{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:43:23Z","timestamp":1786297403747,"version":"build-2736575974"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103851"],"award-info":[{"award-number":["82103851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["JCYJ20230807120215031"],"award-info":[{"award-number":["JCYJ20230807120215031"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515010617"],"award-info":[{"award-number":["2022A1515010617"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515220026"],"award-info":[{"award-number":["2024A1515220026"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ecoenv.2026.120190","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:08:56Z","timestamp":1777464536000},"page":"120190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prenatal metal exposure moderates the effect of CRH-related DNA methylation in the placenta on infant communication outcomes at 2 months of age"],"prefix":"10.1016","volume":"317","author":[{"given":"Sisi","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Ying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120190_bib1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrm2369","article-title":"Tracking the ends: a dynamic protein network controls the fate of microtubule tips","volume":"9","author":"Akhmanova","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrm4084","article-title":"Control of microtubule organization and dynamics: two ends in the limelight","volume":"16","author":"Akhmanova","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib3","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309469121","article-title":"DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons","volume":"121","author":"Anderson","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2026.120190_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41581-019-0116-9","article-title":"Cellular signalling by primary cilia in development, organ function and disease","volume":"15","author":"Anvarian","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/15592294.2017.1320637","article-title":"Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation","volume":"12","author":"Appleton","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humupd\/dmz025","article-title":"In-utero stress and mode of conception: impact on regulation of imprinted genes, fetal development and future health","volume":"25","author":"Argyraki","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2026.120190_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3389\/fgene.2020.00671","article-title":"Methylation data processing protocol and comparison of blood and cerebral spinal fluid following aneurysmal subarachnoid hemorrhage","volume":"11","author":"Arockiaraj","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10519-009-9281-0","article-title":"Rank-based inverse normal transformations are increasingly used, but are they merited?","volume":"39","author":"Beasley","year":"2009","journal-title":"Behav. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-6-405","article-title":"DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines","volume":"12","author":"Bell","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib11","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1007\/s00204-024-03871-7","article-title":"Revisiting cadmium-induced toxicity in the male reproductive system: an update","volume":"98","author":"Bhardwaj","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22823","article-title":"Effects of heavy metals on reproduction owing to infertility","volume":"35","author":"Bhardwaj","year":"2021","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jat.4055","article-title":"Cadmium as a testicular toxicant: a review","volume":"41","author":"Bhardwaj","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","article-title":"High density DNA methylation array with single CpG site resolution","volume":"98","author":"Bibikova","year":"2011","journal-title":"Genomics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib15","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/tox.24505","article-title":"N-Acetyl-L-Cysteine mediated attenuation of cadmium induced oxidative stress and apoptosis in ovarian antral follicles in vitro","volume":"40","author":"Bikal","year":"2025","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109541","article-title":"Metals, autoimmunity, and neuroendocrinology: is there a connection?","volume":"187","author":"Bj\u00f8rklund","year":"2020","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib17","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6240","article-title":"Challenges raised by mediation analysis in a high-dimension setting","volume":"128","author":"Blum","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120190_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng.3721","article-title":"Disease variants alter transcription factor levels and methylation of their binding sites","volume":"49","author":"Bonder","year":"2017","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13148-021-01198-z","article-title":"Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals","volume":"13","author":"Bozack","year":"2021","journal-title":"Clin. Epigenet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib20","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.1510569","article-title":"What can epidemiological studies tell us about the impact of chemical mixtures on human health?","volume":"124","author":"Braun","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120190_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108490","article-title":"Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children","volume":"185","author":"Brennan Kearns","year":"2024","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/15592294.2018.1497387","article-title":"Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort","volume":"13","author":"Brunst","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib23","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120190_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.placenta.2013.11.005","article-title":"Optimising sample collection for placental research","volume":"35","author":"Burton","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2026.120190_bib25","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1152\/physrev.00021.2020","article-title":"G protein-coupled receptor-G protein interactions: a single-molecule perspective","volume":"101","author":"Calebiro","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2026.120190_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neubiorev.2017.05.016","article-title":"Prenatal stress and epigenetics","volume":"117","author":"Cao-Lei","year":"2020","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ecoenv.2026.120190_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.ecoenv.2026.120190_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2017.71","article-title":"Zinc-finger proteins in health and disease","volume":"3","author":"Cassandri","year":"2017","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2026.120190_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133147","article-title":"Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999\u20132018","volume":"289","author":"Chen","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120190_bib30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev-pharmtox-010818-021031","article-title":"Metals and mechanisms of carcinogenesis","volume":"59","author":"Chen","year":"2019","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib32","doi-asserted-by":"crossref","DOI":"10.1289\/EHP925","article-title":"Maternal and cord blood manganese concentrations and early childhood neurodevelopment among residents near a mining-impacted Superfund site","volume":"125","author":"Claus Henn","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120190_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105793","article-title":"Prenatal stress impacts foetal neurodevelopment: temporal windows of gestational vulnerability","volume":"164","author":"Collins","year":"2024","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ecoenv.2026.120190_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s40572-017-0165-9","article-title":"Sex-specific effects of combined exposure to chemical and non-chemical stressors on neuroendocrine development: a review of recent findings and putative mechanisms","volume":"4","author":"Cowell","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2026.120190_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/15592294.2020.1795605","article-title":"Genome-wide DNA methylation differences and polychlorinated biphenyl (PCB) exposure in a US population","volume":"16","author":"Curtis","year":"2021","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib36","article-title":"Mediterranean diet during pregnancy and infant neurodevelopment: a prospective birth cohort study","volume":"9","author":"Dai","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.ecoenv.2026.120190_bib37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41398-024-03094-5","article-title":"Evaluating the association between placenta DNA methylation and cognitive functions in the offspring","volume":"14","author":"Diez-Ahijado","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ecoenv.2026.120190_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/IJWH.S393067","article-title":"Placental barrier on cadmium transfer from mother to fetus in related to pregnancy complications","volume":"15","author":"Dong","year":"2023","journal-title":"Int J. Women\u2019s. Health"},{"key":"10.1016\/j.ecoenv.2026.120190_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108641","article-title":"Environmental exposure to low-level lead (Pb) co-occurring with other neurotoxicants in early life and neurodevelopment of children","volume":"177","author":"D\u00f3rea","year":"2019","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ecoenv.2026.120190_bib41","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3390\/cells13211775","article-title":"Heavy metals in umbilical cord blood: effects on epigenetics and child development","volume":"13","author":"Dutta","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120190_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116427","article-title":"Associations among neighborhood walkability, metal exposure, and sex steroid hormone levels: results from Hangzhou Birth Cohort Study \u2161","volume":"278","author":"Fang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120190_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13059-014-0503-2","article-title":"Functional normalization of 450k methylation array data improves replication in large cancer studies","volume":"15","author":"Fortin","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib44","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/bioinformatics\/btt311","article-title":"Gene-set analysis is severely biased when applied to genome-wide methylation data","volume":"29","author":"Geeleher","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib45","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.3390\/cells10113025","article-title":"Prenatal air pollution exposure and placental DNA methylation changes: implications on fetal development and future disease susceptibility","volume":"10","author":"Ghazi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120190_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109700","article-title":"The link between prenatal exposure to a chemical mixture, cord blood hormones, and birth weight: an epidemiologic study","volume":"202","author":"Govarts","year":"2025","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118355","article-title":"Toxic metals and essential trace elements in placenta and their relation to placental function","volume":"248","author":"Grundeken","year":"2024","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109571","article-title":"Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: findings from the Dongfeng-Tongji cohort","volume":"201","author":"Guo","year":"2025","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105062","article-title":"The cross-sectional and longitudinal association between air pollution and salivary cortisol: evidence from the multi-ethnic study of atherosclerosis","volume":"131","author":"Hajat","year":"2019","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123329","article-title":"Lead exposure, glucocorticoids, and physiological stress across the life course: a systematic review","volume":"345","author":"Halabicky","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120190_bib51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/cells14040306","article-title":"Prenatal exposure to metals is associated with placental decelerated epigenetic gestational age in a sex-dependent manner in infants born extremely preterm","volume":"14","author":"Huff","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120190_bib52","doi-asserted-by":"crossref","DOI":"10.1017\/SJP.2021.46","article-title":"Mediation, moderation, and conditional process analysis: concepts, computations, and some common confusions","volume":"24","author":"Igartua","year":"2021","journal-title":"Span. J. Psychol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaf035","article-title":"Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood","volume":"12","author":"India-Aldana","year":"2026","journal-title":"Environ. Epigenet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib55","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","volume":"367","author":"Jomova","year":"2022","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2026.120190_bib57","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117404","article-title":"Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries","volume":"284","author":"Julvez","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120190_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.714214","article-title":"Placental CRH as a signal of pregnancy adversity and impact on fetal neurodevelopment","volume":"12","author":"Kassotaki","year":"2021","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib60","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s43682-023-00021-5","article-title":"Comprehensive evaluation of the Infinium human MethylationEPIC v2 BeadChip","volume":"3","author":"Kaur","year":"2023","journal-title":"Epigenetics Commun."},{"key":"10.1016\/j.ecoenv.2026.120190_bib61","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1210\/jc.2017-02780","article-title":"Maternal uniparental disomy for chromosome 20: physical and endocrinological characteristics of five patients","volume":"103","author":"Kawashima","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2026.120190_bib62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ecoenv.2026.120190_bib63","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120190_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107448","article-title":"Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children\u2019s study using the ASQ-3 questionnaire: A prospective birth cohort","volume":"168","author":"Kobayashi","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib65","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tins.2020.03.008","article-title":"Glucocorticoids as mediators of adverse outcomes of prenatal stress","volume":"43","author":"Krontira","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120190_bib66","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrg.2017.32","article-title":"Associating cellular epigenetic models with human phenotypes","volume":"18","author":"Lappalainen","year":"2017","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib67","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib68","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation","volume":"31","author":"Lev Maor","year":"2015","journal-title":"Trends Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib69","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13059-016-1119-5","article-title":"DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases","volume":"17","author":"Ligthart","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133015","article-title":"Associations between prenatal multiple metal exposure and preterm birth: Comparison of four statistical models","volume":"289","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120190_bib71","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12916-024-03834-w","article-title":"Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches","volume":"23","author":"Lund","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.ecoenv.2026.120190_bib72","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41576-018-0092-0","article-title":"Genomic imprinting disorders: lessons on how genome, epigenome and environment interact","volume":"20","author":"Monk","year":"2019","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib73","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41398-023-02701-1","article-title":"Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity","volume":"13","author":"Musillo","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ecoenv.2026.120190_bib74","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuron.2017.09.027","article-title":"Hazards to early development: the biological embedding of early life adversity","volume":"96","author":"Nelson","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ecoenv.2026.120190_bib75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000362336","article-title":"Investigating epigenetic effects of prenatal exposure to toxic metals in newborns: challenges and benefits","volume":"2","author":"Nye","year":"2014","journal-title":"Med Epigenet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-023-04038-8","article-title":"Quercetin supplementation alleviates cadmium induced genotoxicity-mediated apoptosis in caprine testicular cells","volume":"202","author":"Panchal","year":"2024","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib77","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/01913123.2022.2060396","article-title":"Ultrastructural analysis of cadmium-induced toxicity and its alleviation by antioxidant quercetin in caprine testicular germ cells in vitro","volume":"46","author":"Panchal","year":"2022","journal-title":"Ultra Pathol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-8-6","article-title":"De novo identification of differentially methylated regions in the human genome","volume":"8","author":"Peters","year":"2015","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.ecoenv.2026.120190_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab637","article-title":"Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate","volume":"49","author":"Peters","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib80","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12864-024-10027-5","article-title":"Characterisation and reproducibility of the HumanMethylationEPIC v2.0 BeadChip for DNA methylation profiling","volume":"25","author":"Peters","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.ecoenv.2026.120190_bib81","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib82","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng1397","article-title":"The imprinted signaling protein XL\u03b1s is required for postnatal adaptation to feeding","volume":"36","author":"Plagge","year":"2004","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib83","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrg3000","article-title":"Epigenome-wide association studies for common human diseases","volume":"12","author":"Rakyan","year":"2011","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib84","doi-asserted-by":"crossref","first-page":"S907","DOI":"10.1016\/j.ajog.2020.09.047","article-title":"Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways","volume":"226","author":"Redman","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib85","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrm.2017.60","article-title":"Genes and molecular pathways underpinning ciliopathies","volume":"18","author":"Reiter","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106310","article-title":"Association of biomarkers of exposure to metals and metalloids with maternal hormones in pregnant women from Puerto Rico","volume":"147","author":"Rivera-N\u00fa\u00f1ez","year":"2021","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib87","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11171","article-title":"Associations of prenatal chemical and nonchemical stressors with early-adulthood anxiety and depressive symptoms","volume":"131","author":"Rokoff","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120190_bib88","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12916-021-02203-1","article-title":"Human placental mesenchymal stromal cells are ciliated and their ciliation is compromised in preeclampsia","volume":"20","author":"Romberg","year":"2022","journal-title":"BMC Med"},{"key":"10.1016\/j.ecoenv.2026.120190_bib89","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1210\/en.2015-1227","article-title":"Sex-specific placental responses in fetal development","volume":"156","author":"Rosenfeld","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2026.120190_bib90","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s40572-015-0058-8","article-title":"Perinatal and childhood exposure to cadmium, manganese, and metal mixtures and effects on cognition and behavior: a review of recent literature","volume":"2","author":"Sanders","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2026.120190_bib91","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/appi.ajp.2017.16121433","article-title":"Cortical thinning and neuropsychiatric outcomes in children exposed to prenatal adversity: a role for placental CRH?","volume":"175","author":"Sandman","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ecoenv.2026.120190_bib92","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s40572-022-00378-0","article-title":"Environmental metal exposure, neurodevelopment, and the role of iron status: a review","volume":"9","author":"Schildroth","year":"2022","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2026.120190_bib93","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.3390\/nu15204439","article-title":"Impact of a nutrient formulation on longitudinal myelination, cognition, and behavior from birth to 2 years: a randomized clinical trial","volume":"15","author":"Schneider","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2026.120190_bib94","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","author":"Sch\u00fcbeler","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120190_bib95","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1474-4422(25)00226-1","article-title":"The relevance of primary cilia in neurological disorders","volume":"24","author":"Serpieri","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib96","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2217\/epi-2019-0066","article-title":"Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking","volume":"11","author":"Sikdar","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.ecoenv.2026.120190_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70758","article-title":"Protective effect of quercetin against nicotine-induced oxidative stress and granulosa cell apoptosis in caprine ovary in vitro","volume":"40","author":"Siwach","year":"2026","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib98","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4977","article-title":"Lineage- and sex-dependent behavioral and biochemical transgenerational consequences of developmental exposure to lead, prenatal stress, and combined lead and prenatal stress in mice","volume":"128","author":"Sobolewski","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120190_bib99","series-title":"Ages & Stages Questionnaires, Third Edition (ASQ-3)","author":"Squires","year":"2009"},{"key":"10.1016\/j.ecoenv.2026.120190_bib100","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2393","article-title":"Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls","volume":"338","author":"Sterne","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2026.120190_bib101","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2026.120190_bib102","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.placenta.2015.11.013","article-title":"Effects of prenatal maternal stress on serotonin and fetal development","volume":"48","author":"St-Pierre","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2026.120190_bib103","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","article-title":"Population genomics of human gene expression","volume":"39","author":"Stranger","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib104","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1073\/pnas.1814263116","article-title":"Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle","volume":"116","author":"Taylor","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2026.120190_bib105","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1101\/gr.171439.113","article-title":"The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes","volume":"24","author":"Teh","year":"2014","journal-title":"Genome Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108717","article-title":"Stress hormones as potential mediators of air pollutant effects on the brain: rapid induction of glucocorticoid-responsive genes","volume":"178","author":"Thomson","year":"2019","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105508","article-title":"Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts","volume":"137","author":"Tian","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib108","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib109","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ejendo\/lvad163","article-title":"Epi)genetic and clinical characteristics in 84 patients with pseudohypoparathyroidism type 1B","volume":"189","author":"Urakawa","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrneurol.2013.247","article-title":"Primary cilia in neurodevelopmental disorders","volume":"10","author":"Valente","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox- and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120190_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104591","article-title":"Maternal chronic stress correlates with serum levels of cortisol, glucose and C-peptide in the fetus, and maternal non chronic stress with fetal growth","volume":"114","author":"Valsamakis","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ecoenv.2026.120190_bib113","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2017.07.003","article-title":"Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy","volume":"117","author":"Van den Bergh","year":"2020","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ecoenv.2026.120190_bib114","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-publhealth-032315-021402","article-title":"Mediation analysis: a practitioner\u2019s guide","volume":"37","author":"VanderWeele","year":"2016","journal-title":"Annu Rev. Public Health"},{"key":"10.1016\/j.ecoenv.2026.120190_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cch.12397","article-title":"The psychometric properties of the Ages & Stages Questionnaires for ages 2-2.5: a systematic review","volume":"43","author":"Velikonja","year":"2017","journal-title":"Child"},{"key":"10.1016\/j.ecoenv.2026.120190_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106199","article-title":"Assessing the relation of chemical and non-chemical stressors with risk-taking related behavior and adaptive individual attributes among adolescents living near the New Bedford Harbor Superfund site","volume":"146","author":"Vieira","year":"2021","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib117","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/db16-0996","article-title":"Whole-genome bisulfite sequencing of human pancreatic islets reveals novel differentially methylated regions in type 2 diabetes pathogenesis","volume":"66","author":"Volkov","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.ecoenv.2026.120190_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2020.113527","article-title":"Prenatal exposure to a mixture of persistent organic pollutants (POPs) and child reading skills at school age","volume":"228","author":"Vuong","year":"2020","journal-title":"Int J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120190_bib119","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1038\/s41467-022-29792-6","article-title":"DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases","volume":"13","author":"Wielscher","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120190_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107126","article-title":"Longitudinal analyses of maternal and cord blood manganese levels and neurodevelopment in children up to 3 years of age: The Japan Environment and Children\u2019s Study (JECS)","volume":"161","author":"Yamamoto","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120190_bib121","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-statistics-040622-031653","article-title":"Causal mediation analysis for integrating exposure, genomic, and phenotype data","volume":"12","author":"Yang","year":"2025","journal-title":"Annu Rev. Stat. Appl."},{"key":"10.1016\/j.ecoenv.2026.120190_bib122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287037","article-title":"BayesGmed: An R-package for Bayesian causal mediation analysis","volume":"18","author":"Yimer","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2026.120190_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123563","article-title":"Neurotoxic effects of heavy metal pollutants in the environment: focusing on epigenetic mechanisms","volume":"345","author":"Yu","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120190_bib124","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ajhg.2013.06.007","article-title":"ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6","volume":"93","author":"Zariwala","year":"2013","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.ecoenv.2026.120190_bib125","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/acer.13971","article-title":"Brain imaging-guided analysis reveals DNA methylation profiles correlated with insular surface area and alcohol use disorder","volume":"43","author":"Zhao","year":"2019","journal-title":"Alcohol Clin. Exp. Res"},{"key":"10.1016\/j.ecoenv.2026.120190_bib126","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res 45 e22"},{"key":"10.1016\/j.ecoenv.2026.120190_bib127","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41398-020-0704-2","article-title":"Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression","volume":"10","author":"Zoubovsky","year":"2020","journal-title":"Transl. Psychiatry"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:19:25Z","timestamp":1783084765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326005191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":127,"alternative-id":["S0147651326005191"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120190","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal metal exposure moderates the effect of CRH-related DNA methylation in the placenta on infant communication outcomes at 2 months of age","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120190"}}