{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:09:27Z","timestamp":1789934967041,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42567005"],"award-info":[{"award-number":["42567005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010872","name":"Shandong Provincial Department of Agriculture and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012259","name":"Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20225BCJ23016"],"award-info":[{"award-number":["20225BCJ23016"]}],"id":[{"id":"10.13039\/501100012259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ecoenv.2026.120366","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:36:17Z","timestamp":1781210177000},"page":"120366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Manganese enrichment in rice seedlings shifts cadmium accumulation from inhibition to promotion during growth via transcriptomic mechanisms"],"prefix":"10.1016","volume":"320","author":[{"given":"Xinya","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxiu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120366_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.1003953","article-title":"Advances in molecular mechanisms underlying cadmium uptake and translocation in rice","volume":"13","author":"Ai","year":"2022","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.ecoenv.2026.120366_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113941","article-title":"Effects of external Mn2+ activities on OsNRAMP5 expression level and Cd accumulation in indica rice","volume":"260","author":"Cai","year":"2020","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120366_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021247","article-title":"Genetic Regulation Mechanism of Cadmium Accumulation and Its Utilization in Rice Breeding","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120366_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.taap.2016.12.016","article-title":"Relationships among DNA hypomethylation, Cd, and Pb exposure and risk of cigarette smoking-related urothelial carcinoma","volume":"316","author":"Chung","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120366_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135321","article-title":"Phytoavailability, translocation, and accompanying isotopic fractionation of cadmium in soil and rice plants in paddy fields","volume":"477","author":"Dong","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138524","article-title":"Tracing atmospherically deposited cadmium accumulation in rice using stable isotopes","volume":"494","author":"Du","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ecoenv.2018.10.023","article-title":"Effect of cadmium stress on inorganic and organic components in xylem sap of high cadmium accumulating rice line (Oryza sativa L.)","volume":"168","author":"Fu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120366_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/foods14101747","article-title":"A Review of Reducing Cadmium Pollution in the Rice\u2013Soil System in China","volume":"14","author":"Guan","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.ecoenv.2026.120366_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111323","article-title":"Crucial roles of cadmium retention in node\u2161 for restraining cadmium transport from straw to ear at reproductive period in a grain low-cadmium rice line (Oryza sativa L.)","volume":"205","author":"Guo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.120366_bib10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11104-024-06669-9","article-title":"How manganese affects rice cadmium uptake and translocation in vegetative and mature plants","volume":"504","author":"Hu","year":"2024","journal-title":"Plant. Soil."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120366_bib11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S1002-0160(20)60047-9","article-title":"Rice (Oryza sativa L.) seedlings enriched with zinc or manganese: Their impacts on cadmium accumulation and expression of related genes","volume":"31","author":"Huang","year":"2021","journal-title":"Pedosphere"},{"key":"10.1016\/j.ecoenv.2026.120366_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125597","article-title":"Polymer-coated manganese fertilizer and its combination with lime reduces cadmium accumulation in brown rice (Oryza sativa L.)","volume":"415","author":"Huang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127897","article-title":"Liming and tillering application of manganese alleviates iron manganese plaque reduction and cadmium accumulation in rice (Oryza sativa L.)","volume":"427","author":"Huang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115440","article-title":"Effects of high manganese-cultivated seedlings on cadmium uptake by various rice (Oryza sativa L.) genotypes","volume":"264","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"20","key":"10.1016\/j.ecoenv.2026.120366_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252010952","article-title":"WRKY Transcription Factors in Response to Metal Stress in Plants: A Review","volume":"25","author":"Huang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120366_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243174","article-title":"Effects of Fe and Mn cations on Cd uptake by rice plant in hydroponic culture experiment","volume":"15","author":"Hussain","year":"2020","journal-title":"Plos. One"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120366_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep00286","article-title":"Characterizing the role of rice NRAMP5 in Manganese, Iron and Cadmium Transport","volume":"2","author":"Ishimaru","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120366_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135777","article-title":"Manganese enhances cadmium tolerance in barley through mediating chloroplast integrity, antioxidant system, and HvNRAMP expression","volume":"480","author":"Kanwal","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120366_bib19","article-title":"Dietary cadmium exposure assessment among the Chinese population","volume":"12","author":"Kunze","year":"2017","journal-title":"Plos. One"},{"key":"10.1016\/j.ecoenv.2026.120366_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127296","article-title":"Evaluation of manganese application after soil stabilization to effectively reduce cadmium in rice","volume":"424","author":"Liang","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"19","key":"10.1016\/j.ecoenv.2026.120366_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199357","article-title":"Spatiotemporal Transcriptome Profiling Reveals Nutrient Transport Dynamics in Rice Nodes and Roots During Reproductive Development","volume":"26","author":"Lu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120366_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1002-0160(20)60015-7","article-title":"Transport of cadmium from soil to grain in cereal crops: A review","volume":"31","author":"Ma","year":"2021","journal-title":"Pedosphere"},{"key":"10.1016\/j.ecoenv.2026.120366_bib23","first-page":"10","article-title":"National Soil Pollution Status Survey Bulletin","author":"MEPMLR","year":"2014","journal-title":"China Environ. Prot. Ind."},{"key":"10.1016\/j.ecoenv.2026.120366_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105046","article-title":"Soil amendments for immobilization of potentially toxic elements in contaminated soils: A critical review","volume":"134","author":"Palansooriya","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120366_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.envint.2019.01.067","article-title":"Heavy metals in food crops: Health risks, fate, mechanisms, and management","volume":"125","author":"Rai","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120366_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117386","article-title":"Sufficient manganese supply is necessary for OsNramp5 knockout rice plants to ensure normal growth and less Cd uptake","volume":"288","author":"Shahzad","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120366_bib27","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.cj.2024.09.002","article-title":"Transcription factor OsWRKY72 is involved in Cu\/Cd toxicity by regulating lignin synthesis in rice","volume":"12","author":"Shangguan","year":"2024","journal-title":"Crop. J."},{"key":"10.1016\/j.ecoenv.2026.120366_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155006","article-title":"Knockout of OsNRAMP5 enhances rice tolerance to cadmium toxicity in response to varying external cadmium concentrations via distinct mechanisms","volume":"832","author":"Tang","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120366_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2017.1422466","article-title":"Rice reduces Mn uptake in response to Mn stress","volume":"13","author":"Tsunemitsu","year":"2018","journal-title":"Plant. Signal. & Behav."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120366_bib30","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1021\/acs.est.8b06863","article-title":"Iron\u2013manganese (oxyhydro)oxides, rather than oxidation of sulfides, determine mobilization of Cd during soil drainage in paddy soil systems","volume":"53","author":"Wang","year":"2019","journal-title":"Environ. Sci. & Technol."},{"issue":"18","key":"10.1016\/j.ecoenv.2026.120366_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/plants14182844","article-title":"Cadmium contamination in asian rice (Oryza sativa L.): mechanistic insights from soil sources to grain accumulation and mitigation strategies","volume":"14","author":"Wang","year":"2025","journal-title":"Plants"},{"key":"10.1016\/j.ecoenv.2026.120366_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126379","article-title":"A transcriptomic view of cadmium retention in roots of cadmium-safe rice line (Oryza sativa L.)","volume":"418","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145328","article-title":"Soil application of manganese sulfate could reduce wheat Cd accumulation in Cd contaminated soil by the modulation of the key tissues and ionomic of wheat","volume":"770","author":"Wang","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120366_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117634","article-title":"Quantitative analysis and risk assessment of heavy metal pollution in an intensive industrial and agricultural region","volume":"289","author":"Wen","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120366_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132957","article-title":"Molecular mechanisms and physiological responses of rice leaves co-exposed to submicron-plastics and cadmium: Implication for food quality and security","volume":"463","author":"Wu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120366_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160436","article-title":"Nodes play a major role in cadmium (Cd) storage and redistribution in low-Cd-accumulating rice (Oryza sativa L.) cultivars","volume":"859","author":"Xia","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120366_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.rsci.2019.12.002","article-title":"Differential Expression of Rice Valine-Qlutamine Gene Family in Response to Nitric Oxide and Regulatory Circuit of OsVQ7 and OsWRKY24","volume":"27","author":"Xixu","year":"2020","journal-title":"Rice Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120366_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/fes3.452","article-title":"Identification of QTLs and candidate genes for rice seed germinability under low temperature using high-density genetic mapping and RNA-seq","volume":"12","author":"Yang","year":"2023","journal-title":"Food Energy Secur."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120366_bib39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s43016-022-00569-w","article-title":"Duplication of a manganese\/cadmium transporter gene reduces cadmium accumulation in rice grain","volume":"3","author":"Yu","year":"2022","journal-title":"Nat. Food"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120366_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030569","article-title":"Research Advances in Cadmium Uptake, Transport and Resistance in Rice (Oryza sativa L.)","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120366_bib41","first-page":"1","article-title":"Study of the physiological dynamics of cadmium accumulation in two varieties of rice with different cadmium-accumulating properties","volume":"2021","author":"Zhang","year":"2021","journal-title":"J. Chem."},{"key":"10.1016\/j.ecoenv.2026.120366_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122928","article-title":"Mutation of OsNRAMP5 reduces cadmium xylem and phloem transport in rice plants and its physiological mechanism","volume":"341","author":"Zhang","year":"2024","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120366_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/agronomy14112488","article-title":"Effects of nitrogen fertilizer management on cadmium concentration in brown rice","volume":"14","author":"Zhang","year":"2024","journal-title":"Agronomy"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120366_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13080633","article-title":"Interactions of Fe, Mn, Zn, and Cd in soil\u2013rice systems: implications for reducing cd accumulation in rice","volume":"13","author":"Zhang","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120366_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2025.126527","article-title":"The dual role of selenium in mitigating cadmium toxicity and inhibiting trace element uptake in rice highlights the critical trade-off for safe agricultural production","volume":"391","author":"Zhao","year":"2025","journal-title":"J. Environ. Manag."},{"issue":"28","key":"10.1016\/j.ecoenv.2026.120366_bib46","doi-asserted-by":"crossref","first-page":"12467","DOI":"10.1021\/acs.est.4c01851","article-title":"Multifunctional roles of zinc in cadmium transport in soil\u2013rice systems: novel insights from stable isotope fractionation and gene expression","volume":"58","author":"Zhong","year":"2024","journal-title":"Environ. Sci. & Technol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120366_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13080642","article-title":"Integrated proteomic and transcriptomic analysis reveals the mechanism of selenium-mediated cell wall polysaccharide in rice (oryza sativa l.) cadmium detoxification","volume":"13","author":"Zhu","year":"2025","journal-title":"Toxics"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:31:39Z","timestamp":1789932699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326006950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"alternative-id":["S0147651326006950"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120366","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manganese enrichment in rice seedlings shifts cadmium accumulation from inhibition to promotion during growth via transcriptomic mechanisms","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120366"}}