{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:04:30Z","timestamp":1789329870400,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019651","name":"Southern Marine Science and Engineering Guangdong Laboratory - Guangzhou","doi-asserted-by":"publisher","award":["SML2024SP002"],"award-info":[{"award-number":["SML2024SP002"]}],"id":[{"id":"10.13039\/501100019651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574127"],"award-info":[{"award-number":["82574127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42507576"],"award-info":[{"award-number":["42507576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031919","name":"Southern Marine Science and Engineering Guangdong Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120526","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:19:31Z","timestamp":1784528371000},"page":"120526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish"],"prefix":"10.1016","volume":"322","author":[{"given":"Xinying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-7853","authenticated-orcid":false,"given":"Weiyi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120526_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biochi.2016.01.012","article-title":"The interaction of human serum albumin with selected lanthanide and actinide ions: Binding affinities, protein unfolding and conformational changes","volume":"123","author":"Ali","year":"2016","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120526_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40572-019-00231-x","article-title":"Understanding environmental contaminants\u2019 direct effects on non-alcoholic fatty liver disease progression","volume":"6","author":"Armstrong","year":"2019","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2026.120526_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/bs.ctdb.2016.10.007","article-title":"Zebrafish in Toxicology and Environmental Health","volume":"124","author":"Bambino","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib4","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.3389\/fimmu.2019.02993","article-title":"New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages","volume":"10","author":"Batista-Gonzalez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2022.948041","article-title":"Toxicity of rare earth elements: An overview on human health impact","volume":"10","author":"Brouziotis","year":"2022","journal-title":"Front. Environ. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3390\/ijms25021324","article-title":"Regulation of benzo [a] pyrene-induced hepatic lipid accumulation through CYP1B1-induced mTOR-mediated Lipophagy","volume":"25","author":"Bu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120526_bib7","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fphys.2020.00850","article-title":"Lipophagy Impairment Is Associated With Disease Progression in NAFLD","volume":"11","author":"Carotti","year":"2020","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/15401420390271074","article-title":"Experimental study of subchronic toxicity of lanthanum nitrate on liver in rats","volume":"1","author":"Chen","year":"2003","journal-title":"Nonlinear Biol. Toxicol. Med."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120526_bib9","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1\u03b1 and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2026.120526_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124922","article-title":"Unravelling bisphenol A-induced hepatotoxicity: insights into oxidative stress, inflammation, and energy dysregulation","volume":"362","author":"Das","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120526_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106685","article-title":"Toxicokinetics in rats and modeling to support the interpretation of biomonitoring data for rare-earth elements","volume":"155","author":"Desrosiers","year":"2021","journal-title":"Environ. Int."},{"issue":"6016","key":"10.1016\/j.ecoenv.2026.120526_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112587","article-title":"Neurodevelopmental toxicity of alumina nanoparticles to zebrafish larvae: Toxic effects of particle sizes and ions","volume":"157","author":"Fan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134878","article-title":"Polystyrene nanoplastics induce lipophagy via the AMPK\/ULK1 pathway and block lipophagic flux leading to lipid accumulation in hepatocytes","volume":"476","author":"Fan","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120526_bib17","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ecoenv.2026.120526_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155416","article-title":"Inflammation and accompanied disrupted hematopoiesis in adult mouse induced by rare earth element nanoparticles","volume":"831","author":"Gao","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120526_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164287","article-title":"Uranium and lanthanum in Norwegian drinking water - Is there cause for concern?","volume":"889","author":"Gjengedal","year":"2023","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/0192623316677327","article-title":"Sex differences in human and animal toxicology: toxicokinetics","volume":"45","author":"Gochfeld","year":"2017","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1210\/er.2018-00158","article-title":"Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease","volume":"40","author":"Grossmann","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2026.120526_bib22","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert. Rev. Mol. Med."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s12598-024-03204-8","article-title":"A critical review of lanthanum and lanthanum-based materials: synthesis, applications, and challenges","author":"Jadhav","year":"2025","journal-title":"Rare Met.132"},{"key":"10.1016\/j.ecoenv.2026.120526_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134681","article-title":"Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice","volume":"703","author":"Ji","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120526_bib27","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1007\/s00221-017-5102-5","article-title":"Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus","volume":"235","author":"Jin","year":"2017","journal-title":"Exp. brain Res."},{"issue":"21","key":"10.1016\/j.ecoenv.2026.120526_bib28","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"Embo J."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41467-017-00520-9","article-title":"Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy","volume":"8","author":"Laker","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib32","article-title":"Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPAR\u03b1-dependent ApoB suppression","volume":"9","author":"Li","year":"2026","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120526_bib33","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s10661-013-3469-8","article-title":"State of rare earth elements in different environmental components in mining areas of China","volume":"186","author":"Liang","year":"2014","journal-title":"Environ. Monit. Assess."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120526_bib34","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jhep.2016.06.029","article-title":"Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy","volume":"65","author":"Lin","year":"2016","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120526_bib35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","article-title":"Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice","volume":"58","author":"Lin","year":"2013","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jat.4383","article-title":"Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high-fat diet mice through AMP-activated protein kinase\/acetyl-CoA carboxylase (AMPK\/ACC) pathway","volume":"43","author":"Ling","year":"2023","journal-title":"J Appl Toxicol JAT"},{"key":"10.1016\/j.ecoenv.2026.120526_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105994","article-title":"Effect of rare earth element lanthanum on lipid deposition and Wnt10b signaling in the liver of male zebrafish","volume":"240","author":"Liu","year":"2021","journal-title":"Aquatic Toxicol (Amsterdam Netherlands)"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib38","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/hep.30626","article-title":"Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps","volume":"70","author":"Lonardo","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2026.120526_bib39","article-title":"Correlation between urinary rare earth elements and liver function in a Zhuang population aged 35-74 years in Nanning","volume":"84","author":"Luo","year":"2024","journal-title":"J. Trace Elem. Med. Biol. Organ. Soc. Miner. Trace Elem. (GMS)"},{"key":"10.1016\/j.ecoenv.2026.120526_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41421-020-0155-1","article-title":"Activation and targeting of ATG8 protein lipidation","volume":"6","author":"Martens","year":"2020","journal-title":"Cell. Discov."},{"key":"10.1016\/j.ecoenv.2026.120526_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-nutr-071813-105336","article-title":"Autophagy and Lipid Droplets in the Liver","volume":"35","author":"Martinez-Lopez","year":"2015","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120526_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmet.2019.12.009","article-title":"Hepatic ER\u03b1 accounts for sex differences in the ability to cope with an excess of dietary lipids","volume":"32","author":"Meda","year":"2020","journal-title":"Mol. Metab."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib43","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1038\/s41467-023-39404-6","article-title":"Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion","volume":"14","author":"Minami","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120526_bib44","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1038\/s41418-020-0567-3","article-title":"Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver","volume":"27","author":"Mohapatra","year":"2020","journal-title":"Cell. Death Differ."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120526_bib45","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/jcmm.16255","article-title":"Regulation of lipid metabolism by the unfolded protein response","volume":"25","author":"Moncan","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"18","key":"10.1016\/j.ecoenv.2026.120526_bib46","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1016\/j.molcel.2021.06.003","article-title":"SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice","volume":"81","author":"Nguyen","year":"2021","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ecoenv.2026.120526_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135188","article-title":"Lanthanum in Water, Sediment, Macrophytes and chironomid larvae following application of Lanthanum modified bentonite to lake Rauwbraken (The Netherlands)","volume":"706","author":"van Oosterhout","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120526_bib49","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1002\/cncr.22701","article-title":"Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis","volume":"109","author":"Pekow","year":"2007","journal-title":"Cancer"},{"issue":"34","key":"10.1016\/j.ecoenv.2026.120526_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211281120","article-title":"The autophagy machinery interacts with EBV capsids during viral envelope release","volume":"120","author":"Pena-Francesch","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2026.120526_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.836021","article-title":"ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions","volume":"10","author":"Rajak","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.657389","article-title":"Autophagy in hepatic steatosis: a structured review","volume":"9","author":"Ramos","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120526_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/biom10121702","article-title":"Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants","volume":"10","author":"Rives","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2026.120526_bib54","first-page":"177","article-title":"Energy metabolism in the liver","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib55","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhep.2021.09.039","article-title":"Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"76","author":"Sen","year":"2022","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120526_bib56","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1097\/TP.0000000000003691","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Liver Transplantation and Underlying Diseases: New Insights and Therapeutics","volume":"105","author":"Shi","year":"2021","journal-title":"Transplantation"},{"issue":"18","key":"10.1016\/j.ecoenv.2026.120526_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cells12182246","article-title":"Zebrafish as a Useful Model System for Human Liver Disease","volume":"12","author":"Shimizu","year":"2023","journal-title":"Cells"},{"issue":"7242","key":"10.1016\/j.ecoenv.2026.120526_bib58","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib59","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120526_bib60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0030-1267538","article-title":"The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis","volume":"30","author":"Sozio","year":"2010","journal-title":"Semin. liver Dis."},{"issue":"42","key":"10.1016\/j.ecoenv.2026.120526_bib61","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.3748\/wjg.v20.i42.15539","article-title":"Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Takahashi","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120526_bib62","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-0035-1562945","article-title":"Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD","volume":"35","author":"Vacca","year":"2015","journal-title":"Semin. liver Dis."},{"key":"10.1016\/j.ecoenv.2026.120526_bib63","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.envpol.2017.07.046","article-title":"Bio-accumulation of lanthanum from lanthanum modified bentonite treatments in lake restoration","volume":"230","author":"Waajen","year":"2017","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120526_bib64","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbagen.2012.03.010","article-title":"PFOS-induced hepatic steatosis, the mechanistic actions on \u03b2-oxidation and lipid transport","volume":"1820","author":"Wan","year":"2012","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017234","article-title":"2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase","volume":"6","author":"Wang","year":"2011","journal-title":"PloS. One"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jhep.2015.02.029","article-title":"Hepatic estrogen receptor \u03b1 improves hepatosteatosis through upregulation of small heterodimer partner","volume":"63","author":"Wang","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2026.120526_bib67","article-title":"Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy via modulation of the AMPK\/mTOR\/ULK-1 signaling pathway","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120526_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12050317","article-title":"Toxic Effects of Rare Earth Elements on Human Health: A Review","volume":"12","author":"Wang","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120526_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1350146","article-title":"PCB169 exposure aggravated the development of non-alcoholic fatty liver in high-fat diet-induced male C57BL\/6 mice","volume":"11","author":"Wei","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120526_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115655","article-title":"Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes","volume":"267","author":"Weng","year":"2020","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib71","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/auto.23323","article-title":"The ULK1 complex: sensing nutrient signals for autophagy activation","volume":"9","author":"Wong","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120526_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137166","article-title":"Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2","volume":"487","author":"Xie","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120526_bib73","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fphar.2019.00495","article-title":"Lipophagy and alcohol-induced fatty liver","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120526_bib74","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1210\/en.2016-1479","article-title":"Dysregulated Autophagy in Hepatocytes Promotes Bisphenol A\u2013Induced Hepatic Lipid Accumulation in Male Mice","volume":"158","author":"Yang","year":"2017","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120526_bib75","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1080\/17435390.2020.1770887","article-title":"Nanoceria distribution and effects are mouse-strain dependent","volume":"14","author":"Yokel","year":"2020","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2026.120526_bib76","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.2147\/IJN.S230949","article-title":"La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2\/ARE Signaling Pathway in Kunming Mice","volume":"15","author":"Yuan","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120526_bib77","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhep.2009.03.026","article-title":"Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1","volume":"51","author":"Yuan","year":"2009","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120526_bib78","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/EBC20170021","article-title":"The mammalian ULK1 complex and autophagy initiation","volume":"61","author":"Zachari","year":"2017","journal-title":"Essays Biochem."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120526_bib79","article-title":"The SIRT2-AMPK axis regulates autophagy induced by acute liver failure","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120526_bib80","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell. death Dis."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120526_bib81","article-title":"\u03b1-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal \u03b2-Oxidation and Reducing Lipophagy in Chicken Hepatocyte","volume":"12","author":"Zhao","year":"2025","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326008560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:41:51Z","timestamp":1789328511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326008560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":81,"alternative-id":["S0147651326008560"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120526","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120526"}}