{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:12:56Z","timestamp":1778735576787,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009102","name":"Jiangxi Provincial Department of Education","doi-asserted-by":"publisher","award":["490207"],"award-info":[{"award-number":["490207"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017712","name":"Ganzhou City Bureau of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ecoenv.2026.120110","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:15:19Z","timestamp":1775600119000},"page":"120110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting PPAR\u03b1: A novel mechanism for deoxynivalenol-induced hepatic lipid accumulation and its mitigation by nobiletin"],"prefix":"10.1016","volume":"315","author":[{"given":"Yunxia","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3406-2669","authenticated-orcid":false,"given":"Xizu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120110_bib1","article-title":"Hepatic peroxisomal \u03b2-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation","volume":"16","author":"A","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120110_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68712-w","article-title":"The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice","volume":"10","author":"Barbouche","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120110_bib3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2009.05.036","article-title":"Identification of a physiologically relevant endogenous ligand for PPARalpha in liver","volume":"138","author":"Chakravarthy","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120110_bib4","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1056\/NEJMoa2210645","article-title":"Triglyceride lowering with pemafibrate to reduce cardiovascular risk","volume":"387","author":"Das Pradhan","year":"2022","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ecoenv.2026.120110_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41574-020-0349-5","article-title":"Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation","volume":"16","author":"De Bosscher","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120110_bib6","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00204-021-03042-y","article-title":"Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function","volume":"95","author":"Del Favero","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120110_bib7","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1021\/acs.jafc.3c02020","article-title":"Deoxynivalenol: emerging toxic mechanisms and control strategies, current and future perspectives","volume":"71","author":"Deng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120110_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.toxlet.2009.05.011","article-title":"Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures","volume":"189","author":"D\u00f6ll","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2026.120110_bib9","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1039\/D5FO01105A","article-title":"The natural dihydrochalcone phloretin reduces lipid accumulation via downregulation of IIS and sbp-1\/SREBP pathways in HepG2 cells and Caenorhabditis elegans","volume":"16","author":"Gu","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2026.120110_bib10","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/15548627.2020.1797288","article-title":"Hepatic peroxisomal \u03b2-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation","volume":"16","author":"He","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120110_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfae045","article-title":"Comparison of transcriptomic profiles between HFPO-DA and prototypical PPAR\u03b1, PPAR\u03b3, and cytotoxic agents in wild-type and PPAR\u03b1 knockout mouse hepatocytes","volume":"200","author":"Heintz","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120110_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117792","article-title":"Mitochondria damage in ambient particulate matter induced cardiotoxicity: roles of PPAR alpha\/PGC-1 alpha signaling","volume":"288","author":"Jiang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120110_bib13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41392-025-02270-3","article-title":"Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions","volume":"10","author":"Jin","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2026.120110_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108345","article-title":"Combined exposure to deoxynivalenol facilitates lipid metabolism disorder in high-fat-diet-induced obesity mice","volume":"182","author":"Jin","year":"2023","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120110_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12550-019-00344-0","article-title":"Effects of deoxynivalenol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on parameters associated with oxidative stress in HepG2 cells","volume":"35","author":"Juan-Garc\u00eda","year":"2019","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.ecoenv.2026.120110_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101727","article-title":"PPAR\u03b1 ligand-binding domain structures with endogenous fatty acids and fibrates","volume":"23","author":"Kamata","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.ecoenv.2026.120110_bib17","doi-asserted-by":"crossref","first-page":"9076","DOI":"10.1021\/acs.jafc.5c00255","article-title":"Nobiletin enhances skeletal muscle mass and modulates bile acid composition in diet-induced obese mice","volume":"73","author":"Koh","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120110_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116769","article-title":"Heavy metals, oxidative stress, and the role of AhR signaling","volume":"482","author":"Kou","year":"2024","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120110_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tox.2017.05.014","article-title":"B-13 progenitor-derived hepatocytes (B-13\/H cells) model lipid dysregulation in response to drugs and chemicals","volume":"386","author":"Leitch","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120110_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109696","article-title":"Nobiletin promotes lipolysis of white adipose tissue in a circadian clock-dependent manner","volume":"132","author":"Li","year":"2024","journal-title":"J. Nutr. Biochem."},{"issue":"25","key":"10.1016\/j.ecoenv.2026.120110_bib21","first-page":"00157","article-title":"Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy","volume":"S0165-6147","author":"Liu","year":"2025","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.ecoenv.2026.120110_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4142\/jvs.2010.11.2.107","article-title":"Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets","volume":"11","author":"Mikami","year":"2010","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.ecoenv.2026.120110_bib23","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2026.120110_bib24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/apt.16596","article-title":"Randomised clinical trial: pemafibrate, a novel selective peroxisome proliferator-activated receptor \u03b1 modulator (SPPARM\u03b1), versus placebo in patients with non-alcoholic fatty liver disease","volume":"54","author":"Nakajima","year":"2021","journal-title":"Aliment Pharm. Ther."},{"key":"10.1016\/j.ecoenv.2026.120110_bib25","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120110_bib26","first-page":"782","article-title":"A zebrafish model of acute liver injury induced by thioacetamide","volume":"34","author":"QI","year":"2014","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.ecoenv.2026.120110_bib27","article-title":"Nobiletin prevents cardiac hypertrophy via SIRT5-mediated downregulation of p300","author":"Sunagawa","year":"2025","journal-title":"Hypertension"},{"key":"10.1016\/j.ecoenv.2026.120110_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/HEP.0000000000000791","article-title":"PPAR\u03b1, PPAR\u03b4, or both-that is the question!","volume":"80","author":"Wolters","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2026.120110_bib29","article-title":"Nobiletin protected against hypertrophic cardiomyopathy via targeting PPAR\u03b1","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120110_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107862","article-title":"Nuclear receptors in metabolism and diseases: mechanistic and therapeutic insights","volume":"218","author":"Zhu","year":"2025","journal-title":"Pharm. Res"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:54:22Z","timestamp":1778734462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326004392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":30,"alternative-id":["S0147651326004392"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120110","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting PPAR\u03b1: A novel mechanism for deoxynivalenol-induced hepatic lipid accumulation and its mitigation by nobiletin","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120110"}}