{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:29:06Z","timestamp":1793554146160,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010564","name":"German Center for Lung Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project 530370007"],"award-info":[{"award-number":["Project 530370007"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120730","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:54:27Z","timestamp":1788533667000},"page":"120730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Respiratory toxicity of perfluorooctanesulfonic acid (PFOS) via Inflammasome involvement"],"prefix":"10.1016","volume":"323","author":[{"given":"Carola","family":"Voss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ryffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2790-0389","authenticated-orcid":false,"given":"Tobias","family":"Stoeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120730_bib1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/10408444.2025.2501420","article-title":"Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure","volume":"55","author":"Arnesdotter","year":"2025","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127424","article-title":"Intratracheal perfluorooctane sulfonate induces pulmonary injury via TLRs signaling and disrupts sex steroidogenesis through systemic translocation","volume":"389","author":"Chen","year":"2026","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120730_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.ecoenv.2026.120730_bib4","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1039\/D0EM00355G","article-title":"The high persistence of PFAS is sufficient for their management as a chemical class","volume":"22","author":"Cousins","year":"2020","journal-title":"Environmental Science Processes & Impacts"},{"key":"10.1016\/j.ecoenv.2026.120730_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107149","article-title":"Human exposure pathways to poly- and perfluoroalkyl substances (PFAS) from indoor media: a systematic review","volume":"162","author":"DeLuca","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120730_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/s41423-025-01354-y","article-title":"Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns","volume":"22","author":"Dubey","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imr.12285","article-title":"NLRP3 at the interface of metabolism and inflammation","volume":"265","author":"Haneklaus","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ecoenv.2026.120730_bib8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12964-023-01466-w","article-title":"cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation","volume":"22","author":"Liu","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.ecoenv.2026.120730_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib12","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s12276-026-01656-9","article-title":"Molecular mechanisms of NLRP3 inflammasome activation","volume":"58","author":"Shin","year":"2026","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120730_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2024.1423449","article-title":"Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations","volume":"6","author":"Solan","year":"2024","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib14","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/ftox.2024.1423449","article-title":"Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations","volume":"6","author":"Solan","year":"2024","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib15","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120730_bib16","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.chemosphere.2008.08.011","article-title":"Estimating the contribution of precursor compounds in consumer exposure to PFOS and PFOA","volume":"73","author":"Vestergren","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120730_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2025.144703","article-title":"Current knowledge about per- and polyfluoroalkyl substances (PFAS) in the atmosphere: Fate, analytical methods and research priorities","volume":"389","author":"Vieira","year":"2025","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120730_bib18","doi-asserted-by":"crossref","first-page":"39139","DOI":"10.1021\/acsnano.5c12054","article-title":"Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA sequencing reveals initiating cell circuits in pulmonary inflammation","volume":"19","author":"Voss","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ecoenv.2026.120730_bib19","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1038\/s41467-021-23201-0","article-title":"Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120730_bib20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41556-022-00894-z","article-title":"A non-canonical cGAS\u2013STING\u2013PERK pathway facilitates the translational program critical for senescence and organ fibrosis","volume":"24","author":"Zhang","year":"2022","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.ecoenv.2026.120730_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.115188","article-title":"A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure","volume":"220","author":"Zhang","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120730_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41577-024-01112-7","article-title":"Regulation of cGAS\u2013STING signalling and its diversity of cellular outcomes","volume":"25","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Immunol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:16:25Z","timestamp":1793553385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326010602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":22,"alternative-id":["S0147651326010602"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120730","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Respiratory toxicity of perfluorooctanesulfonic acid (PFOS) via Inflammasome involvement","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120730"}}