{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:13:33Z","timestamp":1783606413611,"version":"3.55.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010982","name":"Philippine Council for Industry Energy and Emerging Technology Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014030","name":"R&D Fund of the Swedish Tourism & Hospitality Industry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ecoenv.2026.120378","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:22:03Z","timestamp":1781821323000},"page":"120378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Compound probiotics alleviate aflatoxin B1-induced reproductive toxicity in mice by remodeling gut microbiota and testicular metabolome via NRF2 pathway action"],"prefix":"10.1016","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-9055","authenticated-orcid":false,"given":"Hongwei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xundong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120378_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.fct.2013.12.027","article-title":"Aflatoxin b1 disrupts the androgen biosynthetic pathway in rat leydig cells","volume":"65","author":"Adedara","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"10271","key":"10.1016\/j.ecoenv.2026.120378_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.120378_bib3","article-title":"Nutritional significance and promising therapeutic\/medicinal application of camel milk as a functional food in human and animals: a comprehensive review","author":"Arain","year":"2022","journal-title":"Anim. Biotechnol."},{"issue":"6755","key":"10.1016\/j.ecoenv.2026.120378_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1126\/science.adz0492","article-title":"The gut microbiome-germline axis: Does a prospective father's gut microbiota matter?","volume":"389","author":"Argaw-Denboba","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.120378_bib5","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/microorganisms11071703","article-title":"Protective and therapeutic effects of lactic acid bacteria against aflatoxin B1 toxicity to rat organs","volume":"11","author":"Ashi","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2026.120378_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12011-023-03658-4","article-title":"Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: current knowledge","volume":"202","author":"Ashraf","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2026.120378_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cryobiol.2014.03.007","article-title":"Esterified glucomannan improves the aflatoxin-induced damage of sperm parameters during liquid storage of ram semen at 5 \u2103","volume":"68","author":"Ataman","year":"2014","journal-title":"Cryobiology"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120378_bib8","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.fertnstert.2011.03.066","article-title":"Effect of vaginal probiotic lactobacilli on in vitro-induced sperm lipid peroxidation and its impact on sperm motility and viability","volume":"95","author":"Barbonetti","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2026.120378_bib9","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s43538-024-00369-9","article-title":"Nutritional and health beneficial application of lactoferrin in some animal species: an updated review","volume":"91","author":"Behan","year":"2025","journal-title":"Proc. Indian. Natl. Sci. Acad."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120378_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fertnstert.2021.12.012","article-title":"The sixth edition of the WHO laboratory manual for the examination and processing of human semen: ensuring quality and standardization in basic examination of human ejaculates","volume":"117","author":"Bj\u00f6rndahl","year":"2022","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2026.120378_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10735-024-10325-y","article-title":"Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress: in vivo and in-silico insights into the Nrf2-NF\u03baB pathway","volume":"56","author":"Buzdar","year":"2025","journal-title":"J. Mol. Histol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120378_bib12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41585-024-00866-y","article-title":"Signatures of metabolic diseases on spermatogenesis and testicular metabolism","volume":"21","author":"Carrageta","year":"2024","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ecoenv.2026.120378_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103689","article-title":"The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance","volume":"84","author":"Chang","year":"2025","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120378_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jbt.20402","article-title":"p-Aminophenol-induced cytotoxicity in Jurkat T cells: protective effect of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid","volume":"26","author":"Chang","year":"2012","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120378_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104316","article-title":"Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway","volume":"103","author":"Chen","year":"2024","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120378_bib16","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181833","article-title":"Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120378_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112366","article-title":"Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites","volume":"137","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120378_bib18","first-page":"321","article-title":"Improvement of male mice fecundity by using two new Lactobacillus strains","volume":"65","author":"Darwish","year":"2023","journal-title":"Egypt. J. Chem."},{"key":"10.1016\/j.ecoenv.2026.120378_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.meatsci.2024.109441","article-title":"Carnobacterium maltaromaticum as bioprotective culture against spoilage bacteria in ground meat and cooked ham","volume":"211","author":"de Andrade Cavalari","year":"2024","journal-title":"Meat Sci."},{"key":"10.1016\/j.ecoenv.2026.120378_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114943","article-title":"AFB1 exacerbates testicular and intestinal inflammation by increasing stearoyl ethanolamide and homocysteine levels","volume":"159","author":"Dong","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120378_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5653\/cerm.2019.03496","article-title":"Cichorium intybus L. extract ameliorates testicular oxidative stress induced by lead acetate in male rats","volume":"47","author":"Dorostghoal","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13098-025-01624-9","article-title":"Effect of high-dose N-acetyl cysteine on the clinical outcome of patients with diabetic peripheral neuropathy: a randomized controlled study","volume":"17","author":"Emara","year":"2025","journal-title":"Diabetol. Metab. Syndr. 4"},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120378_bib23","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.3390\/foods14122111","article-title":"Insights into Chemopreventive Effects of Rosmarinic Acid Against Aflatoxin B1-Induced Genotoxic Effects","volume":"14","author":"Furlan","year":"2025","journal-title":"Foods"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120378_bib24","article-title":"Synergistic roles of follicle-stimulating hormone and testosterone in Sertoli cell proliferation and testicular function in roosters","volume":"105","author":"Guo","year":"2026","journal-title":"Poult. Sci. 18"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120378_bib25","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1080\/19440049.2021.1957159","article-title":"Detoxification of aflatoxin B1 in broiler chickens by a triple-action feed additive","volume":"38","author":"Guo","year":"2021","journal-title":"Food Addit. Contam. Part. A Chem. Anal. Control. Expo. Risk Assess."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120378_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102434","article-title":"Compound mycotoxin detoxifier alleviating aflatoxin B1 toxic effects on broiler growth performance, organ damage and gut microbiota","volume":"102","author":"Guo","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2026.120378_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2024.110601","article-title":"Compound probiotics starter: A solution for aflatoxin B1 reduction and meat quality improvement in fermented chicken jerky","volume":"165","author":"Guo","year":"2024","journal-title":"Food Control."},{"key":"10.1016\/j.ecoenv.2026.120378_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116619","article-title":"Compound probiotics regulate the NRF2 antioxidant pathway to inhibit aflatoxin B1-induced autophagy in mouse Sertoli TM4 cells","volume":"281","author":"Guo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10020-022-00473-w","article-title":"Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes","volume":"28","author":"Hao","year":"2022","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120378_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2024.12.010","article-title":"Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis","volume":"50","author":"Hayes","year":"2025","journal-title":"Trends Biochem. Sci."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120378_bib31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/antiox12040819","article-title":"Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms","volume":"12","author":"Huang","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120378_bib32","article-title":"Toxicological impact of Thiamethoxam on adult male rats: Histopathological, biochemical, and oxidative DNA damage assessment","volume":"14","author":"Issa","year":"2025","journal-title":"Toxicol. Rep. 15"},{"key":"10.1016\/j.ecoenv.2026.120378_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153773","article-title":"Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue","volume":"504","author":"Jalili","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120378_bib34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10735-025-10554-9","article-title":"Kaempferol alleviates cypermethrin induced reproductive toxicity in rats via Nrf2-mediated antioxidant and apoptotic regulation with histopathological evidence: in vivo and in silico study","volume":"56","author":"Kabeer","year":"2025","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.ecoenv.2026.120378_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103839","article-title":"Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells","volume":"86","author":"Kanaan","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/and.13908","article-title":"The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4-induced testicular toxicity based on biochemical, histological and molecular analyses in rat","volume":"53","author":"Keshtmand","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.ecoenv.2026.120378_bib37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.11.007","article-title":"Aflatoxin B1 impairs sperm quality and fertilization competence","volume":"393","author":"Komsky-Elbaz","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120378_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108238","article-title":"Co-administration of rifampicin and Boswellia serrata mitigates testicular toxicity caused by Aflatoxin B1","volume":"255","author":"Korkak","year":"2025","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120378_bib39","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.ccell.2023.06.011","article-title":"Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice","volume":"41","author":"Li","year":"2023","journal-title":"Cancer Cell. 14"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120378_bib40","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1080\/00439339.2025.2519329","article-title":"Exploring brown algae and their derivatives for antibiotic-free poultry production: impacts on health and performance","volume":"81","author":"Li","year":"2025","journal-title":"World's. Poult. Sci. J."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120378_bib41","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1080\/00439339.2025.2522902","article-title":"Exploring Magnolia officinalis and their derivatives as a functional feed additive to modulate poultry health and performance: a review","volume":"81","author":"Li","year":"2025","journal-title":"World's. Poult. Sci. J."},{"key":"10.1016\/j.ecoenv.2026.120378_bib42","article-title":"Polystyrene nanoplastics aggravated dibutyl phthalate-induced blood-testis barrier dysfunction via suppressing autophagy in male mice","volume":"264","author":"Ma","year":"2023","journal-title":"Ecotoxicol. Environ. Saf. 1"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s11356-023-31255-4","article-title":"Integrated biomarker responses: a further improvement of IBR and IBRv2 indexes to preserve data variability in statistical analyses","volume":"31","author":"Mattos","year":"2024","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120378_bib44","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1007\/s12035-025-04725-8","article-title":"Investigating the Interplay Between the Nrf2\/Keap1\/HO-1\/SIRT-1 Pathway and the p75NTR\/PI3K\/Akt\/MAPK Cascade in Neurological Disorders: Mechanistic Insights and Therapeutic Innovations","volume":"62","author":"Mukherjee","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2026.120378_bib45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00360-024-01578-w","article-title":"Effects of in ovo supplementation of selenium (Se) and zinc (Zn) on hatchability and production performance of broiler chickens","volume":"194","author":"Nabi","year":"2024","journal-title":"J. Comp. Physiol. B"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39455-1","article-title":"Dietary aflatoxin b1 and antimalarial-a lumefantrine\/artesunate-therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms","volume":"13","author":"Owumi","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120378_bib47","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/15384101.2023.2171544","article-title":"Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia","volume":"22","author":"Ozturk","year":"2023","journal-title":"Cell. Cycle"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120378_bib48","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/00439339.2025.2468696","article-title":"An in-depth overview of the nutritional advantages of medicinal plant supplementation in poultry feed","volume":"81","author":"Rehman","year":"2025","journal-title":"World's. Poult. Sci. J."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120378_bib49","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1007\/s12602-024-10388-z","article-title":"Effect of Probiotics on Sperm Quality in the Adult Mouse","volume":"17","author":"Sanchez-Rodriguez","year":"2025","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120378_bib50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/ijms24043296","article-title":"An Analysis of the Structural Relationship between Thyroid Hormone-Signaling Disruption and Polybrominated Diphenyl Ethers: Potential Implications for Male Infertility","volume":"24","author":"Sheikh","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120378_bib51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-2952(00)00558-X","article-title":"Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice","volume":"61","author":"Srinivasan","year":"2001","journal-title":"Biochem. Pharmacol. 15"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120378_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/jox15050165","article-title":"Endocrine-Disrupting Chemicals and Male Infertility: Mechanisms, Risks, and Regulatory Challenges","volume":"13 15","author":"Stavros","year":"2025","journal-title":"J. Xenobiot."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib53","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1038\/s41467-025-65368-w","article-title":"Selection and transmission of the gut microbiome alone can shift mammalian behavior","volume":"16","author":"Suzuki","year":"2025","journal-title":"Nat. Commun. 27"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120378_bib54","doi-asserted-by":"crossref","first-page":"16","DOI":"10.53388\/TMR20250814001","article-title":"Evaluation of the protective effects of Crocus sativus L. against cypermethrin induced reproductive toxicity in male rats through the Nrf2 pathway and in silico ADMET analysis","volume":"11","author":"Tariq","year":"2026","journal-title":"Tradit. Med. Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120378_bib55","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.theriogenology.2015.07.011","article-title":"Effect of the probiotic Lactobacillus rhamnosus on the expression of genes involved in European eel spermatogenesis","volume":"84","author":"V\u00edlchez","year":"2015","journal-title":"Theriogenology"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120378_bib56","article-title":"Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertility","volume":"10","author":"Valipour","year":"2024","journal-title":"Heliyon 16"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120378_bib57","article-title":"Biological Mechanisms Balancing Torpor and Reproduction in Mammals","volume":"166","author":"Vander","year":"2025","journal-title":"Endocrinology 9"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41392-020-00218-3","article-title":"PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits","volume":"5","author":"Wang","year":"2020","journal-title":"Signal. Transduct. Target. Ther. 30"},{"key":"10.1016\/j.ecoenv.2026.120378_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.137033","article-title":"Chronic exposure to liquid crystal monomer EBCN at environmentally relevant concentrations induces testicular dysfunction via the gut-testis axis","volume":"486","author":"Wu","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120378_bib60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jcmgh.2022.10.009","article-title":"Sex differences in genomic features of hepatitis B\u2013associated hepatocellular carcinoma with distinct antitumor immunity","volume":"15","author":"Xu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120378_bib61","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1021\/acs.jafc.4c10966","article-title":"Vitamin B6 Alleviates Aflatoxin B1-Induced Impairment of Testis Development by Activating the PI3K\/Akt Signaling Pathway","volume":"73","author":"Yan","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"19","key":"10.1016\/j.ecoenv.2026.120378_bib62","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.3390\/molecules30193860","article-title":"Mycotoxin Contamination: Occurrence, Biotransformation, Pathogenic Mechanisms, and Strategies for Nutritional Intervention","volume":"30","author":"Yao","year":"2025","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120378_bib63","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3390\/biom14111460","article-title":"Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions","volume":"14","author":"Ye","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2026.120378_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121729","article-title":"Aflatoxin B1 disrupts testicular development via the cell cycle-related Ras\/PI3K\/Akt signaling in mice and pig","volume":"329","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120378_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133836","article-title":"Bacillus licheniformis ameliorates Aflatoxin b1-induced testicular damage by improving the gut-metabolism-testis axis","volume":"468","author":"Zhang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib66","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5851\/kosfa.2024.e130","article-title":"Microalgae as a nutraceutical and alternative protein source for poultry: a review","volume":"45","author":"Zhang","year":"2025","journal-title":"Food Sci. Anim. Resour."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120378_bib67","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/gutjnl-2020-320992","article-title":"Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2026.120378_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171973","article-title":"Protective effect of selenomethionine on rabbit testicular injury induced by Aflatoxin B1","volume":"927","author":"Zhang","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120378_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108554","article-title":"Aflatoxin B1-Induced male reproductive Toxicity: Bioactivation, mechanisms, molecular pathways, and Mitigation by phytochemicals in humans and animals","volume":"267","author":"Zhu","year":"2025","journal-title":"Toxicon"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326007074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326007074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:18:43Z","timestamp":1783603123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326007074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":69,"alternative-id":["S0147651326007074"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120378","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compound probiotics alleviate aflatoxin B1-induced reproductive toxicity in mice by remodeling gut microbiota and testicular metabolome via NRF2 pathway action","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120378"}}