{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:13:26Z","timestamp":1778735606630,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ecoenv.2026.120154","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:09:26Z","timestamp":1776373766000},"page":"120154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Di-(2-ethylhexyl) phthalate induces spermatogenic dysfunction via p38\/NCOA4-dependent ferritinophagy and ferroptosis in Sertoli cells"],"prefix":"10.1016","volume":"316","author":[{"given":"Anni","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongcheng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120154_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/humupd\/dml018","article-title":"The sensitivity of the child to sex steroids: possible impact of exogenous estrogens","volume":"12","author":"Aksglaede","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2026.120154_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev.ph.47.030185.002123","article-title":"Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: the endosomal apparatus","volume":"47","author":"Bergeron","year":"1985","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib3","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1007\/s00204-024-03871-7","article-title":"Revisiting cadmium-induced toxicity in the male reproductive system: an update","volume":"98","author":"Bhardwaj","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib4","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1095\/biolreprod56.6.1490","article-title":"Induction of apoptosis in the germ cells of adult male rats after exposure to Cyclophosphamide1","volume":"56","author":"Cai","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2026.120154_bib5","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.3390\/ijms26083496","article-title":"Interplay of ferroptosis, cuproptosis, autophagy and pyroptosis in male infertility: molecular crossroads and therapeutic opportunities","volume":"26","author":"Cai","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120154_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147371","article-title":"The effects of phthalate ester exposure on human health: A review","volume":"786","author":"Chang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120154_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/15548627.2020.1720431","article-title":"m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells","volume":"17","author":"Chen","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120154_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/6986445","article-title":"Modulation of the p38 MAPK pathway by anisomycin promotes ferroptosis of hepatocellular carcinoma through phosphorylation of H3S10","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2026.120154_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/toxsci\/kfz013","article-title":"Subchronic exposure to Di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood has immediate and long-term reproductive consequences in female mice","volume":"168","author":"Chiang","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120154_bib10","first-page":"215","article-title":"Agreement and internal quality assurance of the Neubauer hemocytometer and Makler chamber for human sperm concentration determination","volume":"28","author":"Costa","year":"2024","journal-title":"JBRA Assist. Reprod."},{"key":"10.1016\/j.ecoenv.2026.120154_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","article-title":"p38MAPK: stress responses from molecular mechanisms to therapeutics","volume":"15","author":"Coulthard","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.ecoenv.2026.120154_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126101","article-title":"Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes","volume":"373","author":"Feng","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120154_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115151","article-title":"The role of STAT3\/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat","volume":"404","author":"Fu","year":"2020","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120154_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.freeradbiomed.2025.10.287","article-title":"Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models","volume":"242","author":"Gu","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.scitotenv.2016.04.145","article-title":"Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic\u2013pituitary\u2013testis axis and ERK-mediated 5\u03b1-Reductase 2","volume":"563-564","author":"Ha","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120154_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101470","article-title":"Ferroptosis and ferritinophagy in diabetes complications","volume":"60","author":"He","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.ecoenv.2026.120154_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8966368","article-title":"Theaflavin-3,3\u2032-digallate plays a ROS-mediated dual role in ferroptosis and apoptosis via the MAPK pathway in human osteosarcoma cell lines and xenografts","volume":"2022","author":"He","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2026.120154_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112889","article-title":"Exposure to DEHP induces testis toxicity and injury through the ROS\/mTOR\/NLRP3 signaling pathway in immature rats","volume":"227","author":"Hong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120154_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112889","article-title":"Exposure to DEHP induces testis toxicity and injury through the ROS\/mTOR\/NLRP3 signaling pathway in immature rats","volume":"227","author":"Hong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120154_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153831","article-title":"NCOA4-mediated ferritinophagy participates in cadmium-triggered ferroptosis in spermatogonia","volume":"505","author":"Jia","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120154_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib23","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/biolre\/ioae126","article-title":"Environmental toxins and reproductive health: unraveling the effects on Sertoli cells and the blood\u2013testis barrier in animals","volume":"111","author":"Jiang","year":"2024","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2026.120154_bib24","first-page":"112","article-title":"Comparative study on different recovery periods of the spermatogenic dysfunction mouse model induced by cyclophosphamide","volume":"43","author":"Jingwei","year":"2023","journal-title":"Lab. Anim. Comp. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib25","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.envpol.2016.02.008","article-title":"Exposure to widespread environmental endocrine disrupting chemicals and human sperm sex ratio","volume":"213","author":"Jurewicz","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120154_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201700137","article-title":"Design, synthesis, and screening of triazolopyrimidine\u2013pyrazole hybrids as potent apoptotic inducers","volume":"350","author":"Kamal","year":"2017","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120154_bib27","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/PAS.0000000000001704","article-title":"Immunohistochemical characterization of 120 testicular sex cord-stromal tumors with an emphasis on the diagnostic utility of SOX9, FOXL2, and SF-1","volume":"45","author":"Lau","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib28","doi-asserted-by":"crossref","first-page":"E1519","DOI":"10.1152\/ajpendo.00007.2012","article-title":"Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload","volume":"302","author":"Leichtmann-Bardoogo","year":"2012","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2026.120154_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2026.120154_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envpol.2017.08.018","article-title":"Phthalate metabolites related to infertile biomarkers and infertility in Chinese men","volume":"231","author":"Liu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120154_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2023.2260646","article-title":"Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes","volume":"28","author":"Liu","year":"2023","journal-title":"Redox Rep."},{"key":"10.1016\/j.ecoenv.2026.120154_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154172","article-title":"Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet","volume":"516","author":"Liu","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120154_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1302\/2046-3758.124.BJR-2022-0384.R1","article-title":"Dihydrocaffeic acid improves IL-1\u03b2-induced inflammation and cartilage degradation via inhibiting NF-\u03baB and MAPK signalling pathways","volume":"12","author":"Lu","year":"2023","journal-title":"Bone Jt. Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153849","article-title":"Combined exposure of PS-MPs with NaF induces Sertoli cell death and dysfunction via ferroptosis and apoptosis","volume":"506","author":"Ma","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120154_bib35","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3390\/ani15152191","article-title":"Feline testicular biometry and gonadosomatic index: associations among conventional measurements, mathematical estimates, and seminal parameters","volume":"15","author":"Madrigal-Valverde","year":"2025","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2026.120154_bib36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0015-0282(97)81526-9","article-title":"The performance of 10 different methods for the estimation of sperm concentration","volume":"68","author":"Mahmoud","year":"1997","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2026.120154_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10308","article-title":"Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis","volume":"4","author":"Mancias","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.ecoenv.2026.120154_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/tox.24425","article-title":"Se-methylselenocysteine ameliorates DEHP-induced ferroptosis in testicular Sertoli cells via the Nrf2\/GPX4 Axis","volume":"40","author":"Mao","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1387\/ijdb.250005ce","article-title":"Characterization of somatic testicular cells during human development: fetal, peripubertal, adolescent and adult human testis from healthy and infertility related disease","volume":"69","author":"Martin-Inaraja","year":"2025","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/toxics13030151","article-title":"Polycyclic aromatic hydrocarbons (PAHs) in the environment: occupational exposure, health risks and fertility implications","volume":"13","author":"Montano","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120154_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2419096","article-title":"Dihydrocaffeic acid prevents UVB-induced oxidative stress leading to the inhibition of apoptosis and MMP-1 expression via p38 signaling pathway","volume":"2019","author":"Oliveira","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2026.120154_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-023-04038-8","article-title":"Quercetin supplementation alleviates cadmium induced genotoxicity-mediated apoptosis in caprine testicular cells","volume":"202","author":"Panchal","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib44","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1007\/s11356-014-2986-5","article-title":"Reproductive toxicity of lead, cadmium, and phthalate exposure in men","volume":"21","author":"Pant","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1750368","article-title":"Toxic effects of Di-2-ethylhexyl phthalate: an overview","volume":"2018","author":"Rowdhwal","year":"2018","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.ecoenv.2026.120154_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.109022","article-title":"Is ferroptosis a cause for concern in male infertility?","volume":"137","author":"Sahoo","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/ph11040114","article-title":"The role of NCOA4-mediated ferritinophagy in health and disease","volume":"11","author":"Santana-Codina","year":"2018","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ecoenv.2026.120154_bib48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.reprotox.2018.06.015","article-title":"Vitamin E and Vitamin C attenuate Di-(2-ethylhexyl) phthalate-induced blood-testis barrier disruption by p38 MAPK in immature SD rats","volume":"81","author":"Shen","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109533","article-title":"Seminal per- and polyfluoroalkyl substance exposure and sperm quality impairment: from toxic target to rescue","volume":"200","author":"Shi","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120154_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2025.100267","article-title":"Phthalates and epigenetics: an emerging public health concern","volume":"9","author":"Singh","year":"2025","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/genes14010043","article-title":"Ferroptosis: a novel type of cell death in male reproduction","volume":"14","author":"Su","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.ecoenv.2026.120154_bib52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib53","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/tox.22559","article-title":"Di-(2-ethylhexyl) phthalate (DEHP)-induced testicular toxicity through Nrf2-mediated Notch1 signaling pathway in Sprague\u2013Dawley rats","volume":"33","author":"Tang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib54","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s40001-024-01921-5","article-title":"Exploration of tissue fixation methods suitable for digital pathological studies of the testis","volume":"29","author":"Tian","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2018.08.024","article-title":"Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action","volume":"121","author":"Ullah","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib56","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/toxics7020021","article-title":"A review of biomonitoring of phthalate exposures","volume":"7","author":"Wang","year":"2019","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120154_bib58","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad045","article-title":"Cadmium-induced Sertoli Cell injury through p38-MAPK and related signaling proteins\u2014a study by RNA sequencing","volume":"164","author":"Wang","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2026.120154_bib59","doi-asserted-by":"crossref","DOI":"10.34133\/research.0860","article-title":"AMPK-ULK1-mediated ferritinophagy drives ferroptosis in GLA-induced testicular toxicity","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.ecoenv.2026.120154_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127807","article-title":"Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1alpha\/HO-1 signaling pathway in mouse testes","volume":"426","author":"Wu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2026.120154_bib61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijrobp.2023.04.004","article-title":"High-dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38\/NCOA4-mediated ferritinophagy\/ferroptosis of endothelial cells","volume":"117","author":"Wu","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ecoenv.2026.120154_bib62","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120154_bib63","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00204-025-03963-y","article-title":"Nuclear receptor coactive 4-mediated ferritinophagy: a key role of heavy metals toxicity","volume":"99","author":"Xu","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113046","article-title":"DEHP induces ferroptosis in testes via p38alpha-lipid ROS circulation and destroys the BTB integrity","volume":"164","author":"Yang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib65","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/andr.13760","article-title":"A comprehensive review on p38MAPK signaling as a potent radioprotector in testis","volume":"13","author":"Yang","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2026.120154_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140112","article-title":"NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos","volume":"499","author":"Yang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120154_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102886","article-title":"Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice","volume":"67","author":"Zeng","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib68","first-page":"1437","article-title":"Genistein attenuates di\u2011(2\u2011ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2\/HO\u20111 following prepubertal exposure","author":"Zhang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120154_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112151","article-title":"Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K\/Akt\/mTOR signaling pathway in F1 and F2 generation adult mouse testis","volume":"394","author":"Zhang","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41420-020-00356-1","article-title":"Periodontitis-level butyrate-induced ferroptosis in periodontal ligament fibroblasts by activation of ferritinophagy","volume":"6","author":"Zhao","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2026.120154_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102584","article-title":"Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib72","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jare.2022.09.001","article-title":"Connexin-43 is a promising target for lycopene preventing phthalate-induced spermatogenic disorders","volume":"49","author":"Zhao","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ecoenv.2026.120154_bib73","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/toxics13040285","article-title":"Prepubertal exposure to Tris(2-chloroethyl) phosphate disrupts blood-testis barrier integrity via ferritinophagy-mediated ferroptosis","volume":"13","author":"Zhao","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120154_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155996","article-title":"The role of NCOA4-mediated ferritinophagy in the ferroptosis of hepatocytes: a mechanistic viewpoint","volume":"270","author":"Zhao","year":"2025","journal-title":"Pathol. - Res. Pract."},{"key":"10.1016\/j.ecoenv.2026.120154_bib75","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2026.120154_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102413","article-title":"NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib77","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302596R","article-title":"PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin-induced acute kidney injury","volume":"38","author":"Zhou","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2026.120154_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117139","article-title":"Ferritinophagy is involved in hexavalent chromium-induced ferroptosis in Sertoli cells","volume":"492","author":"Zhuge","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120154_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9961628","article-title":"Ferritinophagy-mediated ferroptosis involved in paraquat-induced neurotoxicity of dopaminergic neurons: implication for neurotoxicity in PD","volume":"2021","author":"Zuo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326004835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:58:36Z","timestamp":1778734716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326004835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":79,"alternative-id":["S0147651326004835"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120154","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Di-(2-ethylhexyl) phthalate induces spermatogenic dysfunction via p38\/NCOA4-dependent ferritinophagy and ferroptosis in Sertoli cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120154"}}