural tube defects in diabetic embryopathy","volume":"514","author":"Zhao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2026.120022_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14110758","article-title":"Zearalenone induces apoptosis in porcine endometrial stromal cells through JNK signaling pathway based on endoplasmic reticulum stress","volume":"14","author":"Zhao","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120022_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156952","article-title":"Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function","volume":"144","author":"Zhou","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326003519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326003519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:50:31Z","timestamp":1776153031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326003519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":44,"alternative-id":["S0147651326003519"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120022","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IRE1\/FAM134B-mediated ER-phagy alleviates zearalenone-induced ER stress and developmental defects in porcine embryos","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120022"}}