{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:12:07Z","timestamp":1772115127109,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.eimc.2019.10.006","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T10:22:11Z","timestamp":1576491731000},"page":"219-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased HIV infection in patients with stroke in Spain. A 16-year population-based study"],"prefix":"10.1016","volume":"38","author":[{"given":"Enric","family":"Monreal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gull\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"P\u00e9rez-Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Escobar-Villalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Acebron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Quereda Rodr\u00edguez-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"S\u00e1nchez-Ruano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja M.","family":"Fern\u00e1ndez-F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"P\u00e9rez-El\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Masjuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cd\u00f1igo","family":"Corral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eimc.2019.10.006_bib0155","series-title":"2017 Fact Sheet for HIV\/AIDS","author":"World Health Organization","year":"2017"},{"key":"10.1016\/j.eimc.2019.10.006_bib0160","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1097\/00002030-200409030-00010","article-title":"Cardio- and cerebrovascular events in HIV-infected persons","volume":"18","author":"d\u2019Arminio","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.eimc.2019.10.006_bib0165","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMoa030218","article-title":"Combination antiretroviral therapy and the risk of myocardial infarction","volume":"349","author":"Friis-M\u00f8ller","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eimc.2019.10.006_bib0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.STR.0000105393.57853.11","article-title":"Acquired immunodeficiency syndrome and the risk of stroke","volume":"35","author":"Cole","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.eimc.2019.10.006_bib0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/QAI.0b013e31825c7f24","article-title":"Comparison of ischemic stroke incidence in HIV-infected and non-HIV-infected patients in a US health care system","volume":"60","author":"Chow","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.eimc.2019.10.006_bib0180","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1212\/WNL.0b013e31820a0cfc","article-title":"Increasing incidence of ischemic stroke in patients with HIV infection","volume":"76","author":"Ovbiagele","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.eimc.2019.10.006_bib0185","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/QAD.0b013e3283493fb0","article-title":"Risk of cerebrovascular events in persons with and without HIV: a Danish nationwide population-based cohort study","volume":"25","author":"Rasmussen","year":"2011","journal-title":"AIDS"},{"key":"10.1016\/j.eimc.2019.10.006_bib0190","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00126334-200308010-00012","article-title":"Coronary heart disease in HIV-infected individuals","volume":"33","author":"Currier","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.eimc.2019.10.006_bib0195","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/00002030-200311210-00010","article-title":"Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men","volume":"17","author":"Mary-Krause","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.eimc.2019.10.006_bib0200","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/S0149-2918(03)80283-7","article-title":"An open-label, prospective, observational study of the incidence of coronary artery disease in patients with HIV infection receiving highly active antiretroviral therapy","volume":"25","author":"Barbaro","year":"2003","journal-title":"Clin Ther"},{"key":"10.1016\/j.eimc.2019.10.006_bib0205","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(02)11672-2","article-title":"Protease inhibitors and cardiovascular outcomes in patients with HIV-1","volume":"360","author":"Holmberg","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.eimc.2019.10.006_bib0210","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMoa030218","article-title":"Combination antiretroviral therapy and the risk of myocardial infarction","volume":"349","author":"Friis-M\u00f8ller","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eimc.2019.10.006_bib0215","doi-asserted-by":"crossref","first-page":"e59551","DOI":"10.1371\/journal.pone.0059551","article-title":"Risk of cardiovascular disease from antiretroviral therapy for HIV: a systematic review","volume":"8","author":"Bavinger","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.eimc.2019.10.006_bib0220","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1056\/NEJMoa022048","article-title":"Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection","volume":"348","author":"Bozzette","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eimc.2019.10.006_bib0225","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00126334-200208150-00002","article-title":"Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection","volume":"30","author":"Klein","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.eimc.2019.10.006_bib0230","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/088922203766774487","article-title":"Incidence of myocardial infarction in randomized clinical trials of protease inhibitor-based antiretroviral therapy: an analysis of four different protease inhibitors","volume":"19","author":"Coplan","year":"2003","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1016\/j.eimc.2019.10.006_bib0235","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/QAI.0b013e31826f993c","article-title":"No association of abacavir use with myocardial infarction: findings of an FDA meta-analysis","volume":"61","author":"Ding","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.eimc.2019.10.006_bib0240","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/cid\/ciq244","article-title":"No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001\/ALLRT","volume":"52","author":"Ribaudo","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eimc.2019.10.006_bib0245","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/QAI.0b013e31819ff0e6","article-title":"Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-Sponsored Clinical Trials in adult subjects","volume":"51","author":"Brothers","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.eimc.2019.10.006_bib0250","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1159\/000214219","article-title":"Cerebrovascular ischemic events in HIV-1-infected patients receiving highly active antiretroviral therapy: incidence and risk factors","volume":"27","author":"Corral","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.eimc.2019.10.006_bib0255","unstructured":"Ministerio de Sanidad, Servicios Sociales e Igualdad [Internet]. Madrid: Gobierno de Espa\u00f1a; 2011. Available at: https:\/\/www.msssi.gob.es\/en\/estadEstudios\/estadisticas\/cmbd\/informes\/home.htm [last update 13.12.17; accessed at 15.12.17]"},{"key":"10.1016\/j.eimc.2019.10.006_bib0260","unstructured":"Ministerio de Sanidad, Servicios Sociales e Igualdad [Internet]. Madrid: Gobierno de Espa\u00f1a; 2011. Available at: https:\/\/www.mscbs.gob.es\/ciudadanos\/enfLesiones\/enfTransmisibles\/sida\/vigilancia\/home.htm [last update 30.06.17; accessed at 15.12.17]."},{"key":"10.1016\/j.eimc.2019.10.006_bib0265","unstructured":"Ministerio de Sanidad, Servicios Sociales e Igualdad [Internet]. Madrid: Gobierno de Espa\u00f1a; 2011. Available at: http:\/\/www.boe.es\/boe\/dias\/2015\/03\/17\/pdfs\/BOE-A-2015-2837.pdf [last update 17.03.15; accessed at 15.12.17]."},{"key":"10.1016\/j.eimc.2019.10.006_bib0270","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/00002030-199912240-00002","article-title":"Fat distribution and metabolic changes in patients with HIV infection","volume":"13","author":"Safrin","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.eimc.2019.10.006_bib0275","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.eimc.2019.10.006_bib0280","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jmv.1890470411","article-title":"Productive HIV-1 infection of human vascular endothelial cells requires cell proliferation and is stimulated by combined treatment","volume":"47","author":"Conaldi","year":"1995","journal-title":"J Med Virol"},{"key":"10.1016\/j.eimc.2019.10.006_bib0285","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body-fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eimc.2019.10.006_bib0290","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1189\/jlb.0206113","article-title":"Human immunodeficiency virus infection and macrophage cholesterol metabolism","volume":"80","author":"Bukrinsky","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.eimc.2019.10.006_bib0295","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1136\/jnnp.2007.116103","article-title":"Stroke in patients with human immunodeficiency virus infection","volume":"78","author":"Tipping","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.eimc.2019.10.006_bib0300","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.nrl.2014.12.007","article-title":"Reliability of the minimum basic dataset for diagnoses of cerebrovascular disease","volume":"32","author":"Hern\u00e1ndez Medrano","year":"2017","journal-title":"Neurologia"}],"container-title":["Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213005X19302964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213005X19302964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:06:12Z","timestamp":1759323972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0213005X19302964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0213005X19302964"],"URL":"https:\/\/doi.org\/10.1016\/j.eimc.2019.10.006","relation":{},"ISSN":["0213-005X"],"issn-type":[{"value":"0213-005X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased HIV infection in patients with stroke in Spain. A 16-year population-based study","name":"articletitle","label":"Article Title"},{"value":"Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eimc.2019.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Espa\u00f1a, S.L.U. and Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica. All rights reserved.","name":"copyright","label":"Copyright"}]}}