{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:33:34Z","timestamp":1786988014104,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.eimc.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T23:48:32Z","timestamp":1552520912000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Infecciones por Chlamydia trachomatis (incluye linfogranuloma ven\u00e9reo) y Mycoplasma genitalium"],"prefix":"10.1016","volume":"37","author":[{"given":"Luis","family":"Pi\u00f1eiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00ed","family":"Vall-Mayans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eimc.2019.01.014_bib0285","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1177\/0956462416648585","article-title":"2016 European guideline on the management of non-gonococcal urethritis","volume":"27","author":"Horner","year":"2016","journal-title":"Int J STD AIDS."},{"key":"10.1016\/j.eimc.2019.01.014_bib0290","first-page":"1","article-title":"Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski","year":"2015","journal-title":"MMWR Recomm Rep."},{"key":"10.1016\/j.eimc.2019.01.014_bib0295","unstructured":"World Health Organization. Report on global sexually transmitted infection surveillance \u2013 2015. 2016 [consultado 28 Feb 2019]. Disponible en: http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/249553\/9789241565301-eng.pdf;jsessionid=128F85D866C59142805D64C2B0F2AD0A?sequence=1"},{"key":"10.1016\/j.eimc.2019.01.014_bib0300","unstructured":"European Centre for Disease Prevention and Control. Chlamydia infection. En: ECDC. Annual epidemiological report for 2016. Stockholm: ECDC; 2018 [consultado 28 Feb 2019]. Disponible en: https:\/\/ecdc.europa.eu\/sites\/portal\/files\/documents\/AER_for_2016-chlamydia.pdf"},{"key":"10.1016\/j.eimc.2019.01.014_bib0305","unstructured":"Instituto de Salud Carlos III. Situaci\u00f3n de las Enfermedades de Declaraci\u00f3n Obligatoria. Espa\u00f1a. A\u00f1o 2016 [consultado 28 Feb 2019]. Disponible en: http:\/\/www.isciii.es\/ISCIII\/es\/contenidos\/fd-servicios-cientifico-tecnicos\/fd-vigilancias-alertas\/fd-enfermedades\/pdf_2019\/EDO2016_1.pdf"},{"key":"10.1016\/j.eimc.2019.01.014_bib0310","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s40064-016-2268-4","article-title":"Prevalence of Chlamydia trachomatis infection in parturient women in Gipuzkoa, Norther Spain","volume":"5","author":"Pi\u00f1eiro","year":"2016","journal-title":"SpringerPlus."},{"key":"10.1016\/j.eimc.2019.01.014_bib0315","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/1471-2334-13-388","article-title":"Prevalence of genital Chlamydia trachomatis infection among young men and women in Spain","volume":"13","author":"Fern\u00e1ndez-Ben\u00edtez","year":"2013","journal-title":"BMC Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0320","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s15010-014-0665-6","article-title":"Minimum spread of the new Swedish variant of Chlamydia trachomatis and distribution of C. trachomatis ompA genotypes in three geographically distant areas of Spain, 2011-2012","volume":"42","author":"Pi\u00f1eiro","year":"2014","journal-title":"Infection."},{"key":"10.1016\/j.eimc.2019.01.014_bib0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20220","article-title":"The natural history of Chlamydia trachomatis infection in women: A multi-parameter evidence synthesis","volume":"20","author":"Price","year":"2016","journal-title":"Health Technol Assess."},{"key":"10.1016\/j.eimc.2019.01.014_bib0330","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cmi.2018.01.025","article-title":"Chlamydia trachomatis genotypes A and B from urogenital specimens of patients in Spain: Molecular characterization","volume":"24","author":"Pi\u00f1eiro","year":"2018","journal-title":"Clin Microbiol Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0335","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/aje\/kws583","article-title":"Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model","volume":"178","author":"Price","year":"2013","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.eimc.2019.01.014_bib0340","first-page":"1","article-title":"Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections--2002","volume":"51","author":"Johnson","year":"2002","journal-title":"MMWR Recomm Rep."},{"key":"10.1016\/j.eimc.2019.01.014_bib0345","article-title":"Is the vertical transmission of Chlamydia trachomatis a little known problema in Spain?","author":"Pi\u00f1eiro","year":"2018","journal-title":"An Pediatr (Barc)."},{"key":"10.1016\/j.eimc.2019.01.014_bib0350","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/OLQ.0b013e31816ddb9a","article-title":"Cost-effectiveness of screening strategies for Chlamydia trachomatis using cervical swabs, urine, and self-obtained vaginal swabs in a sexually transmitted disease clinic setting","volume":"35","author":"Blake","year":"2008","journal-title":"Sex Transm Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0355","doi-asserted-by":"crossref","first-page":"e020394","DOI":"10.1136\/bmjopen-2017-020394","article-title":"Modelling-based evaluation of the costs, benefits and cost-effectiveness of multipathogen point-of-care tests for sexually transmitted infections in symptomatic genitourinary medicine clinic attendees","volume":"8","author":"Huntington","year":"2018","journal-title":"BMJ Open."},{"key":"10.1016\/j.eimc.2019.01.014_bib0360","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000314998","article-title":"Decreased susceptibility to azithromycin and doxycycline in clinical isolates of Chlamydia trachomatis obtained from recurrently infected female patients in India","volume":"56","author":"Bhengraj","year":"2010","journal-title":"Chemotherapy."},{"key":"10.1016\/j.eimc.2019.01.014_bib0365","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1128\/AAC.48.4.1347-1349.2004","article-title":"Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides","volume":"48","author":"Misyurina","year":"2004","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.eimc.2019.01.014_bib0370","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3892\/etm.2015.2595","article-title":"Differences in 23S ribosomal RNA mutations between wild-type and mutant macrolide-resistant Chlamydia trachomatis isolates","volume":"10","author":"Jiang","year":"2015","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.eimc.2019.01.014_bib0375","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2217\/fmb.10.96","article-title":"Antibiotic resistance in Chlamydiae","volume":"5","author":"Sandoz","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.eimc.2019.01.014_bib0380","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/07853890.2010.546365","article-title":"Chlamydia trachomatis infections of the female genital tract: State of the art","volume":"44","author":"Paavonen","year":"2012","journal-title":"Ann Med."},{"key":"10.1016\/j.eimc.2019.01.014_bib0385","first-page":"37","article-title":"Guidelines for evaluating prevalence studies","volume":"1","author":"Boyle","year":"1998","journal-title":"EBMH."},{"key":"10.1016\/j.eimc.2019.01.014_bib0390","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/sti.2005.019067","article-title":"Modelling the effectiveness of Chlamydia screening in England","volume":"82","author":"Turner","year":"2006","journal-title":"Sex Transm Infect."},{"issue":"10156","key":"10.1016\/j.eimc.2019.01.014_bib0395","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0140-6736(18)32465-6","article-title":"No benefit of chlamydia screening in primary care?","volume":"392","author":"Adamson","year":"2018","journal-title":"Lancet."},{"key":"10.1016\/j.eimc.2019.01.014_bib0400","doi-asserted-by":"crossref","unstructured":"Abrams A.J. Lymphogranuloma venereum.JAMA. 205 199 202 19682","DOI":"10.1001\/jama.1968.03140300017005"},{"key":"10.1016\/j.eimc.2019.01.014_bib0405","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/sti.79.6.453","article-title":"Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: Effective treatment with 1g azithromycin","volume":"79","author":"Nieuwenhuis","year":"2003","journal-title":"Sex Transm Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0410","first-page":"985","article-title":"Lymphogranuloma venereum among men who have sex with men--Netherlands, 2003-2004","volume":"53","year":"2004","journal-title":"MMWR."},{"key":"10.1016\/j.eimc.2019.01.014_bib0415","unstructured":"European Centre for Disease Prevention and Control. Lymphogranuloma venereum. En: ECDC. Annual epidemiological report for 2016. Stockholm: ECDC; 2018."},{"key":"10.1016\/j.eimc.2019.01.014_bib0420","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1469-0691.12256","article-title":"Clinical and epidemiological characterization of a lymphogranuloma venereum outbreak in Madrid, Spain: co-circulation of two variants","volume":"20","author":"Rodr\u00edguez-Dom\u00ednguez","year":"2014","journal-title":"Clin Microbiol Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0425","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3201\/eid2211.160247","article-title":"Changing pattern of Chlamydia trachomatis strains in lymphogranuloma venereum outbreak, France, 2010-2015","volume":"22","author":"Peuchant","year":"2016","journal-title":"Emerg Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0430","first-page":"3317","article-title":"Lymphogranuloma venereum proctosigmoiditis is a mimicker of inflammatory bowel disease","volume":"18","author":"Gallegos","year":"2012","journal-title":"World J Gastroenterol."},{"key":"10.1016\/j.eimc.2019.01.014_bib0435","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1586\/14787210.2014.901169","article-title":"Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review","volume":"12","author":"De Vrieze","year":"2014","journal-title":"Expert Rev Anti Infect Ther."},{"key":"10.1016\/j.eimc.2019.01.014_bib0440","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1056\/NEJM198107233050404","article-title":"Chlamydia trachomatis proctitis","volume":"305","author":"Quinn","year":"1981","journal-title":"N Engl J Med."},{"key":"10.1016\/j.eimc.2019.01.014_bib0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2016.03.018","article-title":"The L2b real-time PCR targeting the pmpH gene of Chlamydia trachomatis used for the diagnosis of lymphogranuloma venereum is not specific to L2b strains","volume":"22","author":"Touati","year":"2016","journal-title":"Clin Microbiol Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0450","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3201\/eid2404.171872","article-title":"Chlamydia trachomatis in cervical lymph node of man with lymphogranuloma venereum, Croatia, 2014(1)","volume":"24","author":"Gjura\u0161in","year":"2018","journal-title":"Emerg Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0455","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3201\/eid1108.050535","article-title":"Real-time polymerase chain reaction to diagnose lymphogranuloma venereum","volume":"11","author":"Morr\u00e9","year":"2005","journal-title":"Emerg Infect Dis."},{"issue":"Suppl 3","key":"10.1016\/j.eimc.2019.01.014_bib0460","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1086\/511427","article-title":"Treatment of lymphogranuloma venereum","volume":"44","author":"McLean","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eimc.2019.01.014_bib0465","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1086\/597011","article-title":"Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment","volume":"48","author":"De Vries","year":"2009","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0470","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1056\/NEJMoa1502599","article-title":"Azithromycin versus doxycycline for Urogenital Chlamydia trachomatis Infection","volume":"373","author":"Geisler","year":"2015","journal-title":"N Engl J Med."},{"key":"10.1016\/j.eimc.2019.01.014_bib0475","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/OLQ.0000000000000772","article-title":"Observed treatment responses to short-course doxycycline therapy for rectal lymphogranuloma venereum in men who have sex with men","volume":"45","author":"Simons","year":"2018","journal-title":"Sex Transm Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0480","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0956462413501158","article-title":"Bubonic lymphogranuloma venereum with multidrug treatment failure","volume":"25","author":"Vall-Mayans","year":"2014","journal-title":"Int J STD AIDS."},{"key":"10.1016\/j.eimc.2019.01.014_bib0485","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1017\/S0950268816000996","article-title":"Higher organism load associated with failure of azithromycin to treat rectal chlamydia","volume":"144","author":"Kong","year":"2016","journal-title":"Epidemiol Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0490","unstructured":"European Centre for Disease Prevention and Control. Chlamydia control in Europe: Literature review. Stockholm: ECDC; 2014."},{"key":"10.1016\/j.eimc.2019.01.014_bib0495","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/CMR.00006-11","article-title":"Mycoplasma genitalium: From Chrysalis to multicolored butterfly","volume":"24","author":"Taylor-Robinson","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.eimc.2019.01.014_bib0500","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/jdv.13849","article-title":"European guideline on Mycoplasma genitalium infections","volume":"30","author":"Jensen","year":"2016","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"10.1016\/j.eimc.2019.01.014_bib0505","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/cid\/cix853","article-title":"High prevalence of multidrug-resistant Mycoplasma genitalium in human immunodeficiency virus-infected men who have sex with men in Alabama","volume":"66","author":"Dionne-Odom","year":"2018","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0510","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/OLQ.0000000000000631","article-title":"Mycoplasma genitalium macrolide and fluoroquinolone resistance: Prevalence and risk factors among a 2013-2014 cohort of patients in Barcelona, Spain","volume":"44","author":"Barber\u00e0","year":"2017","journal-title":"Sex Transm Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0515","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.eimc.2017.01.006","article-title":"Mycoplasma genitalium in Spain: Prevalence of genital infection and frequency of resistance to macrolides","volume":"36","author":"Asenjo","year":"2018","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"10.1016\/j.eimc.2019.01.014_bib0520","article-title":"Guided antibiotic therapy for Mycoplasma genitalium infections: Analysis of mutations associated with resistance to macrolides and fluoroquinolones","author":"Pi\u00f1eiro","year":"2018","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"10.1016\/j.eimc.2019.01.014_bib0525","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Huerta M, Barber\u00e1 MJ, Esperalba J, \u00c1lvarez-Zaragoza MA, Arellano E, Linas M, et al. Prevalence of Mycoplasma genitalium infection among asymptomatic people with sexual risk behaviours; screen or not to screen. 2018 IUSTI World and European Congress (abstract 275). Dublin, 27-30 June 2018.","DOI":"10.26226\/morressier.5af060641dd164001d5ef4a1"},{"key":"10.1016\/j.eimc.2019.01.014_bib0530","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmi.2015.11.016","article-title":"The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men","volume":"22","author":"Bissessor","year":"2016","journal-title":"Clin Microbiol Infect."},{"key":"10.1016\/j.eimc.2019.01.014_bib0535","doi-asserted-by":"crossref","first-page":"e0156740","DOI":"10.1371\/journal.pone.0156740","article-title":"Multiplex assay for simultaneous detection of Mycoplasma genitalium and macrolide resistance using PlexZyme and PlexPrime technology","volume":"11","author":"Tabrizi","year":"2016","journal-title":"PLoS One."},{"key":"10.1016\/j.eimc.2019.01.014_bib0540","unstructured":"Australian STI Management guidelines [consultado 28 Feb 2019]. Disponible en: http:\/\/www.sti.guidelines.org.au\/sexually-transmissible-infections\/mycoplasma-genitalium#diagnosis"},{"key":"10.1016\/j.eimc.2019.01.014_bib0545","unstructured":"SEIMC. Documento de consenso sobre diagn\u00f3stico y tratamiento de las infecciones de transmisi\u00f3n sexual en adultos, ni\u00f1os y adolescentes (marzo 2017) [consultado 28 Feb 2019]. Disponible en: http:\/\/www.seimc.org\/contenidos\/gruposdeestudio\/gesida\/dcientificos\/documentos\/2017\/gesida-guiasclinicas-ITS-201703.pdf"},{"key":"10.1016\/j.eimc.2019.01.014_bib0550","doi-asserted-by":"crossref","first-page":"16162","DOI":"10.1038\/s41598-017-16302-8","article-title":"Should we screen for the sexually-transmitted infection Mycoplasma genitalium? Evidence synthesis using a transmission-dynamic model","volume":"7","author":"Birger","year":"2017","journal-title":"Sci Rep."},{"issue":"Suppl.2","key":"10.1016\/j.eimc.2019.01.014_bib0555","article-title":"Developing a public health response to Mycoplasma genitalium","volume":"216","author":"Golden","year":"2017","journal-title":"J Infect Dis."},{"key":"10.1016\/j.eimc.2019.01.014_bib0560","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1473-3099(18)30080-X","article-title":"Syndromic management of STIs and the threat of untreatable Mycoplasma genitalium","volume":"18","author":"Bradshaw","year":"2018","journal-title":"Lancet Infect Dis."}],"container-title":["Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213005X19301314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213005X19301314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:05:22Z","timestamp":1759323922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0213005X19301314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0213005X19301314"],"URL":"https:\/\/doi.org\/10.1016\/j.eimc.2019.01.014","relation":{},"ISSN":["0213-005X"],"issn-type":[{"value":"0213-005X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infecciones por Chlamydia trachomatis (incluye linfogranuloma ven\u00e9reo) y Mycoplasma genitalium","name":"articletitle","label":"Article Title"},{"value":"Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eimc.2019.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Espa\u00f1a, S.L.U. and Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica. All rights reserved.","name":"copyright","label":"Copyright"}]}}