{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T15:28:40Z","timestamp":1793633320177,"version":"4.5.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ecoenv.2026.120897","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:41:13Z","timestamp":1791578473000},"page":"120897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sodium arsenite accelerates aging of Caenorhabditis elegans parents and offspring through the insulin signaling pathway, oxidative stress, and autophagy"],"prefix":"10.1016","volume":"325","author":[{"given":"Le","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanshuai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-3715","authenticated-orcid":false,"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2026.120897_bib1","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1002\/bjs.10053","article-title":"Molecular and biological hallmarks of ageing","volume":"103","author":"Aunan","year":"2016","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.ecoenv.2026.120897_bib2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/antiox7110156","article-title":"Superoxide dismutases (SODs) and SOD mimetics","volume":"7","author":"Borgstahl","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2026.120897_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","article-title":"Lipofuscin: mechanisms of age-related accumulation and influence on cell function","volume":"33","author":"Brunk","year":"2002","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2026.120897_bib4","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.jprot.2011.06.005","article-title":"Oxidative stress, inflamm-aging and immunosenescence","volume":"74","author":"Cannizzo","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.ecoenv.2026.120897_bib5","doi-asserted-by":"crossref","unstructured":"Chen, Z.Y., Qi, C.Y., Feng, J., Xue, K., Quan, H.B., Zhou, J., Liu, W.Z., Lu, G.D., 2026. Escitalopram accelerated aging via impaired IIS\/autophagy signaling pathway. GeroScience. Advance online publication. https:\/\/doi.org\/10.1007\/s11357-026-02190-2.","DOI":"10.1007\/s11357-026-02190-2"},{"key":"10.1016\/j.ecoenv.2026.120897_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pharmtox-030220-013418","article-title":"Arsenic: a global environmental challenge","volume":"61","author":"Chen","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120897_bib7","article-title":"The significance of antioxidants and their cellular mechanisms that defend against oxidative stress: a review","volume":"10","author":"Dilshad","year":"2026","journal-title":"Res"},{"key":"10.1016\/j.ecoenv.2026.120897_bib8","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.3390\/antiox10111697","article-title":"Oleuropein enhances stress resistance and extends lifespan via insulin\/IGF-1 and SKN-1\/Nrf2 signaling pathway in Caenorhabditis elegans","volume":"10","author":"Feng","year":"2021","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2026.120897_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/cdd.2014.150","article-title":"Oxidative stress and autophagy: the clash between damage and metabolic needs","volume":"22","author":"Filomeni","year":"2015","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.ecoenv.2026.120897_bib10","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.ecoenv.2026.120897_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1474-9726.2005.00153.x","article-title":"In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans","volume":"4","author":"Gerstbrein","year":"2005","journal-title":"Aging Cell."},{"key":"10.1016\/j.ecoenv.2026.120897_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2020.03.002","article-title":"Arsenite-induced transgenerational glycometabolism is associated with up-regulation of H3K4me2 via inhibiting spr-5 in Caenorhabditis elegans","volume":"326","author":"Gu","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2026.120897_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2026.120897_bib14","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1080\/15548627.2024.2396793","article-title":"A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity","volume":"20","author":"Hofer","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120897_bib15","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11981","article-title":"Arsenic exposure and epigenetic aging: the association with cardiovascular disease and all-cause mortality in the Strong Heart Study","volume":"131","author":"Jiang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2026.120897_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature16483","article-title":"The C. elegans adult neuronal IIS\/FOXO transcriptome reveals adult phenotype regulators","volume":"529","author":"Kaletsky","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120897_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.109","article-title":"Mechanisms of aging-related proteinopathies in Caenorhabditis elegans","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ecoenv.2026.120897_bib18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.ecoenv.2026.120897_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jes.2020.12.016","article-title":"Reproductive toxicity and underlying mechanisms of di(2-ethylhexyl) phthalate in nematode Caenorhabditis elegans","volume":"105","author":"Li","year":"2021","journal-title":"J. Environ. Sci. (China)."},{"key":"10.1016\/j.ecoenv.2026.120897_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(03)00889-4","article-title":"Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan","volume":"115","author":"Libina","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120897_bib21","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/cells13161364","article-title":"Molecular mechanisms of autophagy decline during aging","volume":"13","author":"Lim","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2026.120897_bib22","doi-asserted-by":"crossref","first-page":"39273","DOI":"10.1007\/s11356-023-25675-5","article-title":"Caenorhabditis elegans: a model organism in the toxicity assessment of environmental pollutants","volume":"30","author":"Long","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2026.120897_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120897_bib24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jat.3927","article-title":"Transgenerational reproductive and developmental toxicity of tebuconazole in Caenorhabditis elegans","volume":"40","author":"Lu","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120897_bib25","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans","volume":"301","author":"Mel\u00e9ndez","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2026.120897_bib26","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120897_bib27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/382536a0","article-title":"A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans","volume":"382","author":"Morris","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120897_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature01789","article-title":"Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans","volume":"424","author":"Murphy","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2026.120897_bib29","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/ncomms3300","article-title":"Overexpression of Atg5 in mice activates autophagy and extends lifespan","volume":"4","author":"Pyo","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120897_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117940","article-title":"Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management","volume":"289","author":"Rahaman","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2026.120897_bib31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/biom5020545","article-title":"Oxidative stress in aging human skin","volume":"5","author":"Rinnerthaler","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2026.120897_bib32","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cmet.2012.04.007","article-title":"TOR signaling and rapamycin influence longevity by regulating SKN-1\/Nrf and DAF-16\/FoxO","volume":"15","author":"Robida-Stubbs","year":"2012","journal-title":"Cell. Metab."},{"key":"10.1016\/j.ecoenv.2026.120897_bib33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2026.120897_bib34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/cr.2011.200","article-title":"Autophagy is required for self-renewal and differentiation of adult human stem cells","volume":"22","author":"Salemi","year":"2012","journal-title":"Cell. Res."},{"key":"10.1016\/j.ecoenv.2026.120897_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ecoenv.2026.120897_bib36","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ecoenv.2026.120897_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111543","article-title":"Acrylamide inhibits autophagy, induces apoptosis and alters cellular metabolic profiles","volume":"208","author":"Song","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2026.120897_bib38","first-page":"1","article-title":"Caenorhabditis elegans, a biological model for research in toxicology","volume":"237","author":"Tejeda-Benitez","year":"2016","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2026.120897_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106871","article-title":"Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde","volume":"158","author":"van der Laan","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2026.120897_bib40","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/etc.5620091007","article-title":"Aquatic toxicity testing using the nematode, Caenorhabditis elegans","volume":"9","author":"Williams","year":"1990","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2026.120897_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102428","article-title":"Autophagy in aging-related diseases and cancer: principles, regulatory mechanisms and therapeutic potential","volume":"100","author":"Wu","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ecoenv.2026.120897_bib42","doi-asserted-by":"crossref","first-page":"11319","DOI":"10.1039\/D1FO02128A","article-title":"Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin\/IGF1 signaling pathway-mediated activation of autophagy","volume":"12","author":"Yang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2026.120897_bib43","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/15548627.2022.2105561","article-title":"Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity","volume":"19","author":"Yang","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2026.120897_bib44","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.chemosphere.2016.01.004","article-title":"Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16\/FOXO in Caenorhabditis elegans","volume":"150","author":"Yu","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2026.120897_bib45","doi-asserted-by":"crossref","first-page":"10673","DOI":"10.1021\/acs.est.6b02173","article-title":"Transgenerational reproductive effects of arsenite are associated with H3K4 dimethylation and SPR-5 downregulation in Caenorhabditis elegans","volume":"50","author":"Yu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2026.120897_bib46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10522-025-10322-y","article-title":"Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1\/PMK-1\/SKN-1 pathway","volume":"26","author":"Yu","year":"2025","journal-title":"Biogerontology"},{"key":"10.1016\/j.ecoenv.2026.120897_bib47","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1038\/s41467-023-40317-7","article-title":"Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging","volume":"14","author":"Yuan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2026.120897_bib48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/oemed-2012-101350","article-title":"Environmental and occupational exposure to chemicals and telomere length in human studies","volume":"70","author":"Zhang","year":"2013","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2026.120897_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126510","article-title":"Arsenic induces transgenerational behavior disorders in Caenorhabditis elegans and its underlying mechanisms","volume":"252","author":"Zhang","year":"2020","journal-title":"Chemosphere"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326012273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651326012273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:49:44Z","timestamp":1793630984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651326012273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":49,"alternative-id":["S0147651326012273"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120897","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium arsenite accelerates aging of Caenorhabditis elegans parents and offspring through the insulin signaling pathway, oxidative stress, and autophagy","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2026.120897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120897"}}