{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:24:54Z","timestamp":1793921094543,"version":"4.8.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004317","name":"Shihezi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009967","name":"Xinjiang Production and Construction Corps","doi-asserted-by":"publisher","award":["2025ZDSF01"],"award-info":[{"award-number":["2025ZDSF01"]}],"id":[{"id":"10.13039\/501100009967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ecoenv.2026.120851","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:52:02Z","timestamp":1790470322000},"page":"120851","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells"],"prefix":"10.1016","volume":"324","author":[{"given":"Haotian","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120851_bib1","doi-asserted-by":"crossref","first-page":"D1038","DOI":"10.1093\/nar\/gky1151","article-title":"OMIM.org: leveraging knowledge across phenotype-gene relationships","volume":"47","author":"Amberger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120851_bib2","doi-asserted-by":"crossref","first-page":"26834","DOI":"10.1074\/jbc.C800156200","article-title":"Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans","volume":"283","author":"Anzai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120851_bib3","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120851_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050197","article-title":"SLC2A9 is a high-capacity urate transporter in humans","volume":"5","author":"Caulfield","year":"2008","journal-title":"PLoS. Med."},{"key":"10.1016\/j.ecoenv.2026.120851_bib5","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401801RR","article-title":"Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single-cell level","volume":"39","author":"Chang","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2026.120851_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate\u2013anion exchanger that regulates blood urate levels","volume":"417","author":"Enomoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120851_bib7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/aje\/kws392","article-title":"Positive association between perfluoroalkyl chemicals and hyperuricemia in children","volume":"177","author":"Geiger","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00244-004-0133-x","article-title":"Perfluorinated compounds in aquatic organisms at various trophic levels in a Great Lakes food chain","volume":"48","author":"Kannan","year":"2005","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib9","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem Substance and Compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120851_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2026.120851_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133500","article-title":"Relationship of single and co-exposure of per-and polyfluoroalkyl substances and their alternatives with uric acid: a community-based study in China","volume":"466","author":"Liang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120851_bib12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00204-022-03428-6","article-title":"Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)","volume":"97","author":"Louisse","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib13","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1021\/es404008g","article-title":"Bioaccumulation of perfluorinated alkyl acids: observations and models","volume":"48","author":"Ng","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib14","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11885","article-title":"A state-of-the-science review of interactions of per- and polyfluoroalkyl substances (PFAS) with renal transporters in health and disease: implications for population variability in PFAS toxicokinetics","volume":"131","author":"Niu","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120851_bib15","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctane sulfonate, perfluorohexane sulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120851_bib16","doi-asserted-by":"crossref","first-page":"F1041","DOI":"10.1152\/ajprenal.00640.2013","article-title":"Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4\u03b1","volume":"307","author":"Prestin","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-9525(97)01103-7","article-title":"GeneCards: integrating information about genes, proteins and diseases","volume":"13","author":"Rebhan","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/j.ecoenv.2026.120851_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tox.2017.05.013","article-title":"PPAR\u03b1-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling","volume":"387","author":"Rosen","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2026.120851_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127446","article-title":"Perfluoroalkyl acids, hyperuricemia and gout in adults: analyses of NHANES 2009\u20132014","volume":"259","author":"Scinicariello","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120851_bib20","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1038\/s41467-024-49420-9","article-title":"Structural basis for urate recognition and apigenin inhibition of human GLUT9","volume":"15","author":"Shen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120851_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.ecoenv.2026.120851_bib22","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1038\/s41467-025-60480-3","article-title":"Molecular basis of the urate transporter URAT1 inhibition by gout drugs","volume":"16","author":"Suo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120851_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12020-016-0896-7","article-title":"SIRT1 prevents hyperuricemia via the PGC-1\u03b1\/PPAR\u03b3-ABCG2 pathway","volume":"53","author":"Wang","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.ecoenv.2026.120851_bib24","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3390\/toxics10080436","article-title":"The role of ferroptosis in the damage of human proximal tubule epithelial cells caused by perfluorooctane sulfonate","volume":"10","author":"Wang","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2026.120851_bib25","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2026.120851_bib26","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1038\/s41467-025-61226-x","article-title":"Molecular mechanism of drug inhibition of URAT1","volume":"16","author":"Yu","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:29:05Z","timestamp":1793917745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326011814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":26,"alternative-id":["S0147651326011814"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120851","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120851"}}