{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:29:15Z","timestamp":1793554155329,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017366","name":"Key Research and Development Program of Heilongjiang","doi-asserted-by":"publisher","award":["2023ZX06C09"],"award-info":[{"award-number":["2023ZX06C09"]}],"id":[{"id":"10.13039\/100017366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014418","name":"Harbin Medical University Cancer Hospital","doi-asserted-by":"publisher","award":["JJZD2024 - 16"],"award-info":[{"award-number":["JJZD2024 - 16"]}],"id":[{"id":"10.13039\/100014418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62372141"],"award-info":[{"award-number":["62372141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303742"],"award-info":[{"award-number":["82303742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120679","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:37:19Z","timestamp":1787171839000},"page":"120679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CEBPB as a candidate mediator of DEGDB-induced tumor-associated phenotypes in colorectal cancer cells"],"prefix":"10.1016","volume":"323","author":[{"given":"Jingrong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120679_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Anon","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120679_bib2","first-page":"9","article-title":"Some chemicals present in industrial and consumer products, food and drinking-water","volume":"101","author":"Anon","year":"2013","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.ecoenv.2026.120679_bib3","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120679_bib4","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2026.120679_bib5","doi-asserted-by":"crossref","first-page":"D437","DOI":"10.1093\/nar\/gkaa1038","article-title":"RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences","volume":"49","author":"Burley","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120679_bib6","first-page":"7988E","article-title":"Extensive literature review on plasticisers","volume":"20","author":"Calvano","year":"2023","journal-title":"EFSA Supporting Publications"},{"key":"10.1016\/j.ecoenv.2026.120679_bib7","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2026.120679_bib8","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ecoenv.2026.120679_bib9","first-page":"10","article-title":"Designing green plasticizers: linear alkyl diol dibenzoate plasticizers and a thermally reversible plasticizer","author":"Erythropel","year":"2018","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120679_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/polym10080834","article-title":"How green is your plasticizer?","volume":"10","author":"Jamarani","year":"2018","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120679_bib11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41588-022-01100-4","article-title":"Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer","volume":"54","author":"Joanito","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2026.120679_bib12","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120679_bib13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41588-020-0636-z","article-title":"Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer","volume":"52","author":"Lee","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2026.120679_bib14","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1021\/acs.est.3c09503","article-title":"Association of Di(2-ethylhexyl) terephthalate and its metabolites with nonalcoholic fatty liver disease: an epidemiology and toxicology study","volume":"58","author":"Li","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120679_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ecoenv.2026.120679_bib16","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1039\/D4EM00317A","article-title":"Plasticizers: distribution and impact in aquatic and terrestrial environments","volume":"26","author":"Manatunga","year":"2024","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.ecoenv.2026.120679_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001453","article-title":"Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value","volume":"10","author":"Marisa","year":"2013","journal-title":"PLoS. Med."},{"key":"10.1016\/j.ecoenv.2026.120679_bib18","article-title":"scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation","volume":"3","author":"Osorio","year":"2022","journal-title":"Patterns (N. Y)"},{"key":"10.1016\/j.ecoenv.2026.120679_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jsbmb.2018.01.014","article-title":"Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells","volume":"178","author":"Pomatto","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2026.120679_bib20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.scitotenv.2018.04.291","article-title":"Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio","volume":"636","author":"Santangeli","year":"2018","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120679_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106748","article-title":"Discovery and validation of new potential biomarkers for early detection of colon cancer","volume":"9","author":"Sol\u00e9","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.ecoenv.2026.120679_bib22","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1021\/acs.est.2c08110","article-title":"Nonphthalate Plasticizers in house dust from multiple countries: an increasing threat to humans","volume":"57","author":"Tan","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120679_bib23","unstructured":"The PyMOL Molecular Graphics System, Version 2.0, in: L. Schr\u00f6dinger (Ed.), 2015."},{"key":"10.1016\/j.ecoenv.2026.120679_bib24","unstructured":"World Health Organization, Colorectal Cancer Fact Sheet, World Health Organization (2026)."},{"key":"10.1016\/j.ecoenv.2026.120679_bib25","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120679_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126843","article-title":"Assessing the toxicological impact of DEGDB plasticizer exposure on glioblastoma multiforme via network toxicology, machine learning and in vitro methods","volume":"383","author":"Ye","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120679_bib27","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/CM9.0000000000003601","article-title":"Decoding the genetic and environmental forces in propelling the surge of early-onset colorectal cancer","volume":"138","author":"Zhao","year":"2025","journal-title":"Chin. Med. J. (Engl.)"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:23:31Z","timestamp":1793553811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326010092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S0147651326010092"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120679","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CEBPB as a candidate mediator of DEGDB-induced tumor-associated phenotypes in colorectal cancer cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120679"}}