{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:25:49Z","timestamp":1783081549027,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202206010190"],"award-info":[{"award-number":["202206010190"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2022-GDUT-A0007"],"award-info":[{"award-number":["2022-GDUT-A0007"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ecoenv.2026.120171","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:09:18Z","timestamp":1776949758000},"page":"120171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gestational\/lactational tetrachlorobisphenol A exposure induces gut microbiota dysbiosis and metabolic disruption: Implications for intergenerational health risks"],"prefix":"10.1016","volume":"316","author":[{"given":"Yinfeng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenghua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofa","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120171_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/microorganisms10061231","article-title":"Escherichia\/Shigella, SCFAs, and metabolic pathways-the triad that orchestrates intestinal dysbiosis in patients with decompensated alcoholic cirrhosis from Western Mexico","volume":"10","author":"Baltazar-D\u00edaz","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2026.120171_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13567-018-0605-z","article-title":"Associations between digital dermatitis lesion grades in dairy cattle and the quantities of four Treponema species","volume":"49","author":"Beninger","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.ecoenv.2026.120171_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162615","article-title":"DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota","volume":"875","author":"Chai","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120171_bib4","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1039\/D2FO02524H","article-title":"Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota","volume":"14","author":"Chen","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2026.120171_bib5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1021\/acs.est.5b04130","article-title":"Occurrence and maternal transfer of chlorinated bisphenol A and nonylphenol in pregnant women and their matching embryos","volume":"50","author":"Chen","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/gutjnl-2019-319101","article-title":"Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation","volume":"69","author":"Chen","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2026.120171_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117316","article-title":"Ambient PMs pollution, blood pressure, potential mediation by short-chain fatty acids: A prospective panel study of young adults in China","volume":"287","author":"Chou","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120171_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.847073","article-title":"Effect of 6-methoxybenzoxazolinone on the cecal microbiota of adult male Brandt\u2019s Vole","volume":"13","author":"Dai","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/antibiotics9010031","article-title":"Antimicrobial susceptibility testing for Corynebacterium species isolated from clinical samples in Romania","volume":"9","author":"Dragomirescu","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.ecoenv.2026.120171_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089682","article-title":"Diversity of rumen bacteria in Canadian cervids","volume":"9","author":"Gruninger","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ecoenv.2026.120171_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115290","article-title":"Procyanidin B2 alleviates uterine toxicity induced by cadmium exposure in rats: The effect of oxidative stress, inflammation, and gut microbiota","volume":"263","author":"Hu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120171_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid\u2013microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2017","journal-title":"Nat. Rev. Gastroenterol. & Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1126257","article-title":"Gut microbiota of white-headed black langurs (Trachypithecus leucocephalus) in responses to habitat fragmentation","volume":"14","author":"Lai","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168643","article-title":"Molecular insights into the effects of tetrachlorobisphenol A on puberty initiation in Wistar rats","volume":"911","author":"Lei","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120171_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137846","article-title":"Protective effects of insoluble dietary fiber from cereal bran against DSS-induced chronic colitis in mice: From inflammatory responses, oxidative stress, intestinal barrier, and gut microbiota","volume":"283","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib16","doi-asserted-by":"crossref","first-page":"F73","DOI":"10.1152\/ajprenal.00563.2018","article-title":"Bile acid signaling in renal water regulation","volume":"317","author":"Li","year":"2019","journal-title":"Am. J. Physiol. -Ren. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/tox.24420","article-title":"Pentachlorophenol exposure delays the recovery of colitis in association with altered gut microbiota and purine metabolism","volume":"40","author":"Li","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbrc.2016.10.031","article-title":"Anti-obese effects of two Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet","volume":"480","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2026.120171_bib19","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1021\/acs.est.2c03980","article-title":"Metabolomics reveal nanoplastic-induced mitochondrial damage in human liver and lung cells","volume":"56","author":"Lin","year":"2022","journal-title":"Environ. Sci. & Technol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108039","article-title":"Maternal transfer of resorcinol-bis(diphenyl)-phosphate perturbs gut microbiota development and gut metabolism of offspring in rats","volume":"178","author":"Liu","year":"2023","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120171_bib21","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.29540","article-title":"CHOP-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury","volume":"67","author":"Liu","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2026.120171_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jes.2022.04.022","article-title":"Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics","volume":"127","author":"Liu","year":"2023","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2026.120171_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105543","article-title":"Dysbacteriosis induces abnormal neurogenesis via LPS in a pathway requiring NF-\u03baB\/IL-6","volume":"167","author":"Long","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ecoenv.2026.120171_bib24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1289\/ehp.1307429","article-title":"Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis","volume":"122","author":"Lu","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120171_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120171_bib26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/ajcn\/nqz301","article-title":"A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer","volume":"111","author":"Ocvirk","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120171_bib27","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3389\/fimmu.2019.01486","article-title":"Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00093-17","article-title":"Perinatal Bisphenol A Exposure Induces Chronic Inflammation in Rabbit Offspring via Modulation of Gut Bacteria and Their Metabolites","volume":"2","author":"Reddivari","year":"2017","journal-title":"mSystems"},{"key":"10.1016\/j.ecoenv.2026.120171_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.01109675","article-title":"Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels","volume":"109","author":"Rubin","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120171_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.804248","article-title":"Metabolomic profiling reveals that 5-hydroxylysine and 1-methylnicotinamide are metabolic indicators of keloid severity","volume":"12","author":"Shan","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.ecoenv.2026.120171_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/ijms21010124","article-title":"Deep-fried Atractylodis rhizoma protects against spleen deficiency-induced diarrhea through regulating intestinal inflammatory response and gut microbiota","volume":"21","author":"Shi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120171_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/toxics8010019","article-title":"Gut microbiome toxicity: connecting the environment and gut microbiome-associated diseases","volume":"8","author":"Tu","year":"2020","journal-title":"Toxics"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120171_bib33","first-page":"626","article-title":"Research progress on the role of gut microbiota dysregulation in the pathogenesis of diabetic nephropathy","volume":"28","author":"Wang","year":"2022","journal-title":"J. Hainan Med. Univ."},{"key":"10.1016\/j.ecoenv.2026.120171_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110965","article-title":"Perilla oil regulates intestinal microbiota and alleviates insulin resistance through the PI3K\/AKT signaling pathway in type-2 diabetic KKAy mice","volume":"135","author":"Wang","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156815","article-title":"Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice","volume":"842","author":"Wei","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120171_bib36","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1017\/S000711451600386X","article-title":"Effects of arginine on intestinal epithelial cell integrity and nutrient uptake","volume":"116","author":"Xia","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120171_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1083432","article-title":"The role of short-chain fatty acids in inflammatory skin diseases","volume":"13","author":"Xiao","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2147\/CIA.S298743","article-title":"Quantitative assessment of serum amino acids and association with early-onset coronary artery disease","volume":"16","author":"Xuan","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.ecoenv.2026.120171_bib39","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.3390\/ijms24044132","article-title":"Intestinal Farnesoid X receptor modulates duodenal surface area but does not control glucose absorption in mice","volume":"24","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120171_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115895","article-title":"The impact of tetrachlorobisphenol A exposure during puberty: Altered Leydig cell development and induced endoplasmic reticulum stress in male mice","volume":"270","author":"Yao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120171_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/srep35257","article-title":"Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol A and tetrachlorobisphenol A","volume":"6","author":"Ye","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120171_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108677","article-title":"Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy","volume":"129","author":"Zha","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120171_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105770","article-title":"Intergenerational transfer of Dechlorane Plus and the associated long-term effects on the structure and function of gut microbiota in offspring","volume":"141","author":"Zhang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120171_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107802","article-title":"Associated long-term effects of decabromodiphenyl ethane on the gut microbial profiles and metabolic homeostasis in Sprague-Dawley rat offspring","volume":"172","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120171_bib45","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.envpol.2018.08.086","article-title":"Differences in reproductive toxicity of TBBPA and TCBPA exposure in male Rana nigromaculata","volume":"243","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120171_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801187","article-title":"Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion","volume":"63","author":"Zhuang","year":"2019","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:03:25Z","timestamp":1783080205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326005002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"alternative-id":["S0147651326005002"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120171","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational\/lactational tetrachlorobisphenol A exposure induces gut microbiota dysbiosis and metabolic disruption: Implications for intergenerational health risks","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120171"}}