{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:29:08Z","timestamp":1793554148907,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ecoenv.2026.120796","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:50:06Z","timestamp":1789249806000},"page":"120796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neuroactive effects of nootkatone against Haemaphysalis longicornis vectors: AChE inhibition and CYP450-linked metabolic modulation"],"prefix":"10.1016","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2455-6639","authenticated-orcid":false,"given":"Na-Hyun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah-Hyeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-2850","authenticated-orcid":false,"given":"Namhyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-3373","authenticated-orcid":false,"given":"Hoi-Seon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120796_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2020.109090","article-title":"Terpenes on Rhipicephalus (Boophilus) microplus: acaricidal activity and acetylcholinesterase inhibition","volume":"280","author":"Cardoso","year":"2020","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib2","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2012.0429","article-title":"Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth","volume":"368","author":"David","year":"2013","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120796_bib3","series-title":"Insect Molecular Biology and Biochemistry","first-page":"236","article-title":"Insect CYP genes and P450 enzymes","author":"Feyereisen","year":"2012"},{"key":"10.1016\/j.ecoenv.2026.120796_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein\u2013ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ecoenv.2026.120796_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10493-016-0046-1","article-title":"Acaricide resistance in Rhipicephalus (Boophilus) microplus and Hyalomma anatolicum collected from Haryana and Rajasthan states of India","volume":"69","author":"Gaur","year":"2016","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib6","article-title":"Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa","volume":"5","author":"Gleave","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ecoenv.2026.120796_bib7","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1007\/s11356-019-07332-y","article-title":"Eco-friendly pesticide based on peppermint oil nanoemulsion: preparation, physicochemical properties, and its aphicidal activity against cotton aphid","volume":"27","author":"Heydari","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2026.120796_bib8","first-page":"140","article-title":"Chemical component analysis of Alpinia\u202foxyphylla\u202fMiq. essential oil and its antimicrobial mechanism against Listeria monocytogenes","volume":"45","author":"Hu","year":"2024","journal-title":"Food Sci."},{"key":"10.1016\/j.ecoenv.2026.120796_bib9","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/ps.4627","article-title":"Insecticidal activities of their components derived from the essential oils of Cinnamomum sp. barks and against Ricania sp. (Homoptera: Ricaniidae), a newly recorded pest","volume":"73","author":"Jeon","year":"2017","journal-title":"Pest. Manag. Sci."},{"key":"10.1016\/j.ecoenv.2026.120796_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2019.104832","article-title":"Ultrasound assisted formation of essential oil nanoemulsions: emerging alternative for Culex pipiens pipiens Say (Diptera: Culicidae) and Plodia interpunctella H\u00fcbner (Lepidoptera: Pyralidae) management","volume":"61","author":"Jesser","year":"2020","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ecoenv.2026.120796_bib11","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1021\/acssuschemeng.0c02224","article-title":"Optimization and characterization of essential oil nanoemulsions using ultrasound for new ecofriendly insecticides","volume":"8","author":"Jesser","year":"2020","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.ecoenv.2026.120796_bib12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.ecoenv.2026.120796_bib13","unstructured":"Korea Disease Control and Prevention Agency (KDCA), 2024. Annual report on the notified infectious diseases in Korea. Publication Registration No. 11-1352159-000048-10, pp. 1\u201338."},{"key":"10.1016\/j.ecoenv.2026.120796_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1752-153X-7-134","article-title":"Analysis of nine compounds from Alpinia oxyphylla fruit at different harvest time using UFLC-MS\/MS and an extraction method optimized by orthogonal design","volume":"7","author":"Li","year":"2013","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.ecoenv.2026.120796_bib15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1021\/jf000325z","article-title":"Insecticidal sesquiterpene from Alpinia oxyphylla against Drosophila melanogaster","volume":"48","author":"Miyazawa","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2026.120796_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105085","article-title":"Mode of action and toxicological effects of the sesquiterpenoid nootkatone in insects","volume":"183","author":"Norris","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/jmedent\/42.3.352","article-title":"Use of novel compounds for pest control: insecticidal and acaricidal activity of essential oil components from heartwood of Alaska yellow cedar","volume":"42","author":"Panella","year":"2005","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib18","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/molecules23081899","article-title":"Binding affinity via docking: fact and fiction","volume":"23","author":"Pantsar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2026.120796_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev-ento-120710-100554","article-title":"Essential oils in insect control: low-risk products in a high-stakes world","volume":"57","author":"Regnault-Roger","year":"2012","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib20","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3389\/fpls.2018.01579","article-title":"Understanding synergistic toxicity of terpenes as insecticides: contribution of metabolic detoxification in Musca domestica","volume":"9","author":"Scalerandi","year":"2018","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.ecoenv.2026.120796_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1017\/S000748530004832X","article-title":"A method for measuring the acaricide-susceptibility of the cattle tick Boophilus microplus (Can.)","volume":"53","author":"Stone","year":"1962","journal-title":"Bull. Entomol. Res."},{"key":"10.1016\/j.ecoenv.2026.120796_bib22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1017\/S0007485313000710","article-title":"Nanoemulsion of eucalyptus oil and its larvicidal activity against Culex quinquefasciatus","volume":"104","author":"Sugumar","year":"2014","journal-title":"Bull. Entomol. Res."},{"key":"10.1016\/j.ecoenv.2026.120796_bib23","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3390\/microorganisms8060910","article-title":"Interrupted blood feeding in ticks: causes and consequences","volume":"8","author":"Tahir","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2026.120796_bib24","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/ps.3280","article-title":"Quantitative structure\u2013activity relationships of monoterpenoid binding activities to the housefly GABA receptor","volume":"68","author":"Tong","year":"2012","journal-title":"Pest. Manag. Sci."},{"key":"10.1016\/j.ecoenv.2026.120796_bib25","unstructured":"US EPA, 2020. Nootkatone: Registration of a New Active Ingredient (EPA Registration No. 91873\u20131). Office of Pesticide Programs, Washington, DC, USA."},{"key":"10.1016\/j.ecoenv.2026.120796_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2020.109155","article-title":"Transcription profiling and characterization of Dermanyssus gallinae cytochrome P450 genes involved in beta-cypermethrin resistance","volume":"283","author":"Wang","year":"2020","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ecoenv.2026.120796_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39898-6","article-title":"Cuticular property affects the insecticidal synergy of major constituents in thyme oil against houseflies, Musca domestica","volume":"13","author":"Yoon","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:17:25Z","timestamp":1793553445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326011267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S0147651326011267"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120796","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroactive effects of nootkatone against Haemaphysalis longicornis vectors: AChE inhibition and CYP450-linked metabolic modulation","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120796"}}