{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:29:15Z","timestamp":1793554155286,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260631"],"award-info":[{"award-number":["82260631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202501AT070406"],"award-info":[{"award-number":["202501AT070406"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202101AZ070001-085"],"award-info":[{"award-number":["202101AZ070001-085"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120611","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:45:24Z","timestamp":1786347924000},"page":"120611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cadmium exposure is associated with ferroptosis-related redox\/iron imbalance and altered abundance of selected m5C regulatory proteins in NIT-1 cells and mouse pancreatic tissue: A preliminary descriptive study"],"prefix":"10.1016","volume":"323","author":[{"given":"Zongqin","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoshun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120611_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/genes10020102","article-title":"Eukaryotic 5-methylcytosine (m(5)C) RNA methyltransferases: mechanisms, cellular functions, and links to disease","volume":"10","author":"Bohnsack","year":"2019","journal-title":"Genes"},{"key":"10.1016\/j.ecoenv.2026.120611_bib2","doi-asserted-by":"crossref","unstructured":"H. Castiglione, L. Madrange, T. Lemonnier, et al., Development and Optimization of a Lactate Dehydrogenase Assay Adapted to 3D Cell Cultures, 3 (2024) 113-125. https:\/\/www.mdpi.com\/2674-1172\/3\/2\/8.","DOI":"10.3390\/organoids3020008"},{"key":"10.1016\/j.ecoenv.2026.120611_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116954","article-title":"Cadmium exposure induces skeletal muscle insulin resistance through the reactive oxygen species-mediated PINK1\/Parkin pathway","volume":"284","author":"Chen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120611_bib4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ecoenv.2018.11.069","article-title":"Alterations in the properties of sperm protamine-like II protein after exposure of Mytilus galloprovincialis (Lamarck 1819) to sub-toxic doses of cadmium","volume":"169","author":"De Guglielmo","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120611_bib5","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15206","article-title":"Iron overload induces islet \u03b2 cell ferroptosis by activating ASK1\/P-P38\/CHOP signaling pathway","volume":"11","author":"Deng","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.ecoenv.2026.120611_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-025-06547-8","article-title":"Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes","author":"Dyson","year":"2025","journal-title":"Diabetologia"},{"key":"10.1016\/j.ecoenv.2026.120611_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010360","article-title":"Pancreatic islets accumulate cadmium in a rodent model of cadmium-induced hyperglycemia","volume":"22","author":"Fitzgerald","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120611_bib8","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1158\/0008-5472.CAN-20-3477","article-title":"Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer","volume":"81","author":"Ghoochani","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.ecoenv.2026.120611_bib9","article-title":"Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells","volume":"71","author":"Hong","year":"2022","journal-title":"J. Trace Elem. Med. Biol. Organ. Soc. Miner. Trace Elem. (GMS)"},{"key":"10.1016\/j.ecoenv.2026.120611_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157819","article-title":"Cadmium induces ferroptosis mediated inflammation by activating Gpx4\/Ager\/p65 axis in pancreatic \u03b2-cells","volume":"849","author":"Hong","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120611_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106406","article-title":"Cadmium exposure impairs pancreatic beta-cell function and exaggerates diabetes by disrupting lipid metabolism","volume":"149","author":"Hong","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120611_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","article-title":"Heavy metals: toxicity and human health effects","volume":"99","author":"Jomova","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120611_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102396","article-title":"Protocol for preparing murine tissue for comparative proteomics study of vaccine adjuvant mechanisms","volume":"4","author":"Li","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ecoenv.2026.120611_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-024-02041-8","article-title":"The role of RNA methylation in tumor immunity and its potential in immunotherapy","volume":"23","author":"Li","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ecoenv.2026.120611_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1390257","article-title":"Saikosaponin A attenuates osteoclastogenesis and bone loss by inducing ferroptosis","volume":"11","author":"Li","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ecoenv.2026.120611_bib16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12967-022-03427-2","article-title":"5-methylcytosine RNA methyltransferases and their potential roles in cancer","volume":"20","author":"Li","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ecoenv.2026.120611_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103087","article-title":"METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer","volume":"71","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120611_bib18","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ecoenv.2026.120611_bib19","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1038\/s41467-025-61883-y","article-title":"UCP2 inhibition eliminates pancreatic \u03b2 cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120611_bib20","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.24976\/Discov.Med.202436184.95","article-title":"UNC93B1 mediates the effects of cGAS-STING on ER stress and iron death, and reduces renal toxicity in cadmium-exposed rats","volume":"36","author":"Liu","year":"2024","journal-title":"Discov. Med."},{"key":"10.1016\/j.ecoenv.2026.120611_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186485","article-title":"Biological responses to cadmium stress in liverwort conocephalum conicum (Marchantiales)","volume":"21","author":"Maresca","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120611_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109749","article-title":"Comparative neurotoxic effects and mechanism of cadmium chloride and cadmium sulfate in neuronal cells","volume":"203","author":"Mei","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120611_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69937-9","article-title":"Screening of differentially expressed RNAs and identifying a ceRNA axis during cadmium-induced oxidative damage in pancreatic \u03b2 cells","volume":"14","author":"Mou","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120611_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117479","article-title":"Arsenic inducible islet \u03b2-cell dysfunction and ferroptosis through m(6)A-YTHDF2-dependent CHAC1 enhancement","volume":"289","author":"Qiu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120611_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121385","article-title":"Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and\/or type 2 diabetes?","volume":"315","author":"Saedi","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2026.120611_bib26","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/toxsci\/53.2.474","article-title":"Acute, nontoxic cadmium exposure inhibits pancreatic protease activities in the mouse","volume":"53","author":"Shimada","year":"2000","journal-title":"Toxicological sciences official journal Society Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120611_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116672","article-title":"Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic beta cell death","volume":"282","author":"Sun","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120611_bib28","first-page":"219","article-title":"Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors","volume":"33","author":"Vance","year":"2022","journal-title":"Cancer biomarkers section A Disease markers"},{"key":"10.1016\/j.ecoenv.2026.120611_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119228","article-title":"Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium","volume":"305","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120611_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110259","article-title":"Cadmium exposure, fasting blood glucose changes, and type 2 diabetes mellitus: a longitudinal prospective study in China","volume":"192","author":"Xiao","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120611_bib31","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12772","article-title":"Ferrostatin\u20111 alleviates oxalate\u2011induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis","volume":"26","author":"Xie","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ecoenv.2026.120611_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12935-023-02848-3","article-title":"Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis","volume":"23","author":"Zhang","year":"2023","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.ecoenv.2026.120611_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114885","article-title":"STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m(5)C methylation of Gpx4 mRNA","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell. Rep."},{"key":"10.1016\/j.ecoenv.2026.120611_bib34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2026.120611_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118365","article-title":"Association between heavy metal exposure and diabetic retinopathy related homeostatic dysregulation value in Type 2 diabetic population: a cross-sectional study of NHANES 2003-2016","volume":"299","author":"Zhou","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326009413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:24:43Z","timestamp":1793553883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326009413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":35,"alternative-id":["S0147651326009413"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120611","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure is associated with ferroptosis-related redox\/iron imbalance and altered abundance of selected m5C regulatory proteins in NIT-1 cells and mouse pancreatic tissue: A preliminary descriptive study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120611"}}