{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:46:19Z","timestamp":1792129579450,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ecoenv.2026.120868","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:45Z","timestamp":1790776605000},"page":"120868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrating network toxicology, molecular modeling, and in vitro experiments to reveal potential targets and mechanism of BPS-induced osteoporosis"],"prefix":"10.1016","volume":"324","author":[{"given":"Shoukui","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongye","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120868_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41370-026-00868-5","article-title":"Bisphenol S and female reproductive toxicity: a scoping review of human studies","author":"Andrews","year":"2026","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ecoenv.2026.120868_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biom14080970","article-title":"Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis","volume":"14","author":"Chen","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2026.120868_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2026.120868_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jbmr.1747","article-title":"ER\u03b1 signaling regulates MMP3 expression to induce FasL cleavage and osteoclast apoptosis","volume":"28","author":"Garcia","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ecoenv.2026.120868_bib6","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1002\/eji.200939670","article-title":"A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss","volume":"39","author":"Goswami","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113639","article-title":"Association of bisphenol A and its alternatives bisphenol S and F exposure with hypertension and blood pressure: A cross-sectional study in China","volume":"257","author":"Jiang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120868_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158032","article-title":"Celosiae Semen and Celosin I alleviate postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2\/GPX4 pathway","volume":"154","author":"Jin","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2026.120868_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136895","article-title":"A comprehensive atlas of multi-tissue metabolome and microbiome shifts: Exploring obesity and insulin resistance induced by perinatal bisphenol S exposure in high-fat diet-fed offspring","volume":"485","author":"Li","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120868_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111171","article-title":"Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p\/SIRT1 axis","volume":"527","author":"Li","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118747","article-title":"Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses","volume":"302","author":"Liu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120868_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1021\/acs.est.5c12267","article-title":"Unraveling the mechanisms of osteoporosis triggered by methylparaben and monomethyl phthalate through integrated mendelian randomization, in silico simulations, and experimental validation","volume":"60","author":"Liu","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib13","article-title":"Network pharmacology analysis and biological validation systemically identified the active ingredients and molecular targets of kudzu root on osteoporosis","volume":"26","author":"Liu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120868_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7150\/ijbs.78654","article-title":"Novel Role of the SIRT1 in Endocrine and Metabolic Diseases","volume":"19","author":"Lu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2026.120868_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135704","article-title":"Mechanisms insights into bisphenol S-induced oxidative stress, lipid metabolism disruption, and autophagy dysfunction in freshwater crayfish","volume":"479","author":"Pu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120868_bib16","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1021\/acs.est.9b06213","article-title":"Transcriptomic responses of bisphenol s predict involvement of immune function in the cardiotoxicity of early life-stage zebrafish (Danio rerio)","volume":"54","author":"Qiu","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: a still increasing prevalence","volume":"38","author":"Reginster","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2026.120868_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120868_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157817","article-title":"Typhaneoside suppresses osteoclastogenesis and osteoporosis by stabilizing ADORA1","volume":"152","author":"Shi","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2026.120868_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116652","article-title":"METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m(6)A level of SIRT1 mRNA","volume":"168","author":"Wang","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2026.120868_bib22","doi-asserted-by":"crossref","first-page":"15463","DOI":"10.1021\/acs.est.4c03870","article-title":"A Potential Neurotoxic Mechanism: Bisphenol S-Induced Inhibition of Glucose Transporter 1 Leads to ATP Excitotoxicity in the Zebrafish Brain","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120868_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137166","article-title":"Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2","volume":"487","author":"Xie","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2026.120868_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120293","article-title":"Bisphenol S exposure promotes stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway","volume":"264","author":"Yi","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2026.120868_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/prd.12422","article-title":"Osteoporosis and periodontal diseases - An update on their association and mechanistic links","volume":"89","author":"Yu","year":"2022","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.ecoenv.2026.120868_bib26","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1515\/hsz-2018-0253","article-title":"Inhibition of JAK2\/STAT3 signaling suppresses bone marrow stromal cells proliferation and osteogenic differentiation, and impairs bone defect healing","volume":"399","author":"Yu","year":"2018","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120868_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120128","article-title":"Bisphenol S induces lipid metabolic disruption associated with SREBP signaling in Caenorhabditis elegans","volume":"317","author":"Zhang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120868_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111148","article-title":"Integrated analysis reveals the immunotoxicity mechanism of BPs on human lymphocytes","volume":"399","author":"Zhang","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2026.120868_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117820","article-title":"Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking","volume":"291","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120868_bib30","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1021\/acs.analchem.7b04540","article-title":"MALDI-MS Imaging Reveals Asymmetric Spatial Distribution of Lipid Metabolites from Bisphenol S-Induced Nephrotoxicity","volume":"90","author":"Zhao","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ecoenv.2026.120868_bib31","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/eci.12158","article-title":"Immune regulation of bone loss by Th17 cells in oestrogen-deficient osteoporosis","volume":"43","author":"Zhao","year":"2013","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2026.120868_bib32","first-page":"1807","article-title":"Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy-induced osteoporosis rats","volume":"16","author":"Zheng","year":"2018","journal-title":"Exp. Ther. Med."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132601198X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132601198X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:02:50Z","timestamp":1792126970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132601198X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"alternative-id":["S014765132601198X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120868","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating network toxicology, molecular modeling, and in vitro experiments to reveal potential targets and mechanism of BPS-induced osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120868"}}