{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:04:26Z","timestamp":1789329866876,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260733"],"award-info":[{"award-number":["82260733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120551","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:16:03Z","timestamp":1785071763000},"page":"120551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated multi-omics analysis suggests a potential mechanism of DEHP-induced monocyte infiltration in MASH via the FOS-CCL3\/4 axis"],"prefix":"10.1016","volume":"322","author":[{"given":"Chaojie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ecoenv.2026.120551_bib1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s10620-016-4049-x","article-title":"Innate immunity and inflammation in NAFLD\/NASH","volume":"61","author":"Arrese","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ecoenv.2026.120551_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jhazmat.2017.06.036","article-title":"Phthalates impact human health: Epidemiological evidences and plausible mechanism of action","volume":"340","author":"Benjamin","year":"2017","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120551_bib3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120551_bib4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.120551_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","article-title":"PPAR-mediated activity of phthalates: A link to the obesity epidemic?","volume":"304","author":"Desvergne","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120551_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrendo.2017.42","article-title":"Endocrine-disrupting chemicals and fatty liver disease","volume":"13","author":"Foulds","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120551_bib7","first-page":"1","article-title":"Regularization Paths for Generalized Linear Models via Coordinate Descent","volume":"33","author":"Friedman","year":"2010"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120551_bib8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120551_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120551_bib10","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120551_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ecoenv.2026.120551_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"Pt 25","key":"10.1016\/j.ecoenv.2026.120551_bib13","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: quarrel and harmony among siblings","volume":"117","author":"Hess","year":"2004","journal-title":"J. Cell. Sci."},{"issue":"7640","key":"10.1016\/j.ecoenv.2026.120551_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120551_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113119","article-title":"Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR\/SREBP-1c\/PPAR\u03b1\/\u03b3 and NF-\u03baB signaling pathway","volume":"165","author":"Huang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120551_bib16","first-page":"1","article-title":"Single-cell RNA sequencing technologies and bioinformatics pipelines","volume":"50","author":"Hwang","year":"2018"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120551_bib17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"issue":"7949","key":"10.1016\/j.ecoenv.2026.120551_bib18","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41586-022-05688-9","article-title":"Dissecting cell identity via network inference and in silico gene perturbation","volume":"614","author":"Kamimoto","year":"2023","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120551_bib19","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120551_bib20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120551_bib21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120551_bib22","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120551_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrg3920","article-title":"Machine learning applications in genetics and genomics","volume":"16","author":"Libbrecht","year":"2015","journal-title":"Nat. Rev. Genet."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120551_bib24","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120551_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"Marra","year":"2014","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120551_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Comput. Aided Drug. Des."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120551_bib27","article-title":"scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation","volume":"3","author":"Osorio","year":"2022","journal-title":"Patterns (N. Y)"},{"issue":"10290","key":"10.1016\/j.ecoenv.2026.120551_bib28","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.120551_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.04.040","article-title":"Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence","volume":"132","author":"Radke","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120551_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ecoenv.2026.120551_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1750368","article-title":"Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview","volume":"2018","author":"Rowdhwal","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120551_bib32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10408440600779065","article-title":"Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver","volume":"36","author":"Rusyn","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"issue":"19","key":"10.1016\/j.ecoenv.2026.120551_bib33","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1093\/bioinformatics\/btm344","article-title":"A review of feature selection techniques in bioinformatics","volume":"23","author":"Saeys","year":"2007","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120551_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120551_bib35","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120551_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12979-026-00561-z","article-title":"Aging-induced decrease in progenitor B cells enhances the osteoclastogenesis of bone marrow macrophages via ROS-activated Fos\/CCL3 signaling pathway","volume":"23","author":"Sun","year":"2026","journal-title":"Immun. Ageing"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120551_bib37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120551_bib38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120551_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120551_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120551_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120551_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132600881X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132600881X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:42:00Z","timestamp":1789328520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132600881X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S014765132600881X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120551","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated multi-omics analysis suggests a potential mechanism of DEHP-induced monocyte infiltration in MASH via the FOS-CCL3\/4 axis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120551"}}