{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T13:12:35Z","timestamp":1778332355971,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91843302"],"award-info":[{"award-number":["91843302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60623"],"award-info":[{"award-number":["2025JJ60623"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ecoenv.2026.120115","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:15:19Z","timestamp":1775600119000},"page":"120115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PLCH2 gene modifies the U-shaped association between environmental selenium exposure and blood total cholesterol: A gene-environment interaction study"],"prefix":"10.1016","volume":"315","author":[{"given":"Xiuquan","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyou","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-7311","authenticated-orcid":false,"given":"Weihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120115_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120115_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233843","article-title":"The role of oxidative stress in atherosclerosis","volume":"11","author":"Batty","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120115_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0165-6147(00)01719-3","article-title":"Hormesis: U-shaped dose responses and their centrality in toxicology","volume":"22","author":"Calabrese","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120115_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.archger.2014.09.005","article-title":"The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese","volume":"60","author":"Chen","year":"2015","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.ecoenv.2026.120115_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0035-1569276","article-title":"Selenium supplementation affects insulin resistance and serum hs-CRP in patients with type 2 diabetes and coronary heart disease","volume":"48","author":"Farrokhian","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.ecoenv.2026.120115_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1289\/ehp.1307563","article-title":"Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China","volume":"123","author":"Feng","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120115_bib7","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1373\/clinchem.2004.039875","article-title":"Selenium metabolites in urine: a critical overview of past work and current status","volume":"50","author":"Francesconi","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ecoenv.2026.120115_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jtemb.2016.12.002","article-title":"Relationship between serum selenium, sociodemographic variables, other trace elements and lipid profile in an adult Spanish population","volume":"43","author":"Gonzalez-Estecha","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41574-020-0385-1","article-title":"Towards precision nutrition","volume":"16","author":"Greenhill","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00420-019-01489-2","article-title":"Evaluation of urinary selenium as a biomarker of human occupational exposure to elemental and inorganic selenium","volume":"93","author":"Greiner","year":"2020","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120115_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2021.126801","article-title":"Absorption, distribution, metabolism and excretion (ADME) of oral selenium from organic and inorganic sources: a review","volume":"67","author":"Hadrup","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127572","article-title":"Associations between serum selenium and serum lipids in adolescents aged 12-19: a cross-sectional study","volume":"87","author":"He","year":"2025","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00204-014-1380-x","article-title":"Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenate dependent on trimethylselenium ion (TMSe) status","volume":"90","author":"Jager","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00204-015-1548-z","article-title":"Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenite and selenized yeast dependent on the trimethylselenium ion (TMSe) status","volume":"90","author":"Jager","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib15","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.clnu.2017.08.025","article-title":"Relationship between higher serum selenium level and adverse blood lipid profile","volume":"37","author":"Ju","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120115_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/gme.0b013e31806bf32c","article-title":"Associations of blood selenium and serum lipid levels in Japanese premenopausal and postmenopausal women","volume":"15","author":"Karita","year":"2008","journal-title":"Menopause- J. North Am. Menopause Soc."},{"key":"10.1016\/j.ecoenv.2026.120115_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3177\/jnsv.49.397","article-title":"The relationship between serum selenium levels and lipid profiles in adult women","volume":"49","author":"Lee","year":"2003","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.ecoenv.2026.120115_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002539","article-title":"Primary prevention of cardiovascular disease: the past, present, and future of blood pressure- and cholesterol-lowering treatments","volume":"15","author":"Leening","year":"2018","journal-title":"PLoS Med."},{"key":"10.1016\/j.ecoenv.2026.120115_bib19","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1161\/CIRCULATIONAHA.105.581934","article-title":"Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk","volume":"112","author":"Lewington","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ecoenv.2026.120115_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2019.03.004","article-title":"Gene-environment interaction in the era of precision medicine","volume":"177","author":"Li","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120115_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","article-title":"Hormesis defined","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ecoenv.2026.120115_bib22","doi-asserted-by":"crossref","first-page":"29128","DOI":"10.1074\/jbc.M503817200","article-title":"A novel phospholipase C, PLC eta 2, is a neuron-specific isozyme","volume":"280","author":"Nakahara","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120115_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161815","article-title":"Associations of selenium exposure with blood lipids: exploring mediating DNA methylation sites in general Chinese urban non-smokers","volume":"869","author":"Nie","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120115_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119898","article-title":"AMER3 variants modify the U-shaped association of urinary total hydroxyphenanthrene with fasting plasma glucose: a newfound gene-environment interaction","volume":"310","author":"Nie","year":"2022","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"key":"10.1016\/j.ecoenv.2026.120115_bib25","first-page":"821","article-title":"Gene-environment interaction and public health","volume":"56","author":"Ottman","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ecoenv.2026.120115_bib26","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2007.1528","article-title":"From selenium to selenoproteins: synthesis, identity, and their role in human health","volume":"9","author":"Papp","year":"2007","journal-title":"Antioxid. & Redox Signal."},{"key":"10.1016\/j.ecoenv.2026.120115_bib27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jcb.24690","article-title":"A canonical EF-loop directs Ca(2+) -sensitivity in phospholipase C-eta2","volume":"115","author":"Popovics","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ecoenv.2026.120115_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1042\/BST20110622","article-title":"Putative roles for phospholipase Ceta enzymes in neuronal Ca2+ signal modulation","volume":"40","author":"Popovics","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ecoenv.2026.120115_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0749-0720(15)30081-5","article-title":"Selenosis","volume":"16","author":"Raisbeck","year":"2000","journal-title":"Vet. Clin. North Am. -Food Anim. Pract."},{"key":"10.1016\/j.ecoenv.2026.120115_bib30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-154-10-201105170-00005","article-title":"Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial","volume":"154","author":"Rayman","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ecoenv.2026.120115_bib31","first-page":"127","article-title":"Urinary selenium status of healthy people","volume":"33","author":"Rodriguez Rodriguez","year":"1995","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.ecoenv.2026.120115_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C3MT00185G","article-title":"Selenium biochemistry and its role for human health","volume":"6","author":"Roman","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2026.120115_bib33","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1093\/clinchem\/39.10.2040","article-title":"Urinary selenium concentrations","volume":"39","author":"Sanz Alaejos","year":"1993","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ecoenv.2026.120115_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-14-994","article-title":"The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort","volume":"14","author":"Song","year":"2014","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ecoenv.2026.120115_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000107795","article-title":"Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues","volume":"86","author":"Stewart","year":"2007","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ecoenv.2026.120115_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3321","article-title":"A subcellular map of the human proteome","volume":"356","author":"Thul","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.120115_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.120115_bib38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein & Cell"},{"key":"10.1016\/j.ecoenv.2026.120115_bib39","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/BJ20050839","article-title":"Molecular cloning and characterization of PLC-eta 2","volume":"391","author":"Zhou","year":"2005","journal-title":"Biochem. J."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T13:05:54Z","timestamp":1778331954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326004446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"alternative-id":["S0147651326004446"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120115","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PLCH2 gene modifies the U-shaped association between environmental selenium exposure and blood total cholesterol: A gene-environment interaction study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120115"}}