{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T13:13:17Z","timestamp":1778332397337,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ecoenv.2026.120118","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:37:32Z","timestamp":1775752652000},"page":"120118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The associations between prenatal exposure to organophosphate esters and children\u2019s anogenital distance growth trajectory: A birth cohort study"],"prefix":"10.1016","volume":"315","author":[{"given":"Yujie","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangqian","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchao","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuheng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-355X","authenticated-orcid":false,"given":"Maohua","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120118_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.reprotox.2020.04.001","article-title":"Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression","volume":"94","author":"Adams","year":"2020","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120118_bib2","first-page":"675","article-title":"Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men","volume":"83","author":"Andersson","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib3","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae050","article-title":"Correlation of anogenital distance from childhood to age 9 years-a prospective population-based birth cohort-the Odense Child Cohort","volume":"2024","author":"Andreasen","year":"2024","journal-title":"Hum. Reprod. Open"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120118_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1039\/C8EM00389K","article-title":"A pilot study of metabolites of organophosphorus flame retardants in paired maternal urine and amniotic fluid samples: potential exposure risks of tributyl phosphate to pregnant women","volume":"21","author":"Bai","year":"2019","journal-title":"Environ. Sci. Process Impacts"},{"key":"10.1016\/j.ecoenv.2026.120118_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fendo.2020.00187","article-title":"Ontogeny of hypothalamus-pituitary gonadal axis and minipuberty: an ongoing debate?","volume":"11","author":"Bizzarri","year":"2020","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120118_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/eje.1.02066","article-title":"Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study of 1962 normal boys","volume":"154","author":"Boas","year":"2006","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostatistics"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib8","doi-asserted-by":"crossref","first-page":"37009","DOI":"10.1289\/EHP8990","article-title":"Biomarkers of exposure to phthalate mixtures and adverse birth outcomes in a puerto rico birth cohort","volume":"130","author":"Cathey","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120118_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137730","article-title":"Tracing impacts of prenatal exposure to bisphenol analogues on child anogenital distance development: a birth-cohort study","volume":"490","author":"Chen","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120118_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/humrep\/deae025","article-title":"Anogenital distance in a cohort of 169 infant boys with uni- or bilateral cryptorchidism including 18 boys with vanishing testes","volume":"39","author":"Cortes","year":"2024","journal-title":"Hum. Reprod."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120118_bib11","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1161\/CIRCRESAHA.118.312946","article-title":"Letter by De Meyer regarding article, \"short leukocyte telomere length precedes clinical expression of atherosclerosis: the blood-and-muscle model\"","volume":"122","author":"De Meyer","year":"2018","journal-title":"Circ. Res"},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120118_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chemosphere.2012.03.067","article-title":"Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis","volume":"88","author":"van der Veen","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120118_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119581","article-title":"Organophosphate ester flame retardant chemicals and maternal depression during pregnancy","volume":"259","author":"Hernandez-Castro","year":"2024","journal-title":"Environ. Res"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/acs.estlett.6b00475","article-title":"Temporal trends in exposure to organophosphate flame retardants in the United States","volume":"4","author":"Hoffman","year":"2017","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120118_bib15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijheh.2018.05.001","article-title":"The association between urinary concentrations of phosphorous-containing flame retardant metabolites and semen parameters among men from a fertility clinic","volume":"221","author":"Ingle","year":"2018","journal-title":"Int J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120118_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145119","article-title":"Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: a study from the Odense Child Cohort","volume":"769","author":"Jensen","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120118_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2013.09.004","article-title":"vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors","volume":"314","author":"Kojima","year":"2013","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5152\/tpa.2014.2038","article-title":"Mini puberty and its interpretation","volume":"49","author":"Kurto\u011flu","year":"2014","journal-title":"Turk. Pediatr. Ars"},{"issue":"22","key":"10.1016\/j.ecoenv.2026.120118_bib19","doi-asserted-by":"crossref","first-page":"14525","DOI":"10.1021\/acs.est.0c04376","article-title":"Structure-oriented research on the antiestrogenic effect of organophosphate esters and the potential mechanism","volume":"54","author":"Li","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120118_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12958-025-01390-3","article-title":"Associations between organophosphate flame retardants metabolites in follicular fluid and reproductive outcomes among women undergoing IVF\/ICSI treatment in Southwest China","volume":"23","author":"Li","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120118_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161202","article-title":"Urinary concentrations of organophosphate esters in relation to semen quality: a cross-sectional study","volume":"865","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120118_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2012.02.019","article-title":"Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish","volume":"114-115","author":"Liu","year":"2012","journal-title":"Aquat. Toxicol."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2026.120118_bib23","article-title":"Prenatal exposure to organophosphate esters is associated with decreased anogenital distance in offspring","volume":"856","author":"Luan","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120118_bib24","article-title":"Minipuberty: looking back to understand moving forward","volume":"8","author":"Lucaccioni","year":"2020","journal-title":"Front Pedia"},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2026.120118_bib25","article-title":"Exposure to organophosphate ester flame retardants and plasticizers and associations with preeclampsia and blood pressure in pregnancy","volume":"262","author":"Lueth","year":"2024","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120118_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000542580","article-title":"Contribution of clinical and biological mini-puberty and genetic analysis in 57 46,xy differences of sex development: a monocentric retrospective cohort","author":"Marie","year":"2025","journal-title":"Horm. Res Paediatr."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120118_bib27","article-title":"Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health","volume":"1","author":"Meeker","year":"2013","journal-title":"Endocr. Disruptors (Austin)"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120118_bib28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1289\/ehp.1103421","article-title":"Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York","volume":"119","author":"Mendiola","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120118_bib29","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/humrep\/dew163","article-title":"Endometriomas and deep infiltrating endometriosis in adulthood are strongly associated with anogenital distance, a biomarker for prenatal hormonal environment","volume":"31","author":"Mendiola","year":"2016","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120118_bib30","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/andr.12863","article-title":"Short anogenital distance is associated with testicular germ cell tumour development","volume":"8","author":"Moreno-Mendoza","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2026.120118_bib31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.foodchem.2017.02.103","article-title":"Trace determination of organophosphate esters in white wine, red wine, and beer samples using dispersive liquid-liquid microextraction combined with ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"229","author":"Pang","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120118_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124701","article-title":"Concentrations and loadings of organophosphate and replacement brominated flame retardants in house dust from the home study during the PBDE phase-out","volume":"239","author":"Percy","year":"2020","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120118_bib33","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/humrep\/deab162","article-title":"Testicular cancer survivors have shorter anogenital distance that is not increased by 1 year of testosterone replacement therapy","volume":"36","author":"Priskorn","year":"2021","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120118_bib34","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/and.12507","article-title":"Maternal and infant characteristics influencing the anogenital distance and penile length in newborns","volume":"48","author":"Singal","year":"2016","journal-title":"Andrologia"},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2026.120118_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.envint.2018.08.055","article-title":"Maternal exposure to bisphenol A and anogenital distance throughout infancy: a longitudinal study from Shanghai, China","volume":"121","author":"Sun","year":"2018","journal-title":"Environ. Int"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120118_bib36","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/humrep\/deu363","article-title":"First trimester phthalate exposure and anogenital distance in newborns","volume":"30","author":"Swan","year":"2015","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120118_bib37","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1289\/ehp.0900881","article-title":"Anogenital distance from birth to 2 years: a population study","volume":"117","author":"Thankamony","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/jhrs.jhrs_44_23","article-title":"Association between Late manifestations of testicular dysgenesis syndrome and anogenital distance: a systematic review and meta-analysis","volume":"16","author":"Tsutida","year":"2023","journal-title":"J. Hum. Reprod. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120118_bib39","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jat.4056","article-title":"Maternal organophosphate flame-retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually-dimorphic manner in mice","volume":"41","author":"Walley","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120118_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117011","article-title":"Exposure of children and mothers to organophosphate esters: prediction by house dust and silicone wristbands","volume":"282","author":"Xie","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120118_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/da\/6655082","article-title":"Association of prenatal depression with second to fourth digit ratio in children aged 4 and 6 years","volume":"2025","author":"Zhang","year":"2025","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.ecoenv.2026.120118_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109120","article-title":"A comprehensive evaluation of the endocrine-disrupting effects of emerging organophosphate esters","volume":"193","author":"Zhang","year":"2024","journal-title":"Environ. Int"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120118_bib43","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1021\/acs.est.7b01122","article-title":"Organophosphorus flame retardants in pregnant women and their transfer to chorionic villi","volume":"51","author":"Zhao","year":"2017","journal-title":"Environ. Sci. Technol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T13:07:08Z","timestamp":1778332028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326004471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S0147651326004471"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120118","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The associations between prenatal exposure to organophosphate esters and children\u2019s anogenital distance growth trajectory: A birth cohort study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120118"}}