{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:27:23Z","timestamp":1793557643946,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82575094"],"award-info":[{"award-number":["82575094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515012062"],"award-info":[{"award-number":["2024A1515012062"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023B03J0056"],"award-info":[{"award-number":["2023B03J0056"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["20254028"],"award-info":[{"award-number":["20254028"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120597","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:42:13Z","timestamp":1785915733000},"page":"120597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Diethylene glycol dibenzoate an emerging plasticizer disrupts bone formation via MMP3 targeting: Insights from bioinformatics and in vitro validation"],"prefix":"10.1016","volume":"323","author":[{"given":"Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genning","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheya","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbamcr.2009.07.002","article-title":"Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice","volume":"1803","author":"Aiken","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib2","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1038\/s41598-022-10518-z","article-title":"HDAC6 regulates NF-\u03baB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression","volume":"12","author":"Barter","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120597_bib3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.scitotenv.2015.09.036","article-title":"Human exposure, hazard and risk of alternative plasticizers to phthalate esters","volume":"541","author":"Bui","year":"2016","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120597_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.etap.2017.08.015","article-title":"Differential tissue regulation of peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo model","volume":"55","author":"Cocci","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120597_bib5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/bib\/bbt056","article-title":"Similarity-based machine learning methods for predicting drug-target interactions: a brief review","volume":"15","author":"Ding","year":"2014","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.ecoenv.2026.120597_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106903","article-title":"Human health impacts of exposure to phthalate plasticizers: An overview of reviews","volume":"158","author":"Eales","year":"2022","journal-title":"Environ. Int."},{"issue":"24","key":"10.1016\/j.ecoenv.2026.120597_bib7","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1007\/s00253-014-6183-8","article-title":"Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure","volume":"98","author":"Erythropel","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120597_bib8","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/j.jid.2017.07.095","article-title":"Research Techniques Made Simple: Bioinformatics for Genome-Scale Biology","volume":"137","author":"Foulkes","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120597_bib9","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ymthe.2024.02.034","article-title":"Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration","volume":"32","author":"Gao","year":"2024","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2026.120597_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fphys.2020.00047","article-title":"Destroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases","volume":"11","author":"Hardy","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120597_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116866","article-title":"Elucidating the mechanism of plasticizers inducing breast cancer through network toxicology and molecular docking analysis","volume":"284","author":"He","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120597_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.110807","article-title":"Correlation of serum matrix metalloproteinase 3 with osteoporosis in patients of postmenopausal rheumatoid arthritis","volume":"85","author":"Ji","year":"2024","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120597_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107750","article-title":"MMP3 at the crossroads: Linking molecular pathways to disease diagnosis and therapy","volume":"216","author":"Jiang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120597_bib15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120597_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00774-017-0834-7","article-title":"Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study","volume":"36","author":"Kodama","year":"2018","journal-title":"J. Bone Miner. Metab."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bone.2008.03.020","article-title":"Matrix metalloproteinases and bone","volume":"43","author":"Krane","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2026.120597_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.envint.2017.02.006","article-title":"Phthalates, non-phthalate plasticizers and bisphenols in Swedish preschool dust in relation to children's exposure","volume":"102","author":"Larsson","year":"2017","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13020-022-00596-6","article-title":"Development of software enabling Chinese medicine-based precision treatment for osteoporosis at the gene and pathway levels","volume":"17","author":"Li","year":"2022","journal-title":"Chin. Med."},{"issue":"15","key":"10.1016\/j.ecoenv.2026.120597_bib20","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.7150\/ijbs.63889","article-title":"SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-\u03baB Activation in Macrophages","volume":"17","author":"Li","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"13","key":"10.1016\/j.ecoenv.2026.120597_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24132358","article-title":"Molecular Computing and Bioinformatics","volume":"24","author":"Liang","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120597_bib22","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1021\/jf1046738","article-title":"Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-\u03baB signaling in activated SW1353 cells","volume":"59","author":"Lu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120597_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1749-6632.2003.tb03214.x","article-title":"How proteases regulate bone morphogenesis","volume":"995","author":"Ortega","year":"2003","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120597_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/bib\/bbu010","article-title":"Toward more realistic drug-target interaction predictions","volume":"16","author":"Pahikkala","year":"2015","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.ecoenv.2026.120597_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s00414-026-03766-5","article-title":"Profiling of hypoxic and extracellular matrix remodeling markers in biofluids and cerebral tissue after traumatic brain injury: expression and signaling crosstalk of HIF-1\u03b1, MMP-9\/14 and EPHA2","author":"Poniatowski","year":"2026","journal-title":"Int. J. Leg. Med."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120597_bib26","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1039\/D3GC03428C","article-title":"Global Environmental and Toxicological Data of Emerging Plasticizers: Current Knowledge, Regrettable Substitution Dilemma, Green Solution and Future Perspectives","volume":"26","author":"Qadeer","year":"2024","journal-title":"Green. Chem."},{"key":"10.1016\/j.ecoenv.2026.120597_bib27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.scitotenv.2018.04.291","article-title":"Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio","volume":"636","author":"Santangeli","year":"2018","journal-title":"Sci. Total. Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120597_bib28","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jcb.21747","article-title":"Inhibition of osteoblastic metalloproteinases in mice prevents bone loss induced by oestrogen deficiency","volume":"104","author":"Schiltz","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/iej.13206","article-title":"Alendronate inhibits osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats","volume":"53","author":"Silva","year":"2020","journal-title":"Int. Endod. J."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120597_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJMc2314624","article-title":"Postmenopausal Osteoporosis","volume":"390","author":"Silverstein","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120597_bib31","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1021\/acs.est.2c08110","article-title":"Nonphthalate Plasticizers in House Dust from Multiple Countries: An Increasing Threat to Humans","volume":"57","author":"Tan","year":"2023","journal-title":"Environ. Sci. Technol."},{"issue":"24","key":"10.1016\/j.ecoenv.2026.120597_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells11243950","article-title":"Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-\u03baB Pathway as Mode of Action","volume":"11","author":"Trentini","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120597_bib33","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1101\/gad.4.11.1975","article-title":"The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity","volume":"4","author":"Urban","year":"1990","journal-title":"Genes. Dev."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120597_bib34","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in Cell Death, Inflammation, and Disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120597_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.etap.2013.03.014","article-title":"Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity","volume":"36","author":"Ventrice","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120597_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/life12020134","article-title":"Inhibition of Pathological Increased Matrix Metalloproteinase (MMP) Activity for Improvement of Bone Regeneration in Diabetes","volume":"12","author":"Wagner","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.ecoenv.2026.120597_bib37","article-title":"Prognostic analysis and validation of diagnostic marker genes in patients with osteoporosis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120597_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042117","article-title":"The Role of Rosavin in the Pathophysiology of Bone Metabolism","volume":"25","author":"Wojdasiewicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120597_bib39","article-title":"Screening of genes co-associated with osteoporosis and chronic HBV infection based on bioinformatics analysis and machine learning","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120597_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126843","article-title":"Assessing the toxicological impact of DEGDB plasticizer exposure on glioblastoma multiforme via network toxicology, machine learning and in vitro methods","volume":"383","author":"Ye","year":"2025","journal-title":"Environ. Pollut."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120597_bib41","article-title":"Associations of Changes in Serum Inflammatory Factors, MMP-3, 25(OH)D and Intestinal Flora with Osteoporosis and Disease Activity in Rheumatoid Arthritis Patients","volume":"66","author":"Yong","year":"2020","journal-title":"Clin. Lab."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:31:06Z","timestamp":1793554266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326009279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"alternative-id":["S0147651326009279"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120597","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diethylene glycol dibenzoate an emerging plasticizer disrupts bone formation via MMP3 targeting: Insights from bioinformatics and in vitro validation","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120597"}}