{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:51:54Z","timestamp":1792669914777,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["20242044"],"award-info":[{"award-number":["20242044"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073582"],"award-info":[{"award-number":["82073582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404301"],"award-info":[{"award-number":["82404301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["JDXM2024048"],"award-info":[{"award-number":["JDXM2024048"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["GDMULCJC2025240"],"award-info":[{"award-number":["GDMULCJC2025240"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["GDMULCJC2024165"],"award-info":[{"award-number":["GDMULCJC2024165"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515140178"],"award-info":[{"award-number":["2024A1515140178"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140169"],"award-info":[{"award-number":["2023A1515140169"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ecoenv.2026.120130","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:28:59Z","timestamp":1776079739000},"page":"120130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ATF3 links endoplasmic reticulum stress to ferroptosis via transcriptional activation of ALOX12 in benzene-induced hematotoxicity"],"prefix":"10.1016","volume":"316","author":[{"given":"HuaFeng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuXi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongTing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShaoYing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuFan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaoChen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuYun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunnian","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FengZhen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-2103","authenticated-orcid":false,"given":"Huanwen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120130_bib1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3390\/polym13050684","article-title":"Supramolecular functionalizable linear\u2013dendritic block copolymers for the preparation of nanocarriers by microfluidics","volume":"13","author":"Abad","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.ecoenv.2026.120130_bib2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-025-09370-8","article-title":"Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy","volume":"646","author":"Baruch","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120130_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2005.03.007","article-title":"An overview of occupational benzene exposures and occupational exposure limits in Europe and North America","volume":"153-154","author":"Capleton","year":"2005","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2026.120130_bib4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s13046-019-1413-7","article-title":"Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK\/ATF4\/HSPA5 pathway in glioma cells","volume":"38","author":"Chen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"10.1016\/j.ecoenv.2026.120130_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113757","article-title":"SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells","volume":"241","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120130_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103030","article-title":"SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3","volume":"69","author":"Chen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib7","article-title":"RAD51 m6A and PARylation modification orchestrate benzene-induced haematological toxicity","volume":"501","author":"Chen","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.120130_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108493","article-title":"HIF-1alpha\/m(6)A\/NF-kappaB\/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity","volume":"184","author":"Cong","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120130_bib10","doi-asserted-by":"crossref","first-page":"41897","DOI":"10.1021\/jacs.5c14856","article-title":"Intramolecular hydrogen atom transfer enables hydroperoxyl radical formation during the peroxidation of unsaturated lipids","volume":"147","author":"Dehdari","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ecoenv.2026.120130_bib11","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1016\/j.molcel.2021.05.008","article-title":"ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia","volume":"81","author":"Di Marcantonio","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2026.120130_bib12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120130_bib13","doi-asserted-by":"crossref","first-page":"W415","DOI":"10.1093\/nar\/gkae456","article-title":"WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics","volume":"52","author":"Elizarraras","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120130_bib14","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","article-title":"SnapShot: Ferroptosis","volume":"181","author":"Hadian","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120130_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","article-title":"ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis","volume":"79","author":"He","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1182\/blood.2023023788","article-title":"Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress","volume":"144","author":"Hofmann","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.ecoenv.2026.120130_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado3141","article-title":"Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis","volume":"10","author":"Hu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2026.120130_bib18","unstructured":"Hudhud, L., In vitro investigations of the role, signaling and effects of novel antiinflammatory, analgesic, and anti- cancer drug targets. University of P\u00e9cs, Medical School. University of P\u00e9cs, Medical School, 2023."},{"key":"10.1016\/j.ecoenv.2026.120130_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104791","article-title":"The role of ATF3 in the crosstalk between cellular stress response and ferroptosis in tumors","volume":"213","author":"Jia","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib20","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1038\/s41467-024-48330-0","article-title":"IRE1\u03b1 determines ferroptosis sensitivity through regulation of glutathione synthesis","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120130_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib22","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401475R","article-title":"Lipoxin A(4)\/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury","volume":"39","author":"Kollareth","year":"2025","journal-title":"Faseb J."},{"key":"10.1016\/j.ecoenv.2026.120130_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073420","article-title":"Comparative analysis of transcriptional responses to genotoxic and non-genotoxic agents in the blood cell model TK6 and the liver model HepaRG","volume":"23","author":"Kreuzer","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120130_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1158\/1541-7786.MCR-18-0055","article-title":"Ferroptosis-induced endoplasmic reticulum stress: cross-talk between ferroptosis and apoptosis","volume":"16","author":"Lee","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ecoenv.2026.120130_bib25","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/tox.23814","article-title":"Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR","volume":"38","author":"Li","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/1673-5374.380870","article-title":"Ferroptosis and endoplasmic reticulum stress in ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.ecoenv.2026.120130_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113488","article-title":"Association between exposure to a mixture of benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) and small airways function: a cross-sectional study","volume":"212","author":"Liao","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120130_bib28","doi-asserted-by":"crossref","first-page":"13149","DOI":"10.1039\/C7RA00185A","article-title":"Metabolomics analysis reveals aminoquinazolin derivative 9d-induced oxidative stress and cell cycle arrest in A549 cells","volume":"7","author":"Liu","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.ecoenv.2026.120130_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.585771","article-title":"ATF3 prevents stress-induced hematopoietic stem cell exhaustion","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2020","key":"10.1016\/j.ecoenv.2026.120130_bib30","article-title":"Endoplasmic reticulum stress in diseases","volume":"5","author":"Liu","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.ecoenv.2026.120130_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116295","article-title":"Linc01588 deletion inhibits the malignant biological characteristics of hydroquinone-induced leukemic cells via miR-9-5p\/SIRT1","volume":"276","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120130_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103787","article-title":"Decoding Parkinson's Disease: the interplay of cell death pathways, oxidative stress, and therapeutic innovations","volume":"85","author":"Liu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2026.120130_bib34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2015.08.006","article-title":"The role of lipoxygenases in pathophysiology; new insights and future perspectives","volume":"6","author":"Mashima","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050804","article-title":"Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis","volume":"12","author":"Mortensen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120130_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14030307","article-title":"The PERK-eIF2alpha-ATF4 axis is involved in mediating er-stress-induced ferroptosis via DDIT4-mTORC1 inhibition and acetaminophen-induced hepatotoxicity","volume":"14","author":"Nghiem","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2026.120130_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202502249","article-title":"ATF3 deficiency exacerbates ageing-induced atherosclerosis and clinical intervention strategy","volume":"12","author":"Nie","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ecoenv.2026.120130_bib38","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41375-021-01499-5","article-title":"HMCES safeguards genome integrity and long-term self-renewal of hematopoietic stem cells during stress responses","volume":"36","author":"Pan","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.ecoenv.2026.120130_bib39","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120130_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102833","article-title":"Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc\u207b) in colorectal cancer","volume":"65","author":"Saini","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib41","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41556-025-01668-z","article-title":"Endoplasmic reticulum-mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis","volume":"27","author":"Sassano","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1164\/rccm.202311-2023ED","article-title":"Occupational benzene exposure: an unrecognized threat for lung cancer development","volume":"209","author":"Steiling","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2026.120130_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110004","article-title":"Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway","volume":"362","author":"Sun","year":"2022","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2026.120130_bib44","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature14131","article-title":"Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells","volume":"520","author":"Walter","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120130_bib45","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2026.120130_bib46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1164\/rccm.202308-1440OC","article-title":"Long-term exposure to low concentrations of ambient benzene and mortality in a national english cohort","volume":"209","author":"Wang","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2026.120130_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108645","article-title":"Specific CpG sites methylation is associated with hematotoxicity in low-dose benzene-exposed workers","volume":"186","author":"Wang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120130_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116773","article-title":"UBE2L3 promotes benzene-induced hematotoxicity via autophagy-dependent ferroptosis","volume":"283","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120130_bib49","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120130_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169260","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress","volume":"912","author":"Wu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120130_bib51","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/s41375-023-02055-z","article-title":"STING activation in TET2-mutated hematopoietic stem\/progenitor cells contributes to the increased self-renewal and neoplastic transformation","volume":"37","author":"Xie","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.ecoenv.2026.120130_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120130_bib53","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2026.120130_bib54","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.est.3c06127","article-title":"Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120130_bib55","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.cmet.2021.08.014","article-title":"Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2026.120130_bib56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.freeradbiomed.2022.10.273","article-title":"Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis","volume":"193","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120130_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165678","article-title":"Probiotics ameliorate benzene-induced systemic inflammation and hematopoietic toxicity by inhibiting Bacteroidaceae-mediated ferroptosis","volume":"899","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120130_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107355","article-title":"ATF family members as therapeutic targets in cancer: from mechanisms to pharmacological interventions","volume":"208","author":"Zhang","year":"2024","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ecoenv.2026.120130_bib59","article-title":"Mechanisms of vitamins inhibiting ferroptosis","volume":"13","author":"Zhang","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120130_bib60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2021.09.008","article-title":"Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells","volume":"175","author":"Zhao","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120130_bib61","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.2024027846","article-title":"PERK signaling maintains hematopoietic stem cell pool integrity under endoplasmic reticulum stress by promoting proliferation","volume":"146","author":"Zheng","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.ecoenv.2026.120130_bib62","doi-asserted-by":"crossref","DOI":"10.34133\/research.0159","article-title":"TRPM2 mediates hepatic ischemia-reperfusion injury via Ca(2+)-induced mitochondrial lipid peroxidation through increasing alox12 expression","volume":"6","author":"Zhong","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.ecoenv.2026.120130_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116734","article-title":"Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15","volume":"175","author":"Zhu","year":"2024","journal-title":"Biomed. Pharm."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:07:10Z","timestamp":1778724430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326004598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":63,"alternative-id":["S0147651326004598"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120130","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATF3 links endoplasmic reticulum stress to ferroptosis via transcriptional activation of ALOX12 in benzene-induced hematotoxicity","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120130"}}