{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:45:23Z","timestamp":1786221923761,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120603","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:38:21Z","timestamp":1785699501000},"page":"120603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes"],"prefix":"10.1016","volume":"322","author":[{"given":"Yuting","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijuan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-4756","authenticated-orcid":false,"given":"Jiajun","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12967-024-05996-w","article-title":"Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis","volume":"23","author":"Berlingerio","year":"2025","journal-title":"J. Transl. Med."},{"issue":"41","key":"10.1016\/j.ecoenv.2026.120603_bib2","article-title":"IL6 Derived from Macrophages under Intermittent Hypoxia Exacerbates NAFLD by Promoting Ferroptosis via MARCH3-Led Ubiquitylation of GPX4","volume":"11","author":"Cai","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120603_bib3","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.est.1c07376","article-title":"New Evidence of Rubber-Derived Quinones in Water, Air, and Soil","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120603_bib4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41419-021-03444-x","article-title":"A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3","volume":"12","author":"Chen","year":"2021","journal-title":"Cell. Death Dis."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41420-024-02243-5","article-title":"NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination","volume":"10","author":"Chen","year":"2024","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.ecoenv.2026.120603_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2025.106147","article-title":"Toxicity assessment of 6PPD-quinone in human lung cells: Insights from BEAS-2B and A549 cell lines","volume":"110","author":"Damdam","year":"2026","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2026.120603_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2023.108268","article-title":"Heterologous expression of rice OsEXO70FX1 confers tolerance to cadmium in Arabidopsis thaliana and fission yeast","volume":"206","author":"Ding","year":"2024","journal-title":"Plant. Physiol. Biochem."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120603_bib8","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202401084","article-title":"Non-cell autonomous regulation of cell-cell signaling and differentiation by mitochondrial ROS","volume":"223","author":"Du","year":"2024","journal-title":"J. Cell. Biol."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120603_bib9","first-page":"919","article-title":"Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes","volume":"57","author":"Feng","year":"2025","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib10","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1038\/s41467-020-19202-0","article-title":"USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s10020-023-00733-3","article-title":"Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury","volume":"29","author":"Gong","year":"2023","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120603_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.353","article-title":"Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis","volume":"11","author":"Gong","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ecoenv.2026.120603_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103179","article-title":"Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis","volume":"73","author":"Guo","year":"2024","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120603_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1513\/pats.200409-046TA","article-title":"Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery","volume":"1","author":"Heyder","year":"2004","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.ecoenv.2026.120603_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-0716-2624-5_6","article-title":"Limited Proteolysis-Mass Spectrometry to Identify Metabolite-Protein Interactions","volume":"2554","author":"Holfeld","year":"2023","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120603_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114604","article-title":"TGM1\/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation","volume":"43","author":"Hou","year":"2024","journal-title":"Cell. Rep."},{"issue":"48","key":"10.1016\/j.ecoenv.2026.120603_bib17","doi-asserted-by":"crossref","first-page":"19295","DOI":"10.1021\/acs.est.3c05325","article-title":"Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans","volume":"57","author":"Hua","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120603_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132265","article-title":"Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity","volume":"459","author":"Hua","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib19","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120603_bib20","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1021\/acs.est.4c11156","article-title":"Mass Spectrometry Imaging Unveils the Metabolic Effect of 6PPD-Quinone in Exposed Mice","volume":"59","author":"Jia","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120603_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108677","article-title":"Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone","volume":"187","author":"Jiang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120603_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140637","article-title":"Mono(2-ethylhexyl) phthalate activates JNK signaling via TLR4-MD2 binding to induce podocyte injury in chronic kidney disease","volume":"501","author":"Jing","year":"2026","journal-title":"J. Hazard. Mater."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120603_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032077","article-title":"Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans","volume":"7","author":"Jiu","year":"2012","journal-title":"PLoS. One"},{"issue":"165","key":"10.1016\/j.ecoenv.2026.120603_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.sger.2023.12.003","article-title":"[The kidney, its anatomy and main functions]","volume":"29","author":"Levassort","year":"2024","journal-title":"Soins Gerontol."},{"issue":"21","key":"10.1016\/j.ecoenv.2026.120603_bib25","doi-asserted-by":"crossref","first-page":"10204","DOI":"10.1021\/acs.est.5c03906","article-title":"Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice","volume":"59","author":"Li","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120603_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115670","article-title":"Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120603_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41419-022-04708-w","article-title":"Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury","volume":"13","author":"Lin","year":"2022","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.ecoenv.2026.120603_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134356","article-title":"Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans","volume":"471","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"22","key":"10.1016\/j.ecoenv.2026.120603_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216387","article-title":"Whole-Transcriptome RNA Sequencing Uncovers the Global Expression Changes and RNA Regulatory Networks in Duck Embryonic Myogenesis","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.ecoenv.2026.120603_bib30","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1091\/mbc.e08-09-0967","article-title":"The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation","volume":"20","author":"Liu","year":"2009","journal-title":"Mol. Biol. Cell."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120603_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108883","article-title":"EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission","volume":"34","author":"Maier","year":"2021","journal-title":"Cell. Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41467-019-13923-7","article-title":"ULK1 phosphorylates Exo70 to suppress breast cancer metastasis","volume":"11","author":"Mao","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120603_bib33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.nefro.2020.03.005","article-title":"Ferroptosis and kidney disease","volume":"40","author":"Martin-Sanchez","year":"2020","journal-title":"Nefrol. (Engl. Ed. )"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.immuni.2016.06.023","article-title":"Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex","volume":"45","author":"Miao","year":"2016","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120603_bib36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1681\/ASN.2019060570","article-title":"Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers","volume":"31","author":"Mishima","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvac092","article-title":"Ubiquitin-mediated mitochondrial regulation by MITOL\/MARCHF5 at a glance","volume":"173","author":"Nagashima","year":"2022","journal-title":"J. Biochem."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120603_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.kint.2019.02.009","article-title":"Regulated necrosis in kidney ischemia-reperfusion injury","volume":"96","author":"Pefanis","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.ecoenv.2026.120603_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.178626","article-title":"Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease","volume":"964","author":"Pei","year":"2025","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120603_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121947","article-title":"Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney","volume":"333","author":"Qiu","year":"2023","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120603_bib41","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004820","article-title":"Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex","volume":"10","author":"van Rees","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120603_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201745603","article-title":"MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins","volume":"19","author":"Stefanovic-Barrett","year":"2018","journal-title":"EMBO Rep."},{"issue":"36","key":"10.1016\/j.ecoenv.2026.120603_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105287118","article-title":"Plasma membrane phospholipid signature recruits the plant exocyst complex via the EXO70A1 subunit","volume":"118","author":"Synek","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6525","key":"10.1016\/j.ecoenv.2026.120603_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber-derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120603_bib45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1158\/1541-7786.MCR-21-0342","article-title":"The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis","volume":"20","author":"Wang","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ecoenv.2026.120603_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137574","article-title":"Low-dose tire wear chemical 6PPD-Q exposure elicit fatty liver via promoting fatty acid biosynthesis in ICR mice","volume":"489","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120603_bib47","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41419-023-06222-z","article-title":"The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120603_bib48","article-title":"VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2\/HO-1 Signaling Pathway in Diabetic Nephropathy","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.ecoenv.2026.120603_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102303","article-title":"SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK\/p53 pathway","volume":"52","author":"Wu","year":"2022","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.ecoenv.2026.120603_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.347","article-title":"Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress","volume":"8","author":"Xia","year":"2017","journal-title":"Cell. Death Dis."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120603_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41419-024-06836-x","article-title":"LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer","volume":"15","author":"Yan","year":"2024","journal-title":"Cell. Death Dis."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2026.120603_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120603_bib53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s10020-023-00732-4","article-title":"Research progress on multiple cell death pathways of podocytes in diabetic kidney disease","volume":"29","author":"Yang","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120603_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109579","article-title":"Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish","volume":"201","author":"Yi","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120603_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119529","article-title":"Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis","volume":"278","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120603_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103761","article-title":"The role and mechanism of the cGAS-STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure","volume":"85","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120603_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123591","article-title":"Akt mitigates ER stress-instigated cardiac dysfunction via regulation of ferroptosis and mitochondrial integrity in a DHODH-dependent manner","volume":"371","author":"Zhou","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120603_bib58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.freeradbiomed.2025.08.049","article-title":"Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis","volume":"240","author":"Zhou","year":"2025","journal-title":"Free. Radic. Biol. Med."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:31:59Z","timestamp":1786221119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326009334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"alternative-id":["S0147651326009334"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120603","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120603","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120603"}}