{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:24:09Z","timestamp":1793921049431,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024-MSLH-554"],"award-info":[{"award-number":["2024-MSLH-554"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010086","name":"Liaoning Provincial Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ecoenv.2026.120853","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:33:38Z","timestamp":1790696018000},"page":"120853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative multi-omics analysis identifies programmed cell death-related biomarkers and their environmentally relevant toxicological interactions in abdominal aortic aneurysm"],"prefix":"10.1016","volume":"324","author":[{"given":"Jingjing","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"32","key":"10.1016\/j.ecoenv.2026.120853_bib1","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.1016\/j.biomaterials.2012.07.040","article-title":"Size-dependent genotoxicity of graphene nanoplatelets in human stem cells","volume":"33","author":"Akhavan","year":"2012","journal-title":"Biomaterials"},{"issue":"48","key":"10.1016\/j.ecoenv.2026.120853_bib2","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1039\/C7TB01689A","article-title":"Antioxidant nanomaterials in advanced diagnoses and treatments of ischemia reperfusion injuries","volume":"5","author":"Amani","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120853_bib3","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/s41598-019-42633-9","article-title":"Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling","volume":"9","author":"Amani","year":"2019","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.ecoenv.2026.120853_bib4","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1001\/jama.2022.18638","article-title":"What Is an Abdominal Aortic Aneurysm?","volume":"328","author":"Baman","year":"2022","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120853_bib5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12872-024-04343-7","article-title":"The diagnostic value investigation of programmed cell death genes in heart failure","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120853_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41392-024-01840-1","article-title":"Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2026.120853_bib7","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.2147\/IJN.S558247","article-title":"Metal-Based Nanomedicines for Inducing Programmed Cell Death to Enhance the Efficacy of Cancer Immunotherapy","volume":"20","author":"Cheng","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ecoenv.2026.120853_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102257","article-title":"T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2","volume":"50","author":"Dang","year":"2022","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120853_bib9","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/s41401-022-00876-9","article-title":"Activating \u03b17nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome","volume":"43","author":"Fu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.ecoenv.2026.120853_bib10","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1161\/ATVBAHA.120.314962","article-title":"TSP-1 (Thrombospondin-1) Deficiency Protects ApoE-\/- Mice Against Leptin-Induced Atherosclerosis","volume":"41","author":"Ganguly","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120853_bib11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.tem.2006.09.006","article-title":"Development of leptin antagonists and their potential use in experimental biology and medicine","volume":"17","author":"Gertler","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120853_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","article-title":"Abdominal aortic aneurysm: update on pathogenesis and medical treatments","volume":"16","author":"Golledge","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"20","key":"10.1016\/j.ecoenv.2026.120853_bib13","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1161\/CIRCULATIONAHA.107.717926","article-title":"Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study","volume":"116","author":"Golledge","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ecoenv.2026.120853_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.reprotox.2016.07.009","article-title":"Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats","volume":"68","author":"Green","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"19","key":"10.1016\/j.ecoenv.2026.120853_bib15","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1039\/C5NR00520E","article-title":"Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide","volume":"7","author":"Hajipour","year":"2015","journal-title":"Nanoscale"},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120853_bib16","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3390\/antiox9121251","article-title":"Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals","author":"Hariri","year":"2020","journal-title":"Antioxid. (Basel)"},{"issue":"5-6","key":"10.1016\/j.ecoenv.2026.120853_bib17","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10495-025-02089-x","article-title":"PANoptosis: a potential target of atherosclerotic cardiovascular disease","volume":"30","author":"Jin","year":"2025","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120853_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12020-007-9002-5","article-title":"Possible implications of leptin, adiponectin and ghrelin in the regulation of energy homeostasis by thyroid hormone","volume":"32","author":"Kokkinos","year":"2007","journal-title":"Endocrine"},{"issue":"11","key":"10.1016\/j.ecoenv.2026.120853_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5694\/mja2.50198","article-title":"Propylthiouracil-induced vasculitis in carbimazole-refractory Graves disease","volume":"210","author":"Lam","year":"2019","journal-title":"Med. J. Aust."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120853_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41419-022-04923-5","article-title":"Programmed cell death in atherosclerosis and vascular calcification","volume":"13","author":"Li","year":"2022","journal-title":"Cell. Death Dis."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120853_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.028081","article-title":"Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice","volume":"12","author":"Li","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ecoenv.2026.120853_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123349","article-title":"Exposure to copper oxide nanoparticles triggers oxidative stress and endoplasmic reticulum (ER)-stress induced toxicology and apoptosis in male rat liver and BRL-3A cell","volume":"401","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120853_bib23","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/eurheartj\/ehad886","article-title":"Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study","volume":"45","author":"Ma","year":"2024","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.ecoenv.2026.120853_bib24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/cbdd.14136","article-title":"A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery","volume":"100","author":"Maghsoudi","year":"2022","journal-title":"Chem. Biol. Drug. Des."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120853_bib25","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.123.323617","article-title":"Heavy Metal Exposure and Cardiovascular Disease","volume":"134","author":"Pan","year":"2024","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ecoenv.2026.120853_bib26","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1161\/ATVBAHA.112.300930","article-title":"Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice","volume":"33","author":"Poupel","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2026.120853_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31327","article-title":"SATB1, senescence and senescence-related diseases","volume":"239","author":"Qi","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ecoenv.2026.120853_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2024.05.036","article-title":"Neutrophil extracellular trap-induced ferroptosis promotes abdominal aortic aneurysm formation via SLC25A11-mediated depletion of mitochondrial glutathione","volume":"221","author":"Qi","year":"2024","journal-title":"Free. Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120853_bib29","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/cvr\/cvaa234","article-title":"Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction","volume":"117","author":"Roy-Chowdhury","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2026.120853_bib30","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/SLA.0000000000005716","article-title":"The Global and Regional Prevalence of Abdominal Aortic Aneurysms: A Systematic Review and Modeling Analysis","volume":"277","author":"Song","year":"2023","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ecoenv.2026.120853_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2023.114124","article-title":"Arsenic exposure alters the expression of genes related to metabolic diseases in differentiated adipocytes and in newborns and children","volume":"250","author":"Srisuporn","year":"2023","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2026.120853_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.trsl.2023.03.002","article-title":"Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation","volume":"258","author":"Sun","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.ecoenv.2026.120853_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.618434","article-title":"Role of Adipokines and Perivascular Adipose Tissue in Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis of Animal and Human Observational Studies","volume":"12","author":"Thanigaimani","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120853_bib34","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41577-024-01103-8","article-title":"Adipokines: masterminds of metabolic inflammation","volume":"25","author":"Tilg","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120853_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.180356","article-title":"From contamination to remediation: Understanding the toxicity, risk assessment, and degradation pathways of triphenyl phosphate and related organophosphate flame retardants in water and soil","volume":"999","author":"Vasinthiya Tej","year":"2025","journal-title":"Sci. Total. Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2026.120853_bib36","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/CIRCRESAHA.116.304899","article-title":"Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation","volume":"116","author":"Wang","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ecoenv.2026.120853_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115757","article-title":"Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1\/RAGE, PI3K\/AKT, and TGF-\u03b21\/SMAD pathways","volume":"432","author":"Wang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.ecoenv.2026.120853_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.008024","article-title":"Inflammation, Autophagy, and Apoptosis After Myocardial Infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ecoenv.2026.120853_bib39","first-page":"q517","article-title":"Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study. BMJ. 2024 Feb 21;384:e076939. doi: 10.1136\/bmj-2023-076939","volume":"384","author":"Wei","year":"2024","journal-title":"Errat-.-. BMJ"},{"key":"10.1016\/j.ecoenv.2026.120853_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127082","article-title":"Assessing the toxicological effects of exposure to environmental pollutants PET-MPs on vascular diseases: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation","volume":"385","author":"Xu","year":"2025","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.ecoenv.2026.120853_bib41","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/SLA.0b013e3181b41a18","article-title":"Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm","volume":"250","author":"Zhang","year":"2009","journal-title":"Ann. Surg."},{"issue":"1","key":"10.1016\/j.ecoenv.2026.120853_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCRESAHA.120.314458","article-title":"Adiponectin, leptin and cardiovascular disorders","volume":"128","author":"Zhao","year":"2021","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.ecoenv.2026.120853_bib43","first-page":"2378","article-title":"Inflammation in abdominal aortic aneurysm: cause or comorbidity?","volume":"40","author":"Zhu","year":"2024","journal-title":"Can. J. Cardiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326011838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:24:33Z","timestamp":1793917473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326011838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S0147651326011838"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120853","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative multi-omics analysis identifies programmed cell death-related biomarkers and their environmentally relevant toxicological interactions in abdominal aortic aneurysm","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120853"}}