{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:16:39Z","timestamp":1772151399610,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enfermedades infecciosas y microbiologia clinica (English ed.)"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.eimce.2026.503030","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:38:35Z","timestamp":1770309515000},"page":"503030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tecovirimat hepatotoxicity in a man with Mpox infection"],"prefix":"10.1016","volume":"44","author":[{"given":"Diana","family":"Ruiz-Cabrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"S\u00e1ez-Pe\u00f1ataro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Riera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Manuel","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"L\u00f3pez-Su\u00f1\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"L\u00f3pez-Pont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Martinez-Ill\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Catala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Tuset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Fuertes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Forns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eimce.2026.503030_bib0105","series-title":"Mpox in the United States and Around the World: Current Situation","year":"2025"},{"key":"10.1016\/j.eimce.2026.503030_bib0110","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/jama.2024.21091","article-title":"Mpox clinical presentation, diagnostic approaches, and treatment strategies. A review","volume":"332","author":"Titanji","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.eimce.2026.503030_bib0115","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofae105","article-title":"Clinical and epidemiological characteristics of the 2022 Mpox outbreak in Spain (CEME-22 Study)","volume":"11","author":"Ram\u00edrez-Olivencia","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00705-023-05808-4","article-title":"A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus","volume":"168","author":"Chenchua","year":"2023","journal-title":"Arch Virol"},{"key":"10.1016\/j.eimce.2026.503030_bib0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/infdis\/jiad034","article-title":"Clinical features, antiviral treatment, and patient outcomes: a systematic review and comparative analysis of the previous and the 2022 Mpox outbreaks","volume":"228","author":"Li","year":"2023","journal-title":"J Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0130","article-title":"Therapeutics for treating mpox in humans","volume":"3","author":"Fox","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.eimce.2026.503030_bib0135","series-title":"FDA Approves the First Drug with an Indication for Treatment of Smallpox","year":"2018"},{"key":"10.1016\/j.eimce.2026.503030_bib0140","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/cid\/ciac622","article-title":"Antivirals with activity against mpox: a clinically oriented review","volume":"76","author":"Siegrist","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0145","series-title":"Tecovirimat SIGA (tecovirimat). EMA\/44982\/2022","year":"2022"},{"key":"10.1016\/j.eimce.2026.503030_bib0150","series-title":"The Antiviral Tecovirimat is Safe but did not Improve Clade I Mpox Resolution in the Democratic Republic of the Congo","year":"2024"},{"key":"10.1016\/j.eimce.2026.503030_bib0155","series-title":"NIH Study Finds Tecovirimat was Safe but did not Improve Mpox Resolution or Pain","year":"2024"},{"key":"10.1016\/j.eimce.2026.503030_bib0160","series-title":"Presented at: Conference on Retroviruses and Opportunistic Infections, March 12, San Francisco, CA","article-title":"Tecovirimat is safe but not efficacious in people with clade II Mpox","author":"Wilkin","year":"2025"},{"key":"10.1016\/j.eimce.2026.503030_bib0165","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2400189","article-title":"Tecovirimat use under expanded access to treat mpox in the United States, 2022\u20132023","volume":"3","author":"Yu","year":"2024","journal-title":"NEJM Evid"},{"key":"10.1016\/j.eimce.2026.503030_bib0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12879-024-09000-0","article-title":"Monkeypox virus-associated meningoencephalitis diagnosed by detection of intrathecal antibody production","volume":"24","author":"Hansen","year":"2024","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0175","series-title":"European Assessment Report of Tecovirimat","year":"2025"},{"key":"10.1016\/j.eimce.2026.503030_bib0180","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.15585\/mmwr.mm7137e1","article-title":"Clinical use of tecovirimat (Tpoxx) for treatment of Monkeypox under an investigational new drug protocol \u2013 United States, May\u2013August 2022","volume":"71","author":"O\u2019Laughlin","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.eimce.2026.503030_bib0185","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S1473-3099(22)00228-6","article-title":"Clinical features and management of human monkeypox: a retrospective observational study in the UK","volume":"22","author":"Adler","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0190","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1186\/s12879-024-09884-y","article-title":"Multi-organ clinical manifestations of Mpox: an umbrella review of systematic reviews","volume":"24","author":"Satapathy","year":"2024","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.eimce.2026.503030_bib0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijms17010014","article-title":"RUCAM in drug and herb induced liver injury: the update","volume":"17","author":"Danan","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.eimce.2026.503030_bib0200","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug-induced liver injury","volume":"70","year":"2019","journal-title":"J Hepatol"}],"container-title":["Enfermedades infecciosas y microbiologia clinica (English ed.)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2529993X26000043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2529993X26000043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:39:21Z","timestamp":1770309561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2529993X26000043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2529993X26000043"],"URL":"https:\/\/doi.org\/10.1016\/j.eimce.2026.503030","relation":{},"ISSN":["2529-993X"],"issn-type":[{"value":"2529-993X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tecovirimat hepatotoxicity in a man with Mpox infection","name":"articletitle","label":"Article Title"},{"value":"Enfermedades infecciosas y microbiologia clinica (English ed.)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eimce.2026.503030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"503030"}}