{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:06:37Z","timestamp":1794049597598,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010614","name":"Putian University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J011008"],"award-info":[{"award-number":["2023J011008"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026J008234"],"award-info":[{"award-number":["2026J008234"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026J0011262"],"award-info":[{"award-number":["2026J0011262"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ecoenv.2026.120812","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:47:51Z","timestamp":1789602471000},"page":"120812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Spatial multi-omics reveals OAT-associated arginine-proline metabolic remodeling in Paraquat-induced Parkinsonian and depression-like phenotypes"],"prefix":"10.1016","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-2372","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120812_bib1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3390\/brainsci12091248","article-title":"Imaging the limbic system in parkinson's disease-a review of limbic pathology and clinical symptoms","volume":"12","author":"Banwinkler","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.ecoenv.2026.120812_bib2","article-title":"Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson\u2019s disease-like neurodegeneration by causing energy metabolism disorders in mice","volume":"430","author":"Boxuan","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120812_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116190","article-title":"Occupational exposure to pesticides and symptoms of depression in agricultural workers. A systematic review","volume":"231","author":"Cancino","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120812_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2025.01.036","article-title":"Neurobiology of L-proline: from molecules to behavior","volume":"568","author":"Carvalho","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.ecoenv.2026.120812_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/1673-5374.374142","article-title":"Lactate metabolism in neurodegenerative diseases","volume":"19","author":"Chaoguang","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ecoenv.2026.120812_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116413","article-title":"Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage","volume":"272","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120812_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104749","article-title":"Prevalence and clinical aspects of depression in Parkinson's disease: a systematic review and meta-analysis of 129 studies","volume":"141","author":"Cong","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ecoenv.2026.120812_bib8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/jnc.16032","article-title":"Brain energy metabolism: a roadmap for future research","volume":"168","author":"D","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ecoenv.2026.120812_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/biology6010018","article-title":"Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways","volume":"6","author":"Ginguay","year":"2017","journal-title":"Biology"},{"key":"10.1016\/j.ecoenv.2026.120812_bib10","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1021\/acs.jproteome.1c00179","article-title":"Spatially resolved metabolomics based on air-flow-assisted desorption electrospray ionization-mass spectrometry imaging reveals region-specific metabolic alterations in diabetic encephalopathy","volume":"20","author":"Huo","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ecoenv.2026.120812_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jphs.2020.07.011","article-title":"Glutamate-induced excitotoxicity in Parkinson's disease: the role of glial cells","volume":"144","author":"Iovino","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120812_bib12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.chembiol.2014.09.016","article-title":"Brain region mapping using global metabolomics","volume":"21","author":"Ivanisevic","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ecoenv.2026.120812_bib13","article-title":"The interplay between lncRNA NR030777 and SF3B3 in neuronal damage caused by paraquat","volume":"255","author":"Junxiang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120812_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf536","article-title":"A comprehensive review of spatial transcriptomics data alignment and integration","volume":"53","author":"Khan","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120812_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/oemed-2012-101005","article-title":"Depressive symptoms and severity of acute occupational pesticide poisoning among male farmers","volume":"70","author":"Kim","year":"2013","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2026.120812_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12035-014-9003-3","article-title":"Metabolomic analysis provides insights on paraquat-induced parkinson-Like symptoms in Drosophila melanogaster","volume":"53","author":"Kumar","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2026.120812_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3892\/ijmm.2026.5747","article-title":"Spatial metabolomics: a new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)","volume":"57","author":"Li","year":"2026","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120812_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41531-025-01226-2","article-title":"Metabolomic profiles of depression in Parkinson's disease patients","volume":"12","author":"Lin","year":"2025","journal-title":"npj Park. Dis."},{"key":"10.1016\/j.ecoenv.2026.120812_bib19","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1186\/s12885-024-13275-6","article-title":"Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ecoenv.2026.120812_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-023-05891-2","article-title":"Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer","volume":"616","author":"MinSik","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120812_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jpsychires.2019.10.004","article-title":"Altered plasma levels of arginine metabolites in depression","volume":"120","author":"Ozden","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ecoenv.2026.120812_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13024-023-00694-5","article-title":"Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease","volume":"18","author":"Paul","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ecoenv.2026.120812_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s40266-022-00942-1","article-title":"Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment","volume":"39","author":"Prange","year":"2022","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ecoenv.2026.120812_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-026-01419-3","article-title":"Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson's disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts","author":"Ren","year":"2026","journal-title":"NPJ Park. 's. Dis."},{"key":"10.1016\/j.ecoenv.2026.120812_bib25","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3390\/cells13201714","article-title":"Brain metabolism in health and neurodegeneration: the interplay among neurons and astrocytes","volume":"13","author":"Shichkova","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120812_bib26","article-title":"Projections for prevalence of Parkinson's disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021","volume":"388","author":"Su","year":"2025","journal-title":"Bmj-Br. Med. J."},{"key":"10.1016\/j.ecoenv.2026.120812_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuro.2026.103433","article-title":"Paraquat-induced rodent models of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis","volume":"114","author":"Swain","year":"2026","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2026.120812_bib28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41531-026-01294-y","article-title":"Serotonergic cortico-limbic and executive network dysfunction in Parkinson's disease impulse control disorders: a PET-fMRI study","volume":"12","author":"Terenzi","year":"2026","journal-title":"npj Park. Dis."},{"key":"10.1016\/j.ecoenv.2026.120812_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107512","article-title":"Paraquat exposure induces parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain","volume":"169","author":"Tong","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120812_bib30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1248\/bpb.b14-00781","article-title":"Metabolic changes in paraquat poisoned patients and support vector machine model of discrimination","volume":"38","author":"Wang","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ecoenv.2026.120812_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116169","article-title":"Single-cell RNA-sequencing of cellular heterogeneity and pathogenic mechanisms in paraquat-induced Parkinson's disease with depression","volume":"273","author":"Weng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120812_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117713","article-title":"Frontiers in mass spectrometry-based spatial metabolomics: current applications and challenges in the context of biomedical research","volume":"175","author":"Wheeler","year":"2024","journal-title":"Trac. -Trends Anal. Chem."},{"key":"10.1016\/j.ecoenv.2026.120812_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2022.09.027","article-title":"Regional heterogeneity in mitochondrial function underlies region specific vulnerability in human brain ageing: implications for neurodegeneration","volume":"193","author":"Yarlagadda","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120812_bib34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.14348\/molcells.2022.0115","article-title":"Proline metabolism in neurological and psychiatric disorders","volume":"45","author":"Yuxiao","year":"2022","journal-title":"Mol. Cells"},{"key":"10.1016\/j.ecoenv.2026.120812_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2021.107538","article-title":"Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: an isobologram analysis","volume":"186","author":"Zarrindast","year":"2021","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ecoenv.2026.120812_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117193","article-title":"Brain single-cell transcriptomics highlights comorbidity-related cell type-specific changes of Parkinson's disease with major depressive disorder after paraquat exposure","volume":"286","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120812_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134559","article-title":"VGluT2 neuron subtypes in the paraventricular thalamic nucleus regulate depression in paraquat-induced Parkinson's disease","volume":"472","author":"Zhang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120812_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118364","article-title":"Characterizing microglial heterogeneity in autophagy impairment of Paraquat-induced Parkinson's disease-like neurodegeneration","volume":"299","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120812_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2026.121430","article-title":"Astrocytes in the paraventricular nucleus mediates inflammation-related depression in mice treated with lipopolysaccharide","volume":"402","author":"Zhang","year":"2026","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ecoenv.2026.120812_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27292","article-title":"Arginine metabolomics in mood disorders","volume":"10","author":"Zinellu","year":"2024","journal-title":"Heliyon"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:20:10Z","timestamp":1793917210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326011425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S0147651326011425"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120812","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial multi-omics reveals OAT-associated arginine-proline metabolic remodeling in Paraquat-induced Parkinsonian and depression-like phenotypes","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120812"}}