{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:53:15Z","timestamp":1791064395333,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470537"],"award-info":[{"award-number":["32470537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2308085MC71"],"award-info":[{"award-number":["2308085MC71"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013461","name":"Anhui Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ecoenv.2026.120367","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:36:33Z","timestamp":1781296593000},"page":"120367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microcystin-LR interferes with the intestinal remodeling during tadpole metamorphosis by disrupting thyroid hormone signaling pathways"],"prefix":"10.1016","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-4219","authenticated-orcid":false,"given":"Huijuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120367_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.608697","article-title":"The association of myo-inositol and selenium contrasts cadmium-induced thyroid c cell hyperplasia and hypertrophy in mice","volume":"12","author":"Benvenga","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120367_bib2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/toxins11120714","article-title":"Structural diversity, characterization and toxicology of Microcystins","volume":"11","author":"Boua\u00efcha","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120367_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ydbio.2007.03.021","article-title":"Amphibian metamorphosis","volume":"306","author":"Brown","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ydbio.2006.11.037","article-title":"Pairing morphology with gene expression in thyroid hormone-induced intestinal remodeling and identification of a core set of TH-induced genes across tadpole tissues","volume":"303","author":"Buchholz","year":"2007","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ygcen.2010.06.001","article-title":"The hypothalamus-pituitary-thyroid axis in teleosts and amphibians: endocrine disruption and its consequences to natural populations","volume":"170","author":"Carr","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.118049","article-title":"Integrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers","volume":"341","author":"Catteau","year":"2023","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ecoenv.2026.120367_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ecoenv.2019.02.024","article-title":"Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38\/MAPK and MEK\/ERK signal pathway","volume":"173","author":"Chen","year":"2019","journal-title":"Ecotox. Environ. Safe"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120367_bib8","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1021\/acs.est.8b00700","article-title":"Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to Perfluorobutanesulfonate","volume":"52","author":"Chen","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"20","key":"10.1016\/j.ecoenv.2026.120367_bib9","doi-asserted-by":"crossref","first-page":"12018","DOI":"10.1021\/acs.est.9b03865","article-title":"Parental exposure to perfluorobutane sulfonate impairs offspring development through inheritance of paternal methylome","volume":"53","author":"Chen","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142319","article-title":"Challenges of using blooms of Microcystis spp. in animal feeds: a comprehensive review of nutritional, toxicological and microbial health evaluation","volume":"764","author":"Chen","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120367_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.scitotenv.2021.145196","article-title":"Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats","volume":"778","author":"Chen","year":"2021","journal-title":"Sci. Total. Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/er.2009-0007","article-title":"Molecular aspects of thyroid hormones actions","volume":"31","author":"Cheng","year":"2010","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120367_bib13","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1038\/jid.2008.445","article-title":"A Wnt survival guide: from flies to human disease","volume":"129","author":"Chien","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib14","article-title":"Amphibian toxicity testing for identification of thyroid disrupting chemicals","volume":"311","author":"Dang","year":"2002","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120367_bib15","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/ecog.03296","article-title":"Dispersal and alternative breeding site fidelity strategies in an amphibian","volume":"41","author":"Deno\u00ebl","year":"2018","journal-title":"Ecography"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib16","first-page":"118","article-title":"A review of common cyanotoxins and their effects on fish","volume":"11","author":"Falfushynska","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120367_bib17","unstructured":"FAO. The state of world fisheries and aquaculture 2022. Towards Blue Transformation. FAO, Rome. 2022."},{"key":"10.1016\/j.ecoenv.2026.120367_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125258","article-title":"Acute microcystin-LR exposure interfere thyroid hormones homeostasis in adult zebrafish (Danio rerio)","volume":"243","author":"Gao","year":"2020","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib19","first-page":"183","article-title":"A simplified table for staging anuran embryos and larvae with notes on identification","volume":"16","author":"Gosner","year":"1960","journal-title":"Herpetologica"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.homp.2016.04.001","article-title":"A morphometric and molecular study of the apoptosis observed on tadpoles' tail explants under the exposition of triiodothyronine in different homeopathic dilutions","volume":"105","author":"Guedes","year":"2016","journal-title":"Homeopathy"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/cz\/zoaa005","article-title":"Weyrich, Epigenomics and gene regulation in mammalian social systems","volume":"66","author":"Guerrero","year":"2020","journal-title":"Curr. Zool."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120367_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2045-3701-3-18","article-title":"Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells","volume":"3","author":"Hasebe","year":"2013","journal-title":"Cell. Biosci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00441-016-2396-8","article-title":"Thyroid hormone activates Wnt\/\u03b2-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis","volume":"365","author":"Hasebe","year":"2016","journal-title":"Cell. Tissue Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120367_bib24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/stem.2544","article-title":"Thyroid hormone-induced activation of notch signaling is required for adult intestinal stem cell development during Xenopus laevis metamorphosis","volume":"35","author":"Hasebe","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.ecoenv.2026.120367_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.vh.2022.11.006","article-title":"Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the amphibian intestine during metamorphosis","volume":"122","author":"Hasebe","year":"2023","journal-title":"Vitam. Horm."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120367_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120367_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envpol.2007.04.012","article-title":"Accumulation of cyanobacterial toxins in freshwater \"seafood\" and its consequences for public health: a review","volume":"150","author":"Ibelings","year":"2007","journal-title":"Environ. Pollut."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.120367_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2008.02.020","article-title":"Thyroid hormone regulation of stem cell development during intestinal remodeling","volume":"288","author":"Ishizuya-Oka","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jmor.1052130205","article-title":"Programmed cell death and heterolysis of larval epithelial cells by macrophage-like cells in the anuran small intestine in vivo and in vitro","volume":"213","author":"Ishizuya-Oka","year":"1992","journal-title":"J. Morphol."},{"issue":"15","key":"10.1016\/j.ecoenv.2026.120367_bib30","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1242\/jcs.00616","article-title":"Thyroid hormone-upregulated expression of Musashi-1 is specific for progenitor cells of the adult epithelium during amphibian gastrointestinal remodeling","volume":"116","author":"Ishizuya-Oka","year":"2003","journal-title":"J. Cell. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejogrb.2012.09.021","article-title":"The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring","volume":"166","author":"Kumar","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134140","article-title":"Disruptive effects of two organotin pesticides on the thyroid signaling pathway in Xenopus laevis during metamorphosis","volume":"697","author":"Li","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120367_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aquatox.2018.07.016","article-title":"Gonadal differentiation and its sensitivity to androgens during development of Pelophylax nigromaculatus","volume":"202","author":"Li","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120367_bib34","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/es052538g","article-title":"Thyrotoxicity of sodium arsenate, sodium perchlorate, and their mixture in zebrafish Danio rerio","volume":"40","author":"Liu","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"22","key":"10.1016\/j.ecoenv.2026.120367_bib35","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1021\/acs.est.4c01322","article-title":"Microcystin-LR induces estrogenic effects at environmentally relevant concentration in black-spotted pond frogs (Pelophylax nigromaculatus): in situ, in vivo, in vitro, and in silico investigations","volume":"58","author":"Liu","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.taap.2004.06.002","article-title":"Detection of the cyanobacterial hepatotoxins microcystins","volume":"203","author":"McElhiney","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7441","key":"10.1016\/j.ecoenv.2026.120367_bib37","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature11916","article-title":"Changes in global nitrogen cycling during the Holocene epoch","volume":"495","author":"McLauchlan","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120367_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139678","article-title":"The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice","volume":"736","author":"Meng","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120367_bib39","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s44221-023-00138-w","article-title":"Geographic redistribution of microcystin hotspots in response to climate warming","volume":"1","author":"Merder","year":"2023","journal-title":"Nat. Water"},{"key":"10.1016\/j.ecoenv.2026.120367_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chemosphere.2008.04.033","article-title":"Maternal transfer of brominated flame retardants in zebrafish (Danio rerio)","volume":"73","author":"Nyholm","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120367_bib41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13578-015-0065-3","article-title":"Molecular and cytological analyses reveal distinct transformations of intestinal epithelial cells during Xenopus metamorphosis","volume":"5","author":"Okada","year":"2015","journal-title":"Cell. Biosci."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib42","first-page":"273","article-title":"Review of current state of knowledge of microcystin and its impacts on fish in Lake Victoria","volume":"25","author":"Onyango","year":"2020","journal-title":"Lake Reserv."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120367_bib43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/toxsci\/kfj083","article-title":"Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles","volume":"90","author":"Opitz","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120367_bib44","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/MCB.26.8.3204-3214.2006","article-title":"Thyroid hormone receptor alpha1 directly controls transcription of the beta-catenin gene in intestinal epithelial cells","volume":"26","author":"Plateroti","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120367_bib45","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.3390\/md12115372","article-title":"High levels of structural diversity observed in microcystins from Microcystis CAWBG11 and characterization of six new microcystin congeners","volume":"12","author":"Puddick","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2026.120367_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0074-7696(08)60754-8","article-title":"Cytophysiology of the amphibian thyroid gland through larval development and metamorphosis","volume":"52","author":"Regard","year":"1978","journal-title":"Int. Rev. Cytol."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120367_bib47","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.0409868102","article-title":"Remodeling of the intestine during metamorphosis of Xenopus laevis","volume":"102","author":"Schreiber","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ecoenv.2026.120367_bib48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ygcen.2015.01.020","article-title":"Parental effects of endocrine disrupting compounds in aquatic wildlife: Is there evidence of transgenerational inheritance?","volume":"19","author":"Schwindt","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120843","article-title":"Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats","volume":"318","author":"Shi","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120367_bib50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13578-020-00411-5","article-title":"Thyroid hormone receptor beta is critical for intestinal remodeling during Xenopus tropicalis metamorphosis","volume":"10","author":"Shibata","year":"2020","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.ecoenv.2026.120367_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113584","article-title":"Microcystin-leucine arginine induces skin barrier damage and reduces resistance to pathogenic bacteria in Lithobates catesbeianus tadpoles","volume":"238","author":"Shu","year":"2022","journal-title":"Ecotoxicol. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2026.120367_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123440","article-title":"Pleurotus ostreatus polysaccharide-mediated modulation of skin damage caused by microcystin-LR in tadpoles","volume":"345","author":"Shu","year":"2024","journal-title":"Environ. Pollut."},{"issue":"19","key":"10.1016\/j.ecoenv.2026.120367_bib53","doi-asserted-by":"crossref","first-page":"9399","DOI":"10.1021\/acs.est.4c12957","article-title":"Microcystin-LR induces lipid metabolism disorder in Pelophylax nigromaculatus tadpoles via the Gut-Liver Axis","volume":"59","author":"Shu","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120367_bib54","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1021\/acs.est.4c12873","article-title":"Perfluorobutanesulfonate interfering with the intestinal remodeling during Lithobates catesbeiana metamorphosis via the Hypothalamic-Pituitary-Thyroid axis","volume":"59","author":"Shu","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121117","article-title":"Microcystin-LR induced transgenerational effects of thyroid disruption in zebra\ufb01sh offspring by endoplasmic reticulum stress-mediated thyroglobulin accumulation and apoptosis","volume":"322","author":"Si","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120367_bib56","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.scitotenv.2013.07.020","article-title":"Trophic transfer of microcystins through the lake pelagic food web: Evidence for the role of zooplankton as a vector in fish contamination","volume":"466-467","author":"Sotton","year":"2014","journal-title":"Keyi chufaSci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120367_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175337","article-title":"Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish","volume":"950","author":"Sun","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120367_bib58","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/thy.2020.0022","volume":"31","author":"Tanizaki","year":"2021","journal-title":"Thyroid"},{"key":"10.1016\/j.ecoenv.2026.120367_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fendo.2019.00276","article-title":"Contaminant and environmental influences on thyroid hormone action in amphibian metamorphosis","volume":"10","author":"Thambirajah","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/toxins10010039","article-title":"Analysis of microcystins in cyanobacterial blooms from freshwater bodies in England","volume":"10","author":"Turner","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2026.120367_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106509","article-title":"Microcystin-leucine arginine causes brain injury and functional disorder in Lithobates catesbeianus tadpoles by oxidative stress and inflammation","volume":"258","author":"Wang","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13578-015-0004-3","article-title":"A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling","volume":"5","author":"Wen","year":"2015","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.ecoenv.2026.120367_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159032","article-title":"Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information","volume":"857","author":"Xu","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120367_bib64","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/gcen.2000.7528","article-title":"Effect of diethylstilbestrol on thyroid hormone binding to amphibian transthyretins","volume":"119","author":"Yamauchi","year":"2000","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib65","first-page":"443","volume":"22","author":"Yunes","year":"2019"},{"issue":"36","key":"10.1016\/j.ecoenv.2026.120367_bib66","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1021\/acs.est.3c04371","article-title":"Chronic Paternal\/maternal exposure to environmental concentrations of imidacloprid and thiamethoxam causes intergenerational toxicity in zebrafish offspring","volume":"57","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120367_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108689","article-title":"Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: a review","volume":"187","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.120367_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10408440601123446","article-title":"General background on the hypothalamic-pituitary-thyroid (HPT) axis","volume":"37","author":"Zoeller","year":"2007","journal-title":"Crit. Rev. Toxicol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326006962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:23:37Z","timestamp":1791062617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326006962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":68,"alternative-id":["S0147651326006962"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120367","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microcystin-LR interferes with the intestinal remodeling during tadpole metamorphosis by disrupting thyroid hormone signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120367"}}