{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:27:21Z","timestamp":1793557641144,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024T170707"],"award-info":[{"award-number":["2024T170707"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xxj032025067"],"award-info":[{"award-number":["xxj032025067"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103934"],"award-info":[{"award-number":["82103934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120790","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:20:33Z","timestamp":1789240833000},"page":"120790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between bisphenol A exposure, methylmalonic acid, and cardiovascular disease among adults aged 60 and younger"],"prefix":"10.1016","volume":"323","author":[{"given":"Youyou","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120790_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110300","article-title":"Relationship between urinary bisphenol a levels and cardiovascular diseases in the U.S. adult population, 2003-2014","volume":"192","author":"Cai","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120790_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2023.105176","article-title":"The association between methylmalonic acid, a biomarker of mitochondria dysfunction, and phenotypic age acceleration: a population-based study","volume":"117","author":"Cao","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.ecoenv.2026.120790_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-071757","article-title":"Understanding how health interventions or exposures produce their effects using mediation analysis","volume":"382","author":"Cashin","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2026.120790_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114850","article-title":"Low doses of bpa induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-drp1 signaling pathway: a comparison between xx and xy cardiomyocytes","volume":"388","author":"Cheng","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2026.120790_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13023-021-01851-z","article-title":"Long-term renal outcome in methylmalonic acidemia in adolescents and adults","volume":"16","author":"Dao","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.ecoenv.2026.120790_bib6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/joim.13610","article-title":"Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study","volume":"293","author":"Dhar","year":"2023","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ecoenv.2026.120790_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-020-2630-0","article-title":"Age-induced accumulation of methylmalonic acid promotes tumour progression","volume":"585","author":"Gomes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120790_bib8","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402505R","article-title":"Maternal exposure to bisphenol a induces congenital heart disease through mitochondrial dysfunction","volume":"39","author":"Guo","year":"2025","journal-title":"Faseb J."},{"key":"10.1016\/j.ecoenv.2026.120790_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fmolb.2017.00053","article-title":"Corrigendum: biomarkers and algorithms for the diagnosis of vitamin b(12) deficiency","volume":"4","author":"Hannibal","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ecoenv.2026.120790_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clinbiochem.2009.02.018","article-title":"Urinary methylmalonic acid levels in patients with acute ischemic stroke","volume":"42","author":"Kara","year":"2009","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.ecoenv.2026.120790_bib11","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1093\/eurheartj\/ehab139","article-title":"Association of the combined effects of air pollution and changes in physical activity with cardiovascular disease in young adults","volume":"42","author":"Kim","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ecoenv.2026.120790_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120037","article-title":"Bisphenol a exposure impairs cardiometabolic health: Integrative human evidence and zebrafish heart multi-omics analysis","volume":"314","author":"Liu","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120790_bib13","article-title":"The regulation and characterization of mitochondrial-derived methylmalonic acid in mitochondrial dysfunction and oxidative stress: From basic research to clinical practice","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2026.120790_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1080\/15548627.2020.1753927","article-title":"Methylmalonyl acidemia: from mitochondrial metabolism to defective mitophagy and disease","volume":"16","author":"Luciani","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120790_bib15","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1093\/eurheartj\/ehad583","article-title":"Economic burden of cardiovascular diseases in the european union: A population-based cost study","volume":"44","author":"Luengo-Fernandez","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ecoenv.2026.120790_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s13098-024-01558-8","article-title":"The modified role including mediating and synergistic interactive effects of glucose tolerance status in the associations between relative fat mass and the risks of cardiovascular disease and all-cause mortality from the 4c cohort study","volume":"16","author":"Luo","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ecoenv.2026.120790_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/ajcn\/nqz045","article-title":"Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the us population","volume":"110","author":"Mineva","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2026.120790_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142941","article-title":"Effects of bisphenol a on cardiovascular disease: An epidemiological study using national health and nutrition examination survey 2003-2016 and meta-analysis","volume":"763","author":"Moon","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2026.120790_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/eurjpc\/zwae240","article-title":"Early-onset atherosclerotic cardiovascular disease","volume":"32","author":"Mousavi","year":"2025","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120790_bib20","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/antiox13121468","article-title":"Bisphenol A and its emergent substitutes: State of the art of the impact of these plasticizers on oxidative stress and its role in vascular dysfunction","volume":"13","author":"Palacios-Valladares","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120790_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/20417314251383006","article-title":"Stage-specific cardiotoxicity induced by bisphenol a using human pluripotent stem cell-derived 2d- and 3d-cardiomyocyte models","volume":"16","author":"Park","year":"2025","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.ecoenv.2026.120790_bib22","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1093\/clinchem\/45.12.2236","article-title":"Comparison of serum and plasma methylmalonic acid measurements in 13 laboratories: an international study","volume":"45","author":"Pfeiffer","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ecoenv.2026.120790_bib23","first-page":"330","article-title":"Methylmalonic acid and vitamin b12 in patients with heart failure","volume":"61","author":"Polytarchou","year":"2020","journal-title":"Hell. J. Cardiol."},{"key":"10.1016\/j.ecoenv.2026.120790_bib24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12916-020-01853-x","article-title":"Methylmalonic acid, vitamin b12, renal function, and risk of all-cause mortality in the general population: Results from the prospective lifelines-minuthe study","volume":"18","author":"Riphagen","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.ecoenv.2026.120790_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cmet.2025.01.005","article-title":"The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer","volume":"37","author":"Shafer","year":"2025","journal-title":"Cell. Metab."},{"key":"10.1016\/j.ecoenv.2026.120790_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/jcm6070071","article-title":"Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders","volume":"6","author":"Stepien","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ecoenv.2026.120790_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165586","article-title":"Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia","volume":"1866","author":"Tamayo","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ecoenv.2026.120790_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.arcmed.2025.103226","article-title":"Mitochondrial metabolite methylmalonic acid, subclinical myocardial injury, and its incremental predictive value for cardiovascular mortality risk","volume":"56","author":"Tang","year":"2025","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ecoenv.2026.120790_bib29","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0026-0495(90)90084-P","article-title":"Sources of propionate in inborn errors of propionate metabolism","volume":"39","author":"Thompson","year":"1990","journal-title":"Metabolism"},{"key":"10.1016\/j.ecoenv.2026.120790_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-021-12805-0","article-title":"Study on the correlation of bisphenol a exposure, pro-inflammatory gene expression, and c-reactive protein with potential cardiovascular disease symptoms in young adults","author":"Tsen","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2026.120790_bib31","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1289\/ehp.0901716","article-title":"Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A","volume":"118","author":"Vandenberg","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120790_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/EDE.0b013e318258f5e4","article-title":"The role of measurement error and misclassification in mediation analysis: Mediation and measurement error","volume":"23","author":"VanderWeele","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2026.120790_bib33","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1373\/clinchem.2009.128678","article-title":"Determinants of plasma methylmalonic acid in a large population: Implications for assessment of vitamin B12 status","volume":"55","author":"Vogiatzoglou","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ecoenv.2026.120790_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101741","article-title":"Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population","volume":"37","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2026.120790_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2337\/dc21-1674","article-title":"Cobalamin intake and related biomarkers: examining associations with mortality risk among adults with type 2 diabetes in nhanes","volume":"45","author":"Wang","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ecoenv.2026.120790_bib36","article-title":"Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ecoenv.2026.120790_bib37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.amepre.2023.12.009","article-title":"Global burden of ischemic heart disease in adolescents and young adults, 1990-2019","volume":"66","author":"Yuan","year":"2024","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.ecoenv.2026.120790_bib38","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/CIRCRESAHA.123.322002","article-title":"Air pollution, built environment, and early cardiovascular disease","volume":"132","author":"Zhang","year":"2023","journal-title":"Circ. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:31:28Z","timestamp":1793554288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326011206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"alternative-id":["S0147651326011206"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120790","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between bisphenol A exposure, methylmalonic acid, and cardiovascular disease among adults aged 60 and younger","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120790"}}