{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:45:32Z","timestamp":1786221932309,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120522","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:41:38Z","timestamp":1784382098000},"page":"120522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gut-liver axis through microbiota-metabolite interplay driving age-dependent susceptibility to arsenite-induced liver injury in mice"],"prefix":"10.1016","volume":"322","author":[{"given":"Yuhan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ecoenv.2026.120522_bib1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2023.02.034","article-title":"The exposome and liver disease - how environmental factors affect liver health","volume":"79","author":"Barouki","year":"2023","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120522_bib2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/febs.14260","article-title":"How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease","volume":"285","author":"Basters","year":"2018","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120522_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120522_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/metabo14030139","article-title":"The correlation between metal mixed exposure and lung function in different ages of the population","volume":"14","author":"Chen","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.ecoenv.2026.120522_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107660","article-title":"The gut microbiome promotes arsenic metabolism and alleviates the metabolic disorder for their mammal host under arsenic exposure","volume":"171","author":"Chen","year":"2023","journal-title":"Environ. Int."},{"issue":"6684","key":"10.1016\/j.ecoenv.2026.120522_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi3332","article-title":"Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG","volume":"383","author":"Chen","year":"2024","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120522_bib7","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s00125-015-3703-8","article-title":"The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice","volume":"58","author":"Chung","year":"2015","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120522_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120522_bib9","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.apsb.2025.01.008","article-title":"Harnessing the UDP-G\/P2Y(14)R axis to promote liver regeneration in acute liver failure","volume":"15","author":"Fang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120522_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147735","article-title":"Uridine diphosphate-glucose\/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation","volume":"131","author":"Foster","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2026.120522_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116283","article-title":"Effects of multiple metals exposure on abnormal liver function: the mediating role of low-density lipoprotein cholesterol","volume":"276","author":"Han","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120522_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01677-22","article-title":"Chemotherapeutic drugs induce different gut microbiota disorder pattern and NOD\/RIP2\/NF-\u03baB signaling pathway activation that lead to different degrees of intestinal injury","volume":"10","author":"Huang","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120522_bib13","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/s41467-024-55085-1","article-title":"Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation","volume":"16","author":"Kang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120522_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109025","article-title":"Long-term arsenic exposure decreases mice body weight and liver lipid droplets","volume":"192","author":"Lai","year":"2024","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120522_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101501","article-title":"Uridine diphosphate glucose (UDP-G) activates oxidative stress and respiratory burst in isolated neutrophils","volume":"16","author":"Lairion","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120522_bib16","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jhep.2018.01.003","article-title":"Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling","volume":"68","author":"Levada","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108824","article-title":"The response of gut microbiota to arsenic metabolism is involved in arsenic-induced liver injury, which is influenced by the interaction between arsenic and methionine synthase","volume":"190","author":"Li","year":"2024","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120522_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1289\/ehp.1307429","article-title":"Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis","volume":"122","author":"Lu","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120522_bib19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s40168-024-01873-2","article-title":"Microbial assimilatory sulfate reduction-mediated H(2)S: an overlooked role in Crohn's disease development","volume":"12","author":"Luo","year":"2024","journal-title":"Microbiome"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120522_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/1758-2229.12814","article-title":"Arsenic and the gastrointestinal tract microbiome","volume":"12","author":"McDermott","year":"2020","journal-title":"Environ. Microbiol. Rep."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120522_bib21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jhep.2012.05.012","article-title":"Nilotinib protects the murine liver from ischemia\/reperfusion injury","volume":"57","author":"Ocuin","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib22","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15591","article-title":"MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1\u03b1\/GYS1\/UDPG\/P2Y(14) pathway","volume":"11","author":"Qian","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.ecoenv.2026.120522_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117940","article-title":"Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management","volume":"289","author":"Rahaman","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120522_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.sbi.2016.07.019","article-title":"MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance","volume":"41","author":"Rauch","year":"2016","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129735","article-title":"Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review","volume":"271","author":"Renu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120522_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118438","article-title":"An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity","volume":"260","author":"Renu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120522_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116147","article-title":"Effects of dietary arsenic exposure on liver metabolism in mice","volume":"274","author":"Shao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120522_bib28","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","article-title":"Intestinal HIF-1\u03b1 deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction","volume":"69","author":"Shao","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envint.2016.07.020","article-title":"Mechanisms of arsenic disruption on gonadal, adrenal and thyroid endocrine systems in humans: A review","volume":"95","author":"Sun","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120522_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112531","article-title":"Arsenic trioxide induces expression of BCL-2 expression via NF-\u03baB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis","volume":"222","author":"Tang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2026.120522_bib31","article-title":"Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"238","author":"Tinkov","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120522_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170962","article-title":"Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis","volume":"919","author":"Wang","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120522_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2019.111160","article-title":"NF-\u03baB signaling in skin aging","volume":"184","author":"Wang","year":"2019","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120522_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13062-025-00622-1","article-title":"E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma","volume":"20","author":"Zhang","year":"2025","journal-title":"Biol. Direct"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120522_bib35","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s42003-021-02898-1","article-title":"Cadmium exposure modulates the gut-liver axis in an Alzheimer's disease mouse model","volume":"4","author":"Zhang","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109655","article-title":"UDP-glucose sensing P2Y(14)R: a novel target for inflammation","volume":"238","author":"Zhang","year":"2023","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120522_bib37","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1038\/s41467-023-38371-2","article-title":"UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120522_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126707","article-title":"Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis","volume":"421","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120522_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127512","article-title":"Effects of tauroursodeoxycholate on arsenic-induced hepatic injury in mice: a comparative transcriptomic analysis","volume":"86","author":"Zheng","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2026.120522_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127725","article-title":"Effects of intestinal Desulfovibrio bacteria on host health and its potential regulatory strategies: a review","volume":"284","author":"Zhou","year":"2024","journal-title":"Microbiol. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:34:27Z","timestamp":1786221267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326008523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S0147651326008523"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120522","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut-liver axis through microbiota-metabolite interplay driving age-dependent susceptibility to arsenite-induced liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120522"}}