{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:53:20Z","timestamp":1791809600222,"version":"4.3.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120578","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:21:13Z","timestamp":1785453673000},"page":"120578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Polystyrene nanoplastics impair placental function and promote embryo resorption through ROS-mediated ferroptosis-related injury"],"prefix":"10.1016","volume":"322","author":[{"given":"Xiaoyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein Min","family":"Tun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-4035","authenticated-orcid":false,"given":"Yankai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120578_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127228","article-title":"Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function","volume":"386","author":"Alahmadi","year":"2025","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120578_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/jama.1950.02920080125043","article-title":"Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death.","volume":"144","author":"Anone","year":"1950","journal-title":"J. Am. Med. Assoc."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib3","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1152\/physrev.00039.2024","article-title":"The human placenta and its role in reproductive outcomes revisited","volume":"105","author":"Aye","year":"2025","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12989-024-00595-5","article-title":"Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78\/IRE1\u03b1\/JNK axis induced apoptosis and endoplasmic reticulum stress","volume":"21","author":"Bai","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120578_bib5","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41588-023-01520-w","article-title":"Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth","volume":"55","author":"Beaumont","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2026.120578_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2021.03.007","article-title":"Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome","volume":"108","author":"Beharier","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2026.120578_bib7","article-title":"Polystyrene nanoplastics-induced lung epithelial cells ferroptosis promotes pulmonary fibrosis via YY1\/FTL axis","volume":"36","author":"Bu","year":"2026","journal-title":"Mater. Today Bio"},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120578_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ajog.2025.07.039","article-title":"Formation of the placental membranes and pathophysiological origin of associated great obstetrical syndromes","volume":"233","author":"Burton","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120578_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/EBC20253053","article-title":"Epigenetics and chemical exposures","volume":"69","author":"C\u00f3rdova-Casanova","year":"2025","journal-title":"Essays Biochem."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/17435390.2017.1343875","article-title":"Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus","volume":"11","author":"Campagnolo","year":"2017","journal-title":"Nanotoxicology"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1186\/s12951-024-02911-9","article-title":"Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus","volume":"22","author":"Chen","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"14","key":"10.1016\/j.ecoenv.2026.120578_bib12","doi-asserted-by":"crossref","first-page":"13825","DOI":"10.1021\/acsnano.4c16786","article-title":"Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ecoenv.2026.120578_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109361","article-title":"Gestational exposure to nanoplastics disrupts fetal development by promoting the placental aging via ferroptosis of syncytiotrophoblast","volume":"197","author":"Chen","year":"2025","journal-title":"Environ. Int."},{"issue":"14","key":"10.1016\/j.ecoenv.2026.120578_bib14","doi-asserted-by":"crossref","first-page":"13825","DOI":"10.1021\/acsnano.4c16786","article-title":"Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"issue":"8021","key":"10.1016\/j.ecoenv.2026.120578_bib15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-024-07623-6","article-title":"Emergence of large-scale cell death through ferroptotic trigger waves","volume":"631","author":"Co","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120578_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2026.154429","article-title":"Polystyrene nanoplastics disrupt iron homeostasis by promoting FPN1 ubiquitination in GC-2spd(ts) cells","volume":"523","author":"Cui","year":"2026","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120578_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2026.01.005","article-title":"IL-17D promotes ferroptosis resistance in lung cancer via activating PPAR\u03b3 pathway","volume":"245","author":"Du","year":"2026","journal-title":"Free. Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120578_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70112","article-title":"Time-of-Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin-Deficient C57BL\/6 Versus Melatonin Proficient CBA\/B6 Hybrid Mice","volume":"78","author":"Duong","year":"2026","journal-title":"J. Pineal Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10815-022-02443-x","article-title":"Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers","volume":"39","author":"El-Khalik","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-020-00385-9","article-title":"Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy","volume":"17","author":"Fournier","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120578_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.marenvres.2014.01.001","article-title":"Evidence of microplastics in samples of zooplankton from Portuguese coastal waters","volume":"95","author":"Frias","year":"2014","journal-title":"Mar. Environ. Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1631\/jzus.B2300138","article-title":"Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice","volume":"25","author":"Fu","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.ecoenv.2026.120578_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115950","article-title":"Nanoplastics in aquatic systems - are they more hazardous than microplastics?","volume":"272","author":"Gaylarde","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120578_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/09603271231167585","article-title":"Treatment with paraquat affects the expression of ferroptosis-related genes","volume":"42","author":"Ge","year":"2023","journal-title":"Hum. Exp. Toxicol."},{"issue":"24","key":"10.1016\/j.ecoenv.2026.120578_bib26","doi-asserted-by":"crossref","first-page":"9460","DOI":"10.1039\/D4FO01605J","article-title":"Glycine attenuates high fructose-induced liver injury in adolescent mice by modulating lipid metabolism and gut microbiota","volume":"16","author":"Ge","year":"2025","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jee\/78.1.19","article-title":"Fenvalerate cross-resistance in a resmethrin-selected strain of the house fly (Diptera: Muscidae)","volume":"78","author":"Golenda","year":"1985","journal-title":"J. Econ. Entomol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12989-024-00599-1","article-title":"Addressing the relevance of polystyrene nano- and microplastic particles used to support exposure, toxicity and risk assessment: implications and recommendations","volume":"21","author":"Gouin","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120578_bib29","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1289\/ehp.1409271","article-title":"Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model","volume":"123","author":"Grafmueller","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120578_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2026.111970","article-title":"Realistic-NPs trigger depression-like behaviors via mitochondrial iron overload mediating ferroptosis","volume":"430","author":"Hao","year":"2026","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120578_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/17435390.2026.2622920","article-title":"Nanoplastic toxicology following gestational and lactational exposure","volume":"20","author":"He","year":"2026","journal-title":"Nanotoxicology"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12951-025-03650-1","article-title":"Gut microbiota contributes to polystyrene nanoplastics-induced fetal growth restriction by disturbing placental nicotinamide metabolism","volume":"23","author":"He","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","article-title":"Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature","volume":"17","author":"Hirt","year":"2020","journal-title":"Part. Fibre Toxicol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/1471-0528.17756","article-title":"Exposure to microplastics and human reproductive outcomes: A systematic review","volume":"131","author":"Hunt","year":"2024","journal-title":"Bjog"},{"key":"10.1016\/j.ecoenv.2026.120578_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139890","article-title":"Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment","volume":"498","author":"Iglesias-Hernandez","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"26","key":"10.1016\/j.ecoenv.2026.120578_bib36","doi-asserted-by":"crossref","first-page":"16790","DOI":"10.1021\/acsnano.4c02335","article-title":"Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction","volume":"18","author":"Ji","year":"2024","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120578_bib37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.devcel.2023.03.012","article-title":"Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta during pregnancy at single-cell resolution","volume":"58","author":"Jiang","year":"2023","journal-title":"Dev. Cell."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib38","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2026.120578_bib39","article-title":"The mist of ferroptosis: The Orpheus journey of mitochondria - Exploring the symphony of cell fate","volume":"319","author":"Jiang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib40","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.255737","article-title":"Ferroptosis induces membrane blebbing in placental trophoblasts","volume":"135","author":"Kajiwara","year":"2022","journal-title":"J. Cell. Sci."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/03008207.2019.1580702","article-title":"N-acetylcysteine reduces glutamate-induced cytotoxicity to fibroblasts of rat supraspinatus tendons","volume":"60","author":"Kim","year":"2019","journal-title":"Connect. Tissue Res."},{"issue":"18","key":"10.1016\/j.ecoenv.2026.120578_bib42","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"30","key":"10.1016\/j.ecoenv.2026.120578_bib43","doi-asserted-by":"crossref","first-page":"27159","DOI":"10.1021\/acsnano.5c00918","article-title":"Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality","volume":"19","author":"Kong","year":"2025","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120578_bib44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.ecoenv.2026.120578_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.178167","article-title":"Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis","volume":"959","author":"Li","year":"2025","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120578_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jes.2025.06.049","article-title":"Polystyrene microplastics impaired decidualization in mice via oxidative stress and inflammation and disrupted the reproductive function of their female offspring","volume":"162","author":"Li","year":"2026","journal-title":"J. Environ. Sci. (China)"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12964-023-01371-2","article-title":"YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications","volume":"21","author":"Lin","year":"2023","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.ecoenv.2026.120578_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154172","article-title":"Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet","volume":"516","author":"Liu","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120578_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121895","article-title":"Differences of microplastics and nanoplastics in urban waters: Environmental behaviors, hazards, and removal","volume":"260","author":"Liu","year":"2024","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120578_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188890","article-title":"GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.ecoenv.2026.120578_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107161","article-title":"Exposure to multiple trace elements and miscarriage during early pregnancy: A mixtures approach","volume":"162","author":"Lu","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120578_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123562","article-title":"Role of circPSEN1 in carbon black and cadmium co-exposure induced autophagy-dependent ferroptosis in respiratory epithelial cells","volume":"346","author":"Mao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120578_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.707959","article-title":"The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy","volume":"9","author":"Meihe","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120578_bib54","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2217\/nnm-2015-0012","article-title":"Nanoparticle transport across the placental barrier: pushing the field forward!","volume":"11","author":"Muoth","year":"2016","journal-title":"Nanomed. (Lond. )"},{"issue":"23","key":"10.1016\/j.ecoenv.2026.120578_bib55","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1182\/blood-2013-11-536219","article-title":"c-Myc regulates expression of NKG2D ligands ULBP1\/2\/3 in AML and modulates their susceptibility to NK-mediated lysis","volume":"123","author":"Nanbakhsh","year":"2014","journal-title":"Blood"},{"issue":"1-3","key":"10.1016\/j.ecoenv.2026.120578_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/ars.2023.0278","article-title":"Dynamic Regulation of Ferroptosis by Lipid Metabolism","volume":"39","author":"Naowarojna","year":"2023","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13795","article-title":"Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice","volume":"234","author":"Napso","year":"2022","journal-title":"Acta Physiol. (Oxf. )"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100816","article-title":"Ferroportin expression and regulation in human placenta\/fetal membranes: Implications for ferroptosis and adverse pregnancy outcomes","volume":"23","author":"Ng","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.ecoenv.2026.120578_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109949","article-title":"The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency","volume":"206","author":"Parenti","year":"2025","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120578_bib60","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humupd\/dmad016","article-title":"The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester","volume":"29","author":"Parisi","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2026.120578_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120578_bib62","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.freeradbiomed.2018.07.001","article-title":"Placental iron transport: The mechanism and regulatory circuits","volume":"133","author":"Sangkhae","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120578_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118960","article-title":"Mechanistic toxicity assessment of differently sized and charged polystyrene nanoparticles based on human placental cells","volume":"223","author":"Shen","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2026.120578_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119572","article-title":"Impact of placental microplastics on birth anthropometrics: A cross-sectional study","volume":"309","author":"Shen","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120578_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097836","article-title":"Decidual Stromal Cell Ferroptosis Associated with Abnormal Iron Metabolism Is Implicated in the Pathogenesis of Recurrent Pregnancy Loss","volume":"24","author":"Sun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120578_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124590","article-title":"Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis","volume":"359","author":"Sun","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120578_bib67","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.freeradbiomed.2024.01.033","article-title":"Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP\/TAZ-ferritinophagy axis","volume":"213","author":"Sun","year":"2024","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120578_bib68","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77241","article-title":"VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development","volume":"11","author":"Sung","year":"2022","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib69","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1038\/s41467-024-47723-5","article-title":"Author Correction: Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells","volume":"15","author":"Ti\u0161ma","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120578_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108956","article-title":"Limited passage and functional effects of polystyrene micro- and nanoplastics in a physiologically-relevant in vitro human placental co-culture model","volume":"136","author":"van Boxel","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120578_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12080553","article-title":"Micro\/Nanoplastic Exposure on Placental Health and Adverse Pregnancy Risks: Novel Assessment System Based upon Targeted Risk Assessment Environmental Chemicals Strategy","volume":"12","author":"Wan","year":"2024","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120578_bib72","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1021\/acsnano.3c11734","article-title":"Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration\/Invasion and Migrasome Formation to Induce Miscarriage","volume":"18","author":"Wan","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-024-00574-w","article-title":"Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage","volume":"21","author":"Wan","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120578_bib74","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"20","key":"10.1016\/j.ecoenv.2026.120578_bib75","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cub.2016.08.014","article-title":"Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex","volume":"26","author":"Weck","year":"2016","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120578_bib76","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10787-022-01086-9","article-title":"Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases","volume":"31","author":"Welcome","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ecoenv.2026.120578_bib77","unstructured":"Wit, Wd and N. Bigaud. No plastic in nature: assessing plastic ingestion from nature to people. 2019."},{"key":"10.1016\/j.ecoenv.2026.120578_bib78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jare.2022.09.004","article-title":"Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence","volume":"49","author":"Wu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ecoenv.2026.120578_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169260","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress","volume":"912","author":"Wu","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120578_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2026.104004","article-title":"Ferrostatin-1 protects against early sepsis-induced acute lung injury by suppressing lipid peroxidation-driven NINJ1-mediated DAMP release and neutrophil activation","volume":"90","author":"Xiao","year":"2026","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120578_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1083838","article-title":"Role of ferroptosis in pregnancy related diseases and its therapeutic potential","volume":"11","author":"Xu","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120578_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133794","article-title":"Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell","volume":"694","author":"Xu","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120578_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132328","article-title":"Effect of short-term ambient air pollution exposure on early miscarriage and pregnancy hormones with critical window identification","volume":"460","author":"Xu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120578_bib84","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.placenta.2025.04.016","article-title":"Homocysteine induces endometrial ferroptosis via MAPK pathway in recurrent pregnancy loss","volume":"165","author":"Yang","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2026.120578_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122803","article-title":"Regulatory mechanisms of amino acids in ferroptosis","volume":"351","author":"Yao","year":"2024","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120578_bib86","first-page":"1607","volume":"36","author":"Yawei Wang","year":"2024","journal-title":"Emerg. Pollut. Progress. Chem."},{"key":"10.1016\/j.ecoenv.2026.120578_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114941","article-title":"The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice","volume":"257","author":"Zeng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120578_bib88","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/s41556-025-01722-w","article-title":"A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis","volume":"27","author":"Zhang","year":"2025","journal-title":"Nat. Cell. Biol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120578_bib89","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.chembiol.2025.04.002","article-title":"N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4","volume":"32","author":"Zheng","year":"2025","journal-title":"Cell. Chem. Biol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:24:29Z","timestamp":1786220669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326009085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":89,"alternative-id":["S0147651326009085"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120578","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene nanoplastics impair placental function and promote embryo resorption through ROS-mediated ferroptosis-related injury","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120578","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120578"}}