{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:02:56Z","timestamp":1781272976726,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ecoenv.2026.120287","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:46:56Z","timestamp":1779313616000},"page":"120287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adverse outcome pathway-based analysis of vanillic acid\u2013induced neurodevelopmental toxicity and cellular senescence in zebrafish"],"prefix":"10.1016","volume":"319","author":[{"given":"Haicheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-7433","authenticated-orcid":false,"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120287_bib1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1021\/acs.jafc.0c06641","article-title":"Review on extraction of phenolic compounds from natural sources using green deep eutectic solvents","volume":"69","author":"Ali Redha","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120287_bib2","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.3390\/ijms23052621","article-title":"The BDNF\/TrkB neurotrophin system in the sensory organs of zebrafish","volume":"23","author":"Aragona","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120287_bib3","article-title":"Loss of circadian rhythmicity in bdnf knockout zebrafish larvae","volume":"25","author":"D'Agostino","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ecoenv.2026.120287_bib4","first-page":"141","article-title":"Vanillic acid as a promising intervention for metabolic syndrome: Preclinical studies","volume":"28","author":"Ghasemzadeh Rahbardar","year":"2025","journal-title":"Iran. J. Basic Med Sci."},{"key":"10.1016\/j.ecoenv.2026.120287_bib5","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2024.01.011","article-title":"A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression","volume":"187","author":"Ghosh","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120287_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fnmol.2017.00274","article-title":"Insm1a Regulates Motor Neuron Development in Zebrafish","volume":"10","author":"Gong","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120287_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116779","article-title":"In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio)","volume":"277","author":"Han","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120287_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113981","article-title":"Systems assessment of statins hazard: Integrating in silico prediction, developmental toxicity profile and transcriptomics in zebrafish","volume":"243","author":"Han","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120287_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12672-025-01746-6","article-title":"Anti-tumor role and molecular mechanism of vanillic acid","volume":"16","author":"Hao","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ecoenv.2026.120287_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fnmol.2017.00241","article-title":"Insm1a Is Required for Zebrafish Posterior Lateral Line Development","volume":"10","author":"He","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120287_bib11","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/glia.22990","article-title":"Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord","volume":"64","author":"Johnson","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.ecoenv.2026.120287_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136415","article-title":"Embryonic exposure to glycopeptides induces acute toxicity and developmental neurotoxicity in zebrafish (Danio rerio)","volume":"480","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120287_bib13","article-title":"Targeted Deletion of Loxl3 by Col2a1-Cre Leads to Progressive Hearing Loss","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120287_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114115","article-title":"bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish","volume":"436","author":"Lucon-Xiccato","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ecoenv.2026.120287_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125137","article-title":"Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae","volume":"363","author":"Luo","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120287_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116383","article-title":"Biological effects of vanillic acid, iso-vanillic acid, and orto-vanillic acid as environmental pollutants","volume":"277","author":"Matejczyk","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120287_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2025.102575","article-title":"Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis","volume":"20","author":"Rajan","year":"2025","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ecoenv.2026.120287_bib18","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122121119","article-title":"SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms","volume":"119","author":"Szeto","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ecoenv.2026.120287_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155552","article-title":"A green approach to phenolic compounds recovery from olive mill and winery wastes","volume":"835","author":"Tapia-Quiros","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2026.120287_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuro.2021.10.014","article-title":"Prolonged ethanol exposure alters glutamate uptake leading to astrogliosis and neuroinflammation in adult zebrafish brain","volume":"88","author":"Vizuete","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2026.120287_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106203","article-title":"Genus Suaeda: Advances in phytology, chemistry, pharmacology and clinical application (1895 - 2021)","volume":"179","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ecoenv.2026.120287_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/jdb10040042","article-title":"Zebrafish Model of Stickler Syndrome Suggests a Role for Col2a1a in the Neural Crest during Early Eye Development","volume":"10","author":"Williams","year":"2022","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120287_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/1440-1681.13736","article-title":"Cardioprotective potential of vanillic acid","volume":"50","author":"Yalameha","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120287_bib24","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41586-018-0425-3","article-title":"Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas","volume":"560","author":"Yao","year":"2018","journal-title":"Nature"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:37:04Z","timestamp":1781271424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326006160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":24,"alternative-id":["S0147651326006160"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120287","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse outcome pathway-based analysis of vanillic acid\u2013induced neurodevelopmental toxicity and cellular senescence in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120287"}}