{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:29:04Z","timestamp":1793554144094,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82404223"],"award-info":[{"award-number":["No.82404223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["No.2023ZD0518800"],"award-info":[{"award-number":["No.2023ZD0518800"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120766","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:54:42Z","timestamp":1788908082000},"page":"120766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Analyses of neurotoxicity following multiple metal exposures among adults living along the Yangtze River in Anhui Province, China: In vitro experiments with mild cognitive impairment integrating community population cohort"],"prefix":"10.1016","volume":"323","author":[{"given":"Chaoyi","family":"Bian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120766_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ebiom.2018.10.021","article-title":"Surgery, neuroinflammation and cognitive impairment","volume":"37","author":"Alam","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ecoenv.2026.120766_bib2","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"ANON","year":"2022","journal-title":"Lancet Public. Health"},{"key":"10.1016\/j.ecoenv.2026.120766_bib3","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","author":"ANON","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ecoenv.2026.120766_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2026.120766_bib5","first-page":"13","article-title":"Is Cadmium Genotoxicity Due to the Induction of Redox Stress and Inflammation? A Systematic Review","author":"Badawi","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120766_bib6","first-page":"26","article-title":"Impact of Peripheral Inflammation on Blood-Brain Barrier Dysfunction and Its Role in Neurodegenerative Diseases","author":"Beltran-Velasco","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120766_bib7","first-page":"9","article-title":"Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System","author":"Branca","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120766_bib8","doi-asserted-by":"crossref","first-page":"75001","DOI":"10.1289\/EHP14340","article-title":"Combined Exposures and Mixtures Research: An Enduring NIEHS Priority","volume":"132","author":"Carlin","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120766_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135814","article-title":"Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach","volume":"480","author":"Chang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120766_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171923","article-title":"Source-specific probabilistic health risk assessment of heavy metals in surface water of the Yangtze River Basin","volume":"926","author":"Chen","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120766_bib11","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fnut.2024.1424614","article-title":"The associations of dietary manganese, iron, copper, zinc, selenium and magnesium with cognitive outcomes in Chinese adults: a cross sectional study in Shanghai","volume":"11","author":"Chen","year":"2024","journal-title":"Front. Nutr."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120766_bib12","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib13","doi-asserted-by":"crossref","first-page":"L754","DOI":"10.1152\/ajplung.00022.2016","article-title":"Cadmium attenuates the macrophage response to LPS through inhibition of the NF-\u03baB pathway","volume":"311","author":"Cox","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib14","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","article-title":"Cadmium stress: an oxidative challenge","volume":"23","author":"Cuypers","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.ecoenv.2026.120766_bib15","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.48286","article-title":"Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis","volume":"7","author":"Domingo-Relloso","year":"2024","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.ecoenv.2026.120766_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-025-04941-2","article-title":"Systematic review and meta-analysis on heavy metals and trace elements in mild cognitive impairment","author":"Dong","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib17","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2018.33.e9","article-title":"Lead, Mercury, and Cadmium Exposure in the Korean General Population","volume":"33","author":"Eom","year":"2018","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.ecoenv.2026.120766_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/envhealth.4c00097","article-title":"Independent and Combined Associations between Metals Exposure and Inflammatory Markers among the General U.S. Adults","volume":"3","author":"Feng","year":"2025","journal-title":"Environ. Health (Wash. )"},{"key":"10.1016\/j.ecoenv.2026.120766_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120038","article-title":"Associations between multiple metals exposure and cognitive function in the middle-aged and older adults from China: A cross-sectional study","volume":"263","author":"Hong","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08923973.2019.1697284","article-title":"The effects of cadmium exposure in the induction of inflammation","volume":"42","author":"Hossein-Khannazer","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113800","article-title":"Thyroid hormones in relation to polybrominated diphenyl ether and metals exposure among rural adult residents along the Yangtze River, China","volume":"236","author":"Hu","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120766_bib23","volume":"290","author":"Huang","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2026.120766_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.appet.2014.08.017","article-title":"Appetite predicts mortality in free-living older adults in association with dietary diversity. A NAHSIT cohort study","volume":"83","author":"Huang","year":"2014","journal-title":"Appetite"},{"key":"10.1016\/j.ecoenv.2026.120766_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12974-020-01820-6","article-title":"The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study","volume":"17","author":"Ismail","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ecoenv.2026.120766_bib26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ecoenv.2026.120766_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172556","article-title":"To breathe or not to breathe: Inhalational exposure to heavy metals and related health risk","volume":"932","author":"Khoshakhlagh","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120766_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17249218","article-title":"Cell Viability and Immune Response to Low Concentrations of Nickel and Cadmium: An In Vitro Model","volume":"17","author":"Kim","year":"2020","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.ecoenv.2026.120766_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/nu14081626","article-title":"Dietary Intake of Toxic Heavy Metals with Major Groups of Food Products-Results of Analytical Determinations","volume":"14","author":"Koch","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2026.120766_bib31","doi-asserted-by":"crossref","first-page":"25800","DOI":"10.1073\/pnas.2008762117","article-title":"Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease","volume":"117","author":"Lau","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2026.120766_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140049","article-title":"Metallomics analysis of metal exposure and cognitive function in older adults: A combined epidemiological and bioinformatics study","volume":"341","author":"Li","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120766_bib33","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1016\/j.clnu.2021.04.012","article-title":"Association of dietary diversity changes and mortality among older people: A prospective cohort study","volume":"40","author":"Liu","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120766_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.01.029","article-title":"Role of oxidative stress in cadmium toxicity and carcinogenesis","volume":"238","author":"Liu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib35","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2026.120766_bib36","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209808","article-title":"Association of urinary cadmium concentration with cognitive impairment in US adults: a longitudinal cohort study","volume":"103","author":"Lu","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.ecoenv.2026.120766_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109396","article-title":"Metals and trace elements in relation to body mass index in a prospective study of US women","volume":"184","author":"Niehoff","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib39","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.18388\/abp.2012_2080","article-title":"Pro-inflammatory properties of cadmium","volume":"59","author":"Olszowski","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.reprotox.2019.06.008","article-title":"Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1\/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells","volume":"89","author":"Paniagua","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118617","article-title":"The role of metal element exposure and oxidative stress in mild cognitive impairment: Evidence from a Shanghai elderly cohort","volume":"302","author":"Qing","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12060388","article-title":"Cadmium exposure: mechanisms and pathways of toxicity and implications for human health","volume":"12","author":"Qu","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120766_bib44","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/toxsci\/kfq266","article-title":"Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions","volume":"118","author":"Rai","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120766_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2026.113172","article-title":"Hyperglycaemia-induced metabolic stress and epigenetic imprinting in the inflammatory pathogenesis of diabetic neuropathy","volume":"234","author":"Razi","year":"2026","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ecoenv.2026.120766_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112110","article-title":"Increased aluminum and lithium and decreased zinc levels in plasma is related to cognitive impairment in workers at an aluminum factory in China: A cross-sectional study","volume":"214","author":"Shang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.017","article-title":"NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches","volume":"21","author":"Sivandzade","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12964-024-01686-8","article-title":"Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq","volume":"22","author":"Soelter","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.ecoenv.2026.120766_bib50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-015-0750-x","article-title":"A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status","volume":"16","author":"Sood","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib51","article-title":"Zn(II)-curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120766_bib52","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s12011-023-03901-y","article-title":"Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011-2016","volume":"202","author":"Sun","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2026.120766_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12120933","article-title":"Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment","volume":"12","author":"Urbano","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120766_bib54","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/brain\/awv029","article-title":"Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage","volume":"138","author":"Vos","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.ecoenv.2026.120766_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110697","article-title":"Circulating metal concentrations, inflammatory cytokines and gestational weight gain: Shanghai MCPC cohort","volume":"199","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib56","article-title":"Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults","volume":"16","author":"Wang","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120766_bib57","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00394-025-03807-6","article-title":"Eastern healthy dietary patterns in relation to all-cause mortality","volume":"64","author":"Wang","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120766_bib58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000539802","article-title":"The Prevalence of Mild Cognitive Impairment in China: Evidence from a Meta-Analysis and Systematic Review of 393,525 Adults","volume":"59","author":"Wu","year":"2025","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ecoenv.2026.120766_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112465","article-title":"Combined exposure to multiple metals and cognitive function in older adults","volume":"222","author":"Xiao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3233\/JAD-170811","article-title":"Circulatory Levels of Toxic Metals (Aluminum, Cadmium, Mercury, Lead) in Patients with Alzheimer's Disease: A Quantitative Meta-Analysis and Systematic Review","volume":"62","author":"Xu","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ecoenv.2026.120766_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/nu17182910","article-title":"Protective Role of Multiple Essential Minerals Against Cadmium-Related Cognitive Decline in Middle-Aged and Older Adults: A Prospective Study","volume":"17","author":"Yang","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2026.120766_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1534303","article-title":"Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases","volume":"17","author":"Yang","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ecoenv.2026.120766_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118941","article-title":"Association between mixed exposure to multiple metal elements and cognitive decline in older adults: The moderating role of sleep quality","volume":"303","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10030116","article-title":"Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review","volume":"10","author":"Yim","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120766_bib65","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.ecoenv.2026.120766_bib66","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1521","article-title":"Plasma metal concentrations and incident coronary heart disease in Chinese adults: the dongfeng-tongji cohort","volume":"125","author":"Yuan","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120766_bib67","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3892\/ijmm.2016.2640","article-title":"NF-\u03baB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells","volume":"38","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120766_bib68","first-page":"408","article-title":"Relationship between nutrient-related dietary pattern and mild cognitive impairment in middle-aged and elderly people in 15 provinces of China","volume":"44","author":"Zhang","year":"2023","journal-title":"Zhonghua Liu Xing Bing. Xue Za Zhi"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120766_bib69","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-023-01045-z","article-title":"Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients","volume":"23","author":"Zhang","year":"2024","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120766_bib70","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1186\/s12889-024-18638-z","article-title":"Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Public. Health"},{"key":"10.1016\/j.ecoenv.2026.120766_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117150","article-title":"Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China","volume":"285","author":"Zhong","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120766_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106538","article-title":"Exposure to multiple metals and the risk of hypertension in adults: A prospective cohort study in a local area on the Yangtze River, China","volume":"153","author":"Zhong","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120766_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113643","article-title":"Interaction of biomass fuels use and metals exposure on hypertension: A prospective cohort study in rural areas along the Yangtze River, China","volume":"239","author":"Zhong","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113643","article-title":"Interaction of biomass fuels use and metals exposure on hypertension: A prospective cohort study in rural areas along the Yangtze River, China","volume":"239","author":"Zhong","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120766_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26189097","article-title":"Exploring gastrodin against aging-related genes in Alzheimer's disease by integrated bioinformatics analysis and machine learning","volume":"26","author":"Zhou","year":"2025","journal-title":"Int. J. Mol. Sci."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326010961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:16:12Z","timestamp":1793553372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326010961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":75,"alternative-id":["S0147651326010961"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120766","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analyses of neurotoxicity following multiple metal exposures among adults living along the Yangtze River in Anhui Province, China: In vitro experiments with mild cognitive impairment integrating community population cohort","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120766"}}