{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:44:51Z","timestamp":1786221891333,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120486","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:28:23Z","timestamp":1783538903000},"page":"120486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasticizer-related toxicogenomic signatures in gestational diabetes: Mendelian randomization, placental single-cell transcriptomics and trophoblast validation"],"prefix":"10.1016","volume":"322","author":[{"given":"Xiaoting","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhou","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120486_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2016.12.007","article-title":"HTR-8\/SVneo cell line contains a mixed population of cells","volume":"50","author":"Abou-Kheir","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2026.120486_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"D1","key":"10.1016\/j.ecoenv.2026.120486_bib3","doi-asserted-by":"crossref","first-page":"D358","DOI":"10.1093\/nar\/gkaf1226","article-title":"AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage","volume":"54","author":"Bertoni","year":"2026","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120486_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nri1745","article-title":"Dectin-1: a signalling non-TLR pattern-recognition receptor","volume":"6","author":"Brown","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120486_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","article-title":"Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur. J. Epidemiol."},{"issue":"1663","key":"10.1016\/j.ecoenv.2026.120486_bib6","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120486_bib7","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s40618-016-0607-5","article-title":"Gestational diabetes mellitus: an updated overview","volume":"40","author":"Chiefari","year":"2017","journal-title":"J. Endocrinol. Invest."},{"issue":"W1","key":"10.1016\/j.ecoenv.2026.120486_bib8","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"R1","key":"10.1016\/j.ecoenv.2026.120486_bib9","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120486_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.ecoenv.2026.120486_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.reprotox.2022.10.001","article-title":"Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP\/PKA signaling pathway in human trophoblastic HTR-8\/Svneo cells","volume":"114","author":"Gu","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120486_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"issue":"13","key":"10.1016\/j.ecoenv.2026.120486_bib13","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120486_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120486_bib15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1110","article-title":"Lysosomal cysteine proteases regulate antigen presentation","volume":"3","author":"Honey","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120486_bib16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.envint.2016.09.009","article-title":"Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors","volume":"96","author":"James-Todd","year":"2016","journal-title":"Environ. Int."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120486_bib17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","article-title":"Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications","volume":"29","author":"Johns","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"issue":"D1","key":"10.1016\/j.ecoenv.2026.120486_bib18","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120486_bib19","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"7944","key":"10.1016\/j.ecoenv.2026.120486_bib20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120486_bib21","first-page":"1133","article-title":"Mendelian randomization","volume":"27","author":"Lawlor","year":"2008","journal-title":"Using. Genes. Instrum. Mak. Causal Inferences Epidemiol. Stud. Stat. Med."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120486_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11892-015-0709-z","article-title":"Genetics of gestational diabetes mellitus and maternal metabolism","volume":"16","author":"Lowe","year":"2016","journal-title":"Curr. Diab Rep."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120486_bib23","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120486_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120486_bib25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120486_bib26","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The Pathophysiology of Gestational Diabetes Mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"43","key":"10.1016\/j.ecoenv.2026.120486_bib27","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120486_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signalling pathways: insights into insulin action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120486_bib29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"D1","key":"10.1016\/j.ecoenv.2026.120486_bib30","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","author":"UniProt Consortium","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120486_bib31","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"issue":"Pt 3","key":"10.1016\/j.ecoenv.2026.120486_bib32","article-title":"Serum concentrations of phthalate metabolites in pregnant women and their association with gestational diabetes mellitus and blood glucose levels","volume":"857","author":"Wang","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120486_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12940-022-00858-8","article-title":"Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis","volume":"21","author":"Yan","year":"2022","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120486_bib34","article-title":"Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell Level","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2026.120486_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis","volume":"377","author":"Ye","year":"2022","journal-title":"BMJ"},{"issue":"D1","key":"10.1016\/j.ecoenv.2026.120486_bib36","doi-asserted-by":"crossref","first-page":"D1180","DOI":"10.1093\/nar\/gkad1004","article-title":"The ChEMBL Database in 2024","volume":"52","author":"Zdrazil","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120486_bib37","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120486_bib38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11892-015-0699-x","article-title":"Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective","volume":"16","author":"Zhu","year":"2016","journal-title":"Curr. Diab Rep."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:25:34Z","timestamp":1786220734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326008158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"alternative-id":["S0147651326008158"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120486","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasticizer-related toxicogenomic signatures in gestational diabetes: Mendelian randomization, placental single-cell transcriptomics and trophoblast validation","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120486"}}