{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:12:10Z","timestamp":1789751530350,"version":"4.0.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017282","name":"Guangxi Overseas High Level Talent Hundred People Program","doi-asserted-by":"publisher","award":["2023-RC-01"],"award-info":[{"award-number":["2023-RC-01"]}],"id":[{"id":"10.13039\/501100017282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["Qian Ke He Ji Chu ZK [2022] Zhong Dian 025"],"award-info":[{"award-number":["Qian Ke He Ji Chu ZK [2022] Zhong Dian 025"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ecoenv.2026.120439","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:14:39Z","timestamp":1782425679000},"page":"120439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The combined toxic effects of long-term exposure to environmentally relevant concentrations of imidacloprid and chromium on Xenopus laevis tadpoles: Growth, oxidative stress, and molecular mechanisms"],"prefix":"10.1016","volume":"321","author":[{"given":"Song","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suran","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.ecoenv.2026.120439_bib1","doi-asserted-by":"crossref","first-page":"54467","DOI":"10.1007\/s11356-021-17863-y","article-title":"Acute and chronic toxicities of prothioconazole and its metabolite prothioconazole-desthio","volume":"29","author":"An","year":"2022","journal-title":"Environ. Sci. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120439_bib2","unstructured":"AQSIQ, 2014. (General Administration of Quality Supervision, Inspection and Quarantine, People's Republic of China) and SAC (Standardization Administration of China) GB\/T 31270.18-2014 (Test Guidelines on Environmental Safety Assessment for Chemical Pesticides (Part 18: Amphibian Acute Toxicity Test)). Standardization Administration of the People's Republic of China, Beijing, China."},{"key":"10.1016\/j.ecoenv.2026.120439_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aquatox.2018.05.001","article-title":"An in vivo analysis of Cr6+ induced biochemical, genotoxicological and transcriptional profiling of genes related to oxidative stress, DNA damage and apoptosis in liver of fish, Channa punctatus (Bloch, 1793)","volume":"200","author":"Awasthi","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pestbp.2015.04.004","article-title":"The global status of insect resistance to neonicotinoid insecticides","volume":"121","author":"Bass","year":"2015","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119054","article-title":"Acute exposure to perfluorooctane sulfonate exacerbates heat-induced oxidative stress in a tropical coral species","volume":"302","author":"Bednarz","year":"2022","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib6","doi-asserted-by":"crossref","first-page":"814S","DOI":"10.3945\/ajcn.2009.27462S","article-title":"Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines","volume":"90","author":"Blachier","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120439_bib7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/ars.2015.6516","article-title":"Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway","volume":"24","author":"Campbell","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120439_bib8","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/biology12060890","article-title":"Xenopus laevis (Daudin, 1802) as a model organism for bioscience: a historic review and perspective","volume":"12","author":"Carotenuto","year":"2023","journal-title":"Biol. -Basel"},{"key":"10.1016\/j.ecoenv.2026.120439_bib9","article-title":"Environmental concentration effects of imidacloprid on the renal system of Xenopus laevis: multifaceted insights from histopathology to molecular biology","volume":"214","author":"Chen","year":"2025","journal-title":"Pestic. Biochem. Physiol. Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2024.106965","article-title":"Bioconcentration, oxidative stress and molecular mechanism of the toxic effect of acetamiprid exposure on Xenopus laevis tadpoles","volume":"272","author":"Chen","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib11","article-title":"Stereoselective toxicity: Investigating the adverse effects of benzovindiflupyr on Xenopus laevis tadpoles","volume":"480","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120439_bib12","article-title":"Stereoselective toxicity: investigating the adverse effects of benzovindiflupyr on Xenopus laevis tadpoles","volume":"480","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120439_bib13","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/biom11091345","article-title":"The histaminergic system in neuropsychiatric disorders","volume":"11","author":"Cheng","year":"2021","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120439_bib14","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1021\/pr4001948","article-title":"Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach","volume":"12","author":"Couto","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ecoenv.2026.120439_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ntt.2015.04.006","article-title":"Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish","volume":"49","author":"Crosby","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ecoenv.2013.07.011","article-title":"Preliminary aquatic risk assessment of imidacloprid after application in an experimental rice plot","volume":"97","author":"Daam","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120439_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114034","article-title":"Combined cytotoxicity of phthalate esters on HepG2 cells: a comprehensive analysis of transcriptomics and metabolomics","volume":"180","author":"Dong","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120439_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"Eijkelenboom","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/tox.22688","article-title":"Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and\/or hexavalent chromium in rats","volume":"34","author":"El-Demerdash","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.aquatox.2017.06.003","article-title":"Impacts of triclosan exposure on zebrafish early-life stage: toxicity and acclimation mechanisms","volume":"189","author":"Elodie","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"3-4","key":"10.1016\/j.ecoenv.2026.120439_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.aquatox.2005.09.011","article-title":"The effect of chronic chromium exposure on the health of Chinook salmon (Oncorhynchus tshawytscha)","volume":"76","author":"Farag","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aquatox.2016.05.017","article-title":"Lethal and sub-lethal effects on the Asian common toad Duttaphrynus melanostictus from exposure to hexavalent chromium","volume":"177","author":"Fernando","year":"2016","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.chemosphere.2010.10.010","article-title":"Growth, photosynthesis and antioxidant responses of two microalgal species, Chlorella vulgaris and Selenastrum capricornutum, to nonylphenol stress","volume":"82","author":"Gao","year":"2011","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120439_bib24","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1021\/jf504895h","article-title":"Oxidative Stress and DNA Damage Induced by Imidacloprid in Zebrafish (Danio rerio)","volume":"63","author":"Ge","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120439_bib25","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.3390\/ijms23052724","article-title":"Metabolomic and transcript analysis revealed a sex-specific effect of glyphosate in zebrafish liver","volume":"23","author":"Giommi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.ecoenv.2026.120439_bib26","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1101\/gad.12.24.3777","article-title":"Polo-like kinases: a team that plays throughout mitosis","volume":"12","author":"Glover","year":"1998","journal-title":"Genes. Dev."},{"key":"10.1016\/j.ecoenv.2026.120439_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176411","article-title":"Occurrence and distribution of neonicotinoids and fiproles within groundwater in Minnesota: effects of lithology, land use and geography","volume":"954","author":"Goedjen","year":"2024","journal-title":"Sci. Total. Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120439_bib28","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/1365-2664.12111","article-title":"REVIEW: an overview of the environmental risks posed by neonicotinoid insecticides","volume":"50","author":"Goulson","year":"2013","journal-title":"J. Appl. Ecol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120439_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040600","article-title":"NMR-based metabolomics to analyze the effects of a series of monoamine oxidases-B inhibitors on U251 Cells","volume":"13","author":"Guo","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120439_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00040-16","article-title":"Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance","volume":"81","author":"Hove-Jensen","year":"2017","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ecoenv.2026.120439_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161539","article-title":"Combined toxicity of acetamiprid and cadmium to larval zebrafish (Danio rerio) based on metabolomic analysis","volume":"867","author":"Hu","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ecoenv.2014.03.027","article-title":"Chronic effects of environmentally-relevant concentrations of lead in Pelophylax nigromaculata tadpoles: threshold dose and adverse effects","volume":"104","author":"Huang","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120439_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.etap.2015.12.008","article-title":"The oxidative stress response of myclobutanil and cyproconazole on Tetrahymena thermophila","volume":"41","author":"Huang","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134681","article-title":"Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice","volume":"703","author":"Ji","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fct.2018.12.052","article-title":"Insights into cellular metabolic pathways of the combined toxicity responses of Caco-2 cells exposed to deoxynivalenol, zearalenone and Aflatoxin B1","volume":"126","author":"Ji","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120765","article-title":"Biochemical, histopathological and untargeted metabolomic analyses reveal hepatotoxic mechanism of acetamiprid to Xenopus laevis","volume":"317","author":"Jiao","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120439_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106401","article-title":"The growth toxicity and neurotoxicity mechanism of waterborne TBOEP to nematodes: insights from transcriptomic and metabolomic profiles","volume":"256","author":"Ju","year":"2023","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120439_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10333-014-0420-8","article-title":"Imidacloprid concentrations in paddy rice fields in northern Vietnam: measurement and probabilistic modeling","volume":"13","author":"La","year":"2015","journal-title":"Paddy Water Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121735","article-title":"Exploring the effects of environmentally relevant concentrations of buprofezin and cadmium on tadpoles: a phenotypic and molecular analysis","volume":"278","author":"Li","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120439_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161541","article-title":"Integrate transcriptomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid","volume":"870","author":"Liu","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"2-3","key":"10.1016\/j.ecoenv.2026.120439_bib41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.aquatox.2009.04.006","article-title":"Comparative toxicity of racemic metolachlor and S-metolachlor to Chlorella pyrenoidosa","volume":"93","author":"Liu","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3970860","article-title":"Decoding aging: understanding the complex relationship among aging, free radicals, and GSH","volume":"2020","author":"Lopez-Navarro","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120439_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11033-016-3962-6","article-title":"The five glucose-6-phosphatase paralogous genes are differentially regulated by insulin alone or combined with high level of amino acids and\/or glucose in trout hepatocytes","volume":"43","author":"Lucie","year":"2016","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120439_bib44","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1096\/fj.08-118414","article-title":"Methionine in proteins defends against oxidative stress","volume":"23","author":"Luo","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2026.120439_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131304","article-title":"Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers","volume":"453","author":"Ma","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120439_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms4083","article-title":"Genome\u2013scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non\u2013alcoholic fatty liver disease","volume":"5","author":"Mardinoglu","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120439_bib47","series-title":"Fundamentals of aquatic toxicology","first-page":"164","article-title":"Toxicity of chemical mixtures","author":"Marking","year":"1985"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120439_bib48","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00204-018-2235-7","article-title":"Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126","volume":"92","author":"Mesnage","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120439_bib49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/tox.21939","article-title":"Effect of acute hexavalent chromium exposure on pituitary-thyroid axis of a freshwater fish, Channa punctatus (Bloch)","volume":"30","author":"Mishra","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: a review","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120439_bib51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: a review","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120439_bib52","unstructured":"OECD, 2019. Guidelines for the Testing of Chemicals. Fish, Acute Toxicity Test203. OECD."},{"key":"10.1016\/j.ecoenv.2026.120439_bib53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O'Mahony","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0742-8413(00)00159-6","article-title":"Combined effects of 2,4-D and azinphosmethyl on antioxidant enzymes and lipid peroxidation in liver of Oreochromis niloticus","volume":"127","author":"Oruc","year":"2000","journal-title":"Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2021.109099","article-title":"Protective effects of Spirulina (Arthrospira maxima) against toxicity induced by cadmium in Xenopus laevis","volume":"248","author":"P\u00e9rez-Alvarez","year":"2021","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120439_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.trac.2018.12.001","article-title":"Ecotoxicological effects of microplastics: examination of biomarkers, current state and future perspectives","volume":"111","author":"Prokic","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.ecoenv.2026.120439_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143914","article-title":"Toxicogenomic fin(ger)prints for thyroid disruption AOP refinement and biomarker identification in zebrafish embryos","volume":"760","author":"Reinwald","year":"2021","journal-title":"Sci. Total. Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120439_bib58","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1152\/jn.00775.2019","article-title":"Acute neurotoxicant exposure induces hyperexcitability in mouse lumbar spinal motor neurons","volume":"123","author":"Sceniak","year":"2020","journal-title":"J. Neurophysiol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib59","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00244-005-0243-0","article-title":"Effects of lead-contaminated sediment on Rana sphenocephala tadpoles","volume":"51","author":"Sparling","year":"2006","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093405","article-title":"L-Serine Treatment May Improve Neurorestoration of Rats after Permanent Focal Cerebral Ischemia Potentially Through Improvement of Neurorepair","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS. ONE"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120439_bib61","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00128-011-0243-x","article-title":"Photodegradation of imidacloprid and fipronil in rice-paddy water","volume":"86","author":"Thuyet","year":"2011","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120439_bib62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.chemosphere.2009.05.002","article-title":"Hazard identification of imidacloprid to aquatic environment","volume":"76","author":"Tisler","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120439_bib63","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.chemosphere.2017.02.047","article-title":"Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity","volume":"175","author":"Topal","year":"2017","journal-title":"Chemosphere"},{"issue":"15","key":"10.1016\/j.ecoenv.2026.120439_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17155438","article-title":"Chromium pollution in european water, sources, health risk, and remediation strategies: an overview","volume":"17","author":"Tumolo","year":"2020","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.ecoenv.2026.120439_bib65","series-title":"Data Summary of the Third Unregulated Contaminant Monitoring Rule (UCMR 3)","author":"US EPA (US Environmental Protection Agency)","year":"2017"},{"key":"10.1016\/j.ecoenv.2026.120439_bib66","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chemosphere.2015.03.002","article-title":"Biological response of earthworm, Eisenia fetida, to five neonicotinoid insecticides","volume":"132","author":"Wang","year":"2015","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120439_bib67","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00726-013-1493-1","article-title":"Glycine metabolism in animals and humans: implications for nutrition and health","volume":"45","author":"Wang","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.ecoenv.2026.120439_bib68","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jes.2023.09.032","article-title":"4-Nitrophenol at environmentally relevant concentrations mediates reproductive toxicity in Caenorhabditis elegans via metabolic disorders-induced estrogen signaling pathway","volume":"147","author":"Wang","year":"2025","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2026.120439_bib69","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.envpol.2017.12.120","article-title":"Joint toxic effects of triazophos and imidacloprid on zebrafish (Danio rerio)","volume":"235","author":"Wu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120439_bib70","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.scitotenv.2018.08.256","article-title":"Occurrence and risk of neonicotinoid insecticides in surface water in a rapidly developing region: application of polar organic chemical integrative samplers","volume":"648","author":"Xiong","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125437","article-title":"Probing the effects of hexavalent chromium exposure on histology and fatty acid metabolism in liver of Bufo gargarizans tadpoles","volume":"243","author":"Yang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120439_bib72","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.chemosphere.2018.10.147","article-title":"Effects of hexavalent chromium on intestinal histology and microbiota in Bufo gargarizans tadpoles","volume":"216","author":"Yao","year":"2019","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120439_bib73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ygeno.2021.12.009","article-title":"Transcriptomics integrated with metabolomics reveals the effect of Lycium barbarum polysaccharide on apoptosis in Nile tilapia (Oreochromis niloticus)","volume":"114","author":"Zhang","year":"2022","journal-title":"Genomics"},{"key":"10.1016\/j.ecoenv.2026.120439_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105719","article-title":"Contamination of neonicotinoid insecticides in soil-water-sediment systems of the urban and rural areas in a rapidly developing region: Guangzhou, South China","volume":"139","author":"Zhang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120439_bib75","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.scitotenv.2017.08.052","article-title":"Acute and chronic toxic effects of fluoxastrobin on zebrafish (Danio rerio)","volume":"610","author":"Zhang","year":"2018","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib76","article-title":"Long-term exposure of zebrafish (Danio rerio) to Cr (VI): reproductive toxicity and neurotoxicity","author":"Zhao","year":"2024","journal-title":"Reg. Stud. Mar. Sci. 74"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120439_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.104723","article-title":"Toxic effects of imidacloprid and sulfoxaflor on Rana nigromaculata tadpoles: Growth, antioxidant indices and thyroid hormone-related endocrine system","volume":"16","author":"Zhou","year":"2023","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.ecoenv.2026.120439_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161794","article-title":"Characterization of imidacloprid-induced hepatotoxicity and its mechanisms based on a metabolomic approach in Xenopus laevis","volume":"869","author":"Zhou","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120439_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125468","article-title":"High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo","volume":"244","author":"Zhu","year":"2020","journal-title":"Chemosphere"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326007682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326007682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:01:17Z","timestamp":1789750877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326007682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":79,"alternative-id":["S0147651326007682"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120439","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The combined toxic effects of long-term exposure to environmentally relevant concentrations of imidacloprid and chromium on Xenopus laevis tadpoles: Growth, oxidative stress, and molecular mechanisms","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120439"}}