{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:47:49Z","timestamp":1785365269520,"version":"3.55.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ecoenv.2026.120211","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:54:48Z","timestamp":1777877688000},"page":"120211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["System-level multi-omics uncover proteomic, peptidomic, and metabolic remodeling in Microcystin-LR exacerbated chronic kidney disease"],"prefix":"10.1016","volume":"317","author":[{"given":"Suppakrit","family":"Kongsintaweesuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitti","family":"Intuyod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sittiruk","family":"Roytrakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wunchana","family":"Seubwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-8700","authenticated-orcid":false,"given":"Sakkarn","family":"Sangkhamanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-7029","authenticated-orcid":false,"given":"Sawanya","family":"Charoenlappanit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-8671","authenticated-orcid":false,"given":"Ubon","family":"Cha\u2019on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7746-5124","authenticated-orcid":false,"given":"Achirawit","family":"Surapinit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9185-5611","authenticated-orcid":false,"given":"Phonpilas","family":"Thongpon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9735-028X","authenticated-orcid":false,"given":"Pakornkiat","family":"Tanasuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasitorn","family":"Chomwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-7247","authenticated-orcid":false,"given":"Somchai","family":"Pinlaor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7436-3355","authenticated-orcid":false,"given":"Porntip","family":"Pinlaor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120211_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/IJNRD.S242235","article-title":"Current management strategies of chronic kidney disease in resource-limited countries","volume":"13","author":"Ameh","year":"2020","journal-title":"Int J. Nephrol. Renov. Dis."},{"key":"10.1016\/j.ecoenv.2026.120211_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128773","article-title":"Sub-chronic microcystin-LR renal toxicity in rats fed a high fat\/high cholesterol diet","volume":"269","author":"Arman","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120211_bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/toxins13080537","article-title":"Microcystin toxicokinetics, molecular toxicology, and pathophysiology in preclinical rodent models and humans","volume":"13","author":"Arman","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib4","article-title":"Role of base excision repair pathway in the processing of complex DNA damage generated by oxidative stress and anticancer drugs","volume":"8","author":"Baiken","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3390\/pathophysiology31040052","article-title":"Chronic kidney disease of unknown etiology: a global health threat in rural agricultural communities-prevalence, suspected causes, mechanisms, and prevention strategies","volume":"31","author":"Ben Khadda","year":"2024","journal-title":"Pathophysiology"},{"key":"10.1016\/j.ecoenv.2026.120211_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.120211_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073076","article-title":"The human urine metabolome","volume":"8","author":"Bouatra","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2026.120211_bib8","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00676.2013","article-title":"Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats","volume":"307","author":"Diwan","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nep.13180","article-title":"Adenine-induced chronic kidney disease in rats","volume":"23","author":"Diwan","year":"2018","journal-title":"Nephrol. (Carlton)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/096032719901800305","article-title":"The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR","volume":"18","author":"Fawell","year":"1999","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","article-title":"Chronic kidney disease and the global public health agenda: an international consensus","volume":"20","author":"Francis","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1390821","article-title":"Cathepsin S (CTSS) in IgA nephropathy: an exploratory study on its role as a potential diagnostic biomarker and therapeutic target","volume":"15","author":"Fu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib13","article-title":"Cathepsin S: molecular mechanisms in inflammatory and immunological processes","volume":"16","author":"Gao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib14","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120211_bib15","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.3390\/md13106319","article-title":"Cyanobacterial toxic and bioactive peptides in freshwater bodies of Greece: concentrations, occurrence patterns, and implications for human health","volume":"13","author":"Gkelis","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2026.120211_bib16","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41467-019-10378-8","article-title":"Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease","volume":"10","author":"Gluck","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120211_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12882-020-02034-x","article-title":"Prevalence and risk factors for chronic kidney disease of unknown cause in Malawi: a cross-sectional analysis in a rural and urban population","volume":"21","author":"Hamilton","year":"2020","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib18","article-title":"Peptidomics","volume":"3","author":"Hellinger","year":"2023","journal-title":"Nat. Rev. Methods Prim."},{"key":"10.1016\/j.ecoenv.2026.120211_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ecoenv.2026.120211_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/toxins8060170","article-title":"A Systematic investigation into the environmental fate of microcystins and the potential risk: study in Lake Taihu","volume":"8","author":"Jia","year":"2016","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115990","article-title":"Regulation of oxidative stress and programmed cell death related genes induced by microcystin-LR in rice suspension cells","volume":"322","author":"Jiang","year":"2022","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ecoenv.2026.120211_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123840","article-title":"Microcystin-LR exacerbates chronic kidney disease in rats: insights into gut microbiome and host proteome dysregulation","volume":"378","author":"Kongsintaweesuk","year":"2025","journal-title":"Life Sci."},{"issue":"2011","key":"10.1016\/j.ecoenv.2026.120211_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int Suppl."},{"key":"10.1016\/j.ecoenv.2026.120211_bib24","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.34067\/KID.0007962021","article-title":"Environmental exposures and kidney disease","volume":"3","author":"Kshirsagar","year":"2022","journal-title":"Kidney360"},{"key":"10.1016\/j.ecoenv.2026.120211_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2026.120211_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.toxrep.2015.01.008","article-title":"An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis","volume":"2","author":"Lone","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ecoenv.2026.120211_bib27","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2026.120211_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/toxins12040268","article-title":"A mini review on microcystins and bacterial degradation","volume":"12","author":"Massey","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109915","article-title":"Ketone bodies in renal function and diabetic kidney disease","volume":"142","author":"Mechchate","year":"2025","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.ecoenv.2026.120211_bib30","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/toxins14050350","article-title":"Microcystin contamination and toxicity: implications for agriculture and public health","volume":"14","author":"Melaram","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.limno.2008.09.001","article-title":"Cyanobacterial toxins in Italian freshwaters","volume":"39","author":"Messineo","year":"2009","journal-title":"Limnologica"},{"key":"10.1016\/j.ecoenv.2026.120211_bib32","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.1216006110","article-title":"Record-setting algal bloom in Lake Erie caused by agricultural and meteorological trends consistent with expected future conditions","volume":"110","author":"Michalak","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2026.120211_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120211_bib34","article-title":"Sediment and algae color the Great Lakes: Image of the day. Vol. 2025","author":"NCCOS","year":"2011","journal-title":"National Oceanic and Atmospheric Administration (NOAA)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120098","article-title":"Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts","volume":"263","author":"Pan","year":"2024","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2026.120211_bib36","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120211_bib37","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00109-021-02066-2","article-title":"Unraveling the epigenetic landscape of glomerular cells in kidney disease","volume":"99","author":"Pereira","year":"2021","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.ecoenv.2026.120211_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41584-022-00905-1","article-title":"Inflammation and DNA damage: cause, effect or both","volume":"19","author":"Pezone","year":"2023","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.ecoenv.2026.120211_bib39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","article-title":"Small molecule metabolites: discovery of biomarkers and therapeutic targets","volume":"8","author":"Qiu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2026.120211_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192531","article-title":"A novel approach to adenine-induced chronic kidney disease associated anemia in rodents","volume":"13","author":"Rahman","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2026.120211_bib41","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/tmi.13913","article-title":"Chronic kidney disease of unknown aetiology: a comprehensive review of a global public health problem","volume":"28","author":"Rao","year":"2023","journal-title":"Trop. Med Int Health"},{"key":"10.1016\/j.ecoenv.2026.120211_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2021.100009","article-title":"Ketone bodies for kidney injury and disease","volume":"2","author":"Rojas-Morales","year":"2021","journal-title":"Adv. Redox Res."},{"key":"10.1016\/j.ecoenv.2026.120211_bib44","article-title":"First report on microcystins contamination in giant freshwater prawn (Macrobrachium rosenbergii) and Nile tilapia (Tilapia nilotica) cultured in earthen ponds","volume":"13","author":"Ruangrit","year":"2011","journal-title":"Int. J. Agric. Biol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13148-024-01642-w","article-title":"Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression","volume":"16","author":"Sagy","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.ecoenv.2026.120211_bib46","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1038\/s41467-021-27234-3","article-title":"Meta-analyses identify DNA methylation associated with kidney function and damage","volume":"12","author":"Schlosser","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120211_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010096","article-title":"Urinary peptidomic biomarkers in kidney diseases","volume":"21","author":"Sirolli","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120211_bib48","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1007\/s10661-013-3270-8","article-title":"Monitoring toxic cyanobacteria and cyanotoxins (microcystins and cylindrospermopsins) in four recreational reservoirs (Khon Kaen, Thailand)","volume":"185","author":"Somdee","year":"2013","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2026.120211_bib49","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/ndt\/gfv466","article-title":"Chronic kidney disease in low- and middle-income countries","volume":"31","author":"Stanifer","year":"2016","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.ecoenv.2026.120211_bib50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0925-4439(99)00039-3","article-title":"In vivo assessment of microcystin-LR-induced hepatotoxicity in the rat using proton nuclear magnetic resonance (1H NMR) imaging","volume":"1454","author":"Sturgeon","year":"1999","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2026.120211_bib51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.hal.2010.11.006","article-title":"The dynamics of cyanobacteria and microcystin production in a tropical reservoir of Singapore","volume":"10","author":"Te","year":"2011","journal-title":"Harmful Algae"},{"key":"10.1016\/j.ecoenv.2026.120211_bib52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/toxins14030209","article-title":"First report on Microcystin-LR occurrence in water reservoirs of eastern Cuba, and environmental trigger factors","volume":"14","author":"Tito","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115940","article-title":"Mining the biomarker potential of the urine peptidome: from amino acids properties to proteases","volume":"22","author":"Trindade","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120211_bib54","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ecoenv.2026.120211_bib55","author":"USEPA","year":"2015"},{"key":"10.1016\/j.ecoenv.2026.120211_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0000000000000463","article-title":"Sex hormones and their influence on chronic kidney disease","volume":"28","author":"Valdivielso","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.ecoenv.2026.120211_bib57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.hal.2015.12.006","article-title":"How rising CO(2) and global warming may stimulate harmful cyanobacterial blooms","volume":"54","author":"Visser","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.ecoenv.2026.120211_bib58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41420-022-00931-8","article-title":"Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5\/6 nephrectomy-induced CKD rat model","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2026.120211_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109547","article-title":"Research progress of microcystin-LR toxicity to the intestine, liver, and kidney and its mechanism","volume":"201","author":"Wang","year":"2025","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2026.120211_bib60","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3390\/cancers11121876","article-title":"HMGCS2 mediates ketone production and regulates the proliferation and metastasis of hepatocellular carcinoma","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib61","first-page":"52","article-title":"Accumulation of microcystins in water and economic fish in Phayao lake, and fish ponds along the Ing river tributary in Chiang Rai, Thailand","volume":"4","author":"Whangchai","year":"2013","journal-title":"Agric. Sci."},{"key":"10.1016\/j.ecoenv.2026.120211_bib62","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/toxins12110693","article-title":"A review of nephrotoxicity of microcystins","volume":"12","author":"Xu","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib63","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib64","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2336128","article-title":"Adenine-induced animal model of chronic kidney disease: current applications and future perspectives","volume":"46","author":"Yang","year":"2024","journal-title":"Ren. Fail"},{"key":"10.1016\/j.ecoenv.2026.120211_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119019","article-title":"HMGCS2 attenuates mitochondrial dysregulation and renal fibrosis induced by triclosan","volume":"303","author":"Yao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120211_bib66","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/toxins15060404","article-title":"Microcystin-LR-exposure-induced kidney damage by inhibiting MKK6-mediated mitophagy in mice","volume":"15","author":"Yao","year":"2023","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120211_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112245","article-title":"Therapeutic potential of targeting cathepsin S in pulmonary fibrosis","volume":"145","author":"Yoo","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ecoenv.2026.120211_bib68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mrgentox.2006.06.038","article-title":"Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells","volume":"611","author":"Zegura","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2026.120211_bib69","doi-asserted-by":"crossref","first-page":"F788","DOI":"10.1152\/ajprenal.00184.2024","article-title":"Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers","volume":"327","author":"Zhang","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120211_bib70","article-title":"The clinical significance and potential role of Cathepsin S in IgA nephropathy","volume":"9","author":"Zhao","year":"2021","journal-title":"Front. Pedia"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326005403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:40:48Z","timestamp":1783150848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326005403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":70,"alternative-id":["S0147651326005403"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120211","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"System-level multi-omics uncover proteomic, peptidomic, and metabolic remodeling in Microcystin-LR exacerbated chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120211"}}